Sanjay Gupta

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. ncbi request reprint Molecular cloning of IBP, a SWAP-70 homologous GEF, which is highly expressed in the immune system
    Sanjay Gupta
    Department of Pathology, Columbia University, New York, NY 10032, USA
    Hum Immunol 64:389-401. 2003
  2. ncbi request reprint Molecular targets for apigenin-induced cell cycle arrest and apoptosis in prostate cancer cell xenograft
    Sanjeev Shukla
    Department of Urology, The James and Eilleen Dicke Research Laboratory, Case Western Reserve University and University Hospitals of Cleveland, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Mol Cancer Ther 5:843-52. 2006
  3. doi request reprint Selective cell cycle arrest and induction of apoptosis in human prostate cancer cells by a polyphenol-rich extract of Solanum nigrum
    Akbar Nawab
    Department of Urology, Case Western Reserve University, Cleveland, OH 44106, USA
    Int J Mol Med 29:277-84. 2012
  4. pmc Upregulation of SATB1 is associated with prostate cancer aggressiveness and disease progression
    Sanjeev Shukla
    Department of Urology, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio, United States of America
    PLoS ONE 8:e53527. 2013
  5. pmc Green tea polyphenols induce p53-dependent and p53-independent apoptosis in prostate cancer cells through two distinct mechanisms
    Karishma Gupta
    Department of Urology, Case Western Reserve University, Cleveland, Ohio, USA
    PLoS ONE 7:e52572. 2012
  6. doi request reprint Plant flavone apigenin binds to nucleic acid bases and reduces oxidative DNA damage in prostate epithelial cells
    Haripaul Sharma
    Department of Urology, Case Western Reserve University, Cleveland, Ohio, United States of America Department of Urology, The Urology Institute, University Hospitals Case Medical Center, Cleveland, Ohio, United States of America
    PLoS ONE 9:e91588. 2014
  7. ncbi request reprint Prostate cancer chemoprevention: models, limitations and potential (Review)
    Sanjay Gupta
    Department of Urology, Case Western Reserve University, Cleveland, OH 44106, USA
    Int J Oncol 25:1133-48. 2004
  8. ncbi request reprint Up-regulation of insulin-like growth factor binding protein-3 by apigenin leads to growth inhibition and apoptosis of 22Rv1 xenograft in athymic nude mice
    Sanjeev Shukla
    Department of Urology, Case Western Reserve University, Cleveland, Ohio, USA
    FASEB J 19:2042-4. 2005
  9. ncbi request reprint Prostate cancer chemoprevention: current status and future prospects
    Sanjay Gupta
    Department of Urology, Case Western Reserve University, Cleveland, OH 44106, USA
    Toxicol Appl Pharmacol 224:369-76. 2007
  10. doi request reprint Apigenin inhibits prostate cancer progression in TRAMP mice via targeting PI3K/Akt/FoxO pathway
    Sanjeev Shukla
    Department of Urology, Case Western Reserve University and The Urology Institute, University Hospitals Case Medical Center, Cleveland, OH 44106, USA
    Carcinogenesis 35:452-60. 2014

Collaborators

Detail Information

Publications80

  1. ncbi request reprint Molecular cloning of IBP, a SWAP-70 homologous GEF, which is highly expressed in the immune system
    Sanjay Gupta
    Department of Pathology, Columbia University, New York, NY 10032, USA
    Hum Immunol 64:389-401. 2003
    ..Taken together these findings indicate that IBP is a novel type of GEF, which participates in the activation of Rho GTPases in lymphoid tissues...
  2. ncbi request reprint Molecular targets for apigenin-induced cell cycle arrest and apoptosis in prostate cancer cell xenograft
    Sanjeev Shukla
    Department of Urology, The James and Eilleen Dicke Research Laboratory, Case Western Reserve University and University Hospitals of Cleveland, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Mol Cancer Ther 5:843-52. 2006
    ..Taken together, this is the first systematic in vivo study showing the involvement of cell cycle regulatory proteins as potential molecular targets of apigenin...
  3. doi request reprint Selective cell cycle arrest and induction of apoptosis in human prostate cancer cells by a polyphenol-rich extract of Solanum nigrum
    Akbar Nawab
    Department of Urology, Case Western Reserve University, Cleveland, OH 44106, USA
    Int J Mol Med 29:277-84. 2012
    ..SN may be developed as a promising therapeutic and/or preventive agent against prostate cancer...
  4. pmc Upregulation of SATB1 is associated with prostate cancer aggressiveness and disease progression
    Sanjeev Shukla
    Department of Urology, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio, United States of America
    PLoS ONE 8:e53527. 2013
    ..Our findings demonstrate that SATB1 has ability to promote prostate cancer aggressiveness through epithelial-mesenchymal transition...
  5. pmc Green tea polyphenols induce p53-dependent and p53-independent apoptosis in prostate cancer cells through two distinct mechanisms
    Karishma Gupta
    Department of Urology, Case Western Reserve University, Cleveland, Ohio, USA
    PLoS ONE 7:e52572. 2012
    ....
