Research Topics
Genomes and Genes | Sanjay GuptaSummaryAffiliation: Case Western Reserve University Country: USA Publications
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Publications
Molecular cloning of IBP, a SWAP-70 homologous GEF, which is highly expressed in the immune systemSanjay Gupta
Department of Pathology, Columbia University, New York, NY 10032, USA
Hum Immunol 64:389-401. 2003..Taken together these findings indicate that IBP is a novel type of GEF, which participates in the activation of Rho GTPases in lymphoid tissues...- Molecular targets for apigenin-induced cell cycle arrest and apoptosis in prostate cancer cell xenograftSanjeev Shukla
Department of Urology, The James and Eilleen Dicke Research Laboratory, Case Western Reserve University and University Hospitals of Cleveland, 10900 Euclid Avenue, Cleveland, OH 44106, USA
Mol Cancer Ther 5:843-52. 2006..Taken together, this is the first systematic in vivo study showing the involvement of cell cycle regulatory proteins as potential molecular targets of apigenin... - Prostate cancer chemoprevention: current status and future prospectsSanjay Gupta
Department of Urology, Case Western Reserve University, Cleveland, OH 44106, USA
Toxicol Appl Pharmacol 224:369-76. 2007..This review highlights the present status of prostate cancer chemoprevention and discusses future prospects for chemopreventive strategies that are safe and clinically beneficial... - Prostate cancer chemoprevention: models, limitations and potential (Review)Sanjay Gupta
Department of Urology, Case Western Reserve University, Cleveland, OH 44106, USA
Int J Oncol 25:1133-48. 2004..Here, I provide a review of studies of chemopreventive/therapeutic agents in various models of prostate cancer... - Up-regulation of insulin-like growth factor binding protein-3 by apigenin leads to growth inhibition and apoptosis of 22Rv1 xenograft in athymic nude miceSanjeev Shukla
Department of Urology, Case Western Reserve University, Cleveland, Ohio, USA
FASEB J 19:2042-4. 2005..This study presents the first evidence that the in vitro and in vivo growth inhibitory effects of apigenin involve modulation of IGF-axis signaling in prostate cancer... - Constitutive activation of P I3 K-Akt and NF-kappaB during prostate cancer progression in autochthonous transgenic mouse modelSanjeev Shukla
Department of Urology, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio
Prostate 64:224-39. 2005..Although P I3 K-Akt and NF-kappaB have been implicated in the development and progression of prostate cancer, expression of these molecules during progression of autochthonous disease has not been elucidated... - Role of p53 and NF-kappaB in epigallocatechin-3-gallate-induced apoptosis of LNCaP cellsKedar Hastak
Department of Environmental Health Sciences, Case Western Reserve University, Cleveland, OH 44106, USA
Oncogene 22:4851-9. 2003..Taken together, the data indicate that EGCG induces apoptosis in human prostate carcinoma cells by shifting the balance between pro- and antiapoptotic proteins in favor of apoptosis... 
