Faramarz Ismail-Beigi

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. doi request reprint Determinants of successful glycemic control among participants in the BARI 2D trial: a post-hoc analysis
    Faramarz Ismail-Beigi
    Department of Medicine, Case Western Reserve University and Cleveland VA Medical Center, Cleveland, OH, USA Electronic address
    J Diabetes Complications 28:101-9. 2014
  2. doi request reprint Combined intensive blood pressure and glycemic control does not produce an additive benefit on microvascular outcomes in type 2 diabetic patients
    Faramarz Ismail-Beigi
    Case Western Reserve University, and Cleveland VA Medical Center, Cleveland, Ohio 44106 4951, USA
    Kidney Int 81:586-94. 2012
  3. ncbi request reprint Metabolic programming: fetal origins of obesity and metabolic syndrome in the adult
    Faramarz Ismail-Beigi
    Dept of Medicine, Cleveland Diabetes Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Am J Physiol Endocrinol Metab 291:E439-40. 2006
  4. doi request reprint Individualizing glycemic targets in type 2 diabetes mellitus: implications of recent clinical trials
    Faramarz Ismail-Beigi
    Case Western Reserve University, Cleveland, OH, USA
    Ann Intern Med 154:554-9. 2011
  5. doi request reprint Pathogenesis and glycemic management of type 2 diabetes mellitus: a physiological approach
    Faramarz Ismail-Beigi
    Departments of Medicine and Biochemistry, Case Western Reserve University, Cleveland, OH 44106 4951, USA
    Arch Iran Med 15:239-46. 2012
  6. pmc Supramolecular protein engineering: design of zinc-stapled insulin hexamers as a long acting depot
    Nelson B Phillips
    Department of Biochemistry, Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Biol Chem 285:11755-9. 2010
  7. pmc Hyperglycemia-induced stimulation of glucose transport in skeletal muscle measured by PET-[18F]6FDG and [18F]2FDG
    Hsuan Ming Huang
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA
    Physiol Meas 33:1661-73. 2012
  8. doi request reprint Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial
    Faramarz Ismail-Beigi
    Department of Medicine, Division of Clinical and Molecular Endocrinology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4951, USA
    Lancet 376:419-30. 2010
  9. pmc Insulin fibrillation and protein design: topological resistance of single-chain analogs to thermal degradation with application to a pump reservoir
    Nelson B Phillips
    Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Diabetes Sci Technol 6:277-88. 2012
  10. pmc An Achilles' heel in an amyloidogenic protein and its repair: insulin fibrillation and therapeutic design
    Yanwu Yang
    From the Departments of Biochemistry Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 285:10806-21. 2010

Detail Information

Publications25

  1. doi request reprint Determinants of successful glycemic control among participants in the BARI 2D trial: a post-hoc analysis
    Faramarz Ismail-Beigi
    Department of Medicine, Case Western Reserve University and Cleveland VA Medical Center, Cleveland, OH, USA Electronic address
    J Diabetes Complications 28:101-9. 2014
    ..In this analysis we examine baseline characteristics that are associated with successful long-term glycemic control...
  2. doi request reprint Combined intensive blood pressure and glycemic control does not produce an additive benefit on microvascular outcomes in type 2 diabetic patients
    Faramarz Ismail-Beigi
    Case Western Reserve University, and Cleveland VA Medical Center, Cleveland, Ohio 44106 4951, USA
    Kidney Int 81:586-94. 2012
    ..None of the outcomes were significantly reduced by simultaneous intensive treatment of glycemia and blood pressure, signifying the lack of an additional beneficial effect from combined treatment...
  3. ncbi request reprint Metabolic programming: fetal origins of obesity and metabolic syndrome in the adult
    Faramarz Ismail-Beigi
    Dept of Medicine, Cleveland Diabetes Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Am J Physiol Endocrinol Metab 291:E439-40. 2006
    ..Importantly, these attributes can be passed on to the next generation nongenetically and can be reversed and prevented...
