J Donahue

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. ncbi request reprint Gene therapy for cardiac arrhythmias: a dream soon to come true?
    J Kevin Donahue
    Heart and Vascular Research Center, Case Western Reserve University School of Medicine, Cleveland, Ohio 44116, USA
    J Cardiovasc Electrophysiol 18:553-9. 2007
  2. pmc Gene therapy approaches to ventricular tachyarrhythmias
    J Kevin Donahue
    Heart and Vascular Research Center, MetroHealth Campus, Case Western Reserve University, Cleveland, OH, USA
    J Electrocardiol 40:S187-91. 2007
  3. pmc Vascular disrupting agent for neovascular age related macular degeneration: a pilot study of the safety and efficacy of intravenous combretastatin A-4 phosphate
    Mohamed A Ibrahim
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
    BMC Pharmacol Toxicol 14:7. 2013
  4. pmc Gene therapy for ventricular tachyarrhythmias
    J K Donahue
    Heart and Vascular Research Center, MetroHealth Campus, Case Western Reserve University School of Medicine, 2500 MetroHealth Drive, Cleveland, OH 44109, USA
    Gene Ther 19:600-5. 2012
  5. pmc Connexin gene transfer preserves conduction velocity and prevents atrial fibrillation
    Tomonori Igarashi
    Heart and Vascular Research Center, MetroHealth Campus, Case Western Reserve University, Cleveland, Ohio, USA
    Circulation 125:216-25. 2012
  6. pmc Ventricular tachycardia from the healed myocardial infarction scar: validation of an animal model and utility of gene therapy
    Tetsuo Sasano
    Heart and Vascular Research Center, Case Western Reserve University School of Medicine, Cleveland, OH 44109, USA
    Heart Rhythm 6:S91-7. 2009
  7. pmc Molecular ablation of ventricular tachycardia after myocardial infarction
    Tetsuo Sasano
    Heart and Vascular Research Center, MetroHealth Hospital, Case Western Reserve University School of Medicine, Rammelkamp 653, 2500 MetroHealth Drive, Cleveland, Ohio 44109, USA
    Nat Med 12:1256-8. 2006
  8. pmc Targeted high-efficiency, homogeneous myocardial gene transfer
    Tetsuo Sasano
    Heart and Vascular Research Center, MetroHealth Hospital, Case Western Reserve University School of Medicine, Cleveland, OH 44109, USA
    J Mol Cell Cardiol 42:954-61. 2007
  9. ncbi request reprint Gene therapy for cardiac arrhythmias
    J Kevin Donahue
    Division of Cardiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Trends Cardiovasc Med 15:219-24. 2005
  10. pmc Selective molecular potassium channel blockade prevents atrial fibrillation
    Guy Amit
    Heart and Vascular Research Center, MetroHealth Hospital, Case Western Reserve University, Cleveland, OH 44109, USA
    Circulation 121:2263-70. 2010

Research Grants

Collaborators

  • Guy Amit
  • David Rosenbaum
  • A Bauer
  • Eduardo Marban
  • F Voss
  • Ronald D Berger
  • H Calkins
  • GORDON FRANK TOMASELLI
  • Timm Dickfeld
  • R Becker
  • Tetsuo Sasano
  • Kan Kikuchi
  • Amy D McDonald
  • J Emanuel Finet
  • Mohamed A Ibrahim
  • Tomonori Igarashi
  • Ian D Greener
  • Navin K Kapur
  • Hiroshi Ashikaga
  • Harikrishna Tandri
  • Charles A Henrikson
  • Mitsushige Murata
  • Elizabeth Van Anden
  • Richard Rivers
  • Syed M Shah
  • Peter A Campochiaro
  • Yasir J Sepah
  • Diana V Do
  • James T Handa
  • Quan Dong Nguyen
  • Jai Balkissoon
  • Gulnar Hafiz
  • Yoshihisa Fujino
  • Maria Strom
  • Ayano Takeuchi
  • Kamilla Kelemen
  • Hunter C Champion
  • Saman Nazarian
  • Elliot R McVeigh
  • Robert Evers
  • David A Kass
  • Jun Dong
  • Valeria Castro
  • Albert C Lardo
  • M Muz Zviman
  • M Roselle Abraham
  • Jeffrey J Rade
  • Robert H Helm
  • Bruce Hopenfeld
  • Sunil Kapur
  • Ce Bian
  • Shenghan Lai
  • Clayton B Deming
  • Henry R Halperin
  • Khurram Nasir
  • Chandrasekhar Vasam Reddy
  • Lawrence S Griffith
  • Jeffrey A Brinker
  • Tania Tang
  • Melissa Capps
  • Omeed Zardkoohi
  • Eugenio Cingolani