Deregulation of FOXO3A during prostate cancer progressionSanjeev Shukla
Department of Urology, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, OH 44106, USA
Int J Oncol 34:1613-20. 2009..Our findings demonstrate that tumor associated alterations and redistribution of FOXO3A are frequent events in the etiology of prostate cancer...- Suppression of constitutive and tumor necrosis factor alpha-induced nuclear factor (NF)-kappaB activation and induction of apoptosis by apigenin in human prostate carcinoma PC-3 cells: correlation with down-regulation of NF-kappaB-responsive genesSanjeev Shukla
Department of Urology, The James and Eillen Dicke Research Laboratory, Case Western Reserve University, Cleveland, OH 44106, USA
Clin Cancer Res 10:3169-78. 2004.... - Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo studyParminder Kaur
Department of Urology, Case Western Reserve University, Cleveland, OH 44106, USA
Carcinogenesis 29:2210-7. 2008..These results suggest that Akt inactivation and dephosphorylation of BAD is a critical event, at least in part, in apigenin-induced decreased cell survival and apoptosis... - Essential role of caspases in epigallocatechin-3-gallate-mediated inhibition of nuclear factor kappa B and induction of apoptosisSanjay Gupta
Department of Urology, Case Western Reserve University, Cleveland, OH 44106, USA
Oncogene 23:2507-22. 2004..Taken together, these studies for the first time demonstrate that EGCG-mediated activation of caspases is critical, at least in part, for inhibition of NF-kappa B and subsequent apoptosis... - Nuclear factor-kappaB/p65 (Rel A) is constitutively activated in human prostate adenocarcinoma and correlates with disease progressionSanjeev Shukla
Department of Urology, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH, USA
Neoplasia 6:390-400. 2004..These results demonstrate that NF-kappaB/p65 is constitutively activated in human prostate adenocarcinoma and is related to tumor progression due to transcriptional regulation of NF-kappaB-responsive genes... - Betulinic acid suppresses constitutive and TNFalpha-induced NF-kappaB activation and induces apoptosis in human prostate carcinoma PC-3 cellsThangaiyan Rabi
Department of Urology, The James and Eillen Dicke Research Laboratory, Case Western Reserve University, Cleveland, Ohio 44106, USA
Mol Carcinog 47:964-73. 2008..Our studies demonstrate that BetA effectively inhibits constitutive NF-kappaB activation and supports the rationale for targeting NF-kappaB through combination protocols with BetA in androgen-refractory prostate cancer... - Activation of PI3K-Akt signaling pathway promotes prostate cancer cell invasionSanjeev Shukla
Department of Urology, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland 44106, OH, USA
Int J Cancer 121:1424-32. 2007..Taken together, these results suggest that aberrant activation of PI3K-Akt pathway may contribute to increased cell invasiveness and facilitate prostate cancer progression... - Apigenin suppresses insulin-like growth factor I receptor signaling in human prostate cancer: an in vitro and in vivo studySanjeev Shukla
Department of Urology, Case Western Reserve University, Cleveland, Ohio 44106, USA
Mol Carcinog 48:243-52. 2009..These results suggest that inhibition of cell proliferation and induction of apoptosis by apigenin are mediated, at least in part, by its ability to inhibit IGF/IGF-IR signaling and the PI3K/Akt pathway... 
Plant flavone apigenin inhibits HDAC and remodels chromatin to induce growth arrest and apoptosis in human prostate cancer cells: In vitro and in vivo studyMitali Pandey
Department of Urology, Case Western Reserve University, Cleveland, Ohio
Mol Carcinog 51:952-62. 2012..Our findings confirm for the first time that apigenin inhibits class I HDACs, particularly HDAC1 and HDAC3 and its exposure results in reversal of aberrant epigenetic events that promote malignancy. © 2011 Wiley Periodicals, Inc...- Green tea polyphenols-induced apoptosis in human osteosarcoma SAOS-2 cells involves a caspase-dependent mechanism with downregulation of nuclear factor-kappaBBilal Bin Hafeez
Division of Rheumatic Diseases, Department of Medicine, Case Western Reserve University, 2109 Adelbert Road, BRB-319, Cleveland, OH 44106-4946, USA
