R L Findling

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. ncbi request reprint Somatic treatment for depressive illnesses in children and adolescents
    Robert L Findling
    Department of Psychiatry, University Hospitals of Cleveland, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106 5080, USA
    Psychiatr Clin North Am 27:113-37, x. 2004
  2. ncbi request reprint Long-term, open-label study of risperidone in children with severe disruptive behaviors and below-average IQ
    Robert L Findling
    Department of Psychiatry, Case Western Reserve University, University Hospital of Cleveland, OH 44106, USA
    Am J Psychiatry 161:677-84. 2004
  3. ncbi request reprint A pilot evaluation of the safety, tolerability, pharmacokinetics, and effectiveness of memantine in pediatric patients with attention-deficit/hyperactivity disorder combined type
    Robert L Findling
    Department of Psychiatry, Case Western Reserve University and Division of Child and Adolescent Psychiatry, University Hospitals of Cleveland, Cleveland, Ohio 44106 5080, USA
    J Child Adolesc Psychopharmacol 17:19-33. 2007
  4. ncbi request reprint Atypical antipsychotics in the treatment of children and adolescents
    Robert L Findling
    Department of Psychiatry, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio 44106 5080, USA
    J Clin Psychiatry 65:3-4. 2004
  5. ncbi request reprint Atypical antipsychotics in the treatment of children and adolescents: clinical applications
    Robert L Findling
    Department of Psychiatry, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio 44106 5080, USA
    J Clin Psychiatry 65:30-44. 2004
  6. ncbi request reprint A 26-week open-label study of quetiapine in children with conduct disorder
    Robert L Findling
    Department of Psychiatry, University Hospitals of Cleveland Case Western Reserve University, Cleveland, Ohio 44106 5080, USA
    J Child Adolesc Psychopharmacol 17:1-9. 2007
  7. ncbi request reprint Quetiapine in nine youths with autistic disorder
    Robert L Findling
    Departments of Psychiatry and Pediatrics, University Hospitals of Cleveland Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106 5080, USA
    J Child Adolesc Psychopharmacol 14:287-94. 2004
  8. ncbi request reprint The relevance of pharmacokinetic studies in designing efficacy trials in juvenile major depression
    Robert L Findling
    Departments of Psychiatry and Pediatrics, University Hospitals of Cleveland Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Child Adolesc Psychopharmacol 16:131-45. 2006
  9. ncbi request reprint Combination lithium and divalproex sodium in pediatric bipolar symptom re-stabilization
    Robert L Findling
    Department of Psychiatry, Case Western Reserve University, University Hospitals, Cleveland, OH 44106, USA
    J Am Acad Child Adolesc Psychiatry 45:142-8. 2006
  10. ncbi request reprint Update on the treatment of bipolar disorder in children and adolescents
    Robert L Findling
    Department of Psychiatry, Case Western Reserve University School of Medicine, University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106 5080, USA
    Eur Psychiatry 20:87-91. 2005

Research Grants

Collaborators

Detail Information

Publications87

  1. ncbi request reprint Somatic treatment for depressive illnesses in children and adolescents
    Robert L Findling
    Department of Psychiatry, University Hospitals of Cleveland, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106 5080, USA
    Psychiatr Clin North Am 27:113-37, x. 2004
    ..This article reviews what is known and what needs to be learned about the somatic treatment of pediatric depression...
  2. ncbi request reprint Long-term, open-label study of risperidone in children with severe disruptive behaviors and below-average IQ
    Robert L Findling
    Department of Psychiatry, Case Western Reserve University, University Hospital of Cleveland, OH 44106, USA
    Am J Psychiatry 161:677-84. 2004
    ..This study determined the long-term safety and effectiveness of risperidone in treating severe disruptive behavior in children with subaverage intelligence...
  3. ncbi request reprint A pilot evaluation of the safety, tolerability, pharmacokinetics, and effectiveness of memantine in pediatric patients with attention-deficit/hyperactivity disorder combined type
    Robert L Findling
    Department of Psychiatry, Case Western Reserve University and Division of Child and Adolescent Psychiatry, University Hospitals of Cleveland, Cleveland, Ohio 44106 5080, USA
    J Child Adolesc Psychopharmacol 17:19-33. 2007
    ..Disturbances in N-methyl-D-aspartate (NMDA) receptor activity may play a role in attention-deficit/hyperactivity disorder (ADHD)...
  4. ncbi request reprint Atypical antipsychotics in the treatment of children and adolescents
    Robert L Findling
    Department of Psychiatry, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio 44106 5080, USA
    J Clin Psychiatry 65:3-4. 2004
  5. ncbi request reprint Atypical antipsychotics in the treatment of children and adolescents: clinical applications
    Robert L Findling
    Department of Psychiatry, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio 44106 5080, USA
    J Clin Psychiatry 65:30-44. 2004
    ..Evidence on the use of atypical antipsychotics in children and adolescents is summarized in this review...