Detail Information

Publications25

  1. ncbi request reprint Gene therapy for cardiac arrhythmias: a dream soon to come true?
    J Kevin Donahue
    Heart and Vascular Research Center, Case Western Reserve University School of Medicine, Cleveland, Ohio 44116, USA
    J Cardiovasc Electrophysiol 18:553-9. 2007
    ..Gene transfer continues to be a promising technology, but patience is required as these problems are solved and the therapies make their way through the preclinical and clinical testing process...
  2. pmc Gene therapy approaches to ventricular tachyarrhythmias
    J Kevin Donahue
    Heart and Vascular Research Center, MetroHealth Campus, Case Western Reserve University, Cleveland, OH, USA
    J Electrocardiol 40:S187-91. 2007
    ..In this review, we present a model of postinfarct ventricular tachycardia, a method for gene delivery to this area, and results of KCNH2-G628S gene transfer to manipulate cellular refractory properties in the arrhythmia model...
  3. pmc Vascular disrupting agent for neovascular age related macular degeneration: a pilot study of the safety and efficacy of intravenous combretastatin A-4 phosphate
    Mohamed A Ibrahim
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
    BMC Pharmacol Toxicol 14:7. 2013
    ..This study was designed to assess the safety, tolerability, and efficacy of intravenous infusion of CA4P in patients with neovascular age-related macular degeneration (AMD)...
  4. pmc Gene therapy for ventricular tachyarrhythmias
    J K Donahue
    Heart and Vascular Research Center, MetroHealth Campus, Case Western Reserve University School of Medicine, 2500 MetroHealth Drive, Cleveland, OH 44109, USA
    Gene Ther 19:600-5. 2012
    ..In this review, I discuss the basic mechanisms of ventricular arrhythmias and summarize the literature on the use of gene therapy for ventricular tachyarrhythmias...
  5. pmc Connexin gene transfer preserves conduction velocity and prevents atrial fibrillation
    Tomonori Igarashi
    Heart and Vascular Research Center, MetroHealth Campus, Case Western Reserve University, Cleveland, Ohio, USA
    Circulation 125:216-25. 2012
    ..Fibrosis, cellular dysfunction, and gap junction protein alterations occur in AF and cause conduction delay. We performed this study to test the hypothesis that gap junction protein overexpression would improve conduction and prevent AF...
  6. pmc Ventricular tachycardia from the healed myocardial infarction scar: validation of an animal model and utility of gene therapy
    Tetsuo Sasano
    Heart and Vascular Research Center, Case Western Reserve University School of Medicine, Cleveland, OH 44109, USA
    Heart Rhythm 6:S91-7. 2009
    ..In this work, we characterize the animal model and review the gene transfer results...
  7. pmc Molecular ablation of ventricular tachycardia after myocardial infarction
    Tetsuo Sasano
    Heart and Vascular Research Center, MetroHealth Hospital, Case Western Reserve University School of Medicine, Rammelkamp 653, 2500 MetroHealth Drive, Cleveland, Ohio 44109, USA
    Nat Med 12:1256-8. 2006
    ..No proarrhythmia or other negative effects were discernable. Our results demonstrate the potential viability of gene therapy for ablation of ventricular arrhythmias...
  8. pmc Targeted high-efficiency, homogeneous myocardial gene transfer
    Tetsuo Sasano
    Heart and Vascular Research Center, MetroHealth Hospital, Case Western Reserve University School of Medicine, Cleveland, OH 44109, USA
    J Mol Cell Cardiol 42:954-61. 2007
    ..This method was well tolerated by the animals. We demonstrate targeted, homogeneous, high efficiency gene transfer using a method that should be transferable for eventual human usage...
  9. ncbi request reprint Gene therapy for cardiac arrhythmias
    J Kevin Donahue
    Division of Cardiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Trends Cardiovasc Med 15:219-24. 2005
    ..Arrhythmia gene therapy is a field in its infancy, and future human applications are dependent on solutions to the problems discussed in this review...
  10. pmc Selective molecular potassium channel blockade prevents atrial fibrillation
    Guy Amit
    Heart and Vascular Research Center, MetroHealth Hospital, Case Western Reserve University, Cleveland, OH 44109, USA
    Circulation 121:2263-70. 2010
    ..Safety and efficacy limit currently available atrial fibrillation (AF) therapies. We hypothesized that atrial gene transfer would allow focal manipulation of atrial electrophysiology and, by eliminating reentry, would prevent AF...
  11. doi request reprint Biological therapies for atrial fibrillation
    Guy Amit
    Heart and Vascular Research Center, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio 44109, USA
    J Cardiovasc Pharmacol 52:222-7. 2008
    ..This review will discuss novel biological strategies that are currently under development and may eventually have impact on the management of atrial fibrillation...
  12. pmc Information learned from animal models of atrial fibrillation
    J Emanuel Finet
    The Heart and Vascular Research Center, Case Western Reserve University, MetroHealth Campus, 2500 MetroHealth Drive, Cleveland, OH 44109 1998, USA
    Cardiol Clin 27:45-54, viii. 2009
    ..A variety of animal models exist, including models of lone atrial fibrillation and models of atrial fibrillation in the setting of heart failure, aging, or pericardial inflammation. This article reviews these various models...