Toxicol Appl Pharmacol 216:11-9. 2006..Taken together, these results indicate that GTP is a candidate therapeutic for osteosarcoma that mediates its antiproliferative and apoptotic effects via activation of caspases and inhibition of NF-kappaB... - Green tea polyphenols increase p53 transcriptional activity and acetylation by suppressing class I histone deacetylasesVijay S Thakur
Department of Urology and Nutrition, Case Western Reserve University, Cleveland, OH 44106, USA
Int J Oncol 41:353-61. 2012..Our findings indicate that GTP/EGCG causes acetylation of p53 by inhibiting class I HDACs, a function that is likely to be part of the mechanisms that control the physiological activity of p53... - Chamomile, a novel and selective COX-2 inhibitor with anti-inflammatory activityJanmejai K Srivastava
Department of Urology, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, OH 44106, United States
Life Sci 85:663-9. 2009..Chamomile has long been used in traditional medicine for the treatment of inflammatory diseases. In this study we aimed to investigate whether chamomile interferes with the COX-2 pathway... - Apigenin-induced cell cycle arrest is mediated by modulation of MAPK, PI3K-Akt, and loss of cyclin D1 associated retinoblastoma dephosphorylation in human prostate cancer cellsSanjeev Shukla
Department of Urology, Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
Cell Cycle 6:1102-14. 2007..This study provides an insight into the molecular mechanism of apigenin in modulating various tyrosine kinases and perturbs cell cycle progression, suggesting its future development and use as anticancer agent in humans... - Promoter demethylation and chromatin remodeling by green tea polyphenols leads to re-expression of GSTP1 in human prostate cancer cellsMitali Pandey
Department of Urology, The James and Eilleen Dicke Research Laboratory, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, OH, USA
Int J Cancer 126:2520-33. 2010.... - Apigenin attenuates insulin-like growth factor-I signaling in an autochthonous mouse prostate cancer modelSanjeev Shukla
Department of Urology, Case Western Reserve University, 2109 Adelbert Road, Wood Research Tower, RTG01, Cleveland, Ohio 44106, USA
Pharm Res 29:1506-17. 2012..Deregulation of IGF signaling plays an important role in prostate cancer and contributes to invasion and metastasis. We determined the effect of apigenin, a plant flavone, on IGF signaling and its downstream targets in TRAMP mice... - High-fat diet activates pro-inflammatory response in the prostate through association of Stat-3 and NF-κBEswar Shankar
Department of Urology, Case Western Reserve University and The Urology Institute, University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
Prostate 72:233-43. 2012..We sought to determine whether Stat-3 is involved in the activation of NF-κB in the prostate as a result of HFD feeding, leading to inflammation... - Blockade of beta-catenin signaling by plant flavonoid apigenin suppresses prostate carcinogenesis in TRAMP miceSanjeev Shukla
Department of Urology, Case Western Reserve University and University Hospitals Case Medical Center, 10900 Euclid Avenue, Cleveland, OH 44106, USA
Cancer Res 67:6925-35. 2007..Our results indicate that apigenin effectively suppressed prostate carcinogenesis in TRAMP mice, at least in part, by blocking beta-catenin signaling... - Suppression of prostate carcinogenesis by dietary supplementation of celecoxib in transgenic adenocarcinoma of the mouse prostate modelSanjay Gupta
Department of Urology, The James and Eilleen Dicke Research Laboratory, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio, USA
Cancer Res 64:3334-43. 2004..014), compared with AIN 76A-fed group. Our findings suggest that celecoxib may be useful in chemoprevention of prostate cancer... - Molecular imaging of NF-kappaB in prostate tissue after systemic administration of IL-1 betaEugene V Vykhovanets
Department of Urology, Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
Prostate 68:34-41. 2008..A wide range of human cancers and inflammatory disorders express inappropriate regulation of NF-kappaB. The role of NF-kappaB in intraprostatic inflammation has not been elucidated... - Molecular mechanisms for apigenin-induced cell-cycle arrest and apoptosis of hormone refractory human prostate carcinoma DU145 cellsSanjeev Shukla
