Steven A Fisher

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. ncbi Endothelin-1 alters the contractile phenotype of cultured embryonic smooth muscle cells
    S A Fisher
    Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Circ Res 80:885-93. 1997
  2. ncbi Forced expression of the homeodomain protein Gax inhibits cardiomyocyte proliferation and perturbs heart morphogenesis
    S A Fisher
    Division of Cardiology and Molecular Cardiovascular Research Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Development 124:4405-13. 1997
  3. pmc Competition of PTB with TIA proteins for binding to a U-rich cis-element determines tissue-specific splicing of the myosin phosphatase targeting subunit 1
    Supriya Shukla
    Department of Medicine Cardiology, Case Western Reserve University School of Medicine, BRB 422, Cleveland, OH 44106 4958, USA
    RNA 11:1725-36. 2005
  4. pmc Altered hypoxia-inducible factor-1 alpha expression levels correlate with coronary vessel anomalies
    Jamie Wikenheiser
    Department of Pediatrics, Rainbow Babies and Children s Hospital, Case Western Reserve University, Cleveland, Ohio 44106 6011, USA
    Dev Dyn 238:2688-700. 2009
  5. ncbi Myosin phosphatase isoform switching in vascular smooth muscle development
    Michael C Payne
    Department of Medicine, 422 BRB, 2109 Adelbert Road, Case Western Reserve School of Medicine, Cleveland, OH 44106 4958, USA
    J Mol Cell Cardiol 40:274-82. 2006
  6. ncbi Fas ligand gene transfer to the embryonic heart induces programmed cell death and outflow tract defects
    Denver Sallee
    Department of Pediatrics Cardiology, Case Western Reserve School of Medicine, Cleveland, OH 44106, USA
    Dev Biol 267:309-19. 2004
  7. pmc Tra2beta as a novel mediator of vascular smooth muscle diversification
    Supriya Shukla
    Departments of Medicine Cardiology, Case Western Reserve School of Medicine, Cleveland, Ohio 44106, USA
    Circ Res 103:485-92. 2008
  8. pmc Induction of PDE5 and de-sensitization to endogenous NO signaling in a systemic resistance artery under altered blood flow
    Haiying Zhang
    Department of Medicine Cardiology, Case Western Reserve School of Medicine, 4 533 Wolstein Research Bldg, 2103 Cornell Rd, Cleveland, OH 44106, USA
    J Mol Cell Cardiol 47:57-65. 2009
  9. pmc Tra2β protein is required for tissue-specific splicing of a smooth muscle myosin phosphatase targeting subunit alternative exon
    Kang Fu
    Department of Medicine Cardiology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 287:16575-85. 2012
  10. ncbi The development of the embryonic outflow tract provides novel insights into cardiac differentiation and remodeling
    Yasuyuki Sugishita
    Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Trends Cardiovasc Med 14:235-41. 2004

Collaborators

  • Patricia Parsons-Wingerter
  • Mitsuo Ikebe
  • Jamie Wikenheiser
  • Ke Yang
  • Faton Agani
  • Qiwei Yang
  • Brunhilde Wirth
  • M Watanabe
  • K Walsh
  • Jun Liu
  • Maurizio Mandala
  • KATHY K SVOBODA
  • Edie C Goldsmith
  • Supriya Shukla
  • Haiying Zhang
  • Yasuyuki Sugishita
  • Hongbin Liu
  • Michael C Payne
  • Florence Rothenberg
  • Sanchita Basu
  • Kang Fu
  • Wessel P Dirksen
  • Yuan Lu
  • Katherine M Joyce
  • Yasuhiko Koga
  • Hai Ying Zhang
  • Richard Breathnach
  • Denver Sallee
  • Katherine S Schaefer
  • Qi Quan Huang
  • Rongli Zhang
  • Dinesh Kumar Srinivasan
  • Aaron Proweller
  • Hema Raina
  • Suhanti Banerjee
  • Brian A Perrino
  • Salah Baker
  • Ylva Mende
  • Bhupal P Bhetwal
  • J J Khatri
  • Krishnan Radhakrishnan
  • Dedra E Whitfield
  • Hyon Jae Lee
  • Praveen Pakeerappa
  • Camille L M Everhart
  • George Osol
  • Osamu Sato
  • Natalia Gokina
  • Tony Prosdocimo
  • Fabienne Del Gatto-Konczak
  • Caroline Le Guiner-Blanvillain
  • Frank V Brozovich
  • Joseph N Benoit
  • Yuichi Shirasawa
  • David W Leifer
  • Yong Qiu Doughman
  • Yaling Qiu
  • Sotohy A Mohamed
  • Midori Hitomi
  • F V Brozovich
  • K M Joyce

Detail Information

Publications32

  1. ncbi Endothelin-1 alters the contractile phenotype of cultured embryonic smooth muscle cells
    S A Fisher
    Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Circ Res 80:885-93. 1997
    ....
