Research Topics
| James DennisSummaryAffiliation: Case Western Reserve University Country: USA Publications
Research Grants
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Detail Information
Publications
Clinical-scale expansion of a mixed population of bone-marrow-derived stem and progenitor cells for potential use in bone-tissue regenerationJames E Dennis
Department of Orthopaedics, Case Western Reserve University, University Hospitals of Cleveland, 6 Floor Hanna Building, 11100 Cedar Avenue, Cleveland, Ohio 44106, USA
Stem Cells 25:2575-82. 2007..Disclosure of potential conflicts of interest is found at the end of this article...
Imaging stem cell differentiation for cell-based tissue repairZhenghong Lee
Department of Radiology, Case Western Reserve University, Cleveland, Ohio, USA
Methods Enzymol 506:247-63. 2012..This framework can be easily extended to other cell types and for differentiation into any other cell lineage for which a specific marker gene (promoter) can be identified...- In vitro dexamethasone pretreatment enhances bone formation of human mesenchymal stem cells in vivoIn Hwan Song
Department of Orthopedics, Case Western Reserve University, Cleveland, Ohio, USA
J Orthop Res 27:916-21. 2009..These results indicate that pretreatment of MSCs with dex results in greater bone formation than in untreated controls... - Imaging stem cell implant for cellular-based therapiesZhenghong Lee
Department of Radiology, National Center for Regenerative Medicine, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, Ohio 44106, USA
Exp Biol Med (Maywood) 233:930-40. 2008..Several studies performed by our group using different imaging techniques are described, with further discussion on the issues with these current imaging approaches and potential directions for future development in stem cell imaging... - The STRO-1+ marrow cell population is multipotentialJames E Dennis
Skeletal Research Center, Department of Biology, Case Western Reserve University, Cleveland, Ohio 44106, USA
Cells Tissues Organs 170:73-82. 2002.... - Mesenchymal stem cells as trophic mediatorsArnold I Caplan
Department of Biology, Skeletal Research Center, Case Western Reserve University, 2080 Adelbert Road, Cleveland, OH 44106 7080, USA
J Cell Biochem 98:1076-84. 2006..Several studies which tested the use of MSCs in models of infarct (injured heart), stroke (brain), or meniscus regeneration models are reviewed within the context of MSC-mediated trophic effects in tissue repair... - Imaging of mesenchymal stem cell transplant by bioluminescence and PETZachary Love
Department of Nuclear Medicine Radiology, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Nucl Med 48:2011-20. 2007..In this study, we used a triple-fusion reporter system for multimodal imaging to monitor human mesenchymal stem cell (hMSC) transplants... 
Targeting improves MSC treatment of inflammatory bowel diseaseIn Kap Ko
Department of Orthopedics, Case Western Reserve University, Cleveland, Ohio, USA
Mol Ther 18:1365-72. 2010..This is the first study showing an increased therapeutic efficacy when stem cells are first coated with antibodies specifically target them to inflamed sites...- Targeted delivery of progenitor cells for cartilage repairJames E Dennis
Skeletal Research Center, Department of Biology, Case Western Reserve University and University Hospitals of Cleveland, 2080 Adelbert Road, Cleveland, OH 44106 7080, USA
J Orthop Res 22:735-41. 2004..These results demonstrate that painting cell membranes with antibodies to matrix molecules is an effective method for promoting the adherence of stem or progenitor cells to a cartilage injury site... - Optimizing mesenchymal stem cell-based therapeuticsJoseph Wagner
Cell Targeting, Inc, 11000 Cedar Ave, Cleveland, OH 44106, USA
Curr Opin Biotechnol 20:531-6. 2009..Each of these strategies has its own set of distinct advantages and disadvantages when viewed with a mindset of ultimate commercialization and clinical utility... - Transcriptional profiling of human mesenchymal stem cells transduced with reporter genes for imagingFangjing Wang
Department of Biomedical Engineering, University Hospitals, Case Medical Center, Case Western Reserve University, Cleveland, Ohio, USA
Physiol Genomics 37:23-34. 2009..In conclusion, transduction of reporter genes into MSCs preserved the basic properties of stem cells while enabling noninvasive imaging in living animals to study the biodistribution and other biological activities of the cells... - Sustained Wnt protein expression in chondral constructs from mesenchymal stem cellsKatsuhiro Nishioka
Skeletal Research Center, Department of Biology, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Cell Physiol 203:6-14. 2005..Their different spatial expression patterns suggest that Wnt4 and Wnt5a proteins are not functionally linked to type II collagen and type X collagen synthesis in in vitro chondrogenic models of hMSCs... - Scaffold-free tissue-engineered cartilage implants for laryngotracheal reconstructionDavid A Gilpin
Department of Otolaryngology, University Hospitals Case Medical Center, Cleveland, Ohio, USA
Laryngoscope 120:612-7. 2010.... - Treatment of osteochondral defects with autologous bone marrow in a hyaluronan-based delivery vehicleLuis A Solchaga
