Yiping Han

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. pmc Comparative microbial analysis of paired amniotic fluid and cord blood from pregnancies complicated by preterm birth and early-onset neonatal sepsis
    Xiaowei Wang
    Department of Periodontics, Case Western Reserve University, Cleveland, Ohio, USA
    PLoS ONE 8:e56131. 2013
  2. pmc Mobile microbiome: oral bacteria in extra-oral infections and inflammation
    Y W Han
    Department of Periodontics, Case Western Reserve University, Cleveland, OH 44106, USA
    J Dent Res 92:485-91. 2013
  3. pmc Oral health and adverse pregnancy outcomes - what's next?
    Y W Han
    Department of Periodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, OH 44106 4905, USA
    J Dent Res 90:289-93. 2011
  4. pmc Term stillbirth caused by oral Fusobacterium nucleatum
    Yiping W Han
    Department of Periodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4905, USA
    Obstet Gynecol 115:442-5. 2010
  5. pmc Uncultivated bacteria as etiologic agents of intra-amniotic inflammation leading to preterm birth
    Yiping W Han
    Department of Periodontics, School of Dental Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4905, USA
    J Clin Microbiol 47:38-47. 2009
  6. pmc Sonoporation is an efficient tool for intracellular fluorescent dextran delivery and one-step double-crossover mutant construction in Fusobacterium nucleatum
    Yiping W Han
    Department of Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH 44106 4905, USA
    Appl Environ Microbiol 73:3677-83. 2007
  7. pmc Fusobacterium nucleatum induces premature and term stillbirths in pregnant mice: implication of oral bacteria in preterm birth
    Yiping W Han
    Department of Periodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4905, USA
    Infect Immun 72:2272-9. 2004
  8. pmc Identification and characterization of a novel adhesin unique to oral fusobacteria
    Yiping W Han
    Department of Biological Sciences, School of Dental Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4905, USA
    J Bacteriol 187:5330-40. 2005
  9. pmc Transmission of an uncultivated Bergeyella strain from the oral cavity to amniotic fluid in a case of preterm birth
    Yiping W Han
    Department of Biological Sciences, School of Dental Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4905, USA
    J Clin Microbiol 44:1475-83. 2006
  10. pmc Characterizing traditionally defined periodontal disease in HIV+ adults
    LANCE T VERNON
    Department of Biological Sciences, Case Western Reserve University CWRU, School of Dental Medicine, Cleveland, OH 44106 4905, USA
    Community Dent Oral Epidemiol 37:427-37. 2009