  2. ncbi Forced expression of the homeodomain protein Gax inhibits cardiomyocyte proliferation and perturbs heart morphogenesis
    S A Fisher
    Division of Cardiology and Molecular Cardiovascular Research Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Development 124:4405-13. 1997
    ..These results suggest a role for the Gax protein in heart morphogenesis causing proliferating cardiomyocytes to withdraw from the cell cycle, thus influencing the size and shape that the heart ultimately attains...
  3. pmc Competition of PTB with TIA proteins for binding to a U-rich cis-element determines tissue-specific splicing of the myosin phosphatase targeting subunit 1
    Supriya Shukla
    Department of Medicine Cardiology, Case Western Reserve University School of Medicine, BRB 422, Cleveland, OH 44106 4958, USA
    RNA 11:1725-36. 2005
    ..This provides a novel role for PTB in the tissue-specific regulation of splicing of alternative exons during the generation of smooth muscle phenotypic diversity...
  4. pmc Altered hypoxia-inducible factor-1 alpha expression levels correlate with coronary vessel anomalies
    Jamie Wikenheiser
    Department of Pediatrics, Rainbow Babies and Children s Hospital, Case Western Reserve University, Cleveland, Ohio 44106 6011, USA
    Dev Dyn 238:2688-700. 2009
    ..These findings indicated that developing coronary vessels may be subject to a level of regulation that is dependent on differential oxygen levels within cardiac tissues and subsequent HIF-1 regulation of gene expression...
  5. ncbi Myosin phosphatase isoform switching in vascular smooth muscle development
    Michael C Payne
    Department of Medicine, 422 BRB, 2109 Adelbert Road, Case Western Reserve School of Medicine, Cleveland, OH 44106 4958, USA
    J Mol Cell Cardiol 40:274-82. 2006
    ..We propose that MP isoform switching during neonatal vascular smooth muscle phenotypic specification may determine changing vascular responses to NO/cGMP signaling in the transition from the fetal to the adult circulation...
  6. ncbi Fas ligand gene transfer to the embryonic heart induces programmed cell death and outflow tract defects
    Denver Sallee
    Department of Pediatrics Cardiology, Case Western Reserve School of Medicine, Cleveland, OH 44106, USA
    Dev Biol 267:309-19. 2004
    ....
  7. pmc Tra2beta as a novel mediator of vascular smooth muscle diversification
    Supriya Shukla
    Departments of Medicine Cardiology, Case Western Reserve School of Medicine, Cleveland, Ohio 44106, USA
    Circ Res 103:485-92. 2008
    ....
  8. pmc Induction of PDE5 and de-sensitization to endogenous NO signaling in a systemic resistance artery under altered blood flow
    Haiying Zhang
    Department of Medicine Cardiology, Case Western Reserve School of Medicine, 4 533 Wolstein Research Bldg, 2103 Cornell Rd, Cleveland, OH 44106, USA
    J Mol Cell Cardiol 47:57-65. 2009
    ..Treatment with PDE5 antagonists, in contrast to NO donors, may more specifically and effectively increase blood flow to chronically hypo-perfused tissues...
  9. pmc Tra2β protein is required for tissue-specific splicing of a smooth muscle myosin phosphatase targeting subunit alternative exon
    Kang Fu
    Department of Medicine Cardiology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 287:16575-85. 2012
    ..Tra2β, by regulating the splicing of Mypt1 E23, sets the sensitivity of smooth muscle to cGMP-mediated relaxation...
