AMY HISE

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. ncbi Innate immune responses to endosymbiotic Wolbachia bacteria in Brugia malayi and Onchocerca volvulus are dependent on TLR2, TLR6, MyD88, and Mal, but not TLR4, TRIF, or TRAM
    Amy G Hise
    Center for Global Health and Diseases and Department of Ophthalmology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    J Immunol 178:1068-76. 2007
  2. ncbi An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans
    Amy G Hise
    Center for Global Health and Diseases, Case Western Reserve University, Cleveland, OH 44106, USA
    Cell Host Microbe 5:487-97. 2009
  3. ncbi The role of endosymbiotic Wolbachia bacteria in the pathogenesis of river blindness
    Amélie v Saint André
    Division of Geographic Medicine, Department of Ophthalmology, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, OH 44106, USA
    Science 295:1892-5. 2002
  4. ncbi Toll-like receptor 2 regulates CXC chemokine production and neutrophil recruitment to the cornea in Onchocerca volvulus/Wolbachia-induced keratitis
    Illona Gillette-Ferguson
    Department of Ophthalmology, Case Western Reserve University, Cleveland, OH 44106 7286, USA
    Infect Immun 75:5908-15. 2007
  5. ncbi Activation of toll-like receptor (TLR)2, TLR4, and TLR9 in the mammalian cornea induces MyD88-dependent corneal inflammation
    Angela C Johnson
    Department of Ophthalmology, Case Western University, Cleveland, OH 44106 7286, USA
    Invest Ophthalmol Vis Sci 46:589-95. 2005
  6. ncbi Wolbachia- and Onchocerca volvulus-induced keratitis (river blindness) is dependent on myeloid differentiation factor 88
    Illona Gillette-Ferguson
    Department of Ophthalmology, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106 7286, USA
    Infect Immun 74:2442-5. 2006
  7. ncbi Staphylococcus aureus-induced corneal inflammation is dependent on Toll-like receptor 2 and myeloid differentiation factor 88
    Yan Sun
    Department of Ophthalmology, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106 7286, USA
    Infect Immun 74:5325-32. 2006
  8. ncbi CD14 and toll-like receptors 2 and 4 are required for fibrillar A{beta}-stimulated microglial activation
    Erin G Reed-Geaghan
    Department of Neurosciences, Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Neurosci 29:11982-92. 2009
  9. ncbi Immunopathogenesis of Onchocerca volvulus keratitis (river blindness): a novel role for TLR4 and endosymbiotic Wolbachia bacteria
    Amy G Hise
    Center for Global Health and Diseases, Case Western Reserve University, Cleveland, OH 44106-4983, USA
    J Endotoxin Res 9:390-4. 2003
  10. ncbi TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis
    Michael G Drage
    Department of Pathology, Case Western Reserve University School of Medicine University Hospitals Case Medical Center, Cleveland, OH 44106, USA
    Cell Immunol 258:29-37. 2009

Research Grants

  1. Host Defense in Oral Candidiasis
    AMY HISE; Fiscal Year: 2007
  2. Innate immune responses in lymphatic filariasis
    AMY HISE; Fiscal Year: 2007
  3. Host Defense in Oral Candidiasis
    AMY HISE; Fiscal Year: 2009
  4. Host Defense in Oral Candidiasis
    Amy G Hise; Fiscal Year: 2010

