Patricia A Hunt

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. ncbi request reprint Sex matters in meiosis
    Patricia A Hunt
    Department of Genetics, Case Western Reserve University, Cleveland, OH 44106 4955, USA
    Science 296:2181-3. 2002
  2. ncbi request reprint Bisphenol a exposure causes meiotic aneuploidy in the female mouse
    Patricia A Hunt
    Department of Genetics, Case Western Reserve University, Cleveland, OH 44106 4955, USA
    Curr Biol 13:546-53. 2003
  3. pmc Bisphenol A exposure in utero disrupts early oogenesis in the mouse
    Martha Susiarjo
    Department of Genetics, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS Genet 3:e5. 2007
  4. pmc Genetic control of mammalian meiotic recombination. I. Variation in exchange frequencies among males from inbred mouse strains
    Kara E Koehler
    Department of Genetics and Center for Human Genetics, Case Western Reserve University School of Medicine and the University Hospitals of Cleveland, Cleveland, Ohio 44106 4955, USA
    Genetics 162:297-306. 2002
  5. ncbi request reprint SMC1beta-deficient female mice provide evidence that cohesins are a missing link in age-related nondisjunction
    Craig A Hodges
    Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Nat Genet 37:1351-5. 2005
  6. pmc The Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosis
    Sheila M Cherry
    Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Curr Biol 17:373-8. 2007
  7. ncbi request reprint Cisplatin disrupts mammalian spermatogenesis, but does not affect recombination or chromosome segregation
    Sheila M Cherry
    Department of Genetics and Center for Human Genetics, Case Western Reserve University, University Hospitals of Cleveland, OH 44106 4955, USA
    Mutat Res 564:115-28. 2004
  8. ncbi request reprint Simultaneous analysis of chromosomes and chromosome-associated proteins in mammalian oocytes and embryos
    Craig A Hodges
    Department of Genetics, Case Western Reserve University, Cleveland, Ohio, USA
    Chromosoma 111:165-9. 2002
  9. pmc Sex-specific differences in meiotic chromosome segregation revealed by dicentric bridge resolution in mice
    Kara E Koehler
    Department of Genetics and the Center for Human Genetics, Case Western Reserve University and the University Hospitals of Cleveland, Ohio 44106 4955, USA
    Genetics 162:1367-79. 2002
  10. ncbi request reprint Covariation of synaptonemal complex length and mammalian meiotic exchange rates
    Audrey Lynn
    Department of Genetics, Case Western Reserve University, Cleveland, OH, USA
    Science 296:2222-5. 2002

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Sex matters in meiosis
    Patricia A Hunt
    Department of Genetics, Case Western Reserve University, Cleveland, OH 44106 4955, USA
    Science 296:2181-3. 2002
    ..This female "robustness" comes with a cost, however, because aneuploidy appears to be increased in the resultant oocytes...
  2. ncbi request reprint Bisphenol a exposure causes meiotic aneuploidy in the female mouse
    Patricia A Hunt
    Department of Genetics, Case Western Reserve University, Cleveland, OH 44106 4955, USA
    Curr Biol 13:546-53. 2003
    ....
  3. pmc Bisphenol A exposure in utero disrupts early oogenesis in the mouse
    Martha Susiarjo
    Department of Genetics, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS Genet 3:e5. 2007
    ..This raises concern that brief exposures during fetal development to substances that mimic or antagonize the effects of estrogen may adversely influence oocyte development in the exposed female fetus...
  4. pmc Genetic control of mammalian meiotic recombination. I. Variation in exchange frequencies among males from inbred mouse strains
    Kara E Koehler
    Department of Genetics and Center for Human Genetics, Case Western Reserve University School of Medicine and the University Hospitals of Cleveland, Cleveland, Ohio 44106 4955, USA
    Genetics 162:297-306. 2002
    ..1%. Thus, special mechanisms that segregate achiasmate chromosomes are unlikely to be an important component of mammalian male meiosis...
  5. ncbi request reprint SMC1beta-deficient female mice provide evidence that cohesins are a missing link in age-related nondisjunction
    Craig A Hodges
    Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Nat Genet 37:1351-5. 2005
    ..Additionally, our observations support the hypothesis that deficient cohesion is an underlying cause of human age-related aneuploidy...
  6. pmc The Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosis
    Sheila M Cherry
    Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Curr Biol 17:373-8. 2007
    ..Thus, our findings implicate the Mre11 complex in meiotic DNA repair and synapsis in mammals and indicate that the complex may contribute to the establishment of normal sex-specific differences in meiosis...