  6. doi request reprint Plant flavone apigenin binds to nucleic acid bases and reduces oxidative DNA damage in prostate epithelial cells
    Haripaul Sharma
    Department of Urology, Case Western Reserve University, Cleveland, Ohio, United States of America Department of Urology, The Urology Institute, University Hospitals Case Medical Center, Cleveland, Ohio, United States of America
    PLoS ONE 9:e91588. 2014
    ....
  7. ncbi request reprint Prostate cancer chemoprevention: models, limitations and potential (Review)
    Sanjay Gupta
    Department of Urology, Case Western Reserve University, Cleveland, OH 44106, USA
    Int J Oncol 25:1133-48. 2004
    ..Here, I provide a review of studies of chemopreventive/therapeutic agents in various models of prostate cancer...
  8. ncbi request reprint Up-regulation of insulin-like growth factor binding protein-3 by apigenin leads to growth inhibition and apoptosis of 22Rv1 xenograft in athymic nude mice
    Sanjeev Shukla
    Department of Urology, Case Western Reserve University, Cleveland, Ohio, USA
    FASEB J 19:2042-4. 2005
    ..This study presents the first evidence that the in vitro and in vivo growth inhibitory effects of apigenin involve modulation of IGF-axis signaling in prostate cancer...
  9. ncbi request reprint Prostate cancer chemoprevention: current status and future prospects
    Sanjay Gupta
    Department of Urology, Case Western Reserve University, Cleveland, OH 44106, USA
    Toxicol Appl Pharmacol 224:369-76. 2007
    ..This review highlights the present status of prostate cancer chemoprevention and discusses future prospects for chemopreventive strategies that are safe and clinically beneficial...
  10. doi request reprint Apigenin inhibits prostate cancer progression in TRAMP mice via targeting PI3K/Akt/FoxO pathway
    Sanjeev Shukla
    Department of Urology, Case Western Reserve University and The Urology Institute, University Hospitals Case Medical Center, Cleveland, OH 44106, USA
    Carcinogenesis 35:452-60. 2014
    ..These results provide convincing evidence that apigenin effectively suppressed prostate cancer progression, at least in part, by targeting the PI3K/Akt/FoxO-signaling pathway. ..
  11. ncbi request reprint Protection against oxidative DNA damage and stress in human prostate by glutathione S-transferase P1
    Rajnee Kanwal
    Department of Urology, Case Western Reserve University, Cleveland, Ohio
    Mol Carcinog 53:8-18. 2014
    ..These results suggest that loss of GSTP1 expression in human prostate cells, a process that increases their susceptibility to oxidative stress-induced DNA damage, may be an important target for primary prevention of prostate cancer...
  12. ncbi request reprint Activation of PI3K-Akt signaling pathway promotes prostate cancer cell invasion
    Sanjeev Shukla
    Department of Urology, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland 44106, OH, USA
    Int J Cancer 121:1424-32. 2007
    ..Taken together, these results suggest that aberrant activation of PI3K-Akt pathway may contribute to increased cell invasiveness and facilitate prostate cancer progression...
  13. ncbi request reprint Essential role of caspases in epigallocatechin-3-gallate-mediated inhibition of nuclear factor kappa B and induction of apoptosis
    Sanjay Gupta
    Department of Urology, Case Western Reserve University, Cleveland, OH 44106, USA
    Oncogene 23:2507-22. 2004
    ..Taken together, these studies for the first time demonstrate that EGCG-mediated activation of caspases is critical, at least in part, for inhibition of NF-kappa B and subsequent apoptosis...
  14. pmc Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study
    Parminder Kaur
    Department of Urology, Case Western Reserve University, Cleveland, OH 44106, USA
    Carcinogenesis 29:2210-7. 2008
    ..These results suggest that Akt inactivation and dephosphorylation of BAD is a critical event, at least in part, in apigenin-induced decreased cell survival and apoptosis...
  15. ncbi request reprint Constitutive activation of P I3 K-Akt and NF-kappaB during prostate cancer progression in autochthonous transgenic mouse model
    Sanjeev Shukla
    Department of Urology, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio
    Prostate 64:224-39. 2005
    ..Although P I3 K-Akt and NF-kappaB have been implicated in the development and progression of prostate cancer, expression of these molecules during progression of autochthonous disease has not been elucidated...
  16. ncbi request reprint Role of p53 and NF-kappaB in epigallocatechin-3-gallate-induced apoptosis of LNCaP cells
    Kedar Hastak
    Department of Environmental Health Sciences, Case Western Reserve University, Cleveland, OH 44106, USA
    Oncogene 22:4851-9. 2003
    ..Taken together, the data indicate that EGCG induces apoptosis in human prostate carcinoma cells by shifting the balance between pro- and antiapoptotic proteins in favor of apoptosis...
  17. pmc Deregulation of FOXO3A during prostate cancer progression
    Sanjeev Shukla
    Department of Urology, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, OH 44106, USA
    Int J Oncol 34:1613-20. 2009
    ..Our findings demonstrate that tumor associated alterations and redistribution of FOXO3A are frequent events in the etiology of prostate cancer...
