PATRICK MICHAEL CATALANO

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. ncbi request reprint Downregulated IRS-1 and PPARgamma in obese women with gestational diabetes: relationship to FFA during pregnancy
    Patrick M Catalano
    Department of Reproductive Biology, Case Western Reserve University School of Medicine, and MetroHealth Medical Center, Cleveland, Ohio 44106, USA
    Am J Physiol Endocrinol Metab 282:E522-33. 2002
  2. ncbi request reprint The short- and long-term implications of maternal obesity on the mother and her offspring
    P M Catalano
    Department of Reproductive Biology, Case Western Reserve University, MetroHealth Medical Center, Cleveland, OH 44109, USA
    BJOG 113:1126-33. 2006
  3. ncbi request reprint Longitudinal changes in pancreatic beta-cell function and metabolic clearance rate of insulin in pregnant women with normal and abnormal glucose tolerance
    P M Catalano
    Department of Reproductive Biology, Case Western Reserve University, MetroHealth Medical Center, Cleveland, OH 44109, USA
    Diabetes Care 21:403-8. 1998
  4. ncbi request reprint Increased fetal adiposity: a very sensitive marker of abnormal in utero development
    Patrick M Catalano
    Department of Reproductive Biology, Case Western Reserve University at MetroHealth Medical Center, Cleveland, OH 44109, USA
    Am J Obstet Gynecol 189:1698-704. 2003
  5. pmc Timing of indicated late preterm and early-term birth in chronic medical complications: diabetes
    Patrick M Catalano
    Department of Reproductive Biology, Case Western Reserve University, MetroHealth Medical Center, Cleveland, OH 44109, USA
    Semin Perinatol 35:297-301. 2011
  6. ncbi request reprint Management of obesity in pregnancy
    Patrick M Catalano
    Department of Reproductive Biology, Case Western Reserve University at MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH 44109, USA
    Obstet Gynecol 109:419-33. 2007
  7. ncbi request reprint Phenotype of infants of mothers with gestational diabetes
    Patrick M Catalano
    Department of Reproductive Biology, Case Western Reserve University, MetroHealth Medical Center, Cleveland, OH 44109, USA
    Diabetes Care 30:S156-60. 2007
  8. pmc Fetuses of obese mothers develop insulin resistance in utero
    Patrick M Catalano
    Department of Reproductive Biology, Case Western Reserve University at Metro Health Medical Center, Cleveland, Ohio, USA
    Diabetes Care 32:1076-80. 2009
  9. pmc Perinatal risk factors for childhood obesity and metabolic dysregulation
    Patrick M Catalano
    Department of Reproductive Biology, Case Western Reserve University, MetroHealth Medical Center, Cleveland, OH, USA
    Am J Clin Nutr 90:1303-13. 2009
  10. doi request reprint Obesity, insulin resistance, and pregnancy outcome
    Patrick M Catalano
    Department of Reproductive Biology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio 44109, USA
    Reproduction 140:365-71. 2010

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Downregulated IRS-1 and PPARgamma in obese women with gestational diabetes: relationship to FFA during pregnancy
    Patrick M Catalano
    Department of Reproductive Biology, Case Western Reserve University School of Medicine, and MetroHealth Medical Center, Cleveland, Ohio 44106, USA
    Am J Physiol Endocrinol Metab 282:E522-33. 2002
    ..Decreased PPARgamma and its target genes may be part of the molecular mechanism to accelerate fat catabolism to meet fetal nutrient demand in late gestation...
  2. ncbi request reprint The short- and long-term implications of maternal obesity on the mother and her offspring
    P M Catalano
    Department of Reproductive Biology, Case Western Reserve University, MetroHealth Medical Center, Cleveland, OH 44109, USA
    BJOG 113:1126-33. 2006
    ..Additionally, we will review evidence of both short- and long-term effect of maternal obesity on the in utero environment as it relates to fetal growth, neonatal body composition and adolescent obesity...
  3. ncbi request reprint Longitudinal changes in pancreatic beta-cell function and metabolic clearance rate of insulin in pregnant women with normal and abnormal glucose tolerance
    P M Catalano
    Department of Reproductive Biology, Case Western Reserve University, MetroHealth Medical Center, Cleveland, OH 44109, USA
    Diabetes Care 21:403-8. 1998
    ..To evaluate basal pancreatic beta-cell secretion and suppression during infused insulin and the metabolic clearance rate of insulin in women with normal and abnormal glucose tolerance prior to conception and during pregnancy...
  4. ncbi request reprint Increased fetal adiposity: a very sensitive marker of abnormal in utero development
    Patrick M Catalano
    Department of Reproductive Biology, Case Western Reserve University at MetroHealth Medical Center, Cleveland, OH 44109, USA
    Am J Obstet Gynecol 189:1698-704. 2003
    ....