  13. ncbi request reprint Targeted modification of atrial electrophysiology by homogeneous transmural atrial gene transfer
    Kan Kikuchi
    Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Circulation 111:264-70. 2005
    ....
  14. ncbi request reprint Gene transfer techniques for cardiac arrhythmias
    J Kevin Donahue
    Institute of Molecular Cardiobiology and the Division of Cardiology, Johns Hopkins University School of Medicine, Ross 844, 720 N, Rutland Avenue, Baltimore, Maryland 21205, USA
    Ann Med 36:98-105. 2004
    ..Arrhythmia gene therapy is a field in its infancy, and future human applications are dependent on solutions to the problems discussed in this review...
  15. ncbi request reprint Pro- and antiarrhythmic effects of fast cardiac pacing in a canine model of acquired long QT syndrome
    Alexander Bauer
    Department of Cardiology, University of Heidelberg, Bergheimerstrasse 58, 69115 Heidelberg, Germany
    Naunyn Schmiedebergs Arch Pharmacol 369:447-54. 2004
    ..However, in the acquired LQTs1 and 2 beneficial effects of fastpac diminished and in a combination thereof fastpac-induced PVTs are likely...
  16. ncbi request reprint Pathophysiological findings in a model of persistent atrial fibrillation and severe congestive heart failure
    Alexander Bauer
    Institute of Molecular Cardiobiology, Johns Hopkins University School of Medicine, Ross 844, 720 N Rutland Avenue, Baltimore, MD 21205, USA
    Cardiovasc Res 61:764-70. 2004
    ..Develop and evaluate a model of persistent atrial fibrillation (AF) and severe congestive heart failure (CHF)...
  17. ncbi request reprint Gene therapy for cardiac arrhythmias
    J Kevin Donahue
    Institute for Cardiobiology and Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Ann N Y Acad Sci 1015:332-7. 2004
    ..Arrhythmia gene therapy is a field in its infancy, and future human applications are dependent on solutions to the problems discussed here...
  18. pmc Magnetic resonance-based anatomical analysis of scar-related ventricular tachycardia: implications for catheter ablation
    Hiroshi Ashikaga
    Division of Cardiology, Johns Hopkins University School of Medicine, 720 Rutland Ave, Traylor 903, Baltimore, MD 20215, USA
    Circ Res 101:939-47. 2007
    ..Magnetic resonance-based visualization of scar morphology would potentially contribute to preprocedural planning for catheter ablation of scar-related, unmappable VT...
  19. ncbi request reprint Creation of a genetic calcium channel blocker by targeted gem gene transfer in the heart
    Mitsushige Murata
    Institute of Molecular Cardiobiology and Division of Cardiology, Department of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA
    Circ Res 95:398-405. 2004
    ..Thus, these results indicate that gene transfer of Gem functions as a genetic calcium channel blocker, the local application of which can effectively modulate cardiac electrical and contractile function...
  20. ncbi request reprint Hemodynamic modulation of endocardial thromboresistance
    Navin K Kapur
    Division of Cardiology, Johns Hopkins School of Medicine, 600 N Wolfe St, Baltimore, MD 21287, USA
    Circulation 115:67-75. 2007
    ..Historically attributed to blood stasis, little is known about the adverse effects of elevated chamber filling pressure on endocardial function, which could predispose to intracardiac thrombus formation...
  21. ncbi request reprint Inhibitory G protein overexpression provides physiologically relevant heart rate control in persistent atrial fibrillation
    Alexander Bauer
    Johns Hopkins University, Baltimore, MD 21205, USA
    Circulation 110:3115-20. 2004
    ..Previously, we reported a decreased heart rate in an acute model of atrial fibrillation after atrioventricular nodal gene transfer. Here, we expand those observations to persistent atrial fibrillation and severe heart failure...
  22. ncbi request reprint Clinical course and long-term follow-up of patients receiving implantable cardioverter-defibrillators
    Harikrishna Tandri
    Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Heart Rhythm 3:762-8. 2006
    ..Defibrillators were introduced into clinical practice in 1980. Since that time, factors affecting long-term survival and the natural history of defibrillator patients have not been described...
  23. ncbi request reprint Temporary placement of a defibrillating lead in the treatment of infection and ventricular tachycardia
    Charles A Henrikson
    Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Heart Rhythm 3:222-4. 2006
  24. ncbi request reprint Modification of cellular communication by gene transfer
    J Kevin Donahue
    Institute of Molecular Cardiobiology and Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Ann N Y Acad Sci 1047:157-65. 2005
    ..Challenges facing the field of gene therapy are also reviewed. If these problems can be solved, gene therapy will become a viable alternative for clinical use...
  25. ncbi request reprint Somatic gene transfer and cardiac arrhythmias: problems and prospects
    Gordon F Tomaselli
    Johns Hopkins University, Department of Medicine, Institute of Molecular Cardiobiology, Baltimore, Maryland 21205, USA
    J Cardiovasc Electrophysiol 14:547-50. 2003