  18. ncbi request reprint Suppression of constitutive and tumor necrosis factor alpha-induced nuclear factor (NF)-kappaB activation and induction of apoptosis by apigenin in human prostate carcinoma PC-3 cells: correlation with down-regulation of NF-kappaB-responsive genes
    Sanjeev Shukla
    Department of Urology, The James and Eillen Dicke Research Laboratory, Case Western Reserve University, Cleveland, OH 44106, USA
    Clin Cancer Res 10:3169-78. 2004
    ..Here we examined whether apigenin is effective in inhibiting NF-kappaB expression in androgen-insensitive human prostate carcinoma cells exhibiting high constitutive levels of NF-kappaB...
  19. pmc Apigenin suppresses insulin-like growth factor I receptor signaling in human prostate cancer: an in vitro and in vivo study
    Sanjeev Shukla
    Department of Urology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Mol Carcinog 48:243-52. 2009
    ..These results suggest that inhibition of cell proliferation and induction of apoptosis by apigenin are mediated, at least in part, by its ability to inhibit IGF/IGF-IR signaling and the PI3K/Akt pathway...
  20. pmc Betulinic acid suppresses constitutive and TNFalpha-induced NF-kappaB activation and induces apoptosis in human prostate carcinoma PC-3 cells
    Thangaiyan Rabi
    Department of Urology, The James and Eillen Dicke Research Laboratory, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Mol Carcinog 47:964-73. 2008
    ..Our studies demonstrate that BetA effectively inhibits constitutive NF-kappaB activation and supports the rationale for targeting NF-kappaB through combination protocols with BetA in androgen-refractory prostate cancer...
  21. pmc Nuclear factor-kappaB/p65 (Rel A) is constitutively activated in human prostate adenocarcinoma and correlates with disease progression
    Sanjeev Shukla
    Department of Urology, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH, USA
    Neoplasia 6:390-400. 2004
    ..These results demonstrate that NF-kappaB/p65 is constitutively activated in human prostate adenocarcinoma and is related to tumor progression due to transcriptional regulation of NF-kappaB-responsive genes...
  22. pmc Promoter demethylation and chromatin remodeling by green tea polyphenols leads to re-expression of GSTP1 in human prostate cancer cells
    Mitali Pandey
    Department of Urology, The James and Eilleen Dicke Research Laboratory, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, OH, USA
    Int J Cancer 126:2520-33. 2010
    ....
  23. ncbi request reprint Plant flavone apigenin inhibits HDAC and remodels chromatin to induce growth arrest and apoptosis in human prostate cancer cells: in vitro and in vivo study
    Mitali Pandey
    Department of Urology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Mol Carcinog 51:952-62. 2012
    ..Our findings confirm for the first time that apigenin inhibits class I HDACs, particularly HDAC1 and HDAC3 and its exposure results in reversal of aberrant epigenetic events that promote malignancy. © 2011 Wiley Periodicals, Inc...
  24. ncbi request reprint Green tea polyphenols-induced apoptosis in human osteosarcoma SAOS-2 cells involves a caspase-dependent mechanism with downregulation of nuclear factor-kappaB
    Bilal Bin Hafeez
    Division of Rheumatic Diseases, Department of Medicine, Case Western Reserve University, 2109 Adelbert Road, BRB 319, Cleveland, OH 44106 4946, USA
    Toxicol Appl Pharmacol 216:11-9. 2006
    ..Taken together, these results indicate that GTP is a candidate therapeutic for osteosarcoma that mediates its antiproliferative and apoptotic effects via activation of caspases and inhibition of NF-kappaB...
  25. ncbi request reprint Blockade of beta-catenin signaling by plant flavonoid apigenin suppresses prostate carcinogenesis in TRAMP mice
    Sanjeev Shukla
    Department of Urology, Case Western Reserve University and University Hospitals Case Medical Center, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Cancer Res 67:6925-35. 2007
    ..Our results indicate that apigenin effectively suppressed prostate carcinogenesis in TRAMP mice, at least in part, by blocking beta-catenin signaling...
  26. ncbi request reprint Chamomile confers protection against hydrogen peroxide-induced toxicity through activation of Nrf2-mediated defense response
    Natarajan Bhaskaran
    Department of Urology, Case Western Reserve University, Cleveland, OH 44106, USA
    Phytother Res 27:118-25. 2013
    ..Our results, for the first time, demonstrate that chamomile has protective effects against oxidative stress and might be beneficial to provide defense against cellular damage...
  27. pmc Green tea polyphenols increase p53 transcriptional activity and acetylation by suppressing class I histone deacetylases
    Vijay S Thakur
    Department of Urology and Nutrition, Case Western Reserve University, Cleveland, OH 44106, USA
    Int J Oncol 41:353-61. 2012
    ..Our findings indicate that GTP/EGCG causes acetylation of p53 by inhibiting class I HDACs, a function that is likely to be part of the mechanisms that control the physiological activity of p53...
  28. ncbi request reprint Apigenin-induced cell cycle arrest is mediated by modulation of MAPK, PI3K-Akt, and loss of cyclin D1 associated retinoblastoma dephosphorylation in human prostate cancer cells
    Sanjeev Shukla
    Department of Urology, Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
    Cell Cycle 6:1102-14. 2007
    ..This study provides an insight into the molecular mechanism of apigenin in modulating various tyrosine kinases and perturbs cell cycle progression, suggesting its future development and use as anticancer agent in humans...