  6. ncbi request reprint A 26-week open-label study of quetiapine in children with conduct disorder
    Robert L Findling
    Department of Psychiatry, University Hospitals of Cleveland Case Western Reserve University, Cleveland, Ohio 44106 5080, USA
    J Child Adolesc Psychopharmacol 17:1-9. 2007
    ..The aim of this study was to describe the long-term safety and effectiveness of quetiapine in conduct disorder (CD)...
  7. ncbi request reprint Quetiapine in nine youths with autistic disorder
    Robert L Findling
    Departments of Psychiatry and Pediatrics, University Hospitals of Cleveland Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106 5080, USA
    J Child Adolesc Psychopharmacol 14:287-94. 2004
    ..The aim of this study was to examine the effectiveness of quetiapine in adolescents suffering from autistic disorder (AD)...
  8. ncbi request reprint The relevance of pharmacokinetic studies in designing efficacy trials in juvenile major depression
    Robert L Findling
    Departments of Psychiatry and Pediatrics, University Hospitals of Cleveland Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Child Adolesc Psychopharmacol 16:131-45. 2006
    ..Utilizing scientifically supported dosing strategies provides the best chance for any given drug to demonstrate both efficacy and acceptable tolerability in definitive, placebo-controlled studies...
  9. ncbi request reprint Combination lithium and divalproex sodium in pediatric bipolar symptom re-stabilization
    Robert L Findling
    Department of Psychiatry, Case Western Reserve University, University Hospitals, Cleveland, OH 44106, USA
    J Am Acad Child Adolesc Psychiatry 45:142-8. 2006
    ..The primary goal of this study was to assess the rate of re-stabilization after the resumption of lithium (Li) plus divalproex (DVPX) following relapse on either agent as monotherapy...
  10. ncbi request reprint Update on the treatment of bipolar disorder in children and adolescents
    Robert L Findling
    Department of Psychiatry, Case Western Reserve University School of Medicine, University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106 5080, USA
    Eur Psychiatry 20:87-91. 2005
    ....
  11. ncbi request reprint Double-blind 18-month trial of lithium versus divalproex maintenance treatment in pediatric bipolar disorder
    Robert L Findling
    Department of Psychiatry, Case Western Reserve University, USA
    J Am Acad Child Adolesc Psychiatry 44:409-17. 2005
    ....
  12. ncbi request reprint Early symptoms of mania and the role of parental risk
    Robert L Findling
    Department of Psychiatry, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH 44106, USA
    Bipolar Disord 7:623-34. 2005
    ....
  13. ncbi request reprint Pharmacologic treatment of behavioral symptoms in autism and pervasive developmental disorders
    Robert L Findling
    Division of Child and Adolescent Psychiatry, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio, USA
    J Clin Psychiatry 66:26-31. 2005
    ..This article discusses the efficacy and tolerability of various medications and alternative interventions in addressing the symptoms of autism and other PDDs...
  14. ncbi request reprint Effectiveness, safety, and pharmacokinetics of quetiapine in aggressive children with conduct disorder
    Robert L Findling
    Department of Psychiatry, Case Western Reserve University University Hospitals of Cleveland, Cleveland, OH 44106 5080, USA
    J Am Acad Child Adolesc Psychiatry 45:792-800. 2006
    ..To provide an initial description of the effectiveness and pharmacokinetics (PK) of quetiapine in aggressive children with conduct disorder (CD)...
  15. ncbi request reprint Use of antipsychotics in children and adolescents
    Robert L Findling
    Department of Psychiatry, University Hospitals of Cleveland, Cleveland, Ohio 44106 5080, USA
    J Clin Psychiatry 66:29-40. 2005
    ....
  16. ncbi request reprint Short- and long-term cardiovascular effects of mixed amphetamine salts extended release in children
    Robert L Findling
    University Hospitals of Cleveland, Cleveland, Ohio 44106 5080, USA
    J Pediatr 147:348-54. 2005
    ....
  17. ncbi request reprint Double-blind, placebo-controlled trial of divalproex monotherapy in the treatment of symptomatic youth at high risk for developing bipolar disorder
    Robert L Findling
    Department of Psychiatry, Case Western Reserve University, and the University Hospitals of Cleveland, Cleveland, Ohio 44106 5080, USA
    J Clin Psychiatry 68:781-8. 2007
    ..To determine if divalproex sodium was superior to placebo in the treatment of symptomatic youths who suffer from a bipolar spectrum disorder and who also have a parent with a diagnosis of a bipolar illness...
  18. ncbi request reprint Multiple dose pharmacokinetics of paroxetine in children and adolescents with major depressive disorder or obsessive-compulsive disorder
    Robert L Findling
    Department of Psychiatry, Case Western Reserve University, University Hospitals of Cleveland, OH 44106 5080, USA
    Neuropsychopharmacology 31:1274-85. 2006
    ..Certain gastrointestinal and behavioral activation events (aggressive reaction and nervousness) were reported more frequently in the youngest age group...
