M A Ghannoum


Affiliation: Case Western Reserve University
Country: USA


  1. Larkin E, Long L, Isham N, Borroto Esoda K, Barat S, Angulo D, et al. A Novel 1,3-Beta-d-Glucan Inhibitor, Ibrexafungerp (Formerly SCY-078), Shows Potent Activity in the Lower pH Environment of Vulvovaginitis. Antimicrob Agents Chemother. 2019;63: pubmed publisher
    ..Importantly, activity of IBX in an acidic medium suggests a therapeutic advantage of this novel antifungal in the treatment of vaginal Candida infections. ..
  2. Pristov K, Ghannoum M, Fidsa -. Resistance of Candida to azoles and echinocandins worldwide. Clin Microbiol Infect. 2019;: pubmed publisher
    ..Increased resistance to azoles and echinocandins by Candida species is an increasingly serious problem in clinical setting worldwide. Understanding the mechanisms used against antifungal drugs is imperative to patient treatment. ..
  3. Hager C, Isham N, Schrom K, Chandra J, McCormick T, Miyagi M, et al. Effects of a Novel Probiotic Combination on Pathogenic Bacterial-Fungal Polymicrobial Biofilms. MBio. 2019;10: pubmed publisher
    ..Amylase, which is known to have some antibiofilm activity, was also added to the probiotic mixture. This novel probiotic may have utility for the management of inflammatory bowel diseases by disrupting polymicrobial biofilm formation. ..
  4. Ghannoum M, Welshenbaugh A, Imamura Y, Isham N, Mallefet P, Yamaguchi H. Comparison of the in vitro activity of terbinafine and lanoconazole against dermatophytes. Mycoses. 2010;53:311-3 pubmed publisher
    ..Both LAN and TERB demonstrated potent antifungal activity against dermatophytes; however, the lack of fungicidal activity by LAN needs to be evaluated in terms of potential clinical efficacy. ..
  5. Ghannoum M, Isham N, Jacobs M. Antimicrobial activity of B-Lock against bacterial and Candida spp. causing catheter-related bloodstream infections. Antimicrob Agents Chemother. 2011;55:4430-1 pubmed publisher
    ..003% to 25% against bacterial strains (n = 175). B-Lock was also fungicidal against the majority of the Candida strains at 6% to 25%. B-Lock demonstrates potential value for the prevention and treatment of catheter-associated infections. ..
  6. Ghannoum M, Mukherjee P, Jurevic R, Retuerto M, Brown R, Sikaroodi M, et al. Metabolomics reveals differential levels of oral metabolites in HIV-infected patients: toward novel diagnostic targets. OMICS. 2013;17:5-15 pubmed publisher
  7. request reprint
    Ghannoum M, Mukherjee P, Warshaw E, Evans S, Korman N, Tavakkol A. Molecular analysis of dermatophytes suggests spread of infection among household members. Cutis. 2013;91:237-45 pubmed
    ..This study is unique in that it used molecular evidence to demonstrate the association of certain strains with the spread of dermatophyte infection among members of the same household. ..
  8. Ghannoum M, Long L, Isham N, Bulgheroni A, Setaro M, Caserini M, et al. Ability of hydroxypropyl chitosan nail lacquer to protect against dermatophyte nail infection. Antimicrob Agents Chemother. 2015;59:1844-8 pubmed publisher
    ..Unlike chemicals normally used in cosmetic treatments, repeated application of the HPCH nail solution may help prevent the establishment of new or recurring fungal nail infection. ..
  9. Chandra J, Long L, Isham N, Mukherjee P, DiSciullo G, Appelt K, et al. In Vitro and In Vivo Activity of a Novel Catheter Lock Solution against Bacterial and Fungal Biofilms. Antimicrob Agents Chemother. 2018;62: pubmed publisher
    ..Our results demonstrated that ACL was efficacious against both adhesion-phase and mature biofilms formed by bacteria and fungi in vitro and in vivo. ..