  29. pmc Chamomile, a novel and selective COX-2 inhibitor with anti-inflammatory activity
    Janmejai K Srivastava
    Department of Urology, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, OH 44106, United States
    Life Sci 85:663-9. 2009
    ..Chamomile has long been used in traditional medicine for the treatment of inflammatory diseases. In this study we aimed to investigate whether chamomile interferes with the COX-2 pathway...
  30. ncbi request reprint Involvement of nuclear factor-kappa B, Bax and Bcl-2 in induction of cell cycle arrest and apoptosis by apigenin in human prostate carcinoma cells
    Sanjay Gupta
    Department of Dermatology, Case Western Reserve University and The Research Institute of University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, Ohio 44106, USA
    Oncogene 21:3727-38. 2002
    ..Taken together, these findings suggest that apigenin has strong potential for development as an agent for prevention against prostate cancer...
  31. pmc Induction of heme oxygenase-1 by chamomile protects murine macrophages against oxidative stress
    Natarajan Bhaskaran
    Department of Urology, Case Western Reserve University, Cleveland, OH 44106, United States
    Life Sci 90:1027-33. 2012
    ..In this study we investigated the cytoprotective effect of chamomile and elucidated the underlying mechanisms...
  32. pmc Green tea polyphenols causes cell cycle arrest and apoptosis in prostate cancer cells by suppressing class I histone deacetylases
    Vijay S Thakur
    Department of Urology, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, OH 44106, USA
    Carcinogenesis 33:377-84. 2012
    ..Our findings provide new insight into the mechanisms of GTP action in human prostate cancer cells irrespective of their p53 status and suggest a novel approach to prevention and/or therapy of prostate cancer achieved via HDAC inhibition...
  33. ncbi request reprint Apigenin attenuates insulin-like growth factor-I signaling in an autochthonous mouse prostate cancer model
    Sanjeev Shukla
    Department of Urology, Case Western Reserve University, 2109 Adelbert Road, Wood Research Tower, RTG01, Cleveland, Ohio 44106, USA
    Pharm Res 29:1506-17. 2012
    ..Deregulation of IGF signaling plays an important role in prostate cancer and contributes to invasion and metastasis. We determined the effect of apigenin, a plant flavone, on IGF signaling and its downstream targets in TRAMP mice...
  34. pmc High-fat diet activates pro-inflammatory response in the prostate through association of Stat-3 and NF-κB
    Eswar Shankar
    Department of Urology, Case Western Reserve University and The Urology Institute, University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
    Prostate 72:233-43. 2012
    ..We sought to determine whether Stat-3 is involved in the activation of NF-κB in the prostate as a result of HFD feeding, leading to inflammation...
  35. ncbi request reprint Molecular mechanisms for apigenin-induced cell-cycle arrest and apoptosis of hormone refractory human prostate carcinoma DU145 cells
    Sanjeev Shukla
    Department of Urology, The James and Eilleen Dicke Research Laboratory, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Mol Carcinog 39:114-26. 2004
    ....
  36. ncbi request reprint Suppression of prostate carcinogenesis by dietary supplementation of celecoxib in transgenic adenocarcinoma of the mouse prostate model
    Sanjay Gupta
    Department of Urology, The James and Eilleen Dicke Research Laboratory, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio, USA
    Cancer Res 64:3334-43. 2004
    ..014), compared with AIN 76A-fed group. Our findings suggest that celecoxib may be useful in chemoprevention of prostate cancer...
  37. ncbi request reprint Molecular imaging of NF-kappaB in prostate tissue after systemic administration of IL-1 beta
    Eugene V Vykhovanets
    Department of Urology, Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
    Prostate 68:34-41. 2008
    ..A wide range of human cancers and inflammatory disorders express inappropriate regulation of NF-kappaB. The role of NF-kappaB in intraprostatic inflammation has not been elucidated...
  38. ncbi request reprint Deregulation of FoxO3a accelerates prostate cancer progression in TRAMP mice
    Sanjeev Shukla
    Department of Urology, Case Western Reserve University and The Urology Institute, University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
    Prostate 73:1507-17. 2013
    ..We therefore investigated the role of FoxO transcription factors in prostate cancer progression, in particular FoxO3a, in transgenic adenocarcinoma of the mouse prostate (TRAMP) mice, which mimics progressive forms of human disease...
  39. ncbi request reprint Antiproliferative and apoptotic effects of chamomile extract in various human cancer cells
    Janmejai K Srivastava
    Department of Urology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Agric Food Chem 55:9470-8. 2007
    ..Further investigations of the mechanism of action of chamomile are warranted in evaluating the potential usefulness of this herbal remedy in the management of cancer patients...
  40. pmc IL-17 Expression by macrophages is associated with proliferative inflammatory atrophy lesions in prostate cancer patients
    Eugene V Vykhovanets
    Department of Urology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Int J Clin Exp Pathol 4:552-65. 2011
    ..The accumulation of IL-17 expressing cells in PIA lesions presents direct evidence of an inflammatory microenvironment that may support the development of prostate cancer...