Collaborators

Detail Information

Publications13

  1. ncbi Innate immune responses to endosymbiotic Wolbachia bacteria in Brugia malayi and Onchocerca volvulus are dependent on TLR2, TLR6, MyD88, and Mal, but not TLR4, TRIF, or TRAM
    Amy G Hise
    Center for Global Health and Diseases and Department of Ophthalmology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    J Immunol 178:1068-76. 2007
    ..These results establish that the innate inflammatory pathways activated by endosymbiotic Wolbachia in B. malayi and O. volvulus filaria are dependent on TLR2-TLR6 interactions and are mediated by adaptor molecules MyD88 and TIRAP/Mal...
  2. ncbi An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans
    Amy G Hise
    Center for Global Health and Diseases, Case Western Reserve University, Cleveland, OH 44106, USA
    Cell Host Microbe 5:487-97. 2009
    ..Therefore, in addition to sensing bacterial and viral pathogens, the NLRP3 inflammasome senses fungal pathogens and is critical in host defense against Candida...
  3. ncbi The role of endosymbiotic Wolbachia bacteria in the pathogenesis of river blindness
    Amélie v Saint André
    Division of Geographic Medicine, Department of Ophthalmology, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, OH 44106, USA
    Science 295:1892-5. 2002
    ..In addition, the inflammatory response induced by these bacteria was dependent on expression of functional Toll-like receptor 4 (TLR4) on host cells...
  4. ncbi Toll-like receptor 2 regulates CXC chemokine production and neutrophil recruitment to the cornea in Onchocerca volvulus/Wolbachia-induced keratitis
    Illona Gillette-Ferguson
    Department of Ophthalmology, Case Western Reserve University, Cleveland, OH 44106 7286, USA
    Infect Immun 75:5908-15. 2007
    ..volvulus/Wolbachia-induced neutrophil activation and development of corneal haze...
  5. ncbi Activation of toll-like receptor (TLR)2, TLR4, and TLR9 in the mammalian cornea induces MyD88-dependent corneal inflammation
    Angela C Johnson
    Department of Ophthalmology, Case Western University, Cleveland, OH 44106 7286, USA
    Invest Ophthalmol Vis Sci 46:589-95. 2005
    ..The purpose of the present study was to determine whether activation of these receptors leads to development of keratitis and to assess the role of the common adaptor molecule myeloid differentiation factor-88 (MyD88)...
  6. ncbi Wolbachia- and Onchocerca volvulus-induced keratitis (river blindness) is dependent on myeloid differentiation factor 88
    Illona Gillette-Ferguson
    Department of Ophthalmology, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106 7286, USA
    Infect Immun 74:2442-5. 2006
    ..The current study demonstrates that corneal inflammation induced by Wolbachia or O. volvulus antigens containing Wolbachia is completely dependent on expression of myeloid differentiation factor 88...
  7. ncbi Staphylococcus aureus-induced corneal inflammation is dependent on Toll-like receptor 2 and myeloid differentiation factor 88
    Yan Sun
    Department of Ophthalmology, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106 7286, USA
    Infect Immun 74:5325-32. 2006
    ..These findings indicate that S. aureus-induced corneal inflammation is mediated by TLR2 and MyD88 in resident epithelial cells and infiltrating neutrophils...
  8. ncbi CD14 and toll-like receptors 2 and 4 are required for fibrillar A{beta}-stimulated microglial activation
    Erin G Reed-Geaghan
    Department of Neurosciences, Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Neurosci 29:11982-92. 2009
    ..These data indicate these innate immune receptors function as members of the microglial fAbeta receptor complex and identify the signaling mechanisms whereby they contribute to microglial activation...
  9. ncbi Immunopathogenesis of Onchocerca volvulus keratitis (river blindness): a novel role for TLR4 and endosymbiotic Wolbachia bacteria
    Amy G Hise
    Center for Global Health and Diseases, Case Western Reserve University, Cleveland, OH 44106-4983, USA
    J Endotoxin Res 9:390-4. 2003
    ..Inflammatory responses and corneal changes were measured. We demonstrated a major role for endosymbiont Wolbachia bacteria and Toll-like receptor 4 (TLR4) in the pathogenesis of ocular onchocerciasis...
  10. ncbi TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis
    Michael G Drage
    Department of Pathology, Case Western Reserve University School of Medicine University Hospitals Case Medical Center, Cleveland, OH 44106, USA
    Cell Immunol 258:29-37. 2009
    ..Thus, lung APC subsets differ in TLR expression, which may determine differences in responses to Mtb...
  11. ncbi An early complement-dependent and TLR-4-independent phase in the pathogenesis of ethanol-induced liver injury in mice
    Sanjoy Roychowdhury
    Department of Pathobiology, Cleveland Clinic Foundation, Cleveland, OH, USA
    Hepatology 49:1326-34. 2009
    ..CONCLUSION: We have identified a complement- and macrophage-dependent, but TLR-4 independent, phase in the pathogenesis of ethanol-induced liver injury...
  12. ncbi Wolbachia-induced neutrophil activation in a mouse model of ocular onchocerciasis (river blindness)
    Illona Gillette-Ferguson
    Department of Ophthalmology, Case Western Reserve University, Cleveland, Ohio 44106-4983, USA
    Infect Immun 72:5687-92. 2004
    ..Taken together, these findings indicate that neutrophil activation is an important mechanism by which Wolbachia organisms contribute to the pathogenesis of ocular onchocerciasis...
  13. ncbi Bacterial pathogen-associated molecular patterns stimulate biological activity of orthopaedic wear particles by activating cognate Toll-like receptors
    Edward M Greenfield
    Department of Orthopaedics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 285:32378-84. 2010
    ..These results support the hypothesis that PAMPs produced by low levels of bacterial colonization may contribute to aseptic loosening of orthopaedic implants...

Research Grants6

  1. Host Defense in Oral Candidiasis
    AMY HISE; Fiscal Year: 2007
    ....
  2. Innate immune responses in lymphatic filariasis
    AMY HISE; Fiscal Year: 2007
    ..abstract_text> ..
  3. Host Defense in Oral Candidiasis
    AMY HISE; Fiscal Year: 2009
    ..abstract_text> ..
  4. Host Defense in Oral Candidiasis
    Amy G Hise; Fiscal Year: 2010
    ....