  19. ncbi request reprint Prolactin levels during long-term risperidone treatment in children and adolescents
    Robert L Findling
    University Hospitals of Cleveland Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Clin Psychiatry 64:1362-9. 2003
    ..This analysis was designed to investigate prolactin levels in children and adolescents on long-term risperidone treatment and explore any relationship with side effects hypothetically attributable to prolactin (SHAP)...
  20. ncbi request reprint An open-label pilot study of St. John's wort in juvenile depression
    Robert L Findling
    Department of Psychiatry, Case Western Reserve University University Hospitals of Cleveland, USA
    J Am Acad Child Adolesc Psychiatry 42:908-14. 2003
    ..This pilot study examined the effectiveness, safety, tolerability, and pharmacodynamics of Hypericum perforatum (St. John's wort) in the treatment of youths diagnosed with major depressive disorder...
  21. ncbi request reprint Combination lithium and divalproex sodium in pediatric bipolarity
    Robert L Findling
    Department of Psychiatry, Case Western Reserve University School of Medicine, USA
    J Am Acad Child Adolesc Psychiatry 42:895-901. 2003
    ..Many youths with bipolar disorder do not respond to DVPX or Li monotherapy. An open-label study was conducted to examine the effectiveness of combination DVPX and Li therapy with youths diagnosed with bipolar disorder...
  22. ncbi request reprint Clinical decision-making using the General Behavior Inventory in juvenile bipolarity
    Robert L Findling
    Department of Psychiatry, University Hospitals of Cleveland Case Western Reserve University School of Medicine, Cleveland, OH 44106 5080, USA
    Bipolar Disord 4:34-42. 2002
    ..The General Behavior Inventory (GBI) is a questionnaire that has utility in the assessment of mood disorders in adults. The purpose of this study was to examine how the GBI might optimally be used in the assessment of youths...
  23. ncbi request reprint Use of quetiapine in children and adolescents
    Robert L Findling
    Division of Child and Adolescent Psychiatry, University Hospitals of Cleveland Case Western Reserve University, Cleveland, Ohio 44106 5080, USA
    J Clin Psychiatry 63:27-31. 2002
    ..Methodologically rigorous studies with substantive numbers of subjects are needed to confirm or refute these preliminary impressions...
  24. ncbi request reprint A prospective, open-label trial of olanzapine in adolescents with schizophrenia
    Robert L Findling
    Department of Psychiatry, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, OH 44106, USA
    J Am Acad Child Adolesc Psychiatry 42:170-5. 2003
    ..Olanzapine is an atypical antipsychotic that has efficacy in adults with psychotic disorders. This preliminary study examined the effectiveness of olanzapine in adolescents with schizophrenia or its related conditions...
  25. ncbi request reprint Rapid, continuous cycling and psychiatric co-morbidity in pediatric bipolar I disorder
    R L Findling
    Department of Psychiatry, University Hospitals of Cleveland Case Western Reserve University School of Medicine, Case Western Reserve University, Cleveland, OH 44106 5080, USA
    Bipolar Disord 3:202-10. 2001
    ..The primary purpose of this study was to describe the clinical presentation of bipolar I disorder (BP-I) as it occurs in children and adolescents and to assess whether the manifestations of BP-I were similar in both age groups...
  26. ncbi request reprint Somatic treatment for depressive illnesses in children and adolescents
    Robert L Findling
    Department of Psychiatry, University Hospitals of Cleveland, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106 5080, USA
    Child Adolesc Psychiatr Clin N Am 11:555-78, ix. 2002
    ..This article reviews what is known and what needs to be learned about the somatic treatment of pediatric depression...
  27. doi request reprint Treatment-emergent mania/hypomania during antidepressant monotherapy in patients with rapid cycling bipolar disorder
    Keming Gao
    Department of Psychiatry, Bipolar Disorder Research Center at Mood Disorders Program, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, 10524 Euclid Avenue, Cleveland, OH 44106, USA
    Bipolar Disord 10:907-15. 2008
    ..To study treatment-emergent mania/hypomania (TEM) associated with second-generation antidepressant monotherapy in patients with rapid cycling bipolar disorder (RCBD)...
  28. pmc A 6-month, double-blind, maintenance trial of lithium monotherapy versus the combination of lithium and divalproex for rapid-cycling bipolar disorder and Co-occurring substance abuse or dependence
    David E Kemp
    Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, Ohio, USA
    J Clin Psychiatry 70:113-21. 2009
    ....