  41. pmc Il-1 beta-induced post-transition effect of NF-kappaB provides time-dependent wave of signals for initial phase of intrapostatic inflammation
    Eugene V Vykhovanets
    Department of Urology, Case Western Reserve University, Case Medical Center and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    Prostate 69:633-43. 2009
    ..It has been hypothesized that NF-kappaB plays a role in the development of prostatitis, and that NF-kappaB activation might provide chemoattractive signals for leukocyte extravasation in the prostate...
  42. pmc Chamomile: an anti-inflammatory agent inhibits inducible nitric oxide synthase expression by blocking RelA/p65 activity
    Natarajan Bhaskaran
    Department of Urology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Int J Mol Med 26:935-40. 2010
    ..These results demonstrate that chamomile inhibits NO production and iNOS gene expression by inhibiting RelA/p65 activation and supports the utilization of chamomile as an effective anti-inflammatory agent...
  43. ncbi request reprint Differential expression of S100A2 and S100A4 during progression of human prostate adenocarcinoma
    Sanjay Gupta
    Department of Urology, Case Western Reserve University and The Research Institute of University Hospitals of Cleveland, Cleveland, OH, USA
    J Clin Oncol 21:106-12. 2003
    ..To establish the clinical significance of calcium binding proteins S100A2 and S100A4 during progression of human prostate adenocarcinoma...
  44. ncbi request reprint Molecular pathway for (-)-epigallocatechin-3-gallate-induced cell cycle arrest and apoptosis of human prostate carcinoma cells
    Sanjay Gupta
    Department of Urology, Jim and Eillen Dicke Research Laboratory, Case Western Reserve University, The Research Institute of University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Arch Biochem Biophys 410:177-85. 2003
    ..This is the first systematic study showing the involvement of each component of cdk inhibitor-cyclin-cdk machinery during cell cycle arrest and apoptosis of human prostate carcinoma cells by EGCG...
  45. ncbi request reprint Tocotrienol-rich fraction of palm oil induces cell cycle arrest and apoptosis selectively in human prostate cancer cells
    Janmejai K Srivastava
    Department of Urology, Case Western Reserve University, Cleveland, OH 44106, USA
    Biochem Biophys Res Commun 346:447-53. 2006
    ..TRF offers significant promise as a chemopreventive and/or therapeutic agent against prostate cancer...
  46. pmc Apigenin-induced prostate cancer cell death is initiated by reactive oxygen species and p53 activation
    Sanjeev Shukla
    Department of Urology, Case Western Reserve University, Cleveland, OH 44106, USA
    Free Radic Biol Med 44:1833-45. 2008
    ..These results indicate that apigenin-induced apoptosis in 22Rv1 cells is initiated by a ROS-dependent disruption of the mitochondrial membrane potential through transcriptional-dependent and -independent p53 pathways...
  47. pmc The chemopreventive and chemotherapeutic potentials of tea polyphenols
    Vijay S Thakur
    Department of Urology and Nutrition, Case Western Reserve University, Cleveland, OH 44106, USA
    Curr Pharm Biotechnol 13:191-9. 2012
    ..Finally, we discuss on the scope and development of tea polyphenols in cancer prevention and therapy...
  48. ncbi request reprint Dietary agents in the chemoprevention of prostate cancer
    Sanjeev Shukla
    Department of Urology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Nutr Cancer 53:18-32. 2005
    ....
  49. ncbi request reprint Dietary terpenoids and prostate cancer chemoprevention
    Thangaiyan Rabi
    Department of Urology, Case Western Reserve University, University Hospitals, University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
    Front Biosci 13:3457-69. 2008
    ..Here we review naturally occurring dietary terpenoids as useful agents for prostate cancer chemoprevention with reference to their classes and sources...
  50. ncbi request reprint Green tea and prostate cancer
    Sanjay Gupta
    Department of Urology, University Hospitals of Cleveland, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Urol Clin North Am 29:49-57, viii. 2002
    ..In this article, we address the use of green tea for prostate cancer chemoprevention. Experimental as well as the epidemiological basis for this possibility is provided...
  51. ncbi request reprint The influence of chronic inflammation in prostatic carcinogenesis: a 5-year followup study
    Gregory T MacLennan
    Department of Pathology, University Hospitals of Cleveland, Cleveland, Ohio, USA
    J Urol 176:1012-6. 2006
    ..We investigated an association between chronic prostatic inflammation and prostate carcinogenesis...
  52. pmc Green tea and prostate cancer: from bench to clinic
    Mitali Pandey
    Department of Urology and Nutrition, Case Western Reserve University, Clevelamd, OH 44106, USA
    Front Biosci (Elite Ed) 1:13-25. 2009
    ..The review concludes with a brief discussion of the future direction and development of clinical trials employing green tea catechins which could be developed for prevention and/or intervention of prostate cancer...
  53. pmc The role of histone deacetylases in prostate cancer
    Ata Abbas
    Department of Urology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Epigenetics 3:300-9. 2008
    ..In this review, we discuss the molecular mechanism(s) through which HDACs influence prostate cancer progression and the potential roles of HDAC inhibitors in prostate cancer prevention and therapy...
