Research Topics
| PATRICK MICHAEL CATALANOSummaryAffiliation: Case Western Reserve University Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Downregulated IRS-1 and PPARgamma in obese women with gestational diabetes: relationship to FFA during pregnancyPatrick M Catalano
Department of Reproductive Biology, Case Western Reserve University School of Medicine, and MetroHealth Medical Center, Cleveland, Ohio 44106, USA
Am J Physiol Endocrinol Metab 282:E522-33. 2002..Decreased PPARgamma and its target genes may be part of the molecular mechanism to accelerate fat catabolism to meet fetal nutrient demand in late gestation...- The short- and long-term implications of maternal obesity on the mother and her offspringP M Catalano
Department of Reproductive Biology, Case Western Reserve University, MetroHealth Medical Center, Cleveland, OH 44109, USA
BJOG 113:1126-33. 2006..Additionally, we will review evidence of both short- and long-term effect of maternal obesity on the in utero environment as it relates to fetal growth, neonatal body composition and adolescent obesity... - Longitudinal changes in pancreatic beta-cell function and metabolic clearance rate of insulin in pregnant women with normal and abnormal glucose toleranceP M Catalano
Department of Reproductive Biology, Case Western Reserve University, MetroHealth Medical Center, Cleveland, OH 44109, USA
Diabetes Care 21:403-8. 1998..To evaluate basal pancreatic beta-cell secretion and suppression during infused insulin and the metabolic clearance rate of insulin in women with normal and abnormal glucose tolerance prior to conception and during pregnancy... - Increased fetal adiposity: a very sensitive marker of abnormal in utero developmentPatrick M Catalano
Department of Reproductive Biology, Case Western Reserve University at MetroHealth Medical Center, Cleveland, OH 44109, USA
Am J Obstet Gynecol 189:1698-704. 2003.... 
Timing of indicated late preterm and early-term birth in chronic medical complications: diabetesPatrick M Catalano
Department of Reproductive Biology, Case Western Reserve University, MetroHealth Medical Center, Cleveland, OH 44109, USA
Semin Perinatol 35:297-301. 2011..Additional prospective data are urgently needed to better understand the short and long-term risks and benefits of the timing of delivery in this very common obstetrical dilemma...- Management of obesity in pregnancyPatrick M Catalano
Department of Reproductive Biology, Case Western Reserve University at MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH 44109, USA
Obstet Gynecol 109:419-33. 2007..During pregnancy, weight gain should be limited to Institute of Medicine guidelines (currently under review) and encouragement given for physical activity... - Phenotype of infants of mothers with gestational diabetesPatrick M Catalano
Department of Reproductive Biology, Case Western Reserve University, MetroHealth Medical Center, Cleveland, OH 44109, USA
Diabetes Care 30:S156-60. 2007 - Fetuses of obese mothers develop insulin resistance in uteroPatrick M Catalano
Department of Reproductive Biology, Case Western Reserve University at Metro Health Medical Center, Cleveland, Ohio, USA
Diabetes Care 32:1076-80. 2009..The purpose of this study was to determine whether fetuses of obese women have increased obesity, insulin resistance, and markers of inflammation, supporting the concept of fetal programming... - Perinatal risk factors for childhood obesity and metabolic dysregulationPatrick M Catalano
Department of Reproductive Biology, Case Western Reserve University, MetroHealth Medical Center, Cleveland, OH, USA
Am J Clin Nutr 90:1303-13. 2009..Childhood obesity has increased significantly in recent decades... 
