James Dennis

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. ncbi request reprint Clinical-scale expansion of a mixed population of bone-marrow-derived stem and progenitor cells for potential use in bone-tissue regeneration
    James E Dennis
    Department of Orthopaedics, Case Western Reserve University, University Hospitals of Cleveland, 6 Floor Hanna Building, 11100 Cedar Avenue, Cleveland, Ohio 44106, USA
    Stem Cells 25:2575-82. 2007
  2. doi request reprint Imaging stem cell differentiation for cell-based tissue repair
    Zhenghong Lee
    Department of Radiology, Case Western Reserve University, Cleveland, Ohio, USA
    Methods Enzymol 506:247-63. 2012
  3. doi request reprint In vitro dexamethasone pretreatment enhances bone formation of human mesenchymal stem cells in vivo
    In Hwan Song
    Department of Orthopedics, Case Western Reserve University, Cleveland, Ohio, USA
    J Orthop Res 27:916-21. 2009
  4. doi request reprint Imaging stem cell implant for cellular-based therapies
    Zhenghong Lee
    Department of Radiology, National Center for Regenerative Medicine, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, Ohio 44106, USA
    Exp Biol Med (Maywood) 233:930-40. 2008
  5. ncbi request reprint The STRO-1+ marrow cell population is multipotential
    James E Dennis
    Skeletal Research Center, Department of Biology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Cells Tissues Organs 170:73-82. 2002
  6. ncbi request reprint Mesenchymal stem cells as trophic mediators
    Arnold I Caplan
    Department of Biology, Skeletal Research Center, Case Western Reserve University, 2080 Adelbert Road, Cleveland, OH 44106 7080, USA
    J Cell Biochem 98:1076-84. 2006
  7. ncbi request reprint Imaging of mesenchymal stem cell transplant by bioluminescence and PET
    Zachary Love
    Department of Nuclear Medicine Radiology, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Nucl Med 48:2011-20. 2007
  8. pmc Targeting improves MSC treatment of inflammatory bowel disease
    In Kap Ko
    Department of Orthopedics, Case Western Reserve University, Cleveland, Ohio, USA
    Mol Ther 18:1365-72. 2010
  9. ncbi request reprint Targeted delivery of progenitor cells for cartilage repair
    James E Dennis
    Skeletal Research Center, Department of Biology, Case Western Reserve University and University Hospitals of Cleveland, 2080 Adelbert Road, Cleveland, OH 44106 7080, USA
    J Orthop Res 22:735-41. 2004
  10. doi request reprint Optimizing mesenchymal stem cell-based therapeutics
    Joseph Wagner
    Cell Targeting, Inc, 11000 Cedar Ave, Cleveland, OH 44106, USA
    Curr Opin Biotechnol 20:531-6. 2009

Research Grants

  1. Targeted Cellular Repair of Articular Cartilage
    James Dennis; Fiscal Year: 2007
  2. Tissue Engineering of Cartilage Subtypes
    James Dennis; Fiscal Year: 2007

