Gemma Casadesus

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. ncbi request reprint Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged rats
    Gemma Casadesus
    USDA, HNRC on Aging at Tufts University, Boston, MA, USA
    Nutr Neurosci 7:309-16. 2004
  2. ncbi request reprint Hippocampal neurogenesis and PSA-NCAM expression following exposure to 56Fe particles mimics that seen during aging in rats
    Gemma Casadesus
    VSDA, HNRC on Aging, Tufts University, Boston, MA, USA
    Exp Gerontol 40:249-54. 2005
  3. ncbi request reprint Alzheimer disease: evidence for a central pathogenic role of iron-mediated reactive oxygen species
    Gemma Casadesus
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Alzheimers Dis 6:165-9. 2004
  4. doi request reprint Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer's disease
    Jaewon Chang
    Department of Neuroscience, Case Western Reserve University, Cleveland, OH 44106, USA
    Neurobiol Aging 33:2062-71. 2012
  5. pmc Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease
    Sandra L Siedlak
    Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA
    Free Radic Res 43:156-64. 2009
  6. pmc Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's disease
    Baiyang Sheng
    Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Neurochem 120:419-29. 2012
  7. pmc Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease
    Hyoung gon Lee
    Department of Pathology, Case Western Reserve University, Cleveland, OH, USA
    Neurochem Int 54:84-8. 2009
  8. ncbi request reprint Indices of metabolic dysfunction and oxidative stress
    Gemma Casadesus
    Department of Neuroscience, Case Western Reserve University, Cleveland, OH, USA
    Neurochem Res 32:717-22. 2007
  9. pmc Down-regulation of serum gonadotropins is as effective as estrogen replacement at improving menopause-associated cognitive deficits
    Kathryn J Bryan
    Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio, USA
    J Neurochem 112:870-81. 2010
  10. pmc The effect of mGluR2 activation on signal transduction pathways and neuronal cell survival
    Hyoung gon Lee
    Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA
    Brain Res 1249:244-50. 2009

Collaborators

Detail Information

Publications53

  1. ncbi request reprint Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged rats
    Gemma Casadesus
    USDA, HNRC on Aging at Tufts University, Boston, MA, USA
    Nutr Neurosci 7:309-16. 2004
    ..Therefore, cognitive improvements afforded by polyphenolic-rich fruits such as blueberries appear, in part, to be mediated by their effects on hippocampal plasticity...
  2. ncbi request reprint Hippocampal neurogenesis and PSA-NCAM expression following exposure to 56Fe particles mimics that seen during aging in rats
    Gemma Casadesus
    VSDA, HNRC on Aging, Tufts University, Boston, MA, USA
    Exp Gerontol 40:249-54. 2005
    ..Additionally, irradiated subjects show decreased levels of PSA-NCAM expression. These changes are consistent with those found in aged subjects indicating that heavy-particle irradiation is an adequate model for the study of aging...
  3. ncbi request reprint Alzheimer disease: evidence for a central pathogenic role of iron-mediated reactive oxygen species
    Gemma Casadesus
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Alzheimers Dis 6:165-9. 2004
    ..In this review, we consider the wealth of evidence implicating a central role for metals in Alzheimer disease...
  4. doi request reprint Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer's disease
    Jaewon Chang
    Department of Neuroscience, Case Western Reserve University, Cleveland, OH 44106, USA
    Neurobiol Aging 33:2062-71. 2012
    ....
  5. pmc Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease
    Sandra L Siedlak
    Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA
    Free Radic Res 43:156-64. 2009
    ....
  6. pmc Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's disease
    Baiyang Sheng
    Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Neurochem 120:419-29. 2012
    ..Overall, this study demonstrated that impaired mitochondrial biogenesis likely contributes to mitochondrial dysfunction in AD...
  7. pmc Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease
    Hyoung gon Lee
    Department of Pathology, Case Western Reserve University, Cleveland, OH, USA
    Neurochem Int 54:84-8. 2009
    ..Therefore, the study of aberrant cell cycle regulation in model systems, both cellular and animal, may provide extremely important insights into the pathogenesis of AD and also serve as a means to test novel therapeutic approaches...