Obesity, insulin resistance, and pregnancy outcomePatrick M Catalano
Department of Reproductive Biology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio 44109, USA
Reproduction 140:365-71. 2010..Finally, based on the concept of in utero programming, these lifestyle measures may not only have short- and long-term benefits for the woman but also for her offspring as well...- Maternal factors that determine neonatal size and body fatP M Catalano
Department of Reproductive Biology, MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH 44109, USA
Curr Diab Rep 1:71-7. 2001..Additional studies of maternal glucose and lipid metabolism are needed to better evaluate fetal growth... - Gestational diabetes and insulin resistance: role in short- and long-term implications for mother and fetusPatrick M Catalano
Department of Reproductive Biology, Schwartz Center for Metabolism and Nutrition, Case Western Reserve University School of Medicine at MetroHealth Medical Center, Cleveland, OH 44109, USA
J Nutr 133:1674S-1683S. 2003.... - Effect of maternal metabolism on fetal growth and body compositionP M Catalano
Department of Reproductive Biology, Case Western Reserve University, MetroHealth Medical Center, Cleveland, Ohio 44109, USA
Diabetes Care 21:B85-90. 1998..Additional studies of maternal glucose and lipid metabolism are needed to better evaluate fetal growth... - Estimates of insulin sensitivity using glucose and C-Peptide from the hyperglycemia and adverse pregnancy outcome glucose tolerance testTatjana Radaelli
Department of Obstetrics and Gynecology, IRCCS Ospedale Policlinico, Mangiagalli and Regina Elena, University of Milan, Milan, Italy
Diabetes Care 33:490-4. 2010..CONCLUSIONS These data suggest that calculated IS(OGTT C-pep) is an excellent predictor of insulin sensitivity in pregnancy and can be used to estimate insulin sensitivity in over 25,000 women participating in the HAPO study... - Increased skeletal muscle tumor necrosis factor-alpha and impaired insulin signaling persist in obese women with gestational diabetes mellitus 1 year postpartumJacob E Friedman
Department of Pediatrics, University of Colorado Denver, P O Box 6511, MS 8106, Aurora, CO 80045, USA
Diabetes 57:606-13. 2008..However, the cellular mechanisms underlying this insulin resistance are unknown... - Metabolic changes in pregnancyKristine Y Lain
Departments of Obstetrics and Gynecology and Internal Medicine, University of Kentucky, Lexington, Kentucky 40536 0293, USA
Clin Obstet Gynecol 50:938-48. 2007..An increase in insulin resistance results in increases in maternal glucose and free fatty acid concentrations, allowing for greater substrate availability for fetal growth... - Body mass index: a true indicator of body fat in obese gravidasMark F Sewell
Maternal Fetal Medicine, Department of Obstetrics and Gynecology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio 44109 1989, USA
J Reprod Med 52:907-11. 2007..To determine the relationship between body mass index (BMI) and percent body fat in overweight/obese pregnant women (BMI >25) before and during pregnancy... - Increasing maternal obesity and weight gain during pregnancy: the obstetric problems of plentitudePatrick M Catalano
Obstet Gynecol 110:743-4. 2007 - Cellular mechanisms for insulin resistance in normal pregnancy and gestational diabetesLinda A Barbour
Department of Medicine, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
Diabetes Care 30:S112-9. 2007 - TNF-alpha is a predictor of insulin resistance in human pregnancyJohn P Kirwan
Department of Reproductive Biology, Case Western Reserve University School of Medicine at MetroHealth Medical Center, Bell Greve Building Rm G 232E, 2500 MetroHealth Drive, Cleveland, OH 44109 1998, USA
Diabetes 51:2207-13. 2002.... - What proportion of birth weight is attributable to maternal glucose among infants of diabetic women?David A Sacks
Department of Obstetrics and Gynecology, Kaiser Foundation Hospital, Bellflower, CA, USA
Am J Obstet Gynecol 194:501-7. 2006..This study was undertaken to determine the proportion of birth weight attributable to glucose concentrations of diabetic mothers... - Twenty-four-hour urine insulin as a measure of hyperinsulinaemia/insulin resistance before onset of pre-eclampsia and gestational hypertensionStephen P Emery
Department of Obstetrics and Gynecology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
BJOG 112:1479-85. 2005..6] x 10(3)microIU/24 hour, P= 0.04; severe pre-eclampsia vs controls: 12.3 [2.2] vs 11.5 [1.2], P= 0.69). CONCLUSION: The data suggest that early hyperinsulinaemia, a marker of insulin resistance, may predispose to mild pre-eclampsia... - Clinical utility and approaches for estimating insulin sensitivity in pregnancyPatrick M Catalano
Department of Reproductive Biology, Case Western Reserve University School of Medicine at MetroHealth Medical Center, Cleveland, OH 44109-1998, USA
Semin Perinatol 26:181-9. 2002..The information obtained from the IS(OGTT) will be useful in making clinical decisions on maternal care and facilitating optimal pregnancy outcome... - The influence of obesity and diabetes on the prevalence of macrosomiaHugh M Ehrenberg
Case Western Reserve University School of Medicine, Department of Reproductive Biology, MetroHealth Medical Center, Cleveland, Ohio, USA
Am J Obstet Gynecol 191:964-8. 2004..7% vs 4.1%), abnormal maternal body habitus exhibits the strongest influence on the prevalence of LGA delivery in our population... - Reversal of insulin resistance postpartum is linked to enhanced skeletal muscle insulin signalingJohn P Kirwan
Departments of Pediatrics, Biochemistry, and Molecular Genetics, University of Colorado Health Sciences Center, 4200 East 9th Avenue, B-195, Denver, Colorado 80262, USA