  29. ncbi request reprint Discriminative validity of parent report of hypomanic and depressive symptoms on the General Behavior Inventory
    E A Youngstrom
    Department of Psychology, Case Western Reserve University, 11220 Bellflower Road, Cleveland, Ohio 44106, USA
    Psychol Assess 13:267-76. 2001
    ..80. Results indicate that clinicians can use the parent-completed GBI to derive clinically meaningful information about mood disorders in youths...
  30. ncbi request reprint New data on the use of lithium, divalproate, and lamotrigine in rapid cycling bipolar disorder
    J R Calabrese
    Case Western Reserve University School of Medicine, University Hospitals of Cleveland, 11400 Euclid Avenue, Suite 200, Cleveland, OH 44106, USA
    Eur Psychiatry 20:92-5. 2005
    ..In addition, lamotrigine has the potential to complement the spectrum of lithium and divalproate through its greater efficacy for depressive symptoms...
  31. pmc Correlates of historical suicide attempt in rapid-cycling bipolar disorder: a cross-sectional assessment
    Keming Gao
    Department of Psychiatry, Case Western University School of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio, USA
    J Clin Psychiatry 70:1032-40. 2009
    ..A rapid-cycling course in bipolar disorder has previously been identified as a risk factor for attempted suicide. This study investigated factors associated with suicide attempts in patients with rapid-cycling bipolar I or II disorder...
  32. pmc Medical and substance use comorbidity in bipolar disorder
    David E Kemp
    Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH, USA
    J Affect Disord 116:64-9. 2009
    ....
  33. doi request reprint A multiple-center, randomized, double-blind, placebo-controlled study of oral aripiprazole for treatment of adolescents with schizophrenia
    Robert L Findling
    Department of Child and Adolescent Psychiatry, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106 5080, USA
    Am J Psychiatry 165:1432-41. 2008
    ..This study was designed to examine the acute efficacy, safety, and tolerability of aripiprazole for adolescents with schizophrenia...
  34. doi request reprint A pilot pharmacotherapy trial for depressed youths at high genetic risk for bipolarity
    Robert L Findling
    Department of Psychiatry, University Hospitals Case Medical Center Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Child Adolesc Psychopharmacol 18:615-21. 2008
    ..As a result, future treatment studies in this population appear to be warranted, not only due to the putative impending risk of developing bipolar disorder, but also the manifest risk of current depressive episodes...
  35. doi request reprint Pharmacological treatment of pathologic aggression in children
    Drew H Barzman
    Division of Child and Adolescent Psychiatry, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Int Rev Psychiatry 20:151-7. 2008
    ..Future research is needed to evaluate whether the long-term risks associated with the pharmacological treatment of PA outweigh the potential benefits to the child...
  36. doi request reprint Acute treatment of pediatric bipolar I disorder, manic or mixed episode, with aripiprazole: a randomized, double-blind, placebo-controlled study
    Robert L Findling
    Department of Psychiatry, Division of Child and Adolescent Psychiatry, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH 44106, USA
    J Clin Psychiatry 70:1441-51. 2009
    ..To determine the efficacy and safety of aripiprazole for the treatment of pediatric bipolar I disorder, manic or mixed episode, with or without psychotic features...
  37. pmc Differential interactions between comorbid anxiety disorders and substance use disorder in rapid cycling bipolar I or II disorder
    Keming Gao
    Department of Psychiatry, Bipolar Disorder Research Center at Mood Disorders Program, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio, USA
    J Affect Disord 110:167-73. 2008
    ..Anxiety disorders (AD) and substance use disorders (SUD) commonly co-occur with bipolar disorder. This study was undertaken to assess AD-SUD-bipolar subtype interactions...
  38. pmc Current research in child and adolescent bipolar disorder
    Christine A Demeter
    Department of Psychiatry, University Hospitals Case Medical Center Case Western Reserve University, Cleveland, Ohio 44106 5080, USA
    Dialogues Clin Neurosci 10:215-28. 2008
    ..This paper will review what is currently known and what still is left to learn about clinically salient topics that pertain to bipolar disorder in children and adolescents...
  39. doi request reprint Family conflict moderates response to pharmacological intervention in pediatric bipolar disorder
    Lisa D Townsend
    Case Western Reserve University, Cleveland, 11400 Euclid Avenue, OH 44106, USA
    J Child Adolesc Psychopharmacol 17:843-52. 2007
    ..Family conflict affects the expression of psychopathology in youth. This study investigated whether family conflict moderates response to medication in youth with bipolar disorder...
  40. ncbi request reprint Adherence to pharmacological treatment for juvenile bipolar disorder
    Dennis Drotar
    Department of Psychiatry, Case Western Reserve University, USA
    J Am Acad Child Adolesc Psychiatry 46:831-9. 2007
    ..The objective of this study was to describe the prevalence and correlates of adherence to divalproex sodium (DVPX) and lithium carbonate (Li) combination treatment during the initial stabilization treatment phase...