  5. pmc Timing of indicated late preterm and early-term birth in chronic medical complications: diabetes
    Patrick M Catalano
    Department of Reproductive Biology, Case Western Reserve University, MetroHealth Medical Center, Cleveland, OH 44109, USA
    Semin Perinatol 35:297-301. 2011
    ..Additional prospective data are urgently needed to better understand the short and long-term risks and benefits of the timing of delivery in this very common obstetrical dilemma...
  6. ncbi request reprint Management of obesity in pregnancy
    Patrick M Catalano
    Department of Reproductive Biology, Case Western Reserve University at MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH 44109, USA
    Obstet Gynecol 109:419-33. 2007
    ..During pregnancy, weight gain should be limited to Institute of Medicine guidelines (currently under review) and encouragement given for physical activity...
  7. ncbi request reprint Phenotype of infants of mothers with gestational diabetes
    Patrick M Catalano
    Department of Reproductive Biology, Case Western Reserve University, MetroHealth Medical Center, Cleveland, OH 44109, USA
    Diabetes Care 30:S156-60. 2007
  8. pmc Fetuses of obese mothers develop insulin resistance in utero
    Patrick M Catalano
    Department of Reproductive Biology, Case Western Reserve University at Metro Health Medical Center, Cleveland, Ohio, USA
    Diabetes Care 32:1076-80. 2009
    ..The purpose of this study was to determine whether fetuses of obese women have increased obesity, insulin resistance, and markers of inflammation, supporting the concept of fetal programming...
  9. pmc Perinatal risk factors for childhood obesity and metabolic dysregulation
    Patrick M Catalano
    Department of Reproductive Biology, Case Western Reserve University, MetroHealth Medical Center, Cleveland, OH, USA
    Am J Clin Nutr 90:1303-13. 2009
    ..Childhood obesity has increased significantly in recent decades...
  10. doi request reprint Obesity, insulin resistance, and pregnancy outcome
    Patrick M Catalano
    Department of Reproductive Biology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio 44109, USA
    Reproduction 140:365-71. 2010
    ..Finally, based on the concept of in utero programming, these lifestyle measures may not only have short- and long-term benefits for the woman but also for her offspring as well...
  11. ncbi request reprint Maternal factors that determine neonatal size and body fat
    P M Catalano
    Department of Reproductive Biology, MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH 44109, USA
    Curr Diab Rep 1:71-7. 2001
    ..Additional studies of maternal glucose and lipid metabolism are needed to better evaluate fetal growth...
  12. ncbi request reprint Gestational diabetes and insulin resistance: role in short- and long-term implications for mother and fetus
    Patrick M Catalano
    Department of Reproductive Biology, Schwartz Center for Metabolism and Nutrition, Case Western Reserve University School of Medicine at MetroHealth Medical Center, Cleveland, OH 44109, USA
    J Nutr 133:1674S-1683S. 2003
    ....
  13. ncbi request reprint Effect of maternal metabolism on fetal growth and body composition
    P M Catalano
    Department of Reproductive Biology, Case Western Reserve University, MetroHealth Medical Center, Cleveland, Ohio 44109, USA
    Diabetes Care 21:B85-90. 1998
    ..Additional studies of maternal glucose and lipid metabolism are needed to better evaluate fetal growth...
  14. pmc Estimates of insulin sensitivity using glucose and C-Peptide from the hyperglycemia and adverse pregnancy outcome glucose tolerance test
    Tatjana Radaelli
    Department of Obstetrics and Gynecology, IRCCS Ospedale Policlinico, Mangiagalli and Regina Elena, University of Milan, Milan, Italy
    Diabetes Care 33:490-4. 2010
    ..CONCLUSIONS These data suggest that calculated IS(OGTT C-pep) is an excellent predictor of insulin sensitivity in pregnancy and can be used to estimate insulin sensitivity in over 25,000 women participating in the HAPO study...
  15. ncbi request reprint Increased skeletal muscle tumor necrosis factor-alpha and impaired insulin signaling persist in obese women with gestational diabetes mellitus 1 year postpartum
    Jacob E Friedman
    Department of Pediatrics, University of Colorado Denver, P O Box 6511, MS 8106, Aurora, CO 80045, USA
    Diabetes 57:606-13. 2008
    ..However, the cellular mechanisms underlying this insulin resistance are unknown...
  16. ncbi request reprint Metabolic changes in pregnancy
    Kristine Y Lain
    Departments of Obstetrics and Gynecology and Internal Medicine, University of Kentucky, Lexington, Kentucky 40536 0293, USA
    Clin Obstet Gynecol 50:938-48. 2007
    ..An increase in insulin resistance results in increases in maternal glucose and free fatty acid concentrations, allowing for greater substrate availability for fetal growth...