Department of Urology, The James and Eilleen Dicke Research Laboratory, Case Western Reserve University, Cleveland, Ohio 44106, USA
Mol Carcinog 39:114-26. 2004.... - Induction of heme oxygenase-1 by chamomile protects murine macrophages against oxidative stressNatarajan Bhaskaran
Department of Urology, Case Western Reserve University, Cleveland, OH 44106, United States
Life Sci 90:1027-33. 2012..In this study we investigated the cytoprotective effect of chamomile and elucidated the underlying mechanisms... - Antiproliferative and apoptotic effects of chamomile extract in various human cancer cellsJanmejai K Srivastava
Department of Urology, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Agric Food Chem 55:9470-8. 2007..Further investigations of the mechanism of action of chamomile are warranted in evaluating the potential usefulness of this herbal remedy in the management of cancer patients... - Involvement of nuclear factor-kappa B, Bax and Bcl-2 in induction of cell cycle arrest and apoptosis by apigenin in human prostate carcinoma cellsSanjay Gupta
Department of Dermatology, Case Western Reserve University and The Research Institute of University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, Ohio 44106, USA
Oncogene 21:3727-38. 2002..Taken together, these findings suggest that apigenin has strong potential for development as an agent for prevention against prostate cancer... - Green tea polyphenols causes cell cycle arrest and apoptosis in prostate cancer cells by suppressing class I histone deacetylasesVijay S Thakur
Department of Urology, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, OH 44106, USA
Carcinogenesis 33:377-84. 2012..Our findings provide new insight into the mechanisms of GTP action in human prostate cancer cells irrespective of their p53 status and suggest a novel approach to prevention and/or therapy of prostate cancer achieved via HDAC inhibition... - IL-17 Expression by macrophages is associated with proliferative inflammatory atrophy lesions in prostate cancer patientsEugene V Vykhovanets
Department of Urology, Case Western Reserve University, Cleveland, Ohio 44106, USA
Int J Clin Exp Pathol 4:552-65. 2011..The accumulation of IL-17 expressing cells in PIA lesions presents direct evidence of an inflammatory microenvironment that may support the development of prostate cancer... - Il-1 beta-induced post-transition effect of NF-kappaB provides time-dependent wave of signals for initial phase of intrapostatic inflammationEugene V Vykhovanets
Department of Urology, Case Western Reserve University, Case Medical Center and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
Prostate 69:633-43. 2009..It has been hypothesized that NF-kappaB plays a role in the development of prostatitis, and that NF-kappaB activation might provide chemoattractive signals for leukocyte extravasation in the prostate... - Apigenin-induced prostate cancer cell death is initiated by reactive oxygen species and p53 activationSanjeev Shukla
Department of Urology, Case Western Reserve University, Cleveland, OH 44106, USA
Free Radic Biol Med 44:1833-45. 2008..These results indicate that apigenin-induced apoptosis in 22Rv1 cells is initiated by a ROS-dependent disruption of the mitochondrial membrane potential through transcriptional-dependent and -independent p53 pathways... - Molecular pathway for (-)-epigallocatechin-3-gallate-induced cell cycle arrest and apoptosis of human prostate carcinoma cellsSanjay Gupta
Department of Urology, Jim and Eillen Dicke Research Laboratory, Case Western Reserve University, The Research Institute of University Hospitals of Cleveland, Cleveland, OH 44106, USA
Arch Biochem Biophys 410:177-85. 2003..This is the first systematic study showing the involvement of each component of cdk inhibitor-cyclin-cdk machinery during cell cycle arrest and apoptosis of human prostate carcinoma cells by EGCG... - Tocotrienol-rich fraction of palm oil induces cell cycle arrest and apoptosis selectively in human prostate cancer cellsJanmejai K Srivastava
Department of Urology, Case Western Reserve University, Cleveland, OH 44106, USA