  41. doi request reprint Evaluation and comparison of psychometric instruments for pediatric bipolar spectrum disorders in four age groups
    Thomas W Frazier
    Department of Psychiatry, University Hospitals Case Medical Center, Cleveland, OH, USA
    J Child Adolesc Psychopharmacol 17:853-66. 2007
    ..The CDRS-R may be better conceptualized as a two-factor measure in older adolescents. The semistructured K-SADS interview can be used to generate reliable diagnoses across a broad age range...
  42. ncbi request reprint Atypical antipsychotic treatment of disruptive behavior disorders in children and adolescents
    Robert L Findling
    Department of Psychiatry, University Hospitals Case Medical Center, Cleveland, Ohio 44106 5080, USA
    J Clin Psychiatry 69:9-14. 2008
    ....
  43. ncbi request reprint Short-term cardiovascular effects of methylphenidate and adderall
    R L Findling
    Department of Psychiatry and Pediatrics, University Hospitals of Cleveland, Case Western Reserve University, OH 44106-5080, USA
    J Am Acad Child Adolesc Psychiatry 40:525-9. 2001
    ..In addition, under similar conditions, using similar methods, both medication treatments led to changes in blood pressure and pulse that were clinically insignificant...
  44. ncbi request reprint Employing parent, teacher, and youth self-report checklists in identifying pediatric bipolar spectrum disorders: an examination of diagnostic accuracy and clinical utility
    Shoshana Y Kahana
    Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Child Adolesc Psychopharmacol 13:471-88. 2003
    ..Results indicate that the Child Behavior Checklist has limited utility when attempting to derive clinically meaningful information about the presentation of juvenile BPSD...
  45. ncbi request reprint Who are the comorbid adolescents? Agreement between psychiatric diagnosis, youth, parent, and teacher report
    Eric A Youngstrom
    Department of Psychology, Case Western Reserve University, Cleveland, Ohio 44106 7123, USA
    J Abnorm Child Psychol 31:231-45. 2003
    ..14-.40). Results also indicate that single DSM-IV disorders, such as bipolar disorder, can manifest "comorbid" patterns of behavior problems on checklists...
  46. ncbi request reprint Clinical correlates of patients with rapid-cycling bipolar disorder and a recent history of substance use disorder: a subtype comparison from baseline data of 2 randomized, placebo-controlled trials
    Keming Gao
    Department of Psychiatry, Bipolar Disorder Research Center at the Mood Disorders Program, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
    J Clin Psychiatry 69:1057-63. 2008
    ..To compare clinical variables in patients with rapid-cycling bipolar I or II disorder and a recent history of substance use disorder (SUD)...
  47. pmc Efficacy and tolerability of second-generation antipsychotics in children and adolescents with schizophrenia
    Sanjiv Kumra
    Division of Child and Adolescent Psychiatry, University of Minnesota Medical School, Minneapolis, MN 55454, USA
    Schizophr Bull 34:60-71. 2008
    ..Such a substantial risk points to the urgent need to develop therapeutic strategies to prevent and/or mitigate weight gain and diabetes early in the course of treatment in this population...
  48. doi request reprint Guns, adolescents, and mental illness
    Nora K McNamara
    Department of Psychiatry, University Hospitals Case Medical Center Case Western Reserve University, 11100 Euclid Ave, Cleveland, OH 44106 5080, USA
    Am J Psychiatry 165:190-4. 2008
  49. doi request reprint Aripiprazole in children with attention-deficit/hyperactivity disorder
    Robert L Findling
    Department of Psychiatry, University Hospitals Case Medical Center Case Western Reserve University, Cleveland, Ohio 44106 5080, USA
    J Child Adolesc Psychopharmacol 18:347-54. 2008
    ..To examine the effectiveness and cognitive effects of aripiprazole (APZ) in children with a primary diagnosis of attention-deficit/hyperactivity disorder (ADHD)...
  50. ncbi request reprint Psychopharmacology of pediatric bipolar disorder: a review
    Sylvester Smarty
    Child and Adolescent Psychiatry, University Hospitals of Cleveland Case Western Reserve University, 11100 Euclid Ave, Cleveland, OH 44106, USA
    Psychopharmacology (Berl) 191:39-54. 2007
    ..For these reasons, there is a need for effective treatment for PBD...
  51. pmc Double-blind randomized trial of risperidone versus divalproex in pediatric bipolar disorder
    Mani N Pavuluri
    Department of Psychiatry, Institute for Juvenile Research, University of Illinois at Chicago, USA
    Bipolar Disord 12:593-605. 2010
    ..To determine the relative effects of risperidone and divalproex in pediatric mania...
  52. ncbi request reprint Developmental and subtype differences in behavioral assets and problems in children diagnosed with ADHD
    Elizabeth J Short
    Case Western Reserve University, Cleveland, OH 44106, USA
    J Atten Disord 11:28-36. 2007
    ..Developmental and subtype differences in behavioral assets and problems were examined in 318 children newly diagnosed with ADHD...