  8. ncbi request reprint Indices of metabolic dysfunction and oxidative stress
    Gemma Casadesus
    Department of Neuroscience, Case Western Reserve University, Cleveland, OH, USA
    Neurochem Res 32:717-22. 2007
    ..Overall, clarifying cellular and molecular manifestations involved in metabolic alterations may contribute to a better understanding of early Alzheimer disease pathophysiology...
  9. pmc Down-regulation of serum gonadotropins is as effective as estrogen replacement at improving menopause-associated cognitive deficits
    Kathryn J Bryan
    Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio, USA
    J Neurochem 112:870-81. 2010
    ..These findings provide a potential novel protective strategy to treat menopause/age-related cognitive decline and/or prevent the development of AD...
  10. pmc The effect of mGluR2 activation on signal transduction pathways and neuronal cell survival
    Hyoung gon Lee
    Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA
    Brain Res 1249:244-50. 2009
    ..Additionally, our findings lend support to the notion that tau phosphorylation is a neuroprotective antioxidant response to cellular insults...
  11. ncbi request reprint Signal transduction cascades associated with oxidative stress in Alzheimer's disease
    Robert B Petersen
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    J Alzheimers Dis 11:143-52. 2007
    ..In this review, we present the evidence of oxidative stress and compensatory responses that occur in Alzheimer's disease with a particular focus on the roles and mechanism of activation of stress-activated protein kinase pathways...
  12. pmc Vascular oxidative stress in Alzheimer disease
    Xiongwei Zhu
    Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Neurol Sci 257:240-6. 2007
    ..Here, we discuss vascular factors in relation to Alzheimer disease and review hypoperfusion as a potential cause by triggering mitochondrial dysfunction and increased oxidative stress initiating the pathogenic process...
  13. ncbi request reprint Luteinizing hormone modulates cognition and amyloid-beta deposition in Alzheimer APP transgenic mice
    Gemma Casadesus
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
    Biochim Biophys Acta 1762:447-52. 2006
    ..Since both cognitive loss and amyloid-beta deposition are features of Alzheimer disease, leuprolide acetate treatment may prove to be a useful therapeutic strategy for this disease...
  14. pmc The neuronal expression of MYC causes a neurodegenerative phenotype in a novel transgenic mouse
    Hyoung gon Lee
    Department of Pathology, Case Western Reserve University, 2103 Cornell Rd, Cleveland, OH 44106, USA
    Am J Pathol 174:891-7. 2009
    ....
  15. ncbi request reprint Estrogen bows to a new master: the role of gonadotropins in Alzheimer pathogenesis
    Kate M Webber
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Rd, Cleveland, OH 44106, USA
    Ann N Y Acad Sci 1052:201-9. 2005
    ..On this basis, we suggest that the results of the WHI Memory Study are not only predictable but also avoidable by therapeutically targeting the gonadotropins instead of the sex steroids...
  16. ncbi request reprint Therapeutic opportunities in Alzheimer disease: one for all or all for one?
    Michael W Marlatt
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, Ohio 44106, USA
    Curr Med Chem 12:1137-47. 2005
    ..In this review, the scientific basis for common AD therapeutics as well as the efficacy of these treatments will be discussed...
  17. ncbi request reprint The cell cycle in Alzheimer disease: a unique target for neuropharmacology
    Kate M Webber
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
    Mech Ageing Dev 126:1019-25. 2005
    ..Therefore, therapeutic interventions targeted toward ameliorating mitotic changes would be predicted to have a profound and positive impact on Alzheimer disease progression...
  18. doi request reprint Neuronal cell cycle re-entry markers are altered in the senescence accelerated mouse P8 (SAMP8)
    Gemma Casadesus
    Departments of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA
    J Alzheimers Dis 30:573-83. 2012
    ....
  19. doi request reprint Antioxidant approaches for the treatment of Alzheimer's disease
    Hyun Pil Lee
    Case Western Reserve University, OH, USA
    Expert Rev Neurother 10:1201-8. 2010
    ..In this article, we discuss the multiple pathogenic mechanisms of oxidative stress in AD and the potential targeting approaches...