Biochem Biophys Res Commun 346:447-53. 2006..TRF offers significant promise as a chemopreventive and/or therapeutic agent against prostate cancer... - The chemopreventive and chemotherapeutic potentials of tea polyphenolsVijay S Thakur
Department of Urology and Nutrition, Case Western Reserve University, Cleveland, OH 44106, USA
Curr Pharm Biotechnol 13:191-9. 2012..Finally, we discuss on the scope and development of tea polyphenols in cancer prevention and therapy... - The influence of chronic inflammation in prostatic carcinogenesis: a 5-year followup studyGregory T MacLennan
Department of Pathology, University Hospitals of Cleveland, Cleveland, Ohio, USA
J Urol 176:1012-6. 2006..CONCLUSIONS: Chronic inflammation may be a significant risk factor for prostatic adenocarcinoma... - Chamomile: an anti-inflammatory agent inhibits inducible nitric oxide synthase expression by blocking RelA/p65 activityNatarajan Bhaskaran
Department of Urology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
Int J Mol Med 26:935-40. 2010..These results demonstrate that chamomile inhibits NO production and iNOS gene expression by inhibiting RelA/p65 activation and supports the utilization of chamomile as an effective anti-inflammatory agent... - Green tea and prostate cancerSanjay Gupta
Department of Urology, University Hospitals of Cleveland, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
Urol Clin North Am 29:49-57, viii. 2002..In this article, we address the use of green tea for prostate cancer chemoprevention. Experimental as well as the epidemiological basis for this possibility is provided... - Green tea and prostate cancer: from bench to clinicMitali Pandey
Department of Urology and Nutrition, Case Western Reserve University, Clevelamd, OH 44106, USA
Front Biosci (Elite Ed) 1:13-25. 2009..The review concludes with a brief discussion of the future direction and development of clinical trials employing green tea catechins which could be developed for prevention and/or intervention of prostate cancer... - Dietary terpenoids and prostate cancer chemopreventionThangaiyan Rabi
Department of Urology, Case Western Reserve University, University Hospitals, University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
Front Biosci 13:3457-69. 2008..Here we review naturally occurring dietary terpenoids as useful agents for prostate cancer chemoprevention with reference to their classes and sources... - Dietary agents in the chemoprevention of prostate cancerSanjeev Shukla
Department of Urology, Case Western Reserve University, Cleveland, Ohio 44106, USA
Nutr Cancer 53:18-32. 2005.... - Upregulation of SATB1 Is Associated with Prostate Cancer Aggressiveness and Disease ProgressionSanjeev Shukla
Department of Urology, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio, United States of America
PLoS ONE 8:e53527. 2013..Our findings demonstrate that SATB1 has ability to promote prostate cancer aggressiveness through epithelial-mesenchymal transition... - Green Tea Polyphenols Induce p53-Dependent and p53-Independent Apoptosis in Prostate Cancer Cells through Two Distinct MechanismsKarishma Gupta
Department of Urology, Case Western Reserve University, Cleveland, Ohio, United States of America
PLoS ONE 7:e52572. 2012.... - Selective cell cycle arrest and induction of apoptosis in human prostate cancer cells by a polyphenol-rich extract of Solanum nigrumAkbar Nawab
Department of Urology, Case Western Reserve University, Cleveland, OH 44106, USA
Int J Mol Med 29:277-84. 2012..SN may be developed as a promising therapeutic and/or preventive agent against prostate cancer... - Differential expression of S100A2 and S100A4 during progression of human prostate adenocarcinomaSanjay Gupta
Department of Urology, Case Western Reserve University and The Research Institute of University Hospitals of Cleveland, Cleveland, OH, USA
J Clin Oncol 21:106-12. 2003..The high levels of S100A4 observed in cancer tissue correlated with increasing tumor grade. CONCLUSION: Loss of S100A2 and increased expression of S100A4 may be an important event during progression of prostate cancer in humans... - Apigenin: a promising molecule for cancer preventionSanjeev Shukla
Department of Urology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA