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Clinical-scale expansion of a mixed population of bone-marrow-derived stem and progenitor cells for potential use in bone-tissue regeneration
    James E Dennis
    Department of Orthopaedics, Case Western Reserve University, University Hospitals of Cleveland, 6 Floor Hanna Building, 11100 Cedar Avenue, Cleveland, Ohio 44106, USA
    Stem Cells 25:2575-82. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  2. doi request reprint Imaging stem cell differentiation for cell-based tissue repair
    Zhenghong Lee
    Department of Radiology, Case Western Reserve University, Cleveland, Ohio, USA
    Methods Enzymol 506:247-63. 2012
    ..This framework can be easily extended to other cell types and for differentiation into any other cell lineage for which a specific marker gene (promoter) can be identified...
  3. doi request reprint In vitro dexamethasone pretreatment enhances bone formation of human mesenchymal stem cells in vivo
    In Hwan Song
    Department of Orthopedics, Case Western Reserve University, Cleveland, Ohio, USA
    J Orthop Res 27:916-21. 2009
    ..These results indicate that pretreatment of MSCs with dex results in greater bone formation than in untreated controls...
  4. doi request reprint Imaging stem cell implant for cellular-based therapies
    Zhenghong Lee
    Department of Radiology, National Center for Regenerative Medicine, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, Ohio 44106, USA
    Exp Biol Med (Maywood) 233:930-40. 2008
    ..Several studies performed by our group using different imaging techniques are described, with further discussion on the issues with these current imaging approaches and potential directions for future development in stem cell imaging...
  5. ncbi request reprint The STRO-1+ marrow cell population is multipotential
    James E Dennis
    Skeletal Research Center, Department of Biology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Cells Tissues Organs 170:73-82. 2002
    ....
  6. ncbi request reprint Mesenchymal stem cells as trophic mediators
    Arnold I Caplan
    Department of Biology, Skeletal Research Center, Case Western Reserve University, 2080 Adelbert Road, Cleveland, OH 44106 7080, USA
    J Cell Biochem 98:1076-84. 2006
    ..Several studies which tested the use of MSCs in models of infarct (injured heart), stroke (brain), or meniscus regeneration models are reviewed within the context of MSC-mediated trophic effects in tissue repair...
  7. ncbi request reprint Imaging of mesenchymal stem cell transplant by bioluminescence and PET
    Zachary Love
    Department of Nuclear Medicine Radiology, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Nucl Med 48:2011-20. 2007
    ..In this study, we used a triple-fusion reporter system for multimodal imaging to monitor human mesenchymal stem cell (hMSC) transplants...
  8. pmc Targeting improves MSC treatment of inflammatory bowel disease
    In Kap Ko
    Department of Orthopedics, Case Western Reserve University, Cleveland, Ohio, USA
    Mol Ther 18:1365-72. 2010
    ..This is the first study showing an increased therapeutic efficacy when stem cells are first coated with antibodies specifically target them to inflamed sites...
  9. ncbi request reprint Targeted delivery of progenitor cells for cartilage repair
    James E Dennis
    Skeletal Research Center, Department of Biology, Case Western Reserve University and University Hospitals of Cleveland, 2080 Adelbert Road, Cleveland, OH 44106 7080, USA
    J Orthop Res 22:735-41. 2004
    ..These results demonstrate that painting cell membranes with antibodies to matrix molecules is an effective method for promoting the adherence of stem or progenitor cells to a cartilage injury site...
  10. doi request reprint Optimizing mesenchymal stem cell-based therapeutics
    Joseph Wagner
    Cell Targeting, Inc, 11000 Cedar Ave, Cleveland, OH 44106, USA
    Curr Opin Biotechnol 20:531-6. 2009
    ..Each of these strategies has its own set of distinct advantages and disadvantages when viewed with a mindset of ultimate commercialization and clinical utility...
  11. pmc Transcriptional profiling of human mesenchymal stem cells transduced with reporter genes for imaging
    Fangjing Wang
    Department of Biomedical Engineering, University Hospitals, Case Medical Center, Case Western Reserve University, Cleveland, Ohio, USA
    Physiol Genomics 37:23-34. 2009
    ..In conclusion, transduction of reporter genes into MSCs preserved the basic properties of stem cells while enabling noninvasive imaging in living animals to study the biodistribution and other biological activities of the cells...
  12. ncbi request reprint Sustained Wnt protein expression in chondral constructs from mesenchymal stem cells
    Katsuhiro Nishioka
    Skeletal Research Center, Department of Biology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Cell Physiol 203:6-14. 2005
    ..Their different spatial expression patterns suggest that Wnt4 and Wnt5a proteins are not functionally linked to type II collagen and type X collagen synthesis in in vitro chondrogenic models of hMSCs...
  13. doi request reprint Scaffold-free tissue-engineered cartilage implants for laryngotracheal reconstruction
    David A Gilpin
    Department of Otolaryngology, University Hospitals Case Medical Center, Cleveland, Ohio, USA
    Laryngoscope 120:612-7. 2010
    ....
  14. ncbi request reprint Treatment of osteochondral defects with autologous bone marrow in a hyaluronan-based delivery vehicle
    Luis A Solchaga