  4. doi request reprint Individualizing glycemic targets in type 2 diabetes mellitus: implications of recent clinical trials
    Faramarz Ismail-Beigi
    Case Western Reserve University, Cleveland, OH, USA
    Ann Intern Med 154:554-9. 2011
    ..This review explores these issues further and proposes a framework for considering an appropriate and safe HbA(1c) target range for each patient...
  5. doi request reprint Pathogenesis and glycemic management of type 2 diabetes mellitus: a physiological approach
    Faramarz Ismail-Beigi
    Departments of Medicine and Biochemistry, Case Western Reserve University, Cleveland, OH 44106 4951, USA
    Arch Iran Med 15:239-46. 2012
    ....
  6. pmc Supramolecular protein engineering: design of zinc-stapled insulin hexamers as a long acting depot
    Nelson B Phillips
    Department of Biochemistry, Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Biol Chem 285:11755-9. 2010
    ..Zinc stapling provides a general strategy to modify the pharmacokinetic and biological properties of a subcutaneous protein depot...
  7. pmc Hyperglycemia-induced stimulation of glucose transport in skeletal muscle measured by PET-[18F]6FDG and [18F]2FDG
    Hsuan Ming Huang
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA
    Physiol Meas 33:1661-73. 2012
    ..Moreover, based on differences in the TAC shapes, [18F]6FDG appears to be superior to [18F]2FDG for evaluating the effect of hyperglycemia on glucose metabolism in skeletal muscle...
  8. doi request reprint Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial
    Faramarz Ismail-Beigi
    Department of Medicine, Division of Clinical and Molecular Endocrinology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4951, USA
    Lancet 376:419-30. 2010
    ..We investigated whether reduction of blood glucose concentration decreases the rate of microvascular complications in people with type 2 diabetes...
  9. pmc Insulin fibrillation and protein design: topological resistance of single-chain analogs to thermal degradation with application to a pump reservoir
    Nelson B Phillips
    Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Diabetes Sci Technol 6:277-88. 2012
    ..Our findings suggest that ultrastable monomeric SCI analogs may be formulated without protective self-assembly and so permit simultaneous optimization of pharmacokinetics and reservoir life...
  10. pmc An Achilles' heel in an amyloidogenic protein and its repair: insulin fibrillation and therapeutic design
    Yanwu Yang
    From the Departments of Biochemistry Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 285:10806-21. 2010
    ..Together, our studies define an "Achilles' heel" in a globular protein whose repair may enhance the stability of pharmaceutical formulations and broaden their therapeutic deployment in the developing world...
  11. pmc α-Helical element at the hormone-binding surface of the insulin receptor functions as a signaling element to activate its tyrosine kinase
    Jonathan Whittaker
    Department of Biochemistry, Case Western Reserve University, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 109:11166-71. 2012
    ..Taken together, these results suggest that αCT, in addition to its hormone-recognition role, provides a signaling element in the mechanism of receptor activation...
  12. pmc The renal transcriptome of db/db mice identifies putative urinary biomarker proteins in patients with type 2 diabetes: a pilot study
    Michael S Simonson
    Case Western Reserve University, 2109 Adelbert Rd, Cleveland, OH 44106, USA
    Am J Physiol Renal Physiol 302:F820-9. 2012
    ..These results suggest that gene expression profiling in diabetic mouse kidney can complement existing proteomic-based approaches for renal biomarker discovery in humans...
  13. doi request reprint Comparisons of different insulin infusion protocols: a review of recent literature
    Armand Krikorian
    Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Curr Opin Clin Nutr Metab Care 13:198-204. 2010
    ..To provide an update on the currently available insulin infusion protocols for treatment of hyperglycemia in critically ill patients and to discuss the major differences and similarities among them...
  14. pmc A new Michaelis-Menten-based kinetic model for transport and phosphorylation of glucose and its analogs in skeletal muscle
    Hsuan Ming Huang
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Med Phys 38:4587-99. 2011
    ..A new model is introduced that individually resolves the delivery, transport, and phosphorylation steps of metabolism of glucose and its analogs in skeletal muscle by interpreting dynamic positron emission tomography (PET) data...