More Information


  1. Chandra J, Retuerto M, Mukherjee P, Ghannoum M. The Fungal Biome of the Oral Cavity. Methods Mol Biol. 2016;1356:107-35 pubmed publisher
    ..Our group recently characterized the oral mycobiome in health and disease focusing on HIV. In this chapter we will describe the methods used by our group for characterization of the oral mycobiome. ..
  2. Ghannoum M, Long L, Pfister W. Determination of the efficacy of terbinafine hydrochloride nail solution in the topical treatment of dermatophytosis in a guinea pig model. Mycoses. 2009;52:35-43 pubmed publisher
    ..Evaluation of the 1%, 5% and 10% TNS in clinical trials for the treatment of dermatophytosis and onychomycosis is warranted. ..
  3. Ghannoum M, Isham N, Long L. In vitro antifungal activity of ME1111, a new topical agent for onychomycosis, against clinical isolates of dermatophytes. Antimicrob Agents Chemother. 2015;59:5154-8 pubmed publisher
    ..Our studies show that ME1111 possesses potent antifungal activity and suggest that it has low potential for the development of resistance in dermatophytes. ..
  4. Long L, Hager C, Ghannoum M. Evaluation of the Efficacy of ME1111 in the Topical Treatment of Dermatophytosis in a Guinea Pig Model. Antimicrob Agents Chemother. 2016;60:2343-5 pubmed publisher
    ..9% and 25.0%, respectively, with aPvalue of <0.001). The potent efficacy of ME1111 could be attributed to its properties, such as low keratin binding. ..
  5. Mofidfar M, Wang J, Long L, Hager C, Vareechon C, Pearlman E, et al. Polymeric Nanofiber/Antifungal Formulations Using a Novel Co-extrusion Approach. AAPS PharmSciTech. 2017;18:1917-1924 pubmed publisher
    ..electrospun samples. This, coupled with the much higher throughput of the co-extrusion process vs. electrospinning, renders this new approach very attractive for the fabrication of drug-releasing polymer fibers. ..
  6. Muakkassa F, Ghannoum M. Updates on Therapeutic Strategies Against Candida (and Aspergillus) Biofilm Related Infections. Adv Exp Med Biol. 2016;931:95-103 pubmed publisher
    ..In this chapter we describe the emerging therapies for biofilm related infections. ..
  7. Ghannoum M, Long L, Larkin E, Isham N, Sherif R, Borroto Esoda K, et al. Evaluation of the Antifungal Activity of the Novel Oral Glucan Synthase Inhibitor SCY-078, Singly and in Combination, for the Treatment of Invasive Aspergillosis. Antimicrob Agents Chemother. 2018;62: pubmed publisher
    ..SCY-078 may be an important additional antifungal for first-line or salvage monotherapy or combination treatment of invasive aspergillosis. ..
  8. Hager C, Larkin E, Long L, Zohra Abidi F, Shaw K, Ghannoum M. In Vitro and In Vivo Evaluation of the Antifungal Activity of APX001A/APX001 against Candida auris. Antimicrob Agents Chemother. 2018;62: pubmed publisher
    ..Anidulafungin also showed a significant log reduction in CFU in the kidneys and lungs (1.5 and 1.62, respectively) but did not impact brain CFU. These data support further clinical evaluation of this new antifungal agent. ..
  9. Larkin E, Hager C, Chandra J, Mukherjee P, Retuerto M, Salem I, et al. The Emerging Pathogen Candida auris: Growth Phenotype, Virulence Factors, Activity of Antifungals, and Effect of SCY-078, a Novel Glucan Synthesis Inhibitor, on Growth Morphology and Biofilm Formation. Antimicrob Agents Chemother. 2017;61: pubmed publisher
    ..SCY-078, the new orally bioavailable antifungal, had potent antifungal/antibiofilm activity against C. auris, indicating that further evaluation of this antifungal is warranted. ..
  10. Ghannoum M. Cooperative Evolutionary Strategy between the Bacteriome and Mycobiome. MBio. 2016;7: pubmed publisher
  11. Ghannoum M, Chaturvedi V, Diekema D, Ostrosky Zeichner L, Rennie R, Walsh T, et al. Multilaboratory Evaluation of In Vitro Antifungal Susceptibility Testing of Dermatophytes for ME1111. J Clin Microbiol. 2016;54:662-5 pubmed publisher
    ..The MIC endpoint should be 80% inhibition compared with the growth control. T. rubrum ATCC MYA-4438 and T. mentagrophytes ATCC 28185 were selected as QC isolates, with an acceptable range of 0.12 to 1 μg/ml for the two strains. ..
  12. Hager C, Ghannoum M. The mycobiome: Role in health and disease, and as a potential probiotic target in gastrointestinal disease. Dig Liver Dis. 2017;49:1171-1176 pubmed publisher
  13. Chandra J, Ghannoum M. CD101, a Novel Echinocandin, Possesses Potent Antibiofilm Activity against Early and Mature Candida albicans Biofilms. Antimicrob Agents Chemother. 2018;62: pubmed publisher
    ..CD101-treated hyphae failed to grow into mature biofilms. These results suggest that CD101 may be effective in the prevention and treatment of biofilm-associated nosocomial infections. ..
  14. Christensen L, Turner R, Weaver S, Caserta F, Long L, Ghannoum M, et al. Evaluation of the Ability of a Novel Miconazole Formulation To Penetrate Nail by Using Three In Vitro Nail Models. Antimicrob Agents Chemother. 2017;61: pubmed publisher
    ..These assays included the bovine hoof, TurChub zone of inhibition, and infected-nail models. ..
  15. Ghannoum M, Isham N, Herbert J, Henry W, Yurdakul S. Activity of TDT 067 (terbinafine in Transfersome) against agents of onychomycosis, as determined by minimum inhibitory and fungicidal concentrations. J Clin Microbiol. 2011;49:1716-20 pubmed publisher
    ..The Transfersome vehicle appears to potentiate the antifungal activity of terbinafine. Clinical investigation of TDT 067 for the topical treatment of onychomycosis is warranted...
  16. Ghannoum M, Wraith L, Cai B, Nyirady J, Isham N. Susceptibility of dermatophyte isolates obtained from a large worldwide terbinafine tinea capitis clinical trial. Br J Dermatol. 2008;159:711-3 pubmed publisher
    ..Our group, in collaboration with seven other laboratories, has recently developed a method to determine the susceptibility of dermatophytes...