  53. ncbi request reprint Age at onset and gender of schizophrenic patients in relation to neuroleptic resistance
    H Y Meltzer
    Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, USA
    Am J Psychiatry 154:475-82. 1997
    ..The authors compared age at onset in neuroleptic-resistant and -responsive schizophrenic patients to determine whether the gender difference in age at onset is related to response to neuroleptic treatment...
  54. ncbi request reprint Paediatric uses of atypical antipsychotics
    R L Findling
    Departments of Psychiatry and Paediatrics, University Hospitals of Cleveland Case Western Reserve University, Cleveland, Ohio, USA
    Expert Opin Pharmacother 1:935-45. 2000
    ..Based upon what is known about these agents, a rational approach to the use of these drugs in juveniles is offered...
  55. ncbi request reprint Long-term effectiveness and safety of lisdexamfetamine dimesylate in school-aged children with attention-deficit/hyperactivity disorder
    Robert L Findling
    Child and Adolescent Psychiatry, University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
    CNS Spectr 13:614-20. 2008
    ..In short-term studies, once-daily LDX provided efficacy throughout the day. This study presented here was conducted to assess the long-term safety, tolerability, and effectiveness of LDX in 6- to 12-year-olds with ADHD...
  56. doi request reprint A linguistic analysis of in-office dialogue among psychiatrists, parents, and child and adolescent patients with ADHD
    Robert L Findling
    Case Western Reserve University, USA
    J Atten Disord 13:78-86. 2009
    ..The aim was to evaluate in-office discussions of ADHD and psychiatric comorbidities...
  57. pmc First-dose pharmacokinetics of lithium carbonate in children and adolescents
    Robert L Findling
    University Hospitals, Case Medical Center, Case Western Reserve University, Cleveland, OH 44106, USA
    J Clin Psychopharmacol 30:404-10. 2010
    ..The developed population pharmacokinetic model may be used to predict other dosage regimens, support scaling from adult to pediatric pharmacokinetics, and support the design of future clinical trials...
  58. pmc Medical comorbidity in bipolar disorder: relationship between illnesses of the endocrine/metabolic system and treatment outcome
    David E Kemp
    Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH 44106, USA
    Bipolar Disord 12:404-13. 2010
    ..It was hypothesized that illnesses of the endocrine/metabolic system would be associated with greater psychiatric symptom burden and would impact the response to treatment with lithium and valproate...
  59. doi request reprint Effects of guanfacine extended release on oppositional symptoms in children aged 6-12 years with attention-deficit hyperactivity disorder and oppositional symptoms: a randomized, double-blind, placebo-controlled trial
    Daniel F Connor
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut 06030 1410, USA
    CNS Drugs 24:755-68. 2010
    ..Wayne, PA, USA) in the treatment of oppositional symptoms in children aged 6-12 years with a diagnosis of attention-deficit hyperactivity disorder (ADHD) and the presence of oppositional symptoms...
  60. ncbi request reprint A randomized, double-blind, placebo-controlled, parallel-group study of methylphenidate transdermal system in pediatric patients with attention-deficit/hyperactivity disorder
    Robert L Findling
    University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
    J Clin Psychiatry 69:149-59. 2008
    ..To evaluate the efficacy and safety of methylphenidate transdermal system compared with placebo, using osmotic-release oral system (OROS) methylphenidate as a reference therapy...
  61. pmc Initiation of stimulant and antidepressant medication and clinical presentation in juvenile bipolar I disorder
    Maria E Pagano
    Department of Psychiatry, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, OH 44106 5080, USA
    Bipolar Disord 10:334-41. 2008
    ..Another aim was to investigate differences in clinical presentation between youths prescribed stimulant or antidepressant medication before and after the onset of juvenile BP I disorder...
  62. doi request reprint Effectiveness, safety, and tolerability of lisdexamfetamine dimesylate in children with attention-deficit/hyperactivity disorder: an open-label, dose-optimization study
    Robert L Findling
    University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
    J Child Adolesc Psychopharmacol 19:649-62. 2009
    ..The aim of this study was to assess the effectiveness and safety of lisdexamfetamine dimesylate (LDX) in children with attention-deficit/hyperactivity disorder (ADHD)...
  63. ncbi request reprint A US perspective of the CANMAT bipolar guidelines
    Joseph R Calabrese
    Case Western Reserve University, Cleveland, OH 44106, USA
    Bipolar Disord 7:70-2. 2005
  64. ncbi request reprint Venlafaxine in the treatment of children and adolescents with attention-deficit/hyperactivity disorder
    Robert L Findling
    Department of Psychiatry, University Hospitals Case Medical Center, Cleveland, Ohio 44106 5080, USA
    J Child Adolesc Psychopharmacol 17:433-45. 2007
    ..The objectives of this pilot study were to explore the changes in symptom severity, tolerability, and the pharmacodynamics of venlafaxine treatment in youths with attention-deficit/hyperactivity disorder (ADHD)...