  10. ncbi The development of the embryonic outflow tract provides novel insights into cardiac differentiation and remodeling
    Yasuyuki Sugishita
    Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Trends Cardiovasc Med 14:235-41. 2004
    ..This review discusses these aspects of the formation and remodeling of the embryonic OFT in the context of the broader questions of cardiac muscle biology...
  11. ncbi TIA proteins are necessary but not sufficient for the tissue-specific splicing of the myosin phosphatase targeting subunit 1
    Supriya Shukla
    Departments of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4958, USA
    J Biol Chem 279:13668-76. 2004
    ....
  12. ncbi Role of myocardial hypoxia in the remodeling of the embryonic avian cardiac outflow tract
    Yasuyuki Sugishita
    Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Dev Biol 267:294-308. 2004
    ..These results suggest that regional myocardial hypoxia triggers cardiomyocyte apoptosis and remodeling of the OFT in the transition to a dual circulation, and that VEGF autocrine/paracrine signaling may regulate these processes...
  13. ncbi Unzipping the role of myosin light chain phosphatase in smooth muscle cell relaxation
    Qi Quan Huang
    Department of Physiology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 279:597-603. 2004
    ..Thus, the relative expression of LZ+/LZ- MBS isoforms could explain differences in tissue sensitivity to NO-mediated vasodilatation...
  14. ncbi Hypoxia-responsive signaling regulates the apoptosis-dependent remodeling of the embryonic avian cardiac outflow tract
    Yasuyuki Sugishita
    Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Dev Biol 273:285-96. 2004
    ..Autocrine signaling through VEGF/VEGFR2 and Akt provides survival signals for the hypoxic OFT cardiomyocytes, and regulated VEGF signaling is required for the normal development of the OFT...
  15. pmc Hypoxia-inducible transcription factor-1alpha triggers an autocrine survival pathway during embryonic cardiac outflow tract remodeling
    Hongbin Liu
    Department of Medicine Cardiology, Case Western Reserve University, Cleveland, OH 44106, USA
    Circ Res 102:1331-9. 2008
    ..We conclude that hypoxia signaling through HIF-1 and VEGF provides an autocrine survival signal in the developing cardiac OFT and that perturbation in this pathway causes OFT defects that model congenital human conotruncal heart defects...
  16. ncbi Differential levels of tissue hypoxia in the developing chicken heart
    Jamie Wikenheiser
    Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA
    Dev Dyn 235:115-23. 2006
    ....
  17. ncbi Sculpting the cardiac outflow tract
    Florence Rothenberg
    Heart and Vascular Department, MetroHealth, MetroHealth Campus, Case Western Reserve University, School of Medicine, Cleveland, Ohio, USA
    Birth Defects Res C Embryo Today 69:38-45. 2003
    ....
  18. ncbi Dynamic patterns of apoptosis in the developing chicken heart
    Katherine S Schaefer
    Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Dev Dyn 229:489-99. 2004
    ..These data also support a relationship between the differentiating epicardium and cardiomyocyte apoptosis...
  19. ncbi Uterine artery myosin phosphatase isoform switching and increased sensitivity to SNP in a rat L-NAME model of hypertension of pregnancy
    Yuan Lu
    Department of Medicine, Case Western Reserve School of Medicine, Cleveland, OH 44106 7290, USA
    Am J Physiol Cell Physiol 294:C564-71. 2008
    ..We propose that MYPT1 isoform switching is an adaptive response to reduce vascular resistance and maintain uterine blood flow in the setting of hypertension-triggered inward remodeling of the UAs in hypertension of pregnancy...
  20. pmc Role of VEGF and tissue hypoxia in patterning of neural and vascular cells recruited to the embryonic heart
    Hongbin Liu
    Department of Medicine Cardiology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Dev Dyn 238:2760-9. 2009
    ..We propose that vascular and neural patterning in the developing heart share dependence on tissue oxygen gradients but are not interdependent...
  21. pmc Notch transcriptional control of vascular smooth muscle regulatory gene expression and function
    Sanchita Basu
    Department of Medicine, Case Cardiovascular Research Institute, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 288:11191-202. 2013
    ..Genetic or pharmacological manipulation of Notch signaling is a potential strategy for modulating arterial function in human disease...