    Skeletal Research Center, Department of Biology, Case Western Reserve University, Cleveland, Ohio, USA
    Tissue Eng 8:333-47. 2002
    ..The fundamental tissue engineering principles derived from this study should provide guidelines for the development of comparable clinical reconstructive therapies...
  15. pmc Fabrication of a neotrachea using engineered cartilage
    Mark Weidenbecher
    Department of Orthopaedics Otolaryngology Head and Neck Surgery, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Laryngoscope 118:593-8. 2008
    ..This study investigated the feasibility of scaffold-free cartilage to tissue engineer a vascularized neotrachea in rabbits...
  16. pmc Cartilage tissue engineering for laryngotracheal reconstruction: comparison of chondrocytes from three anatomic locations in the rabbit
    James H Henderson
    Departments of Biology and Orthopaedics, Skeletal Research Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Tissue Eng 13:843-53. 2007
    ..The results also suggest that this and similar tissue engineering approaches must be optimized for each potential source of chondrocytes...
  17. ncbi request reprint Repair of osteochondral defect with tissue-engineered two-phase composite material of injectable calcium phosphate and hyaluronan sponge
    Jizong Gao
    Skeletal Research Center, Department of Biology, Case Western Reserve University, 2080 Adelbert Road, Cleveland, OH 44106, USA
    Tissue Eng 8:827-37. 2002
    ....
  18. doi request reprint Tissue-engineered trachea for airway reconstruction
    Mark Weidenbecher
    Department of Otolaryngology Head and Neck Surgery, University Hospitals Medical Center, University Hospitals of Cleveland, Cleveland, Ohio, USA
    Laryngoscope 119:2118-23. 2009
    ..The purpose of this animal study was to determine if neotracheal constructs, implanted paratracheally, could successfully be used for segmental tracheal reconstruction...
  19. ncbi request reprint Endogenous PKI gamma limits the duration of the anti-apoptotic effects of PTH and beta-adrenergic agonists in osteoblasts
    Xin Chen
    Department of Orthopaedics, Case Western Reserve University and Case Medical Center, Cleveland, OH 44106, USA
    J Bone Miner Res 22:656-64. 2007
    ..Therefore, inhibition of PKI gamma activity may provide a useful co-therapy in combination with intermittent PTH or beta-adrenergic agonists for bone loss in conditions such as osteoporosis...
  20. pmc Targeting mesenchymal stem cells to activated endothelial cells
    In Kap Ko
    Department of Orthopaedics, Case Western Reserve University, Cleveland, OH, USA
    Biomaterials 30:3702-10. 2009
    ..These results demonstrate that cell surface coating promotes the attachment of MSCs to endothelial cells, and provides a methodology for the delivery of stem cells to sites of inflammation...
  21. ncbi request reprint Origin and differentiation of human and murine stroma
    James E Dennis
    Skeletal Research Center, Department of Biology, Case Western Reserve University, Cleveland, Ohio, USA
    Stem Cells 20:205-14. 2002
    ..A stochastic Repression/Induction model that would account for this plasticity is proposed...
  22. doi request reprint Dexamethasone inhibition of confluence-induced apoptosis in human mesenchymal stem cells
    In Hwan Song
    Department of Orthopaedics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Orthop Res 27:216-21. 2009
    ..These results may impact how MSCs should be cultured for clinical applications...
  23. pmc Hyaluronan-based scaffolds to tissue-engineer cartilage implants for laryngotracheal reconstruction
    Mark Weidenbecher
    Department of Orthopaedics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Laryngoscope 117:1745-9. 2007
    ..Tissue-engineered cartilage may offer a solution to this problem. This study investigated the feasibility of using Hyalograft C combined with autologous chondrocytes to tissue engineer cartilage grafts for LTR in rabbits...
  24. ncbi request reprint A simple method for stem cell labeling with fluorine 18
    Bing Ma
    Department of Radiology, Division of Nuclear Medicine, University of Michigan Medical School, Ann Arbor, 48109, USA
    Nucl Med Biol 32:701-5. 2005
    ..18)F]HFB is thus simple to prepare and uses labeling agent for short-term distribution studies of injected stem cells...
  25. ncbi request reprint Tissue engineering of autologous cartilage grafts in three-dimensional in vitro macroaggregate culture system
    Andreas Naumann
    Department of Otorhinolaryngology, Head and Neck Surgery, Ludwig Maximilian University, Munich, Germany
    Tissue Eng 10:1695-706. 2004
    ..Further long-term in vitro and in vivo studies must be done before this method can be applied to reconstructive surgery of the nose or auricle...
  26. ncbi request reprint Cellular interactions and bone healing responses to a novel porous tricalcium phosphate bone graft material
    Douglas C Fredericks
    Bone Healing Research Laboratory, University of lowa College of Medicine, Iowa City, Iowa, USA
    Orthopedics 27:s167-73. 2004
    ..Collectively, the tricalcium phosphate material properties, cell seeding capabilities, and in vivo biological responses give evidence of this implant's functionality as a potential alternative for autograft...

Research Grants9

  1. Targeted Cellular Repair of Articular Cartilage
    James Dennis; Fiscal Year: 2007
    ..The long-term goal of these studies is to develop a treatment for osteoarthritis. ..
  2. Tissue Engineering of Cartilage Subtypes
    James Dennis; Fiscal Year: 2007
    ....