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Genomes and Genes | Steven A FisherSummaryAffiliation: Case Western Reserve University Country: USA Publications
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Publications
Endothelin-1 alters the contractile phenotype of cultured embryonic smooth muscle cellsS A Fisher
Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
Circ Res 80:885-93. 1997....- Forced expression of the homeodomain protein Gax inhibits cardiomyocyte proliferation and perturbs heart morphogenesisS A Fisher
Division of Cardiology and Molecular Cardiovascular Research Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
Development 124:4405-13. 1997..These results suggest a role for the Gax protein in heart morphogenesis causing proliferating cardiomyocytes to withdraw from the cell cycle, thus influencing the size and shape that the heart ultimately attains... 
Competition of PTB with TIA proteins for binding to a U-rich cis-element determines tissue-specific splicing of the myosin phosphatase targeting subunit 1Supriya Shukla
Department of Medicine (Cardiology, Case Western Reserve University School of Medicine, BRB 422, Cleveland, OH 44106-4958, USA
RNA 11:1725-36. 2005..This provides a novel role for PTB in the tissue-specific regulation of splicing of alternative exons during the generation of smooth muscle phenotypic diversity...
Altered hypoxia-inducible factor-1 alpha expression levels correlate with coronary vessel anomaliesJamie Wikenheiser
Department of Pediatrics, Rainbow Babies and Children s Hospital, Case Western Reserve University, Cleveland, Ohio 44106 6011, USA
Dev Dyn 238:2688-700. 2009..These findings indicated that developing coronary vessels may be subject to a level of regulation that is dependent on differential oxygen levels within cardiac tissues and subsequent HIF-1 regulation of gene expression...- Myosin phosphatase isoform switching in vascular smooth muscle developmentMichael C Payne
Department of Medicine, 422 BRB, 2109 Adelbert Road, Case Western Reserve School of Medicine, Cleveland, OH 44106-4958, USA
J Mol Cell Cardiol 40:274-82. 2006..We propose that MP isoform switching during neonatal vascular smooth muscle phenotypic specification may determine changing vascular responses to NO/cGMP signaling in the transition from the fetal to the adult circulation... - Induction of PDE5 and de-sensitization to endogenous NO signaling in a systemic resistance artery under altered blood flowHaiying Zhang
Department of Medicine Cardiology, Case Western Reserve School of Medicine, 4 533 Wolstein Research Bldg, 2103 Cornell Rd, Cleveland, OH 44106, USA
J Mol Cell Cardiol 47:57-65. 2009..Treatment with PDE5 antagonists, in contrast to NO donors, may more specifically and effectively increase blood flow to chronically hypo-perfused tissues... - Tra2beta as a novel mediator of vascular smooth muscle diversificationSupriya Shukla
Departments of Medicine Cardiology, Case Western Reserve School of Medicine, Cleveland, Ohio 44106, USA
Circ Res 103:485-92. 2008.... - Fas ligand gene transfer to the embryonic heart induces programmed cell death and outflow tract defectsDenver Sallee
Department of Pediatrics (Cardiology, Case Western Reserve School of Medicine, Cleveland, OH 44106, USA
Dev Biol 267:309-19. 2004.... - Tra2β protein is required for tissue-specific splicing of a smooth muscle myosin phosphatase targeting subunit alternative exonKang Fu
Department of Medicine Cardiology, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Biol Chem 287:16575-85. 2012..Tra2β, by regulating the splicing of Mypt1 E23, sets the sensitivity of smooth muscle to cGMP-mediated relaxation... - TIA proteins are necessary but not sufficient for the tissue-specific splicing of the myosin phosphatase targeting subunit 1Supriya Shukla
Departments of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4958, USA
J Biol Chem 279:13668-76. 2004.... - The development of the embryonic outflow tract provides novel insights into cardiac differentiation and remodelingYasuyuki Sugishita
Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
Trends Cardiovasc Med 14:235-41. 2004..This review discusses these aspects of the formation and remodeling of the embryonic OFT in the context of the broader questions of cardiac muscle biology... - Unzipping the role of myosin light chain phosphatase in smooth muscle cell relaxationQi Quan Huang
Department of Physiology, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Biol Chem 279:597-603. 2004..Thus, the relative expression of LZ+/LZ- MBS isoforms could explain differences in tissue sensitivity to NO-mediated vasodilatation... - Hypoxia-inducible transcription factor-1alpha triggers an autocrine survival pathway during embryonic cardiac outflow tract remodelingHongbin Liu
Department of Medicine Cardiology, Case Western Reserve University, Cleveland, OH 44106, USA
Circ Res 102:1331-9. 2008..We conclude that hypoxia signaling through HIF-1 and VEGF provides an autocrine survival signal in the developing cardiac OFT and that perturbation in this pathway causes OFT defects that model congenital human conotruncal heart defects... - Hypoxia-responsive signaling regulates the apoptosis-dependent remodeling of the embryonic avian cardiac outflow tractYasuyuki Sugishita
Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
Dev Biol 273:285-96. 2004..Autocrine signaling through VEGF/VEGFR2 and Akt provides survival signals for the hypoxic OFT cardiomyocytes, and regulated VEGF signaling is required for the normal development of the OFT... - Role of myocardial hypoxia in the remodeling of the embryonic avian cardiac outflow tractYasuyuki Sugishita
Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
Dev Biol 267:294-308. 2004..These results suggest that regional myocardial hypoxia triggers cardiomyocyte apoptosis and remodeling of the OFT in the transition to a dual circulation, and that VEGF autocrine/paracrine signaling may regulate these processes... - Sculpting the cardiac outflow tractFlorence Rothenberg