  22. ncbi The developing embryonic cardiac outflow tract is highly sensitive to oxidant stress
    Steven A Fisher
    Department of Medicine Cardiology and Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106 7290, USA
    Dev Dyn 236:3496-502. 2007
    ..Thus, the developing OFT is particularly sensitive to ROS-mediated injury, suggesting that ROS could play a role in the development of congenital defects of the cardiac OFT...
  23. ncbi Dynamic changes in expression of myosin phosphatase in a model of portal hypertension
    Michael C Payne
    Departments of Medicine and Physiology, Case Western Reserve School of Medicine, Cleveland, Ohio 44106 4958, USA
    Am J Physiol Heart Circ Physiol 286:H1801-10. 2004
    ..Implications of vascular smooth muscle phenotypic diversity and reversible phenotypic modulation in portal hypertension with regards to regulation of blood flow are discussed...
  24. ncbi Splicing of a myosin phosphatase targeting subunit 1 alternative exon is regulated by intronic cis-elements and a novel bipartite exonic enhancer/silencer element
    Wessel P Dirksen
    Department of Medicine Cardiology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4958, USA
    J Biol Chem 278:9722-32. 2003
    ..This silencer, in conjunction with a distal intronic silencer, is proposed to mediate the silencing of splicing of the MYPT1 central alternative exon in the fast phasic smooth muscle phenotype...
  25. ncbi The pros and cons of apoptosis assays for use in the study of cells, tissues, and organs
    Michiko Watanabe
    Department of Pediatrics UHC, Case Western Reserve University, Cleveland, OH 44106, USA
    Microsc Microanal 8:375-91. 2002
    ..Understanding the strengths and limitations of the assays would allow investigators to select the best methods for their needs...
  26. ncbi Developmental remodeling and shortening of the cardiac outflow tract involves myocyte programmed cell death
    M Watanabe
    Division of Pediatric Cardiology, Department of Pediatrics, Rainbow Babies and Childrens Hospital, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Development 125:3809-20. 1998
    ....
  27. ncbi Apoptosis is required for the proper formation of the ventriculo-arterial connections
    M Watanabe
    Pediatrics, Case Western Reserve School of Medicine, Cleveland, Ohio 44106, USA
    Dev Biol 240:274-88. 2001
    ....
  28. ncbi Conditioning effect of blood flow on resistance artery smooth muscle myosin phosphatase
    Haiying Zhang
    Department of Medicine Cardiology, Case Western Reserve School of Medicine, Cleveland, Ohio 44106, USA
    Circ Res 100:730-7. 2007
    ..The loss of this conditioning effect significantly increases the sensitivity to vasodilator signals in the setting of chronically reduced blood flow...
  29. pmc Vascular smooth muscle phenotypic diversity and function
    Steven A Fisher
    Department of Medicine, and Cardiovascular Research Institute, Case Western Reserve University, Cleveland, Ohio 44106 7290, USA
    Physiol Genomics 42:169-87. 2010
    ..This review focuses on smooth muscle contractile phenotypic diversity in the vascular system, how it is generated, and how it may determine vascular function in developmental and disease contexts...
  30. ncbi Role of hypoxia in the evolution and development of the cardiovascular system
    Steven A Fisher
    Case Western Reserve School of Medicine, Cleveland, Ohio 44106 7290, USA
    Antioxid Redox Signal 9:1339-52. 2007
    ..We conclude by suggesting areas for future research regarding the role of oxygen deprivation and oxidative stress in the normal development of the heart and vasculature or in the pathogenesis of congenital heart defects...
  31. ncbi Initiation of apoptosis in the developing avian outflow tract myocardium
    Florence Rothenberg
    Department of Pediatrics, UHC Case Western Reserve University, Cleveland, Ohio, USA
    Dev Dyn 223:469-82. 2002
    ..These results suggest that a component from the epicardium, possibly endothelial cells, is required for the initiation of apoptosis in OFT cardiomyocytes...
  32. ncbi Role of myosin phosphatase isoforms in cGMP-mediated smooth muscle relaxation
    J J Khatri
    Department of Medicine (Cardiology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-4958, USA
    J Biol Chem 276:37250-7. 2001
    ..These results suggest that the regulated splicing of MYPT1 is an important determinant of smooth muscle phenotypic diversity and the variability in the response of smooth muscles to the calcium desensitizing effect of cGMP signaling...