Pharm Res 27:962-78. 2010..Human clinical trials examining the effect of supplementation of apigenin on disease prevention have not been conducted, although there is considerable potential for apigenin to be developed as a cancer chemopreventive agent... - High-fat diet increases NF-κB signaling in the prostate of reporter miceEugene V Vykhovanets
Department of Urology, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
Prostate 71:147-56. 2011..NF-κB has been implicated in stress response and is deregulated in prostrate disorders; therefore, we sought to determine whether HFD could induce oxidative stress in the prostate which could contribute to prostatic diseases... - Apigenin and cancer chemoprevention: progress, potential and promise (review)Deendayal Patel
Department of Urology, Case Western Reserve University, Cleveland, OH 44106, USA
Int J Oncol 30:233-45. 2007..This review examines the cancer chemopreventive effects of apigenin in an organ-specificity format, evaluating its limitations and its considerable potential for development as a cancer chemopreventive agent... - Chemoprevention of skin cancer: current status and future prospectsSanjay Gupta
Department of Urology, Case Western Reserve University and The Research Institute of University Hospitals of Cleveland, Cleveland, OH, USA
Cancer Metastasis Rev 21:363-80. 2002..We will also discuss the current status and future prospects of these agents for development as promising chemopreventive agents against skin cancer... - Chamomile Confers Protection against Hydrogen Peroxide-Induced Toxicity through Activation of Nrf2-Mediated Defense ResponseNatarajan Bhaskaran
Department of Urology, Case Western Reserve University, Cleveland, OH, 44106, USA Department of Urology, University Hospitals Case Medical Center, Cleveland, OH, 44106, USA
Phytother Res 27:118-25. 2013..Our results, for the first time, demonstrate that chamomile has protective effects against oxidative stress and might be beneficial to provide defense against cellular damage. Copyright © 2012 John Wiley & Sons, Ltd... - Molecular imaging of nuclear factor-κB in bladder as a primary regulator of inflammatory responseEugene V Vykhovanets
Case Western Reserve University and The Urology Institute, University Hospitals Case Medical Center, Cleveland, Ohio, USA
J Urol 187:330-7. 2012..The role of nuclear factor-κB activation in bladder inflammation is not well defined... - The role of histone deacetylases in prostate cancerAta Abbas
Department of Urology, Case Western Reserve University, Cleveland, Ohio 44106, USA
Epigenetics 3:300-9. 2008..In this review, we discuss the molecular mechanism(s) through which HDACs influence prostate cancer progression and the potential roles of HDAC inhibitors in prostate cancer prevention and therapy... - Radiotherapy and survival in prostate cancer patients: a population-based studyEsther H Zhou
Department of Urology, Case Western Reserve University School of Medicine, Cleveland, OH, USA
Int J Radiat Oncol Biol Phys 73:15-23. 2009.... - Role of the retinoblastoma (pRb)-E2F/DP pathway in cancer chemopreventive effects of green tea polyphenol epigallocatechin-3-gallateNihal Ahmad
Department of Dermatology, Case Western Reserve University, The Research Institute of University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, Ohio 44106, USA
Arch Biochem Biophys 398:125-31. 2002..This, to our knowledge, is the first study showing the involvement of the pRb-E2F/DP pathway in antiproliferative and apoptotic effects of EGCG... - Oral consumption of green tea polyphenols inhibits insulin-like growth factor-I-induced signaling in an autochthonous mouse model of prostate cancerVaqar Mustafa Adhami
Department of Dermatology, University of Wisconsin, Madison, Wisconsin 53706, USA
Cancer Res 64:8715-22. 2004.... - Prognostic significance of metastasis-associated protein S100A4 (Mts1) in prostate cancer progression and chemoprevention regimens in an autochthonous mouse modelMohammad Saleem
Department of Dermatology, University of Wisconsin-Madison, Wisconsin 53706, USA
Clin Cancer Res 11:147-53. 2005..CONCLUSIONS: S100A4 represents a promising marker for prostate cancer progression and could be employed as a biomarker in chemoprevention regimens... - Skipping chemo. A lot of breast-cancer survivors are doing it, not always for good reasonsSanjay Gupta