  54. pmc Apigenin: a promising molecule for cancer prevention
    Sanjeev Shukla
    Department of Urology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA
    Pharm Res 27:962-78. 2010
    ..Human clinical trials examining the effect of supplementation of apigenin on disease prevention have not been conducted, although there is considerable potential for apigenin to be developed as a cancer chemopreventive agent...
  55. ncbi request reprint Chemoprevention of skin cancer: current status and future prospects
    Sanjay Gupta
    Department of Urology, Case Western Reserve University and The Research Institute of University Hospitals of Cleveland, Cleveland, OH, USA
    Cancer Metastasis Rev 21:363-80. 2002
    ..We will also discuss the current status and future prospects of these agents for development as promising chemopreventive agents against skin cancer...
  56. ncbi request reprint Apigenin and cancer chemoprevention: progress, potential and promise (review)
    Deendayal Patel
    Department of Urology, Case Western Reserve University, Cleveland, OH 44106, USA
    Int J Oncol 30:233-45. 2007
    ..This review examines the cancer chemopreventive effects of apigenin in an organ-specificity format, evaluating its limitations and its considerable potential for development as a cancer chemopreventive agent...
  57. ncbi request reprint High-fat diet increases NF-κB signaling in the prostate of reporter mice
    Eugene V Vykhovanets
    Department of Urology, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
    Prostate 71:147-56. 2011
    ..NF-κB has been implicated in stress response and is deregulated in prostrate disorders; therefore, we sought to determine whether HFD could induce oxidative stress in the prostate which could contribute to prostatic diseases...
  58. pmc Multifaceted role of EZH2 in breast and prostate tumorigenesis: epigenetics and beyond
    Gauri Deb
    Department of Urology, Case Western Reserve University, Cleveland, OH, USA
    Epigenetics 8:464-76. 2013
    ..We also summarize how EZH2 has emerged as a promising therapeutic target in hormone-refractory cancers and the prospects for integrating EZH2 blockade with available pharmacological inhibitors. ..
  59. ncbi request reprint Role of the retinoblastoma (pRb)-E2F/DP pathway in cancer chemopreventive effects of green tea polyphenol epigallocatechin-3-gallate
    Nihal Ahmad
    Department of Dermatology, Case Western Reserve University, The Research Institute of University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, Ohio 44106, USA
    Arch Biochem Biophys 398:125-31. 2002
    ..This, to our knowledge, is the first study showing the involvement of the pRb-E2F/DP pathway in antiproliferative and apoptotic effects of EGCG...
  60. pmc Plant phytochemicals as epigenetic modulators: role in cancer chemoprevention
    Vijay S Thakur
    Department of Urology, Case Western Reserve University, University Hospitals Case Medical Center, 10900 Euclid Avenue, Cleveland, Ohio, 44106, USA
    AAPS J 16:151-63. 2014
    ..We present in detail the epigenetic mode of action of various phytochemicals and discuss their potential as safe and clinically useful chemopreventive strategies. ..
  61. pmc Molecular imaging of nuclear factor-κB in bladder as a primary regulator of inflammatory response
    Eugene V Vykhovanets
    Case Western Reserve University and The Urology Institute, University Hospitals Case Medical Center, Cleveland, Ohio, USA
    J Urol 187:330-7. 2012
    ..The role of nuclear factor-κB activation in bladder inflammation is not well defined...
  62. ncbi request reprint Apigenin induces apoptosis by targeting inhibitor of apoptosis proteins and Ku70-Bax interaction in prostate cancer
    Sanjeev Shukla
    Department of Urology, Case Western Reserve University and The Urology Institute, University Hospitals Case Medical Center, 10900 Euclid Avenue, Cleveland, OH, 44106, USA
    Apoptosis 19:883-94. 2014
    ..These results suggest that apigenin targets inhibitor of apoptosis proteins and Ku70-Bax interaction in the induction of apoptosis in prostate cancer cells and in athymic nude mouse xenograft model endorsing its in vivo efficacy...
  63. pmc Radiotherapy and survival in prostate cancer patients: a population-based study
    Esther H Zhou
    Department of Urology, Case Western Reserve University School of Medicine, Cleveland, OH, USA
    Int J Radiat Oncol Biol Phys 73:15-23. 2009
    ....
  64. ncbi request reprint Prognostic significance of metastasis-associated protein S100A4 (Mts1) in prostate cancer progression and chemoprevention regimens in an autochthonous mouse model
    Mohammad Saleem
    Department of Dermatology, University of Wisconsin Madison, Wisconsin 53706, USA
    Clin Cancer Res 11:147-53. 2005
    ..Because oral consumption of green tea polyphenols (GTP) has been shown to inhibit metastasis and prostate cancer in TRAMP, we further assessed the significance of S100A4 during chemoprevention regimen...
  65. ncbi request reprint Oral consumption of green tea polyphenols inhibits insulin-like growth factor-I-induced signaling in an autochthonous mouse model of prostate cancer
    Vaqar Mustafa Adhami
    Department of Dermatology, University of Wisconsin, Madison, Wisconsin 53706, USA
    Cancer Res 64:8715-22. 2004
    ....
