Michael W Cho

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. ncbi request reprint Subunit protein vaccines: theoretical and practical considerations for HIV-1
    Michael W Cho
    Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Curr Mol Med 3:243-63. 2003
  2. pmc Structural characterization of HIV gp41 with the membrane-proximal external region
    Wuxian Shi
    Center for Synchrotron Biosciences, Case Western Reserve University, Cleveland, OH 44106, USA
    J Biol Chem 285:24290-8. 2010
  3. pmc Specific asparagine-linked glycosylation sites are critical for DC-SIGN- and L-SIGN-mediated severe acute respiratory syndrome coronavirus entry
    Dong P Han
    Case Western Reserve University School of Medicine, Department of Medicine, Division of Infectious Diseases, 10900 Euclid Avenue, Cleveland, OH 44106 4984, USA
    J Virol 81:12029-39. 2007
  4. ncbi request reprint Identification of critical determinants on ACE2 for SARS-CoV entry and development of a potent entry inhibitor
    Dong P Han
    Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Virology 350:15-25. 2006
  5. pmc Structural analysis of a highly glycosylated and unliganded gp120-based antigen using mass spectrometry
    Liwen Wang
    Center for Proteomics and Bioinformatics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Biochemistry 49:9032-45. 2010
  6. pmc Assessment of antibody responses against gp41 in HIV-1-infected patients using soluble gp41 fusion proteins and peptides derived from M group consensus envelope
    Adam Penn-Nicholson
    Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Virology 372:442-56. 2008
  7. ncbi request reprint Development of a safe neutralization assay for SARS-CoV and characterization of S-glycoprotein
    Dong P Han
    Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Virology 326:140-9. 2004
  8. ncbi request reprint Immunogenicity and ability of variable loop-deleted human immunodeficiency virus type 1 envelope glycoproteins to elicit neutralizing antibodies
    Young B Kim
    Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Virology 305:124-37. 2003
  9. pmc Human immunodeficiency virus type 1 envelope gp120 induces a stop signal and virological synapse formation in noninfected CD4+ T cells
    Gaia Vasiliver-Shamis
    VA Medical Center, 423 E 23rd St, Room 18 124 North, New York, NY 10010, USA
    J Virol 82:9445-57. 2008
  10. pmc Mucosal immunization with surface-displayed severe acute respiratory syndrome coronavirus spike protein on Lactobacillus casei induces neutralizing antibodies in mice
    Jong Soo Lee
    BioLeaders corporation, Daejeon, Korea
    J Virol 80:4079-87. 2006

Research Grants

Collaborators

  • Wuxian Shi
  • Keiji Takamoto
  • D C Montefiori
  • M L Dustin
  • Dong P Han
  • Young B Kim
  • Adam Penn-Nicholson
  • Liwen Wang
  • Rais Ansari
  • Gaia Vasiliver-Shamis
  • Jong Soo Lee
  • Ronald L Willey
  • Serguei Ilchenko
  • Yali Qin
  • Jen Bohon
  • Mark R Chance
  • Hualin Li
  • Russell Thomson
  • Gurvinder Kaur
  • Rajnish Kumar
  • Jianping Liu
  • Thomas O Cameron
  • Toby Starr
  • Michael Tuen
  • Maria Luisa Visciano
  • Catarina E Hioe
  • Hanna Park
  • Teresa W Wu
  • Soon J Kim
  • Motashim Lohani
  • Chul Joong Kim
  • Moon Hee Sung
  • Seung Pyo Hong
  • Kwang Kim
  • Haryoung Poo
  • Eun Kim
  • Leo L M Poon
  • Hyung G Kim
  • Jeffrey D Lifson
  • Russ Byrum
  • Julian Bess
  • Jeffrey L Rossio
  • Yasuyuki Endo
  • Tatsuhiko Igarashi
  • Michael Piatak
  • Malcolm A Martin
  • Larry O Arthur
  • Carlos Cao