  20. pmc Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins
    Xinglong Wang
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 105:19318-23. 2008
    ....
  21. ncbi request reprint Gonadotropins: a cohesive gender-based etiology of Alzheimer disease
    Kate M Webber
    Department of Pathology, Case Western Reserve University, Cleveland, OH, USA
    Mol Cell Endocrinol 260:271-5. 2007
    ..In this review, we examine how the gonadotropins may play a central and determining role in modulating the susceptibility to, and progression of, Alzheimer disease...
  22. pmc LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1
    Xinglong Wang
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    Hum Mol Genet 21:1931-44. 2012
    ..We concluded that LRRK2 regulates mitochondrial dynamics by increasing mitochondrial DLP1 through its direct interaction with DLP1, and LRRK2 kinase activity plays a critical role in this process...
  23. ncbi request reprint Menopause, estrogen, and gonadotropins in Alzheimer's disease
    Gemma Casadesus
    Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Adv Clin Chem 45:139-53. 2008
    ..Moreover, targeting gonadotropins appears to have beneficial actions as a therapeutic regimen...
  24. ncbi request reprint Increases in luteinizing hormone are associated with declines in cognitive performance
    Gemma Casadesus
    Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio, United States
    Mol Cell Endocrinol 269:107-11. 2007
    ..As such, modulation of luteinizing hormone or its receptor levels may prove to be useful therapeutic strategies for cognitive decline associated with aging and age-related neurodegenerative diseases such as Alzheimer disease...
  25. ncbi request reprint The estrogen myth: potential use of gonadotropin-releasing hormone agonists for the treatment of Alzheimer's disease
    Gemma Casadesus
    Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Drugs R D 7:187-93. 2006
    ....
  26. ncbi request reprint The cell cycle and hormonal fluxes in Alzheimer disease: a novel therapeutic target
    Kate M Webber
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106 USA
    Curr Pharm Des 12:691-7. 2006
    ..Therapeutic interventions targeted at gonadotropins, if they are indeed the driving mitogenic force, could both prevent disease in those patients currently asymptomatic or halt, and even reverse, disease in those currently afflicted...
  27. doi request reprint Activation of the extracellular signal-regulated kinase pathway contributes to the behavioral deficit of fragile x-syndrome
    Xinglong Wang
    Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA
    J Neurochem 121:672-9. 2012
    ..These findings suggest that activation of the ERK pathway results in some cardinal cognitive and clinical features in FXS patients and likely have profound translational implications...
  28. ncbi request reprint Oxidative stress and redox-active iron in Alzheimer's disease
    Kazuhiro Honda
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Ann N Y Acad Sci 1012:179-82. 2004
    ..In this review, we consider the role of iron-induced oxidative stress as a key event in AD pathophysiology...
  29. ncbi request reprint Beyond estrogen: targeting gonadotropin hormones in the treatment of Alzheimer's disease
    Gemma Casadesus
    Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    Curr Drug Targets CNS Neurol Disord 3:281-5. 2004
    ..Therefore, the effects of agents that abolish LH, such as leuprolide acetate, which are currently being evaluated in Phase II clinical trials for the treatment of AD, are eagerly anticipated...
  30. ncbi request reprint Perspectives on the amyloid-beta cascade hypothesis
    Hyoung gon Lee
    Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    J Alzheimers Dis 6:137-45. 2004
    ..These findings bring into serious doubt the validity of the Amyloid Cascade Hypothesis as the central cause of Alzheimer disease and, consequently, the potential usefulness of therapeutic targets against amyloid-beta...
  31. pmc The contribution of luteinizing hormone to Alzheimer disease pathogenesis
    Kate M Webber
    Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Clin Med Res 5:177-83. 2007
    ..These promising findings support the importance of luteinizing hormone in AD and bring to the forefront an alternative, and much needed, therapeutic avenue for the treatment of this insidious disease...