Research Grants15

  1. GENE TRANSFER APPROACHES TO ATRIAL FIBRILATION
    J Kevin Donahue; Fiscal Year: 2010
    ..We have preliminary data showing that gene therapies can eliminate AF. In this proposal, we will further develop our understanding of these therapies and their potential use with AF. ..
  2. GENE TRANSFER APPROACHES TO ATRIAL FIBRILATION
    J Donahue; Fiscal Year: 2009
    ..We have preliminary data showing that gene therapies can eliminate AF. In this proposal, we will further develop our understanding of these therapies and their potential use with AF. ..
  3. Improved Methods for Myocardial Gene Transfer
    J Donahue; Fiscal Year: 2005
    ..Successful completion of these aims will bring gene therapy one-step closer to realizing its potential as a cardiovascular therapeutic. ..
  4. Focal Modification of Electrical Conduction in the Heart
    J Donahue; Fiscal Year: 2006
    ..Successful completion of these aims will provide proof of principle that gene therapy strategies are viable options for the future treatment of common cardiac arrhythmias. ..
  5. Focal Modification of Electrical Conduction in the Heart
    J Kevin Donahue; Fiscal Year: 2010
    ..Successful completion of these aims will further our understanding of the mechanism responsible for infarct-related VT and possibly allow translation of these findings into novel therapies. ..