Detail Information

Publications11

  1. ncbi request reprint Subunit protein vaccines: theoretical and practical considerations for HIV-1
    Michael W Cho
    Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Curr Mol Med 3:243-63. 2003
    ..Finally, some of the factors that must be considered in designing and evaluating future vaccine candidates will be discussed...
  2. pmc Structural characterization of HIV gp41 with the membrane-proximal external region
    Wuxian Shi
    Center for Synchrotron Biosciences, Case Western Reserve University, Cleveland, OH 44106, USA
    J Biol Chem 285:24290-8. 2010
    ....
  3. pmc Specific asparagine-linked glycosylation sites are critical for DC-SIGN- and L-SIGN-mediated severe acute respiratory syndrome coronavirus entry
    Dong P Han
    Case Western Reserve University School of Medicine, Department of Medicine, Division of Infectious Diseases, 10900 Euclid Avenue, Cleveland, OH 44106 4984, USA
    J Virol 81:12029-39. 2007
    ..Amino acid sequence analyses of S proteins encoded by viruses isolated from animals and humans suggest that glycosylation sites N227 and N699 have facilitated zoonotic transmission...
  4. ncbi request reprint Identification of critical determinants on ACE2 for SARS-CoV entry and development of a potent entry inhibitor
    Dong P Han
    Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Virology 350:15-25. 2006
    ..a. 22-44 and 351-357) artificially linked together by glycine, exhibited a potent antiviral activity with IC50 of about 0.1 microM. This novel peptide is a promising candidate as a therapeutic agent against this deadly emerging pathogen...
  5. pmc Structural analysis of a highly glycosylated and unliganded gp120-based antigen using mass spectrometry
    Liwen Wang
    Center for Proteomics and Bioinformatics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Biochemistry 49:9032-45. 2010
    ..In addition, the data illustrate interactions between specific sugar moieties and amino acid side chains potentially important to the gp120-OD8 structure...
  6. pmc Assessment of antibody responses against gp41 in HIV-1-infected patients using soluble gp41 fusion proteins and peptides derived from M group consensus envelope
    Adam Penn-Nicholson
    Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Virology 372:442-56. 2008
    ..These soluble gp41 fusion proteins could be an important source of antigens for future vaccine development efforts...
  7. ncbi request reprint Development of a safe neutralization assay for SARS-CoV and characterization of S-glycoprotein
    Dong P Han
    Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Virology 326:140-9. 2004
    ..The high-throughput capacity of this procedure and the safety of using SARS pseudoviruses should make possible large-scale analyses of neutralizing antibody responses against SARS-CoV...
  8. ncbi request reprint Immunogenicity and ability of variable loop-deleted human immunodeficiency virus type 1 envelope glycoproteins to elicit neutralizing antibodies
    Young B Kim
    Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Virology 305:124-37. 2003
    ..However, the observation that the immune responses could be redirected by altering the protein composition might allow us to explore alternative strategies for modifying the antigenic properties of HIV-1 envelope glycoprotein...
  9. pmc Human immunodeficiency virus type 1 envelope gp120 induces a stop signal and virological synapse formation in noninfected CD4+ T cells
    Gaia Vasiliver-Shamis
    VA Medical Center, 423 E 23rd St, Room 18 124 North, New York, NY 10010, USA
    J Virol 82:9445-57. 2008
    ..The virological synapse was formed transiently, with the initiation of migration within 30 min. Thus, HIV-1 gp120-presenting surfaces induce a transient stop signal and supramolecular segregation in noninfected CD4(+) T cells...
  10. pmc Mucosal immunization with surface-displayed severe acute respiratory syndrome coronavirus spike protein on Lactobacillus casei induces neutralizing antibodies in mice
    Jong Soo Lee
    BioLeaders corporation, Daejeon, Korea
    J Virol 80:4079-87. 2006
    ..These results indicate that mucosal immunization with recombinant L. casei expressing SARS-associated coronavirus S protein on its surface provides an effective means for eliciting protective immune response against the virus...
  11. pmc Control of viremia and prevention of simian-human immunodeficiency virus-induced disease in rhesus macaques immunized with recombinant vaccinia viruses plus inactivated simian immunodeficiency virus and human immunodeficiency virus type 1 particles
    Ronald L Willey
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 77:1163-74. 2003
    ..These results indicate that despite the protection from SHIV-induced disease, the vaccinated animals still harbored replication-competent and pathogenic virus...

Research Grants7

  1. Development of a Safer Smallpox Vaccine
    Michael Cho; Fiscal Year: 2003
    ..A successful completion of the proposed projects would allow better understanding of immune correlates of protection against vaccinia virus and could facilitate development of a safer smallpox vaccine. ..
  2. Developing HIV-1 Vaccine Using Parainfluenza Virus
    Michael Cho; Fiscal Year: 2004
    ..abstract_text> ..
  3. Development of a vaccine against SARS-CoV
    Michael Cho; Fiscal Year: 2005
    ..abstract_text> ..
  4. HIV-1 vaccine using variable loop-modified envelopes
    Michael Cho; Fiscal Year: 2006
    ..Successful completion of this study will provide new reagents and strategies for eliciting potent humoral immune response, and would represent a major step forward in AIDS vaccine development efforts. ..
  5. A novel approach of generating combinatorial libraries
    Michael Cho; Fiscal Year: 2006
    ..abstract_text> ..