  32. ncbi request reprint Challenging the amyloid cascade hypothesis: senile plaques and amyloid-beta as protective adaptations to Alzheimer disease
    Hyoung gon Lee
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Ann N Y Acad Sci 1019:1-4. 2004
    ..With this in mind, we suspect that current therapeutic efforts targeted toward lowering amyloid-beta production or removal of deposited amyloid-beta will only serve to exacerbate the disease process...
  33. ncbi request reprint Oxidative imbalance in Alzheimer's disease
    Xiongwei Zhu
    Institute of Pathology, Case Western Reserve University, Cleveland, OH, USA
    Mol Neurobiol 31:205-17. 2005
    ..In this review, we present the evidence for oxidative stress in Alzheimer's disease and its likely sources and consequence in relation to other pathological changes...
  34. ncbi request reprint Oxidative stress signalling in Alzheimer's disease
    Xiongwei Zhu
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
    Brain Res 1000:32-9. 2004
    ..In this paper, we review the evidence of oxidative stress and compensatory responses that occur in AD with a particular focus on the roles and mechanism of activation of SAPK pathways...
  35. pmc The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations
    David J Bonda
    Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA
    Lancet Neurol 10:275-9. 2011
    ..Ultimately, further analysis into both aspects is necessary if any progress is to be made...
  36. ncbi request reprint Gender differences in Alzheimer disease: the role of luteinizing hormone in disease pathogenesis
    Kate M Webber
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Alzheimer Dis Assoc Disord 19:95-9. 2005
    ..Based on this, we suggest that therapeutic interventions targeted at gonadotropins may both prevent disease in those patients currently asymptomatic or may halt, and even reverse, disease in those currently afflicted...
  37. ncbi request reprint Amyloid-beta and tau serve antioxidant functions in the aging and Alzheimer brain
    Mark A Smith
    Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    Free Radic Biol Med 33:1194-9. 2002
    ..The notion that amyloid-beta and tau function as protective components brings into serious question the rationale of current therapeutic efforts targeted toward lesion removal...
  38. ncbi request reprint Reversing the deleterious effects of aging on neuronal communication and behavior: beneficial properties of fruit polyphenolic compounds
    James A Joseph
    US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, and the Institute of Pathology, Case Western Reserve University, Cleveland, USA
    Am J Clin Nutr 81:313S-316S. 2005
    ....
  39. pmc Pet-1 is required across different stages of life to regulate serotonergic function
    Chen Liu
    Case Western Reserve University, School of Medicine, Department of Neurosciences, Cleveland, Ohio, USA
    Nat Neurosci 13:1190-8. 2010
    ..These findings indicate that Pet-1 is required across the lifespan of the mouse and that behavioral pathogenesis can result from both developmental and adult-onset alterations in serotonergic transcription...
  40. ncbi request reprint The role of metabotropic glutamate receptors in Alzheimer's disease
    Hyoung gon Lee
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, Ohio 44106, USA
    Acta Neurobiol Exp (Wars) 64:89-98. 2004
    ..Thus, we here discuss the possible role of mGluR in the pathogenesis of AD based on the results from other neurodegenerative diseases that may give us clues to solve the mysterious selective neurodegeneration evident in AD...
  41. pmc All-trans retinoic acid as a novel therapeutic strategy for Alzheimer's disease
    Hyun Pil Lee
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    Expert Rev Neurother 9:1615-21. 2009
    ..Here, we review the actions of retinoic acid that indicate that it may have therapeutic properties ideally served for the treatment of neurodegenerative diseases such as Alzheimer's disease...
  42. ncbi request reprint Evidence for the role of luteinizing hormone in Alzheimer disease
    Kate M Webber
    Department of Pathology, Case Western Reserve University, 2103 Cornell Road, Cleveland, Ohio 44106, USA
    Endocr Metab Immune Disord Drug Targets 7:300-3. 2007
    ..These promising findings support the importance of luteinizing hormone in Alzheimer disease and bring to the forefront an alternative, and much needed therapeutic avenue for the treatment of this insidious disease...
  43. pmc Frontiers in Alzheimer's disease therapeutics
    Jeremy G Stone
    Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA
    Ther Adv Chronic Dis 2:9-23. 2011
    ..In this review, we summarize novel AD therapeutics that are currently being explored, and also mechanisms of action of specific drugs within the context of current knowledge of AD pathologic pathways...