  66. ncbi request reprint Overexpression of cyclin D1 is associated with the decondensation of chromatin during den-induced sequential hepatocarcinogenesis
    Monisha Sundarrajan
    Carcinogenesis Division, Cancer Research Institute, Tata Memorial Centre, Parel, Mumbai 400 012, India
    Cell Biol Int 26:699-706. 2002
    ..Thus, the functional inter-relationship between chromatin organization and gene expression appears to be of critical importance for liver tumour development...
  67. ncbi request reprint Development of a large animal model for lung tumors
    Kamran Ahrar
    University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Box 325, Houston, Texas 77030, USA
    J Vasc Interv Radiol 13:923-8. 2002
    ..Our goal was to develop a lung tumor model in a large animal to simulate human lung cancer for preclinical assessment of novel therapeutic options...
  68. ncbi request reprint Percutaneous ultrasound-guided biopsy in the definitive diagnosis of osteosarcoma
    Kamran Ahrar
    Department of Interventional Radiology, University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    J Vasc Interv Radiol 15:1329-33. 2004
    ..All 23 US-guided biopsies resulted in definitive diagnosis. Two of the 12 fluoroscopy- or CT-guided biopsies (17%) were inconclusive...
  69. ncbi request reprint Descriptive and prognostic value of patient-reported outcomes: the bortezomib experience in relapsed and refractory multiple myeloma
    Dominique Dubois
    Johnson and Johnson Pharmaceutical Services and Pharmaceutical Research and Development, Beerse, Belgium
    J Clin Oncol 24:976-82. 2006
    ..The goal of this work was to evaluate the added value of patient-reported outcomes (PRO) in the interpretation of bortezomib clinical trial outcomes...
  70. ncbi request reprint Prostate priorities: a new approach to the cancer that 1 in 6 American men will eventually get
    Sanjay Gupta
    Time 164:90. 2004
  71. ncbi request reprint Green tea constituent epigallocatechin-3-gallate selectively inhibits COX-2 without affecting COX-1 expression in human prostate carcinoma cells
    Tajamul Hussain
    University of Wisconsin, Department of Dermatology, 1300 University Ave, Madison, WI 53706, USA
    Int J Cancer 113:660-9. 2005
    ..Based on our study, it is tempting to suggest that a combination of EGCG with chemotherapeutic drugs could be an improved strategy for prevention and treatment of prostate cancer...
  72. ncbi request reprint Cyclooxygenase-2 and prostate carcinogenesis
    Tajamul Hussain
    Department of Dermatology, University of Wisconsin, Medical Science Center, 1300 University Avenue, Madison, WI 53706, USA
    Cancer Lett 191:125-35. 2003
    ..An exciting corollary to this ongoing work is that selective COX-2 inhibitors may exhibit chemopreventive and even chemotherapeutic effects against prostate carcinogenesis in humans...
  73. ncbi request reprint Percutaneous radiofrequency ablation of lung tumors in a large animal model
    Kamran Ahrar
    University of Texas M D Anderson Cancer Center, the Departments of Diagnostic Radiology, 1515 Holcombe Boulevard, Unit 325, Houston, Texas 77030 4009, USA
    J Vasc Interv Radiol 14:1037-43. 2003
    ..We undertook this study to evaluate the feasibility and immediate effectiveness of RFA for treatment of both solitary pulmonary nodules and clusters of lung tumors in a large animal model...
  74. ncbi request reprint T cell receptor engagement leads to the recruitment of IBP, a novel guanine nucleotide exchange factor, to the immunological synapse
    Sanjay Gupta
    Departments of Medicine and Medicine and Pharmacology, Columbia University, New York, New York 10032, USA
    J Biol Chem 278:43541-9. 2003
    ..The recruitment and activation of distinct classes of GEFs may allow for precise control of Rho GTPase function at the crucial interface between T cells and antigen presenting cells...
  75. ncbi request reprint Skipping chemo. A lot of breast-cancer survivors are doing it, not always for good reasons
    Sanjay Gupta
    Time 161:68. 2003
  76. ncbi request reprint Synthesis of N-aryl-5-amino-4-cyanopyrazole derivatives as potent xanthine oxidase inhibitors
    Sanjay Gupta
    Centro de Quimica, Universidade do Minho, Campus de Gualtar, 4710 057 Braga, Portugal
    Eur J Med Chem 43:771-80. 2008
    ..MEP calculations were used to explain different inhibitory efficiency of similar inhibitors...
  77. ncbi request reprint Tocotrienol-rich fraction of palm oil activates p53, modulates Bax/Bcl2 ratio and induces apoptosis independent of cell cycle association
    Mukesh K Agarwal
    Department of Medical Elementology and Toxicology, Hamdard University, New Delhi, India
    Cell Cycle 3:205-11. 2004
    ..Our data suggest that TRF-induced apoptosis in colon carcinoma cells is mediated by p53 signaling network which appears to be independent of cell cycle association...
  78. ncbi request reprint Hyperphosphorylation of extracellular regulated kinase 2 (ERK2) and inhibition of JNK2 phosphorylation are associated with increased S-phase during transformation of Syrian hamster embryo cells by Malachite Green
    Bipasha Bose
    Chemical Carcinogenesis Group, Cancer Research Institute, Advanced Centre for Treatment Research and Education in Cancer ACTREC, Tata Memorial Centre, Kharghar, Navi Mumbai 410 208, India
    Cell Biol Int 28:875-83. 2004
    ....
