Research Topics
Genomes and GenesSpecies | Patricia A HuntSummaryAffiliation: Case Western Reserve University Country: USA Publications
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Detail Information
Publications
Sex matters in meiosisPatricia A Hunt
Department of Genetics, Case Western Reserve University, Cleveland, OH 44106 4955, USA
Science 296:2181-3. 2002..This female "robustness" comes with a cost, however, because aneuploidy appears to be increased in the resultant oocytes...- Bisphenol a exposure causes meiotic aneuploidy in the female mousePatricia A Hunt
Department of Genetics, Case Western Reserve University, Cleveland, OH 44106 4955, USA
Curr Biol 13:546-53. 2003.... 
Bisphenol A exposure in utero disrupts early oogenesis in the mouseMartha Susiarjo
Department of Genetics, Case Western Reserve University, Cleveland, Ohio, United States of America
PLoS Genet 3:e5. 2007..This raises concern that brief exposures during fetal development to substances that mimic or antagonize the effects of estrogen may adversely influence oocyte development in the exposed female fetus...- Genetic control of mammalian meiotic recombination. I. Variation in exchange frequencies among males from inbred mouse strainsKara E Koehler
Department of Genetics and Center for Human Genetics, Case Western Reserve University School of Medicine and the University Hospitals of Cleveland, Cleveland, Ohio 44106-4955, USA
Genetics 162:297-306. 2002..1%. Thus, special mechanisms that segregate achiasmate chromosomes are unlikely to be an important component of mammalian male meiosis... - SMC1beta-deficient female mice provide evidence that cohesins are a missing link in age-related nondisjunctionCraig A Hodges
Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106, USA
Nat Genet 37:1351-5. 2005..Additionally, our observations support the hypothesis that deficient cohesion is an underlying cause of human age-related aneuploidy... - The Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosisSheila M Cherry
Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106, USA
Curr Biol 17:373-8. 2007..Thus, our findings implicate the Mre11 complex in meiotic DNA repair and synapsis in mammals and indicate that the complex may contribute to the establishment of normal sex-specific differences in meiosis... - Cisplatin disrupts mammalian spermatogenesis, but does not affect recombination or chromosome segregationSheila M Cherry
Department of Genetics and Center for Human Genetics, Case Western Reserve University, University Hospitals of Cleveland, OH 44106-4955, USA
Mutat Res 564:115-28. 2004..Unexpectedly, however, no obvious effect on genome-wide recombination levels in CP-treated animals was observed, nor was the level of aneuploidy increased in sperm from exposed males... - Simultaneous analysis of chromosomes and chromosome-associated proteins in mammalian oocytes and embryosCraig A Hodges
Department of Genetics, Case Western Reserve University, Cleveland, Ohio, USA
Chromosoma 111:165-9. 2002.... - Sex-specific differences in meiotic chromosome segregation revealed by dicentric bridge resolution in miceKara E Koehler
Department of Genetics and the Center for Human Genetics, Case Western Reserve University and the University Hospitals of Cleveland, Ohio 44106 4955, USA
Genetics 162:1367-79. 2002.... - Covariation of synaptonemal complex length and mammalian meiotic exchange ratesAudrey Lynn
Department of Genetics, Case Western Reserve University, Cleveland, OH, USA
Science 296:2222-5. 2002..Thus, at least in mammals, a physical structure, the synaptonemal complex, reflects genetic rather than physical distance... - Fertilization in vitro increases non-disjunction during early cleavage divisions in a mouse model systemChristopher J Bean
Department of Genetics and the Center for Human Genetics, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH 44106, USA
Hum Reprod 17:2362-7. 2002.... - Oxidative metabolism of pyruvate is required for meiotic maturation of murine oocytes in vivoMark T Johnson
Department of Genetics, Case School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
Biol Reprod 77:2-8. 2007..At earlier stages of oogenesis this metabolic pathway may not be necessary due to metabolic compensation by the granulosa cells... - An evaluation of evidence for the carcinogenic activity of bisphenol ARuth A Keri
Department of Pharmacology and Division of General Medical Sciences Oncology, Case Western Reserve University, Cleveland, OH 44160, USA
Reprod Toxicol 24:240-52. 2007..The present review consists of the consensus report on the evidence for a role of BPA in carcinogenesis, examining the available evidence in humans and animal models with recommendations for future areas of research... 
Human female meiosis: what makes a good egg go bad?Patricia A Hunt
School of Molecular Biosciences and Center for Reproductive Biology, Washington State University, Pullman, WA 99164 4660, USA
Trends Genet 24:86-93. 2008....- Cohesin SMC1 beta is required for meiotic chromosome dynamics, sister chromatid cohesion and DNA recombinationEkaterina Revenkova
Center for Gene Therapy and Molecular Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Nat Cell Biol 6:555-62. 2004..Thus, SMC1 beta has a key role in meiotic cohesion, the assembly of AEs, synapsis, recombination, and chromosome movements... - Near-human aneuploidy levels in female mice with homeologous chromosomesKara E Koehler
Curr Biol 16:R579-80. 2006 - Sphingosine 1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspringFrancois Paris
Nat Med 8:901-2. 2002 - Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposureFrederick S vom Saal
Reprod Toxicol 24:131-8. 2007 - Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) miceJan Willem F Theunissen
Molecular Biology Program, Memorial Sloan Kettering Cancer Center and Cornell University Graduate School of Medical Sciences, New York, NY 10021, USA
Mol Cell 12:1511-23. 2003..We propose that in Mre11(ATLD1/ATLD1) mice, genome instability and cell cycle checkpoint defects reduce viability in early embryos and in proliferating cells, while promoting malignancy in the context of an initiating lesion... - The mouse A/HeJ Y chromosome: another good Y gone badPatricia A Hunt
School of Molecular Biosciences, Washington State University, Pullman, WA, 99164 4660, USA
Chromosome Res 16:623-36. 2008..We conclude that these centromeric features make the human and mouse Y chromosomes extremely sensitive to minor structural alterations, and that our studies provide yet another example of a good Y chromosome gone 'bad.'..