Time 161:68. 2003 - Development of a large animal model for lung tumorsKamran Ahrar
University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Box 325, Houston, Texas 77030, USA
J Vasc Interv Radiol 13:923-8. 2002..Our goal was to develop a lung tumor model in a large animal to simulate human lung cancer for preclinical assessment of novel therapeutic options... - Hepatic artery embolization for hepatocellular carcinoma: technique, patient selection, and outcomesKamran Ahrar
Section of Vascular and Interventional Radiology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 325, Houston, TX 77030, USA
Surg Oncol Clin N Am 12:105-26. 2003..More recently, two excellent randomized clinical trials have demonstrated significant survival benefit for patients treated with TACE when compared with those treated symptomatically... - Percutaneous radiofrequency ablation of lung tumors in a large animal modelKamran Ahrar
University of Texas M D Anderson Cancer Center, the Departments of Diagnostic Radiology, 1515 Holcombe Boulevard, Unit 325, Houston, Texas 77030 4009, USA
J Vasc Interv Radiol 14:1037-43. 2003..We undertook this study to evaluate the feasibility and immediate effectiveness of RFA for treatment of both solitary pulmonary nodules and clusters of lung tumors in a large animal model... - T cell receptor engagement leads to the recruitment of IBP, a novel guanine nucleotide exchange factor, to the immunological synapseSanjay Gupta
Departments of Medicine and Medicine and Pharmacology, Columbia University, New York, New York 10032, USA
J Biol Chem 278:43541-9. 2003..The recruitment and activation of distinct classes of GEFs may allow for precise control of Rho GTPase function at the crucial interface between T cells and antigen presenting cells... - Tocotrienol-rich fraction of palm oil activates p53, modulates Bax/Bcl2 ratio and induces apoptosis independent of cell cycle associationMukesh K Agarwal
Department of Medical Elementology and Toxicology, Hamdard University, New Delhi, India
Cell Cycle 3:205-11. 2004..Our data suggest that TRF-induced apoptosis in colon carcinoma cells is mediated by p53 signaling network which appears to be independent of cell cycle association... - Cyclooxygenase-2 and prostate carcinogenesisTajamul Hussain
Department of Dermatology, University of Wisconsin, Medical Science Center, 1300 University Avenue, Madison, WI 53706, USA
Cancer Lett 191:125-35. 2003..An exciting corollary to this ongoing work is that selective COX-2 inhibitors may exhibit chemopreventive and even chemotherapeutic effects against prostate carcinogenesis in humans... - Green tea constituent epigallocatechin-3-gallate selectively inhibits COX-2 without affecting COX-1 expression in human prostate carcinoma cellsTajamul Hussain
University of Wisconsin, Department of Dermatology, 1300 University Ave, Madison, WI 53706, USA
Int J Cancer 113:660-9. 2005..Based on our study, it is tempting to suggest that a combination of EGCG with chemotherapeutic drugs could be an improved strategy for prevention and treatment of prostate cancer... - Prostate priorities: a new approach to the cancer that 1 in 6 American men will eventually getSanjay Gupta
Time 164:90. 2004 - Percutaneous ultrasound-guided biopsy in the definitive diagnosis of osteosarcomaKamran Ahrar
Department of Interventional Radiology, University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
J Vasc Interv Radiol 15:1329-33. 2004..All 23 US-guided biopsies resulted in definitive diagnosis. Two of the 12 fluoroscopy- or CT-guided biopsies (17%) were inconclusive... - Hyperphosphorylation of extracellular regulated kinase 2 (ERK2) and inhibition of JNK2 phosphorylation are associated with increased S-phase during transformation of Syrian hamster embryo cells by Malachite GreenBipasha Bose
Chemical Carcinogenesis Group, Cancer Research Institute, Advanced Centre for Treatment Research and Education in Cancer (ACTREC, Tata Memorial Centre, Kharghar, Navi Mumbai 410 208, India
Cell Biol Int 28:875-83. 2004.... - Descriptive and prognostic value of patient-reported outcomes: the bortezomib experience in relapsed and refractory multiple myelomaDominique Dubois
