Research Topics
| Michael W ChoSummaryAffiliation: Case Western Reserve University Country: USA Publications
Research Grants
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Detail Information
Publications
Subunit protein vaccines: theoretical and practical considerations for HIV-1Michael W Cho
Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
Curr Mol Med 3:243-63. 2003..Finally, some of the factors that must be considered in designing and evaluating future vaccine candidates will be discussed...
Structural characterization of HIV gp41 with the membrane-proximal external regionWuxian Shi
Center for Synchrotron Biosciences, Case Western Reserve University, Cleveland, OH 44106, USA
J Biol Chem 285:24290-8. 2010....- Specific asparagine-linked glycosylation sites are critical for DC-SIGN- and L-SIGN-mediated severe acute respiratory syndrome coronavirus entryDong P Han
Case Western Reserve University School of Medicine, Department of Medicine, Division of Infectious Diseases, 10900 Euclid Avenue, Cleveland, OH 44106 4984, USA
J Virol 81:12029-39. 2007..Amino acid sequence analyses of S proteins encoded by viruses isolated from animals and humans suggest that glycosylation sites N227 and N699 have facilitated zoonotic transmission... - Identification of critical determinants on ACE2 for SARS-CoV entry and development of a potent entry inhibitorDong P Han
Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
Virology 350:15-25. 2006..a. 22-44 and 351-357) artificially linked together by glycine, exhibited a potent antiviral activity with IC50 of about 0.1 microM. This novel peptide is a promising candidate as a therapeutic agent against this deadly emerging pathogen... - Structural analysis of a highly glycosylated and unliganded gp120-based antigen using mass spectrometryLiwen Wang
Center for Proteomics and Bioinformatics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
Biochemistry 49:9032-45. 2010..In addition, the data illustrate interactions between specific sugar moieties and amino acid side chains potentially important to the gp120-OD8 structure... - Assessment of antibody responses against gp41 in HIV-1-infected patients using soluble gp41 fusion proteins and peptides derived from M group consensus envelopeAdam Penn-Nicholson
Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
Virology 372:442-56. 2008..These soluble gp41 fusion proteins could be an important source of antigens for future vaccine development efforts... - Development of a safe neutralization assay for SARS-CoV and characterization of S-glycoproteinDong P Han
Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
Virology 326:140-9. 2004..The high-throughput capacity of this procedure and the safety of using SARS pseudoviruses should make possible large-scale analyses of neutralizing antibody responses against SARS-CoV... - Immunogenicity and ability of variable loop-deleted human immunodeficiency virus type 1 envelope glycoproteins to elicit neutralizing antibodiesYoung B Kim
Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
Virology 305:124-37. 2003..However, the observation that the immune responses could be redirected by altering the protein composition might allow us to explore alternative strategies for modifying the antigenic properties of HIV-1 envelope glycoprotein... - Human immunodeficiency virus type 1 envelope gp120 induces a stop signal and virological synapse formation in noninfected CD4+ T cellsGaia Vasiliver-Shamis
VA Medical Center, 423 E 23rd St, Room 18 124 North, New York, NY 10010, USA
J Virol 82:9445-57. 2008..The virological synapse was formed transiently, with the initiation of migration within 30 min. Thus, HIV-1 gp120-presenting surfaces induce a transient stop signal and supramolecular segregation in noninfected CD4(+) T cells... - Mucosal immunization with surface-displayed severe acute respiratory syndrome coronavirus spike protein on Lactobacillus casei induces neutralizing antibodies in miceJong-Soo Lee
BioLeaders corporation, Daejeon, Korea
J Virol 80:4079-87. 2006..These results indicate that mucosal immunization with recombinant L. casei expressing SARS-associated coronavirus S protein on its surface provides an effective means for eliciting protective immune response against the virus... - Control of viremia and prevention of simian-human immunodeficiency virus-induced disease in rhesus macaques immunized with recombinant vaccinia viruses plus inactivated simian immunodeficiency virus and human immunodeficiency virus type 1 particlesRonald L Willey
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Virol 77:1163-74. 2003..These results indicate that despite the protection from SHIV-induced disease, the vaccinated animals still harbored replication-competent and pathogenic virus...
Research Grants
- Development of a Safer Smallpox VaccineMichael Cho; Fiscal Year: 2003..A successful completion of the proposed projects would allow better understanding of immune correlates of protection against vaccinia virus and could facilitate development of a safer smallpox vaccine. ..
- Developing HIV-1 Vaccine Using Parainfluenza VirusMichael Cho; Fiscal Year: 2004..abstract_text> ..
- Development of a vaccine against SARS-CoVMichael Cho; Fiscal Year: 2005..abstract_text> ..
- HIV-1 vaccine using variable loop-modified envelopesMichael Cho; Fiscal Year: 2006..Successful completion of this study will provide new reagents and strategies for eliciting potent humoral immune response, and would represent a major step forward in AIDS vaccine development efforts. ..
- A novel approach of generating combinatorial librariesMichael Cho; Fiscal Year: 2006..abstract_text> ..