  44. doi request reprint Neuroendocrinology-based therapy for Alzheimer's disease
    Russell Palm
    Department of Neurosciences, Case Western Reserve University, Cleveland, OH, USA
    Biofactors 38:123-32. 2012
    ....
  45. pmc Expression of CD74 is increased in neurofibrillary tangles in Alzheimer's disease
    Kathryn J Bryan
    Department of Neurosciences, Case Western Reserve University, Cleveland Ohio, USA
    Mol Neurodegener 3:13. 2008
    ..This is the first finding to our knowledge that CD74 is increased in neurons of AD cases compared to age-matched control cases...
  46. ncbi request reprint A metabolic basis for Alzheimer disease
    George Perry
    Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Neurochem Res 28:1549-52. 2003
    ..Here we present data indicating that metabolic rate, nutrition, and neuronal size are all early indicators of AD. Understanding the cellular and molecular basis for these changes may open a new dimension to understanding AD...
  47. pmc Estrogen-mediated effects on cognition and synaptic plasticity: what do estrogen receptor knockout models tell us?
    Hyun Jin Kim
    Department of Neurosciences, Case Western Reserve University, Cleveland, OH 44106, USA
    Biochim Biophys Acta 1800:1090-3. 2010
    ..This review provides an overview of estrogen receptors in the brain and an update of knowledge gained from transgenic knockout models on cognition and synaptic plasticity...
  48. doi request reprint Retinoids for treatment of Alzheimer's disease
    Alan J Lerner
    Department of Neurology, University Hospitals Case Medical Center, Cleveland, OH, USA
    Biofactors 38:84-9. 2012
    ..These studies need to address safety issues of retinoids in older populations, and hold hope for demonstrating efficacy in translating these basic mechanisms to treatment of a widespread dementing illness...
  49. ncbi request reprint Gonadotropins and Alzheimer's disease: the link between estrogen replacement therapy and neuroprotection
    Kate M Webber
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, Ohio 44106, USA
    Acta Neurobiol Exp (Wars) 64:113-8. 2004
    ..Based on this, we suggest that therapeutic interventions targeted at gonadotropins could both prevent disease in those patients currently asymptomatic or halt, and even reverse, disease in those currently afflicted...
  50. pmc Transection of CA3 does not affect memory performance in rats
    Mohamad Z Koubeissi
    Neurology Department, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH 44106 5040, USA
    Epilepsy Behav 21:267-70. 2011
    ....
  51. ncbi request reprint Qualitative versus quantitative caloric intake: are they equivalent paths to successful aging?
    Gemma Casadesus
    USDA ARS, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Rm 919, Boston, MA 02111, USA
    Neurobiol Aging 23:747-69. 2002
    ..The two interventions will be compared and contrasted in terms of their effectiveness, safety, and generalization capacity for human treatment...
  52. ncbi request reprint Overexpression of the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) in skeletal muscle repatterns energy metabolism in the mouse
    Parvin Hakimi
    Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH 44106 4935, USA
    J Biol Chem 282:32844-55. 2007
    ..5 years ran twice as fast as 6-12-month-old control animals. We conclude that overexpression of PEPCK-C repatterns energy metabolism and leads to greater longevity...
  53. pmc Klf15 orchestrates circadian nitrogen homeostasis
    Darwin Jeyaraj
    Case Cardiovascular Research Institute, Harrington Heart and Vascular Institute, Department of Medicine, Western Reserve University, Cleveland, OH 44106, USA
    Cell Metab 15:311-23. 2012
    ..Thus, in mammals, nitrogen homeostasis exhibits circadian rhythmicity, and is orchestrated by Krüppel-like factor 15...

Research Grants3

  1. Gonadotropin involvement in cognition and Alzheimer's disease: Therapeutic Implic
    Gemma Casadesus; Fiscal Year: 2010
    ..Outcomes of the proposal are not only important from a scientific perspective but could lead to immediate novel therapeutic regimens. ..