  7. ncbi request reprint Cisplatin disrupts mammalian spermatogenesis, but does not affect recombination or chromosome segregation
    Sheila M Cherry
    Department of Genetics and Center for Human Genetics, Case Western Reserve University, University Hospitals of Cleveland, OH 44106 4955, USA
    Mutat Res 564:115-28. 2004
    ..Unexpectedly, however, no obvious effect on genome-wide recombination levels in CP-treated animals was observed, nor was the level of aneuploidy increased in sperm from exposed males...
  8. ncbi request reprint Simultaneous analysis of chromosomes and chromosome-associated proteins in mammalian oocytes and embryos
    Craig A Hodges
    Department of Genetics, Case Western Reserve University, Cleveland, Ohio, USA
    Chromosoma 111:165-9. 2002
    ....
  9. pmc Sex-specific differences in meiotic chromosome segregation revealed by dicentric bridge resolution in mice
    Kara E Koehler
    Department of Genetics and the Center for Human Genetics, Case Western Reserve University and the University Hospitals of Cleveland, Ohio 44106 4955, USA
    Genetics 162:1367-79. 2002
    ....
  10. ncbi request reprint Covariation of synaptonemal complex length and mammalian meiotic exchange rates
    Audrey Lynn
    Department of Genetics, Case Western Reserve University, Cleveland, OH, USA
    Science 296:2222-5. 2002
    ..Thus, at least in mammals, a physical structure, the synaptonemal complex, reflects genetic rather than physical distance...
  11. ncbi request reprint Fertilization in vitro increases non-disjunction during early cleavage divisions in a mouse model system
    Christopher J Bean
    Department of Genetics and the Center for Human Genetics, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Hum Reprod 17:2362-7. 2002
    ....
  12. ncbi request reprint Oxidative metabolism of pyruvate is required for meiotic maturation of murine oocytes in vivo
    Mark T Johnson
    Department of Genetics, Case School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Biol Reprod 77:2-8. 2007
    ..At earlier stages of oogenesis this metabolic pathway may not be necessary due to metabolic compensation by the granulosa cells...
  13. pmc An evaluation of evidence for the carcinogenic activity of bisphenol A
    Ruth A Keri
    Department of Pharmacology and Division of General Medical Sciences Oncology, Case Western Reserve University, Cleveland, OH 44160, USA
    Reprod Toxicol 24:240-52. 2007
    ..The present review consists of the consensus report on the evidence for a role of BPA in carcinogenesis, examining the available evidence in humans and animal models with recommendations for future areas of research...
  14. doi request reprint Human female meiosis: what makes a good egg go bad?
    Patricia A Hunt
    School of Molecular Biosciences and Center for Reproductive Biology, Washington State University, Pullman, WA 99164 4660, USA
    Trends Genet 24:86-93. 2008
    ....
  15. ncbi request reprint Cohesin SMC1 beta is required for meiotic chromosome dynamics, sister chromatid cohesion and DNA recombination
    Ekaterina Revenkova
    Center for Gene Therapy and Molecular Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Nat Cell Biol 6:555-62. 2004
    ..Thus, SMC1 beta has a key role in meiotic cohesion, the assembly of AEs, synapsis, recombination, and chromosome movements...
  16. ncbi request reprint Near-human aneuploidy levels in female mice with homeologous chromosomes
    Kara E Koehler
    Curr Biol 16:R579-80. 2006
  17. ncbi request reprint Sphingosine 1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspring
    Francois Paris
    Nat Med 8:901-2. 2002
  18. pmc Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure
    Frederick S vom Saal
    Reprod Toxicol 24:131-8. 2007
  19. ncbi request reprint Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice
    Jan Willem F Theunissen
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center and Cornell University Graduate School of Medical Sciences, New York, NY 10021, USA
    Mol Cell 12:1511-23. 2003
    ..We propose that in Mre11(ATLD1/ATLD1) mice, genome instability and cell cycle checkpoint defects reduce viability in early embryos and in proliferating cells, while promoting malignancy in the context of an initiating lesion...
  20. doi request reprint The mouse A/HeJ Y chromosome: another good Y gone bad
    Patricia A Hunt
    School of Molecular Biosciences, Washington State University, Pullman, WA, 99164 4660, USA
    Chromosome Res 16:623-36. 2008
    ..We conclude that these centromeric features make the human and mouse Y chromosomes extremely sensitive to minor structural alterations, and that our studies provide yet another example of a good Y chromosome gone 'bad.'..