  79. ncbi request reprint Update on the management of neuroendocrine hepatic metastases
    David C Madoff
    Division of Diagnostic Imaging, Interventional Radiology Section, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 325, Houston, 77030 4009, USA
    J Vasc Interv Radiol 17:1235-49; quiz 1250. 2006
    ..This article reviews the care of patients with NETs and hepatic metastases, with emphasis on the increasingly important role of oncologic image-guided interventions...
  80. ncbi request reprint Hepatic artery embolization for hepatocellular carcinoma: technique, patient selection, and outcomes
    Kamran Ahrar
    Section of Vascular and Interventional Radiology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 325, Houston, TX 77030, USA
    Surg Oncol Clin N Am 12:105-26. 2003
    ..More recently, two excellent randomized clinical trials have demonstrated significant survival benefit for patients treated with TACE when compared with those treated symptomatically...

Research Grants19

  1. Prostate Cancer Chemoprevention by Apigenin
    Sanjay Gupta; Fiscal Year: 2003
    ..These studies could be considered as a starting point for an expanded program for the development of apigenin as a promising agent against CaP in humans. ..
  2. Molecular Mechanisms of GSTP1 Reactivation by Green Tea Polyphenols
    Sanjay Gupta; Fiscal Year: 2007
    ..With the 'proof of principle' more structurally-related non- toxic compounds could be developed in future for prevention of prostate cancer in humans. ..
  3. Chamomile as Medicine for Prostate cancer
    Sanjay Gupta; Fiscal Year: 2006
    ..Completion of the proposed studies will provide a 'head start' to initiate clinical trials in prostate cancer patients and/or high-risk individuals. ..
  4. Mechanisms of Prostate Ca. Chemoprevention by Apigenin
    Sanjay Gupta; Fiscal Year: 2005
    ..The outcome of this proposal will define NF-kappaB as an important molecular target and apigenin as promising agent against prostate cancer. ..
  5. Reactivation of GSTP1 Gene by Green Tea Polyphenols
    Sanjay Gupta; Fiscal Year: 2005
    ..abstract_text> ..
  6. Chamomile as Medicine for Prostate cancer
    Sanjay Gupta; Fiscal Year: 2005
    ..Completion of the proposed studies will provide a 'head start' to initiate clinical trials in prostate cancer patients and/or high-risk individuals. ..
  7. Molecular Mechanisms of GSTP1 Reactivation by Green Tea Polyphenols
    Sanjay Gupta; Fiscal Year: 2009
    ..With the 'proof of principle' more structurally-related non- toxic compounds could be developed in future for prevention of prostate cancer in humans. ..
  8. Chamomile as Medicine for Prostate cancer
    Sanjay Gupta; Fiscal Year: 2009
    ..Completion of the proposed studies will provide a 'head start' to initiate clinical trials in prostate cancer patients and/or high-risk individuals. ..
  9. Molecular Mechanisms of GSTP1 Reactivation by Green Tea Polyphenols
    Sanjay Gupta; Fiscal Year: 2010
    ..With the 'proof of principle'more structurally-related non- toxic compounds could be developed in future for prevention of prostate cancer in humans. ..
  10. Chamomile as Medicine for Prostate cancer
    Sanjay Gupta; Fiscal Year: 2007
    ..Completion of the proposed studies will provide a 'head start' to initiate clinical trials in prostate cancer patients and/or high-risk individuals. ..
  11. Mechanisms of Prostate Cancer Chemoprevention by Apigenin
    Sanjay Gupta; Fiscal Year: 2007
    ..The outcome of this proposal will define NF-kappaB as an important molecular target and apigenin as promising agent against prostate cancer. ..
  12. Mechanisms of Prostate Ca. Chemoprevention by Apigenin
    Sanjay Gupta; Fiscal Year: 2006
    ..The outcome of this proposal will define NF-kappaB as an important molecular target and apigenin as promising agent against prostate cancer. ..
  13. Anti-proliferative Effects of D-limonene against Prosta*
    Sanjay Gupta; Fiscal Year: 2005
    ..Successful completion of this application will establish the cancer chemopreventive and/or therapeutic potential of D-limonene against prostate cancer and mechanisms involved with its anti-proliferative response. ..
  14. Prostate Cancer Chemoprevention by Apigenin
    Sanjay Gupta; Fiscal Year: 2004
    ..The outcome of this proposal will define NF-kappaB as an important molecular target and apigenin as promising agent against prostate cancer. ..
  15. Inhibition of Prostate Carcinogenesis by Apigenin
    Sanjay Gupta; Fiscal Year: 2003
    ..A successful completion of this application will set a platform to define the role of apigenin as a promising agent against prevention and possibly therapy of prostate cancer in humans. ..
  16. Molecular Mechanisms of Prostate Cancer Chemoprevention by Apigenin
    Sanjay Gupta; Fiscal Year: 2010
    ..Understanding the molecular mechanisms of apigenin may reveal key molecular targets for the development of more effective agents with fewer side-effects for future use in chemopreventive/therapeutic regimens. ..