Collaborators

Detail Information

Publications17

  1. pmc Comparative microbial analysis of paired amniotic fluid and cord blood from pregnancies complicated by preterm birth and early-onset neonatal sepsis
    Xiaowei Wang
    Department of Periodontics, Case Western Reserve University, Cleveland, Ohio, USA
    PLoS ONE 8:e56131. 2013
    ..Here, we present a proof-of-concept study to examine the microbial link between intra-amniotic infection (IAI) and early-onset neonatal sepsis (EONS)...
  2. pmc Mobile microbiome: oral bacteria in extra-oral infections and inflammation
    Y W Han
    Department of Periodontics, Case Western Reserve University, Cleveland, OH 44106, USA
    J Dent Res 92:485-91. 2013
    ..mutans non-c serotypes, are prone to extra-oral translocation. These findings advocate the importance of identification and quantification of potential pathogens at the subtype levels for accurate prediction of disease potential...
  3. pmc Oral health and adverse pregnancy outcomes - what's next?
    Y W Han
    Department of Periodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, OH 44106 4905, USA
    J Dent Res 90:289-93. 2011
    ..Only when a thorough understanding of the mechanism is achieved can meaningful intervention studies be designed utilizing effective therapies, targeting appropriate populations, and measuring relevant outcomes...
  4. pmc Term stillbirth caused by oral Fusobacterium nucleatum
    Yiping W Han
    Department of Periodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4905, USA
    Obstet Gynecol 115:442-5. 2010
    ..Intrauterine infection is a recognized cause of adverse pregnancy outcome, but the source of infection is often undetermined. We report a case of stillbirth caused by Fusobacterium nucleatum that originated in the mother's mouth...
  5. pmc Uncultivated bacteria as etiologic agents of intra-amniotic inflammation leading to preterm birth
    Yiping W Han
    Department of Periodontics, School of Dental Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4905, USA
    J Clin Microbiol 47:38-47. 2009
    ..Previously unrecognized, uncultivated, or difficult-to-cultivate species may play a key role in the initiation of PTB...
  6. pmc Sonoporation is an efficient tool for intracellular fluorescent dextran delivery and one-step double-crossover mutant construction in Fusobacterium nucleatum
    Yiping W Han
    Department of Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH 44106 4905, USA
    Appl Environ Microbiol 73:3677-83. 2007
    ..Since sonoporation has consistently generated one-step double-crossover mutants in F. nucleatum by use of intact suicide plasmids, this technology may be developed into an efficient tool for streamlining mutant construction in bacteria...
  7. pmc Fusobacterium nucleatum induces premature and term stillbirths in pregnant mice: implication of oral bacteria in preterm birth
    Yiping W Han
    Department of Periodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4905, USA
    Infect Immun 72:2272-9. 2004
    ..The results strengthen the link between periodontal disease and preterm birth. Our study also indicates that invasion may be an important virulence mechanism for F. nucleatum to infect the placenta...
  8. pmc Identification and characterization of a novel adhesin unique to oral fusobacteria
    Yiping W Han
    Department of Biological Sciences, School of Dental Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4905, USA
    J Bacteriol 187:5330-40. 2005
    ..Furthermore, due to its uniqueness to oral Fusobacterium species, fadA may be used as a marker to detect orally related fusobacteria. F. nucleatum isolated from other parts of the body may originate from the oral cavity...
  9. pmc Transmission of an uncultivated Bergeyella strain from the oral cavity to amniotic fluid in a case of preterm birth
    Yiping W Han
    Department of Biological Sciences, School of Dental Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4905, USA
    J Clin Microbiol 44:1475-83. 2006
    ..Uncultivated species may be overlooked opportunistic pathogens in preterm birth. This study sheds new light on the implication of oral bacteria in preterm birth...
  10. pmc Characterizing traditionally defined periodontal disease in HIV+ adults
    LANCE T VERNON
    Department of Biological Sciences, Case Western Reserve University CWRU, School of Dental Medicine, Cleveland, OH 44106 4905, USA
    Community Dent Oral Epidemiol 37:427-37. 2009
    ..Inconsistent methodological approaches may have resulted in the underestimation of traditionally-defined PD in HIV+ individuals...
  11. pmc Complementation of the fadA mutation in Fusobacterium nucleatum demonstrates that the surface-exposed adhesin promotes cellular invasion and placental colonization
    Akihiko Ikegami
    Department of Periodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4905, USA
    Infect Immun 77:3075-9. 2009
    ..nucleatum colonization in vivo. These results also represent the first complementation studies for F. nucleatum. FadA may be a therapeutic target for preventing F. nucleatum colonization of the host...
  12. ncbi request reprint Fusobacterium nucleatum induces fetal death in mice via stimulation of TLR4-mediated placental inflammatory response
    Hongqi Liu
    Department of Periodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    J Immunol 179:2501-8. 2007
    ..TLR4A had no bactericidal activity nor did it affect the birth outcome in sham-infected mice. TLR4A could have promise as an anti-inflammatory agent for the treatment or prevention of bacterial-induced preterm birth...
  13. pmc Transmission of diverse oral bacteria to murine placenta: evidence for the oral microbiome as a potential source of intrauterine infection
    Yann Fardini
    Department of Periodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4905, USA
    Infect Immun 78:1789-96. 2010
    ..These observations indicate that the placental translocation was species specific. This study provides the first insight into the diversity of oral bacteria associated with intrauterine infection...
  14. ncbi request reprint FadA from Fusobacterium nucleatum utilizes both secreted and nonsecreted forms for functional oligomerization for attachment and invasion of host cells
    Minghua Xu
    Department of Periodontics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 282:25000-9. 2007
    ..The pre-FadA-mFadA complex is probably anchored in the inner membrane and protrudes through the outer membrane. Internalization of the pre-FadA-mFadA ensures invasion of the bacteria into the host cells...
  15. pmc Crystal structure of FadA adhesin from Fusobacterium nucleatum reveals a novel oligomerization motif, the leucine chain
    Stanley Nithianantham
    Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 284:3865-72. 2009
    ..The essential role of these residues in FadA is corroborated by mutagenesis of selected leucine residues, which leads to the abrogation of oligomerization, filament formation, and binding to host cells...
  16. pmc Crystallization and preliminary X-ray data of the FadA adhesin from Fusobacterium nucleatum
    Stanley Nithianantham
    Department of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106 4935, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 62:1215-7. 2006
    ..9 A. The crystals are suitable for X-ray structure determination. The crystal structure of FadA may provide a basis for the development of therapeutic agents to combat periodontal disease and other infections associated with F. nucleatum...
  17. doi request reprint Laboratory maintenance of fusobacteria
    Yiping W Han
    Case Western Reserve University, Cleveland, Ohio, USA
    Curr Protoc Microbiol . 2006
    ..The growth and stock conditions as well as the susceptibility of F. nucleatum to oxygen in a pure culture are also discussed...