Skeletal Research Center, Department of Biology, Case Western Reserve University, Cleveland, Ohio, USA
Tissue Eng 8:333-47. 2002..The fundamental tissue engineering principles derived from this study should provide guidelines for the development of comparable clinical reconstructive therapies... - Fabrication of a neotrachea using engineered cartilageMark Weidenbecher
Department of Orthopaedics Otolaryngology Head and Neck Surgery, Case Western Reserve University, Cleveland, Ohio 44106, USA
Laryngoscope 118:593-8. 2008..This study investigated the feasibility of scaffold-free cartilage to tissue engineer a vascularized neotrachea in rabbits... - Cartilage tissue engineering for laryngotracheal reconstruction: comparison of chondrocytes from three anatomic locations in the rabbitJames H Henderson
Departments of Biology and Orthopaedics, Skeletal Research Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
Tissue Eng 13:843-53. 2007..The results also suggest that this and similar tissue engineering approaches must be optimized for each potential source of chondrocytes... - Repair of osteochondral defect with tissue-engineered two-phase composite material of injectable calcium phosphate and hyaluronan spongeJizong Gao
Skeletal Research Center, Department of Biology, Case Western Reserve University, 2080 Adelbert Road, Cleveland, OH 44106, USA
Tissue Eng 8:827-37. 2002.... - Tissue-engineered trachea for airway reconstructionMark Weidenbecher
Department of Otolaryngology Head and Neck Surgery, University Hospitals Medical Center, University Hospitals of Cleveland, Cleveland, Ohio, USA
Laryngoscope 119:2118-23. 2009..The purpose of this animal study was to determine if neotracheal constructs, implanted paratracheally, could successfully be used for segmental tracheal reconstruction... - Endogenous PKI gamma limits the duration of the anti-apoptotic effects of PTH and beta-adrenergic agonists in osteoblastsXin Chen
Department of Orthopaedics, Case Western Reserve University and Case Medical Center, Cleveland, OH 44106, USA
J Bone Miner Res 22:656-64. 2007..Therefore, inhibition of PKI gamma activity may provide a useful co-therapy in combination with intermittent PTH or beta-adrenergic agonists for bone loss in conditions such as osteoporosis... - Targeting mesenchymal stem cells to activated endothelial cellsIn Kap Ko
Department of Orthopaedics, Case Western Reserve University, Cleveland, OH, USA
Biomaterials 30:3702-10. 2009..These results demonstrate that cell surface coating promotes the attachment of MSCs to endothelial cells, and provides a methodology for the delivery of stem cells to sites of inflammation... - Origin and differentiation of human and murine stromaJames E Dennis
Skeletal Research Center, Department of Biology, Case Western Reserve University, Cleveland, Ohio, USA
Stem Cells 20:205-14. 2002..A stochastic Repression/Induction model that would account for this plasticity is proposed... - Dexamethasone inhibition of confluence-induced apoptosis in human mesenchymal stem cellsIn Hwan Song
Department of Orthopaedics, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Orthop Res 27:216-21. 2009..These results may impact how MSCs should be cultured for clinical applications... - Hyaluronan-based scaffolds to tissue-engineer cartilage implants for laryngotracheal reconstructionMark Weidenbecher
Department of Orthopaedics, Case Western Reserve University, Cleveland, Ohio 44106, USA
Laryngoscope 117:1745-9. 2007..Tissue-engineered cartilage may offer a solution to this problem. This study investigated the feasibility of using Hyalograft C combined with autologous chondrocytes to tissue engineer cartilage grafts for LTR in rabbits... - A simple method for stem cell labeling with fluorine 18Bing Ma
Department of Radiology, Division of Nuclear Medicine, University of Michigan Medical School, Ann Arbor, 48109, USA
Nucl Med Biol 32:701-5. 2005..18)F]HFB is thus simple to prepare and uses labeling agent for short-term distribution studies of injected stem cells... - Tissue engineering of autologous cartilage grafts in three-dimensional in vitro macroaggregate culture systemAndreas Naumann
Department of Otorhinolaryngology, Head and Neck Surgery, Ludwig Maximilian University, Munich, Germany
Tissue Eng 10:1695-706. 2004..Further long-term in vitro and in vivo studies must be done before this method can be applied to reconstructive surgery of the nose or auricle... - Cellular interactions and bone healing responses to a novel porous tricalcium phosphate bone graft materialDouglas C Fredericks
Bone Healing Research Laboratory, University of lowa College of Medicine, Iowa City, Iowa, USA
Orthopedics 27:s167-73. 2004..Collectively, the tricalcium phosphate material properties, cell seeding capabilities, and in vivo biological responses give evidence of this implant's functionality as a potential alternative for autograft...
Research Grants
- Targeted Cellular Repair of Articular CartilageJames Dennis; Fiscal Year: 2007..The long-term goal of these studies is to develop a treatment for osteoarthritis. ..
- Tissue Engineering of Cartilage SubtypesJames Dennis; Fiscal Year: 2007....