  15. doi request reprint Hypoglycemia: minimizing its impact in type 2 diabetes
    Etie Moghissi
    Department of Medicine, University of California, Marina del Rey, California 90292, USA
    Endocr Pract 19:526-35. 2013
    ..To review and discuss the risks and impact of hypoglycemia and provide guidance for the prevention of hypoglycemia in type 2 diabetes (T2DM)...
  16. doi request reprint Effect of dexamethasone on insulin secretion: examination of underlying mechanisms
    Ajay Sood
    Division of Clinical and Molecular Endocrinology, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Endocr Pract 16:763-9. 2010
    ..To study the mechanism of increased insulin secretion in response to short-term administration of dexamethasone...
  17. pmc A controlled trial of CPAP therapy on metabolic control in individuals with impaired glucose tolerance and sleep apnea
    Tanya G Weinstock
    Department of Medicine, Brigham and Women s Hospital and Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Sleep 35:617-625B. 2012
    ..To address whether treatment of sleep apnea improves glucose tolerance...
  18. pmc Use of insulin sensitizers for the treatment of major depressive disorder: a pilot study of pioglitazone for major depression accompanied by abdominal obesity
    David E Kemp
    Case Western Reserve University, University Hospitals Case Medical Center, Department of Psychiatry, Cleveland, OH 44106, USA
    J Affect Disord 136:1164-73. 2012
    ..This study was conducted to examine the safety and efficacy of pioglitazone, a thiazolidinedione insulin sensitizer, in adult outpatients with major depressive disorder...
  19. doi request reprint Preservation of beta-cell function in type 2 diabetes
    Kavita Nyalakonda
    Department of Medicine, Case Western Reserve University, Cleveland, OH, USA
    Endocr Pract 16:1038-55. 2010
    ..To review available data on preservation and potential improvement of beta-cell function in patients with type 2 diabetes mellitus (T2DM) with use of currently available strategies and agents...
  20. doi request reprint Effect of dexamethasone on oral glucose tolerance in healthy adults
    Dima Abdelmannan
    Department of Clinical and Molecular Endocrinology, Case Western Reserve University, Cleveland VA Medical Center, Cleveland, Ohio 44106 4951, USA
    Endocr Pract 16:770-7. 2010
    ..To determine the dose-response and time course of action of a single dose of dexamethasone on plasma glucose and insulin dynamics in healthy adults...
  21. pmc Effect of thiazolidinediones and insulin on cognitive outcomes in ACCORD-MIND
    Elizabeth R Seaquist
    Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA Electronic address
    J Diabetes Complications 27:485-91. 2013
    ..To examine the relationship of cognitive performance to exposure to insulin (INS) and thiazolidinediones (TZD) in the ACCORD-MIND cohort...
  22. pmc Near-Normalization of Glucose and Microvascular Diabetes Complications: Data from ACCORD and ADVANCE
    PATRICK J O'CONNOR
    Case Western Reserve School of Medicine, Cleveland, OH, USA
    Ther Adv Endocrinol Metab 2:17-26. 2011
    ..To compare results of clinical trials that assessed the impact of near-normalization of glucose on microvascular complications in type 2 diabetes...
  23. ncbi request reprint Glycemia management and cardiovascular risk in type 2 diabetes: an evolving perspective
    Faramarz Ismail-Beigi
    Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4951, USA
    Endocr Pract 14:639-43. 2008
    ....
  24. pmc Design of an insulin analog with enhanced receptor binding selectivity: rationale, structure, and therapeutic implications
    Ming Zhao
    Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 284:32178-87. 2009
    ..Future development of clinical analogs lacking significant IGFR cross-binding may enhance the safety of insulin replacement therapy in patients with type 2 diabetes mellitus at increased risk of colorectal cancer...
  25. pmc Analysis of metabolism of 6FDG: a PET glucose transport tracer
    Raymond F Muzic
    Department of Radiology, Case Western Reserve University, Cleveland, OH 44106, USA
    Nucl Med Biol 38:667-74. 2011
    ..Herein the focus is to determine whether, and the degree to which, [(18)F]6FDG remains unchanged following intravenous injection...