Research Grants11

  1. F. nucleatum in periodontal disease and preterm birth
    Yiping Han; Fiscal Year: 2007
    Dr Yiping Han is a PhD microbiologist. Dr Han's research evolves around understanding the virulence mechanism of F. nucleatum...
  2. Molecular Mechanism of F. Nucleatum Virulence
    Yiping Han; Fiscal Year: 2004
    ..Knowledge obtained from this study may enable future development of therapeutic agents to reduce the incidence of PD, PTB, and possibly other common systemic infections. ..
  3. Molecular Mechanism of F. Nucleatum Virulence
    Yiping Han; Fiscal Year: 2005
    ..Knowledge obtained from this study may enable future development of therapeutic agents to reduce the incidence of PD, PTB, and possibly other common systemic infections. ..
  4. Molecular Mechanism of F. Nucleatum Virulence
    Yiping Han; Fiscal Year: 2006
    ..Knowledge obtained from this study may enable future development of therapeutic agents to reduce the incidence of PD, PTB, and possibly other common systemic infections. ..
  5. Sonoporation as a new genetic tool for F. nucleatum
    Yiping Han; Fiscal Year: 2007
    ..nucleatum. In aim 2, the mechanism of sonoporation-mediated DNA delivery into F. nucleatum will be investigated. Our long term goal is to develop sonoporation into a robust tool for genetic manipulation of microorganisms ..
  6. Investigation of FadA adhesin from Fusobacterium nucleatum
    Yiping Han; Fiscal Year: 2009
    ..Identification of host components and pathways affected by FadA will facilitate therapeutic development of modulate specific cellular processes and targeted drug delivery. ..
  7. Molecular Mechanism of F. Nucleatum Virulence
    Yiping Han; Fiscal Year: 2003
    ..Knowledge obtained from this study may enable future development of therapeutic agents to reduce the incidence of PD, PTB, and possibly other common systemic infections. ..
  8. F.nucleatum in Amniotic Fluid Infection
    Yiping Han; Fiscal Year: 2004
    ..nucleatum for diagnostic purposes, and intervention studies aimed at reducing the incidence of preterm birth. ..
  9. Investigation of FadA adhesin from Fusobacterium nucleatum
    Yiping W Han; Fiscal Year: 2010
    ..Identification of host components and pathways affected by FadA will facilitate therapeutic development of modulate specific cellular processes and targeted drug delivery. ..