  65. ncbi request reprint Pharmacologic treatment of adolescent and child schizophrenia
    Christopher M Young
    Division of Child and Adolescent Psychiatry, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Expert Rev Neurother 4:53-60. 2004
    ..Acute management as well as continuation and maintenance therapy recommendations are made...
  66. ncbi request reprint Gender differences in criminality: bipolar disorder with co-occurring substance abuse
    Susan Hatters Friedman
    Department of Psychiatry, University Hospitals of Cleveland, Hanna Pavilion, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    J Am Acad Psychiatry Law 33:188-95. 2005
    ..Implications from this pilot study include the need for earlier identification of bipolar disorder and for the increased availability of psychiatric and substance abuse services within correctional facilities...
  67. ncbi request reprint A 20-month, double-blind, maintenance trial of lithium versus divalproex in rapid-cycling bipolar disorder
    Joseph R Calabrese
    Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Am J Psychiatry 162:2152-61. 2005
    ..The authors tested the hypothesis that divalproex would be more effective than lithium in the long-term management of patients with recently stabilized rapid-cycling bipolar disorder...
  68. ncbi request reprint Mood state at study entry as predictor of the polarity of relapse in bipolar disorder
    Joseph R Calabrese
    Case University School of Medicine, University Hospitals of Cleveland, 11400 Euclid Avenue, Suite 200, Cleveland, OH 44106, USA
    Biol Psychiatry 56:957-63. 2004
    ..We conclude that putative mood stabilizers must be tested in recently manic and recently depressed patients to determine their spectrum of prophylactic efficacy...
  69. pmc Comorbid anxiety and substance use disorders associated with a lower use of mood stabilisers in patients with rapid cycling bipolar disorder: a descriptive analysis of the cross-sectional data of 566 patients
    K Gao
    Department of Psychiatry, Mood and Anxiety Clinic at Mood Disorders Program, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, OH, USA
    Int J Clin Pract 64:336-44. 2010
    ..To study mood stabiliser treatment in patients with bipolar disorder with or without anxiety disorders (ADs) and/or substance use disorders (SUDs)...
  70. ncbi request reprint Prevention of recurrent postpartum depression: a randomized clinical trial
    K L Wisner
    Department of Reproductive Biology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Clin Psychiatry 62:82-6. 2001
    ..We conducted a double-blind, randomized clinical trial to test the efficacy of nortriptyline in the prevention of recurrent PPMD...
  71. ncbi request reprint A double-blind, placebo-controlled study of modified-release methylphenidate in children with attention-deficit/hyperactivity disorder
    Laurence L Greenhill
    New York State Psychiatric Institute, New York, New York 10032, USA
    Pediatrics 109:E39. 2002
    ..To compare the efficacy, safety, and tolerability of once-daily administration of modified-release methylphenidate (MPH MR) with placebo in children with attention-deficit/hyperactivity disorder (ADHD)...
  72. ncbi request reprint A double-blind, randomized, placebo-controlled trial of oxcarbazepine in the treatment of bipolar disorder in children and adolescents
    Karen Dineen Wagner
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77755 0188, USA
    Am J Psychiatry 163:1179-86. 2006
    ..This multicenter trial examined the efficacy and safety of oxcarbazepine in the treatment of bipolar disorder in children and adolescents...
  73. ncbi request reprint Elevated thyrotropin in bipolar youths prescribed both lithium and divalproex sodium
    Barbara L Gracious
    Strong Memorial Hospital, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Am Acad Child Adolesc Psychiatry 43:215-20. 2004
    ..To examine the effect of combined lithium and divalproex sodium on thyroid-stimulating hormone (TSH) levels in children and adolescents with bipolar disorders and to identify risk factors for lithium-induced hypothyroidism...
  74. ncbi request reprint Risperidone in children with disruptive behavior disorders and subaverage intelligence: a 1-year, open-label study of 504 patients
    Jan Croonenberghs
    University Center of Child and Adolescent Psychiatry, University of Antwerp, Belgium
    J Am Acad Child Adolesc Psychiatry 44:64-72. 2005
    ..To determine the long-term safety and effectiveness of risperidone for severe disruptive behaviors in children...
  75. ncbi request reprint Juvenile maladaptive aggression: a review of prevention, treatment, and service configuration and a proposed research agenda
    Daniel F Connor
    Department of Psychiatry MC1410, University of Connecticut Health Center, Farmington 06030 1410, USA
    J Clin Psychiatry 67:808-20. 2006
    ..To propose a research agenda for disorders of aggression in child and adolescent psychiatry...