Heart and Vascular Department, MetroHealth, MetroHealth Campus, Case Western Reserve University, School of Medicine, Cleveland, Ohio, USA
Birth Defects Res C Embryo Today 69:38-45. 2003.... - Role of VEGF and tissue hypoxia in patterning of neural and vascular cells recruited to the embryonic heartHongbin Liu
Department of Medicine Cardiology, Case Western Reserve University, Cleveland, Ohio 44106, USA
Dev Dyn 238:2760-9. 2009..We propose that vascular and neural patterning in the developing heart share dependence on tissue oxygen gradients but are not interdependent... - Uterine artery myosin phosphatase isoform switching and increased sensitivity to SNP in a rat L-NAME model of hypertension of pregnancyYuan Lu
Department of Medicine, Case Western Reserve School of Medicine, Cleveland, OH 44106 7290, USA
Am J Physiol Cell Physiol 294:C564-71. 2008..We propose that MYPT1 isoform switching is an adaptive response to reduce vascular resistance and maintain uterine blood flow in the setting of hypertension-triggered inward remodeling of the UAs in hypertension of pregnancy... - Dynamic patterns of apoptosis in the developing chicken heartKatherine S Schaefer
Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
Dev Dyn 229:489-99. 2004..These data also support a relationship between the differentiating epicardium and cardiomyocyte apoptosis... - Dynamic changes in expression of myosin phosphatase in a model of portal hypertensionMichael C Payne
Departments of Medicine and Physiology, Case Western Reserve School of Medicine, Cleveland, Ohio 44106 4958, USA
Am J Physiol Heart Circ Physiol 286:H1801-10. 2004..Implications of vascular smooth muscle phenotypic diversity and reversible phenotypic modulation in portal hypertension with regards to regulation of blood flow are discussed... - The developing embryonic cardiac outflow tract is highly sensitive to oxidant stressSteven A Fisher
Department of Medicine Cardiology and Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106 7290, USA
Dev Dyn 236:3496-502. 2007..Thus, the developing OFT is particularly sensitive to ROS-mediated injury, suggesting that ROS could play a role in the development of congenital defects of the cardiac OFT... - Differential levels of tissue hypoxia in the developing chicken heartJamie Wikenheiser
Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA
Dev Dyn 235:115-23. 2006.... - Splicing of a myosin phosphatase targeting subunit 1 alternative exon is regulated by intronic cis-elements and a novel bipartite exonic enhancer/silencer elementWessel P Dirksen
Department of Medicine (Cardiology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-4958, USA
J Biol Chem 278:9722-32. 2003..This silencer, in conjunction with a distal intronic silencer, is proposed to mediate the silencing of splicing of the MYPT1 central alternative exon in the fast phasic smooth muscle phenotype... - The pros and cons of apoptosis assays for use in the study of cells, tissues, and organsMichiko Watanabe
Department of Pediatrics UHC, Case Western Reserve University, Cleveland, OH 44106, USA
Microsc Microanal 8:375-91. 2002..Understanding the strengths and limitations of the assays would allow investigators to select the best methods for their needs... - Apoptosis is required for the proper formation of the ventriculo-arterial connectionsM Watanabe
Pediatrics, Case Western Reserve School of Medicine, Cleveland, Ohio 44106, USA
Dev Biol 240:274-88. 2001.... - Developmental remodeling and shortening of the cardiac outflow tract involves myocyte programmed cell deathM Watanabe
Division of Pediatric Cardiology, Department of Pediatrics, Rainbow Babies and Childrens Hospital, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
Development 125:3809-20. 1998.... - Conditioning effect of blood flow on resistance artery smooth muscle myosin phosphataseHaiying Zhang
Department of Medicine Cardiology, Case Western Reserve School of Medicine, Cleveland, Ohio 44106, USA
Circ Res 100:730-7. 2007..The loss of this conditioning effect significantly increases the sensitivity to vasodilator signals in the setting of chronically reduced blood flow... - Vascular smooth muscle phenotypic diversity and functionSteven A Fisher
Department of Medicine, and Cardiovascular Research Institute, Case Western Reserve University, Cleveland, Ohio 44106 7290, USA
Physiol Genomics 42:169-87. 2010..This review focuses on smooth muscle contractile phenotypic diversity in the vascular system, how it is generated, and how it may determine vascular function in developmental and disease contexts... - Role of hypoxia in the evolution and development of the cardiovascular systemSteven A Fisher
Case Western Reserve School of Medicine, Cleveland, Ohio 44106 7290, USA
Antioxid Redox Signal 9:1339-52. 2007..We conclude by suggesting areas for future research regarding the role of oxygen deprivation and oxidative stress in the normal development of the heart and vasculature or in the pathogenesis of congenital heart defects... - Initiation of apoptosis in the developing avian outflow tract myocardiumFlorence Rothenberg
Department of Pediatrics, UHC/Case Western Reserve University, Cleveland, Ohio, USA
Dev Dyn 223:469-82. 2002..These results suggest that a component from the epicardium, possibly endothelial cells, is required for the initiation of apoptosis in OFT cardiomyocytes... - Role of myosin phosphatase isoforms in cGMP-mediated smooth muscle relaxationJ J Khatri
Department of Medicine (Cardiology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-4958, USA
J Biol Chem 276:37250-7. 2001..These results suggest that the regulated splicing of MYPT1 is an important determinant of smooth muscle phenotypic diversity and the variability in the response of smooth muscles to the calcium desensitizing effect of cGMP signaling...