  17. ncbi request reprint Body mass index: a true indicator of body fat in obese gravidas
    Mark F Sewell
    Maternal Fetal Medicine, Department of Obstetrics and Gynecology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio 44109 1989, USA
    J Reprod Med 52:907-11. 2007
    ..To determine the relationship between body mass index (BMI) and percent body fat in overweight/obese pregnant women (BMI >25) before and during pregnancy...
  18. ncbi request reprint Increasing maternal obesity and weight gain during pregnancy: the obstetric problems of plentitude
    Patrick M Catalano
    Obstet Gynecol 110:743-4. 2007
  19. ncbi request reprint Cellular mechanisms for insulin resistance in normal pregnancy and gestational diabetes
    Linda A Barbour
    Department of Medicine, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
    Diabetes Care 30:S112-9. 2007
  20. ncbi request reprint TNF-alpha is a predictor of insulin resistance in human pregnancy
    John P Kirwan
    Department of Reproductive Biology, Case Western Reserve University School of Medicine at MetroHealth Medical Center, Bell Greve Building Rm G 232E, 2500 MetroHealth Drive, Cleveland, OH 44109 1998, USA
    Diabetes 51:2207-13. 2002
    ....
  21. ncbi request reprint What proportion of birth weight is attributable to maternal glucose among infants of diabetic women?
    David A Sacks
    Department of Obstetrics and Gynecology, Kaiser Foundation Hospital, Bellflower, CA, USA
    Am J Obstet Gynecol 194:501-7. 2006
    ..This study was undertaken to determine the proportion of birth weight attributable to glucose concentrations of diabetic mothers...
  22. ncbi request reprint Twenty-four-hour urine insulin as a measure of hyperinsulinaemia/insulin resistance before onset of pre-eclampsia and gestational hypertension
    Stephen P Emery
    Department of Obstetrics and Gynecology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    BJOG 112:1479-85. 2005
    ..To evaluate levels of 24-hour urine insulin excretion before the onset of pre-eclampsia and gestational hypertension...
  23. ncbi request reprint Clinical utility and approaches for estimating insulin sensitivity in pregnancy
    Patrick M Catalano
    Department of Reproductive Biology, Case Western Reserve University School of Medicine at MetroHealth Medical Center, Cleveland, OH 44109 1998, USA
    Semin Perinatol 26:181-9. 2002
    ..The information obtained from the IS(OGTT) will be useful in making clinical decisions on maternal care and facilitating optimal pregnancy outcome...
  24. ncbi request reprint The influence of obesity and diabetes on the prevalence of macrosomia
    Hugh M Ehrenberg
    Case Western Reserve University School of Medicine, Department of Reproductive Biology, MetroHealth Medical Center, Cleveland, Ohio, USA
    Am J Obstet Gynecol 191:964-8. 2004
    ..This study was undertaken to determine the relative contribution of abnormal pregravid maternal body habitus and diabetes on the prevalence of large-for-gestational-age infants...
  25. ncbi request reprint Reversal of insulin resistance postpartum is linked to enhanced skeletal muscle insulin signaling
    John P Kirwan
    Departments of Pediatrics, Biochemistry, and Molecular Genetics, University of Colorado Health Sciences Center, 4200 East 9th Avenue, B 195, Denver, Colorado 80262, USA
    J Clin Endocrinol Metab 89:4678-84. 2004
    ..These changes may allow for greater p85/p110 binding to IRS-1 and play a significant physiological role in the underlying metabolic adaptation to normal human pregnancy and restoration of insulin sensitivity postpartum...
  26. ncbi request reprint Longitudinal changes in energy expenditure and body composition in obese women with normal and impaired glucose tolerance
    Ndubueze C Okereke
    Department of Reproductive Biology, Case Western Reserve University at MetroHealth Medical Center, Cleveland, Ohio 44109, USA
    Am J Physiol Endocrinol Metab 287:E472-9. 2004
    ..The increased reliance on fat metabolism is accompanied by a concomitant decrease in carbohydrate metabolism during hyperinsulinemia. The increase in fat oxidation may be related to increased maternal serum leptin...
  27. ncbi request reprint The influence of obesity and gestational diabetes mellitus on accretion and the distribution of adipose tissue in pregnancy
    Hugh M Ehrenberg
    Department of Reproductive Biology, Case Western Reserve University School of Medicine, Cleveland, OH 44109, USA
    Am J Obstet Gynecol 189:944-8. 2003
    ..The purpose of this study was to evaluate the effect of pregravid obesity and gestational diabetes mellitus (GDM) on the longitudinal accretion and distribution of adipose tissue in pregnancy...
  28. ncbi request reprint Obesity and pregnancy--the propagation of a viscous cycle?