  76. ncbi request reprint Efficacy of Adderall and methylphenidate in attention deficit hyperactivity disorder: a drug-placebo and drug-drug response curve analysis of a naturalistic study
    Stephen V Faraone
    Pediatric Psychopharmacology Unit of the Child Psychiatry Service, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Neuropsychopharmacol 5:121-9. 2002
    ..The analyses also highlight an important subgroup of placebo responders, which suggests that future research should focus on how to predict robust placebo response in ADHD patients...
  77. ncbi request reprint Validation of the Mood Disorder Questionnaire for bipolar disorders in adolescents
    Karen Dineen Wagner
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston 77555 0188, USA
    J Clin Psychiatry 67:827-30. 2006
    ....
  78. pmc Pediatric bipolar disorder: validity, phenomenology, and recommendations for diagnosis
    Eric A Youngstrom
    Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3270, USA
    Bipolar Disord 10:194-214. 2008
    ..To find, review, and critically evaluate evidence pertaining to the phenomenology of pediatric bipolar disorder and its validity as a diagnosis...
  79. ncbi request reprint Treatment of early-onset schizophrenia spectrum disorders (TEOSS): rationale, design, and methods
    Jon McClellan
    University of Washington, Seattle, USA
    J Am Acad Child Adolesc Psychiatry 46:969-78. 2007
    ..The rationale, design, and methods of the Treatment of Early Onset Schizophrenia Spectrum Disorders Study are described...
  80. ncbi request reprint Observed clinical and health services outcomes in pediatric inpatients treated with atypical antipsychotics: 1999-2003
    Scott C Flanders
    Ortho McNeil Janssen Scientific Affairs, L L C, Titusville, New Jersey, USA
    J Child Adolesc Psychopharmacol 17:312-27. 2007
    ..The aim of this study was to compare clinical and health services outcomes in pediatric inpatients prescribed an atypical antipsychotic (AA) to those not prescribed an AA at discharge...
  81. ncbi request reprint Treatment of early-onset schizophrenia spectrum disorders (TEOSS): demographic and clinical characteristics
    Jean A Frazier
    Cambridge Health Alliance, Harvard Medical School, Cambridge, MA, USA
    J Am Acad Child Adolesc Psychiatry 46:979-88. 2007
    ..We examined baseline demographic and clinical profiles of youths enrolled from 2001 to 2006 in the publicly funded multicenter, randomized controlled trial Treatment of Early-Onset Schizophrenia Spectrum Disorders...
  82. ncbi request reprint Efficacy and tolerability of lisdexamfetamine dimesylate (NRP-104) in children with attention-deficit/hyperactivity disorder: a phase III, multicenter, randomized, double-blind, forced-dose, parallel-group study
    Joseph Biederman
    Department of Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Clin Ther 29:450-63. 2007
    ..Following ingestion, the pharmacologically active d-amphetamine molecule is gradually released by rate-limited hydrolysis...
  83. ncbi request reprint Prepubertal bipolar I disorder and bipolar disorder NOS are separable from ADHD
    Robert M Post
    J Clin Psychiatry 65:898-902. 2004
  84. ncbi request reprint A randomized, placebo-controlled trial of citalopram for the treatment of major depression in children and adolescents
    Karen Dineen Wagner
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, TX 77755, USA
    Am J Psychiatry 161:1079-83. 2004
    ..The current study investigated the efficacy and safety of citalopram compared with placebo in the treatment of pediatric patients with major depression...
  85. ncbi request reprint Double-blind, placebo-controlled study of risperidone for the treatment of disruptive behaviors in children with subaverage intelligence
    Michael G Aman
    Nisonger Center UAP, Ohio State University, Columbus 43210 1257, USA
    Am J Psychiatry 159:1337-46. 2002
    ..The short-term efficacy and safety of risperidone in the treatment of disruptive behaviors was examined in a well-characterized cohort of children with subaverage intelligence...
  86. ncbi request reprint Comparing the effects of sampling designs on the diagnostic accuracy of eight promising screening algorithms for pediatric bipolar disorder
    Eric Youngstrom
    Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3270, USA
    Biol Psychiatry 60:1013-9. 2006
    ..The present investigation compared eight screening algorithms in the same sample but under two different design strategies...
  87. doi request reprint Double-blind comparison of first- and second-generation antipsychotics in early-onset schizophrenia and schizo-affective disorder: findings from the treatment of early-onset schizophrenia spectrum disorders (TEOSS) study
    Linmarie Sikich
    University of North Carolina at Chapel Hill, NC 27514, USA
    Am J Psychiatry 165:1420-31. 2008
    ....

Research Grants1

  1. TREATMENT OF EARLY ONSET SCHIZOPHRENIA SPECTRUM (TEOSS)
    Robert Findling; Fiscal Year: 2005
    ..This study will provide information about the comparative effectiveness of the most commonly used and representative antipsychotic drugs in youth with schizophrenia spectrum disorders. ..