Johnson and Johnson Pharmaceutical Services and Pharmaceutical Research and Development, Beerse, Belgium
J Clin Oncol 24:976-82. 2006..The goal of this work was to evaluate the added value of patient-reported outcomes (PRO) in the interpretation of bortezomib clinical trial outcomes... - Synthesis of N-aryl-5-amino-4-cyanopyrazole derivatives as potent xanthine oxidase inhibitorsSanjay Gupta
Centro de Quimica, Universidade do Minho, Campus de Gualtar, 4710 057 Braga, Portugal
Eur J Med Chem 43:771-80. 2008..MEP calculations were used to explain different inhibitory efficiency of similar inhibitors... - Update on the management of neuroendocrine hepatic metastasesDavid C Madoff
Division of Diagnostic Imaging, Interventional Radiology Section, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 325, Houston, 77030 4009, USA
J Vasc Interv Radiol 17:1235-49; quiz 1250. 2006..This article reviews the care of patients with NETs and hepatic metastases, with emphasis on the increasingly important role of oncologic image-guided interventions... - Overexpression of cyclin D1 is associated with the decondensation of chromatin during den-induced sequential hepatocarcinogenesisMonisha Sundarrajan
Carcinogenesis Division, Cancer Research Institute, Tata Memorial Centre, Parel, Mumbai-400 012, India
Cell Biol Int 26:699-706. 2002..Thus, the functional inter-relationship between chromatin organization and gene expression appears to be of critical importance for liver tumour development...
Research Grants
- Prostate Cancer Chemoprevention by ApigeninSanjay Gupta; Fiscal Year: 2003..These studies could be considered as a starting point for an expanded program for the development of apigenin as a promising agent against CaP in humans. ..
- Molecular Mechanisms of GSTP1 Reactivation by Green Tea PolyphenolsSanjay Gupta; Fiscal Year: 2010..With the 'proof of principle'more structurally-related non- toxic compounds could be developed in future for prevention of prostate cancer in humans. ..
- Chamomile as Medicine for Prostate cancerSanjay Gupta; Fiscal Year: 2009..Completion of the proposed studies will provide a 'head start' to initiate clinical trials in prostate cancer patients and/or high-risk individuals. ..
- Molecular Mechanisms of GSTP1 Reactivation by Green Tea PolyphenolsSanjay Gupta; Fiscal Year: 2009..With the 'proof of principle' more structurally-related non- toxic compounds could be developed in future for prevention of prostate cancer in humans. ..
- Chamomile as Medicine for Prostate cancerSanjay Gupta; Fiscal Year: 2007..Completion of the proposed studies will provide a 'head start' to initiate clinical trials in prostate cancer patients and/or high-risk individuals. ..
- Molecular Mechanisms of GSTP1 Reactivation by Green Tea PolyphenolsSanjay Gupta; Fiscal Year: 2007..With the 'proof of principle' more structurally-related non- toxic compounds could be developed in future for prevention of prostate cancer in humans. ..
- Mechanisms of Prostate Cancer Chemoprevention by ApigeninSanjay Gupta; Fiscal Year: 2007..The outcome of this proposal will define NF-kappaB as an important molecular target and apigenin as promising agent against prostate cancer. ..
- Reactivation of GSTP1 Gene by Green Tea PolyphenolsSanjay Gupta; Fiscal Year: 2005..abstract_text> ..
- Anti-proliferative Effects of D-limonene against Prosta*Sanjay Gupta; Fiscal Year: 2005..Successful completion of this application will establish the cancer chemopreventive and/or therapeutic potential of D-limonene against prostate cancer and mechanisms involved with its anti-proliferative response. ..
- Inhibition of Prostate Carcinogenesis by ApigeninSanjay Gupta; Fiscal Year: 2003..A successful completion of this application will set a platform to define the role of apigenin as a promising agent against prevention and possibly therapy of prostate cancer in humans. ..
- Molecular Mechanisms of Prostate Cancer Chemoprevention by ApigeninSanjay Gupta; Fiscal Year: 2010..Understanding the molecular mechanisms of apigenin may reveal key molecular targets for the development of more effective agents with fewer side-effects for future use in chemopreventive/therapeutic regimens. ..