J Clin Endocrinol Metab 89:4678-84. 2004..These changes may allow for greater p85/p110 binding to IRS-1 and play a significant physiological role in the underlying metabolic adaptation to normal human pregnancy and restoration of insulin sensitivity postpartum... - Longitudinal changes in energy expenditure and body composition in obese women with normal and impaired glucose toleranceNdubueze C Okereke
Department of Reproductive Biology, Case Western Reserve University at MetroHealth Medical Center, Cleveland, Ohio 44109, USA
Am J Physiol Endocrinol Metab 287:E472-9. 2004..The increased reliance on fat metabolism is accompanied by a concomitant decrease in carbohydrate metabolism during hyperinsulinemia. The increase in fat oxidation may be related to increased maternal serum leptin... - The influence of obesity and gestational diabetes mellitus on accretion and the distribution of adipose tissue in pregnancyHugh M Ehrenberg
Department of Reproductive Biology, Case Western Reserve University School of Medicine, Cleveland, OH 44109, USA
Am J Obstet Gynecol 189:944-8. 2003..The purpose of this study was to evaluate the effect of pregravid obesity and gestational diabetes mellitus (GDM) on the longitudinal accretion and distribution of adipose tissue in pregnancy... - Obesity and pregnancy--the propagation of a viscous cycle?Patrick M Catalano
J Clin Endocrinol Metab 88:3505-6. 2003 - Estimation of neonatal body composition: isotope dilution versus total-body electrical conductivityKazumasa Hashimoto
Department of Reproductive Biology, Case Western Reserve University at MetroHealth Medical Center, Cleveland, Ohio 44109, USA
Biol Neonate 81:170-5. 2002..22-0.57). Because of the wide variation of water content in individuals, the isotope dilution method may not be the optimal way of assessing body composition, and specifically body fat, in newborns... - The effect of gender and gestational diabetes mellitus on cord leptin concentrationNdubueze C Okereke
Department of Obstetrics and Gynecology, Case Western Reserve University School of Medicine at MetroHealth Medical Center, Cleveland, Ohio 44109-1998, USA
Am J Obstet Gynecol 187:798-803. 2002..12) CONCLUSION: The differences in cord leptin concentration between male and female neonates and between infants of women with gestational diabetes mellitus and control neonates are related to differences in body composition... - Managing preexisting diabetes for pregnancy: summary of evidence and consensus recommendations for careJohn L Kitzmiller
Division of Maternal-Fetal Medicine, Santa Clara Valley Medical Center, San Jose, California 95128, USA
Diabetes Care 31:1060-79. 2008 - Smoking before pregnancy and risk of gestational hypertension and preeclampsiaLucinda J England
Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Bethesda, MD 20892-7510, USA
Am J Obstet Gynecol 186:1035-40. 2002..9-1.3). Results were similar for gestational hypertension and preeclampsia examined separately. CONCLUSION: Women who smoke but quit before becoming pregnant do not have a reduced risk for gestational hypertension or preeclampsia... - Neonatal anthropometric measurements to predict birth weight by ultrasoundBradley P Stetzer
Department of Reproductive Biology, Case Western Reserve University at MetroHealth Medical Center, Cleveland, OH 44109, USA
J Perinatol 22:397-402. 2002..8%. CONCLUSION: Neonatal anthropometric models are strongly predictive of actual BW. This model will be tested prospectively using ultrasound to predict fetal weight... - Metabolic programming: fetal origins of obesity and metabolic syndrome in the adultFaramarz Ismail-Beigi
Dept of Medicine, Cleveland Diabetes Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
Am J Physiol Endocrinol Metab 291:E439-40. 2006..Importantly, these attributes can be passed on to the next generation nongenetically and can be reversed and prevented... - Increased risk of preeclampsia among nulliparous pregnant women with idiopathic hematuriaCatherine O Stehman-Breen
Division of Nephrology, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
Am J Obstet Gynecol 187:703-8. 2002..Our purpose was to determine the risk of preeclampsia and gestational hypertension among nulliparous pregnant women with idiopathic hematuria... - Glucose tolerance and risk of gestational diabetes mellitus in nulliparous women who smoke during pregnancyLucinda J England
Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services, Bethesda, MD, USA
Am J Epidemiol 160:1205-13. 2004..9, 95% confidence interval: 1.0, 3.6). These findings support an association between smoking and gestational diabetes mellitus...
Research Grants
- Insulin Resistance and Glucose and Lipid Metabolism in PregnancyPATRICK MICHAEL CATALANO; Fiscal Year: 2010....
- OMEGA-3 SUPPLMENTATION DECREASES INFLAMMATION AND FETAL OBESITY IN PREGNANCYPatrick Catalano; Fiscal Year: 2009..Pretiminary data witt also be obtained on fetat body composition in order to later address the prevention of the long term adverse effects (devetopmental programming) of maternal obesity in the developing fetus. ..
- Insulin Resistance and Glucose and Lipid Metabolism in PregnancyPatrick Catalano; Fiscal Year: 2007....
- CENTER FOR STUDY OF GROWTH REGULATION IN HUMAN PREGNANCYPatrick Catalano; Fiscal Year: 2004..abstract_text> ..
- INSULIN RESISTANCE AND GLUCOSE METABOLISM IN PREGNANCYPatrick Catalano; Fiscal Year: 2002....
- OMEGA-3 SUPPLMENTATION DECREASES INFLAMMATION AND FETAL OBESITY IN PREGNANCYSylvie Hauguel De Mouzon; Fiscal Year: 2010..Pretiminary data witt also be obtained on fetat body composition in order to later address the prevention of the long term adverse effects (devetopmental programming) of maternal obesity in the developing fetus. ..