    Patrick M Catalano
    J Clin Endocrinol Metab 88:3505-6. 2003
  29. ncbi request reprint Estimation of neonatal body composition: isotope dilution versus total-body electrical conductivity
    Kazumasa Hashimoto
    Department of Reproductive Biology, Case Western Reserve University at MetroHealth Medical Center, Cleveland, Ohio 44109, USA
    Biol Neonate 81:170-5. 2002
    ..22-0.57). Because of the wide variation of water content in individuals, the isotope dilution method may not be the optimal way of assessing body composition, and specifically body fat, in newborns...
  30. ncbi request reprint The effect of gender and gestational diabetes mellitus on cord leptin concentration
    Ndubueze C Okereke
    Department of Obstetrics and Gynecology, Case Western Reserve University School of Medicine at MetroHealth Medical Center, Cleveland, Ohio 44109 1998, USA
    Am J Obstet Gynecol 187:798-803. 2002
    ..We hypothesized that there are no significant differences in fetal leptin concentration between male and female or between neonates of mothers with gestational diabetes mellitus and control neonates, when adjusted for body composition...
  31. pmc Managing preexisting diabetes for pregnancy: summary of evidence and consensus recommendations for care
    John L Kitzmiller
    Division of Maternal Fetal Medicine, Santa Clara Valley Medical Center, San Jose, California 95128, USA
    Diabetes Care 31:1060-79. 2008
  32. ncbi request reprint Smoking before pregnancy and risk of gestational hypertension and preeclampsia
    Lucinda J England
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Bethesda, MD 20892 7510, USA
    Am J Obstet Gynecol 186:1035-40. 2002
    ..Our purpose was to determine whether smoking before pregnancy reduces the risk of gestational hypertension or preeclampsia...
  33. ncbi request reprint Neonatal anthropometric measurements to predict birth weight by ultrasound
    Bradley P Stetzer
    Department of Reproductive Biology, Case Western Reserve University at MetroHealth Medical Center, Cleveland, OH 44109, USA
    J Perinatol 22:397-402. 2002
    ..To develop a more accurate ultrasound birth weight (BW) model using neonatal anthropometric measurements...
  34. ncbi request reprint Metabolic programming: fetal origins of obesity and metabolic syndrome in the adult
    Faramarz Ismail-Beigi
    Dept of Medicine, Cleveland Diabetes Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Am J Physiol Endocrinol Metab 291:E439-40. 2006
    ..Importantly, these attributes can be passed on to the next generation nongenetically and can be reversed and prevented...
  35. ncbi request reprint Increased risk of preeclampsia among nulliparous pregnant women with idiopathic hematuria
    Catherine O Stehman-Breen
    Division of Nephrology, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Am J Obstet Gynecol 187:703-8. 2002
    ..Our purpose was to determine the risk of preeclampsia and gestational hypertension among nulliparous pregnant women with idiopathic hematuria...
  36. ncbi request reprint Glucose tolerance and risk of gestational diabetes mellitus in nulliparous women who smoke during pregnancy
    Lucinda J England
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services, Bethesda, MD, USA
    Am J Epidemiol 160:1205-13. 2004
    ..9, 95% confidence interval: 1.0, 3.6). These findings support an association between smoking and gestational diabetes mellitus...

Research Grants13

  1. Insulin Resistance and Glucose and Lipid Metabolism in Pregnancy
    PATRICK MICHAEL CATALANO; Fiscal Year: 2010
    ....
  2. OMEGA-3 SUPPLMENTATION DECREASES INFLAMMATION AND FETAL OBESITY IN PREGNANCY
    Patrick Catalano; Fiscal Year: 2009
    ..Pretiminary data witt also be obtained on fetat body composition in order to later address the prevention of the long term adverse effects (devetopmental programming) of maternal obesity in the developing fetus. ..
  3. Insulin Resistance and Glucose and Lipid Metabolism in Pregnancy
    Patrick Catalano; Fiscal Year: 2007
    ....
  4. CENTER FOR STUDY OF GROWTH REGULATION IN HUMAN PREGNANCY
    Patrick Catalano; Fiscal Year: 2004
    ..abstract_text> ..
  5. INSULIN RESISTANCE AND GLUCOSE METABOLISM IN PREGNANCY
    Patrick Catalano; Fiscal Year: 2002
    ....
  6. OMEGA-3 SUPPLMENTATION DECREASES INFLAMMATION AND FETAL OBESITY IN PREGNANCY
    Sylvie Hauguel De Mouzon; Fiscal Year: 2010
    ..Pretiminary data witt also be obtained on fetat body composition in order to later address the prevention of the long term adverse effects (devetopmental programming) of maternal obesity in the developing fetus. ..