Jason D Heaney

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. doi request reprint Testicular germ cell tumors in mice: new ways to study a genetically complex trait
    Jason D Heaney
    Department of Genetics, Case Western Reserve University, Cleveland, OH, USA
    Methods Mol Biol 450:211-31. 2008
  2. pmc Loss of the transmembrane but not the soluble kit ligand isoform increases testicular germ cell tumor susceptibility in mice
    Jason D Heaney
    Department of Genetics and Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Cancer Res 68:5193-7. 2008
  3. pmc Transgenerational epigenetic effects of the Apobec1 cytidine deaminase deficiency on testicular germ cell tumor susceptibility and embryonic viability
    Vicki R Nelson
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 109:E2766-73. 2012
  4. pmc Deletion of eIF2beta suppresses testicular cancer incidence and causes recessive lethality in agouti-yellow mice
    Jason D Heaney
    Department of Genetics, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44120, USA
    Hum Mol Genet 18:1395-404. 2009
  5. ncbi request reprint Trans-generational epistasis between Dnd1Ter and other modifier genes controls susceptibility to testicular germ cell tumors
    Man Yee J Lam
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Hum Mol Genet 16:2233-40. 2007
  6. pmc Germ cell pluripotency, premature differentiation and susceptibility to testicular teratomas in mice
    Jason D Heaney
    Department of Genetics, Case Western Reserve University, Cleveland, OH 44106, USA
    Development 139:1577-86. 2012
  7. pmc Mice with a deletion in the gene for CCAAT/enhancer-binding protein beta are protected against diet-induced obesity
    Carrie A Millward
    Department of Nutrition, Case Western Reserve University, Cleveland, OH 44106, USA
    Diabetes 56:161-7. 2007
  8. ncbi request reprint Tissue-specific expression of a BAC transgene targeted to the Hprt locus in mouse embryonic stem cells
    Jason D Heaney
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine H166, 500 University Drive, Hershey, PA 17033 0850, USA
    Genomics 83:1072-82. 2004
  9. ncbi request reprint Artificial chromosome-based transgenes in the study of genome function
    Jason D Heaney
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, The Milton S Hershey Medical Center, 500 University Drive, Hershey, PA 17033 0850, USA
    Mamm Genome 17:791-807. 2006

Research Grants

Collaborators

  • Joseph Nadeau
  • Paul J Tesar
  • David C Page
  • Vicki R Nelson
  • Carrie A Millward
  • Man Yee J Lam
  • Nicholas O Davidson
  • Jean H Kawasoe
  • Stephen F Previs
  • David S Sinasac
  • Eric C Chu
  • Colleen M Croniger
  • Danielle A Gilge
  • Ilya R Bederman
  • Kirsten K Youngren

Detail Information

Publications9

  1. doi request reprint Testicular germ cell tumors in mice: new ways to study a genetically complex trait
    Jason D Heaney
    Department of Genetics, Case Western Reserve University, Cleveland, OH, USA
    Methods Mol Biol 450:211-31. 2008
    ..We discuss the application of modifier genes in genetic interaction tests and sensitized polygenic trait analyses toward the understanding of the complex genetics and biology of TGCT susceptibility in mice...
  2. pmc Loss of the transmembrane but not the soluble kit ligand isoform increases testicular germ cell tumor susceptibility in mice
    Jason D Heaney
    Department of Genetics and Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Cancer Res 68:5193-7. 2008
    ....
  3. pmc Transgenerational epigenetic effects of the Apobec1 cytidine deaminase deficiency on testicular germ cell tumor susceptibility and embryonic viability
    Vicki R Nelson
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 109:E2766-73. 2012
    ..These results suggest that Apobec1 plays a central role in controlling TGCT susceptibility in both a conventional and a transgenerational manner...
  4. pmc Deletion of eIF2beta suppresses testicular cancer incidence and causes recessive lethality in agouti-yellow mice
    Jason D Heaney
    Department of Genetics, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44120, USA
    Hum Mol Genet 18:1395-404. 2009
    ..These results show that germ cell development and TGCT pathogenesis are sensitive to the availability of the eIF2 translation initiation complex and to changes in the rate of translation...
  5. ncbi request reprint Trans-generational epistasis between Dnd1Ter and other modifier genes controls susceptibility to testicular germ cell tumors
    Man Yee J Lam
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Hum Mol Genet 16:2233-40. 2007
    ....
  6. pmc Germ cell pluripotency, premature differentiation and susceptibility to testicular teratomas in mice
    Jason D Heaney
    Department of Genetics, Case Western Reserve University, Cleveland, OH 44106, USA
    Development 139:1577-86. 2012
    ..These results show that deregulation of the mitotic-meiotic switch in XY germ cells contributes to teratoma initiation...
  7. pmc Mice with a deletion in the gene for CCAAT/enhancer-binding protein beta are protected against diet-induced obesity
    Carrie A Millward
    Department of Nutrition, Case Western Reserve University, Cleveland, OH 44106, USA
    Diabetes 56:161-7. 2007
    ..In conclusion, the transcription factor C/EBPbeta is an important regulator in controlling lipid metabolism and in the development of diet-induced obesity...
  8. ncbi request reprint Tissue-specific expression of a BAC transgene targeted to the Hprt locus in mouse embryonic stem cells
    Jason D Heaney
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine H166, 500 University Drive, Hershey, PA 17033 0850, USA
    Genomics 83:1072-82. 2004
    ..This technology will facilitate many studies in which correct interpretation of data depends on developmentally appropriate transgene expression in the absence of rearrangements or deletions of endogenous DNA...
  9. ncbi request reprint Artificial chromosome-based transgenes in the study of genome function
    Jason D Heaney
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, The Milton S Hershey Medical Center, 500 University Drive, Hershey, PA 17033 0850, USA
    Mamm Genome 17:791-807. 2006
    ....

Research Grants2

  1. Testicular tumor susceptibility at the agouti locus
    JASON HEANEY; Fiscal Year: 2007
    ..Chr19M, A(y)/+ mice using BAG transgene complementation tests and conditional knockout mice, and 2) the TGCT frequency and expression levels of Raly and Eif2s2 in 129.A(vy)/+ and 129.Chr19M, A(vy)/+ mice. ..
  2. Testicular tumor susceptibility at the agouti locus
    JASON HEANEY; Fiscal Year: 2007
    ..Chr19M, Ay/+ mice using BAG transgene complementation tests and conditional knockout mice, and 2) the TGCT frequency and expression levels of Raly and Eif2s2 in 129./W+ and 129.Chr19M, Avy/+ mice. ..