Research Topics
Genomes and Genes
| Gemma CasadesusSummaryAffiliation: Case Western Reserve University Country: USA Publications
Research Grants
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Detail Information
Publications
Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged ratsGemma Casadesus
USDA, HNRC on Aging at Tufts University, Boston, MA, USA
Nutr Neurosci 7:309-16. 2004..Therefore, cognitive improvements afforded by polyphenolic-rich fruits such as blueberries appear, in part, to be mediated by their effects on hippocampal plasticity...- Hippocampal neurogenesis and PSA-NCAM expression following exposure to 56Fe particles mimics that seen during aging in ratsGemma Casadesus
VSDA, HNRC on Aging, Tufts University, Boston, MA, USA
Exp Gerontol 40:249-54. 2005..Additionally, irradiated subjects show decreased levels of PSA-NCAM expression. These changes are consistent with those found in aged subjects indicating that heavy-particle irradiation is an adequate model for the study of aging... - Alzheimer disease: evidence for a central pathogenic role of iron-mediated reactive oxygen speciesGemma Casadesus
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Alzheimers Dis 6:165-9. 2004..In this review, we consider the wealth of evidence implicating a central role for metals in Alzheimer disease... 
Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer's diseaseJaewon Chang
Department of Neuroscience, Case Western Reserve University, Cleveland, OH 44106, USA
Neurobiol Aging 33:2062-71. 2012....
Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's diseaseSandra L Siedlak
Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA
Free Radic Res 43:156-64. 2009....- Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's diseaseBaiyang Sheng
Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Neurochem 120:419-29. 2012..Overall, this study demonstrated that impaired mitochondrial biogenesis likely contributes to mitochondrial dysfunction in AD... - Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's diseaseHyoung gon Lee
Department of Pathology, Case Western Reserve University, Cleveland, OH, USA
Neurochem Int 54:84-8. 2009..Therefore, the study of aberrant cell cycle regulation in model systems, both cellular and animal, may provide extremely important insights into the pathogenesis of AD and also serve as a means to test novel therapeutic approaches... - Indices of metabolic dysfunction and oxidative stressGemma Casadesus
Department of Neuroscience, Case Western Reserve University, Cleveland, OH, USA
Neurochem Res 32:717-22. 2007..Overall, clarifying cellular and molecular manifestations involved in metabolic alterations may contribute to a better understanding of early Alzheimer disease pathophysiology... - Signal transduction cascades associated with oxidative stress in Alzheimer's diseaseRobert B Petersen
Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
J Alzheimers Dis 11:143-52. 2007..In this review, we present the evidence of oxidative stress and compensatory responses that occur in Alzheimer's disease with a particular focus on the roles and mechanism of activation of stress-activated protein kinase pathways... - Down-regulation of serum gonadotropins is as effective as estrogen replacement at improving menopause-associated cognitive deficitsKathryn J Bryan
Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio, USA
J Neurochem 112:870-81. 2010..These findings provide a potential novel protective strategy to treat menopause/age-related cognitive decline and/or prevent the development of AD... - Therapeutic opportunities in Alzheimer disease: one for all or all for one?Michael W Marlatt
Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, Ohio 44106, USA
Curr Med Chem 12:1137-47. 2005..In this review, the scientific basis for common AD therapeutics as well as the efficacy of these treatments will be discussed... - Vascular oxidative stress in Alzheimer diseaseXiongwei Zhu
Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Neurol Sci 257:240-6. 2007..Here, we discuss vascular factors in relation to Alzheimer disease and review hypoperfusion as a potential cause by triggering mitochondrial dysfunction and increased oxidative stress initiating the pathogenic process... - Estrogen bows to a new master: the role of gonadotropins in Alzheimer pathogenesisKate M Webber
Institute of Pathology, Case Western Reserve University, 2085 Adelbert Rd, Cleveland, OH 44106, USA
Ann N Y Acad Sci 1052:201-9. 2005..On this basis, we suggest that the results of the WHI Memory Study are not only predictable but also avoidable by therapeutically targeting the gonadotropins instead of the sex steroids... - Luteinizing hormone modulates cognition and amyloid-beta deposition in Alzheimer APP transgenic miceGemma Casadesus
Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
Biochim Biophys Acta 1762:447-52. 2006..Since both cognitive loss and amyloid-beta deposition are features of Alzheimer disease, leuprolide acetate treatment may prove to be a useful therapeutic strategy for this disease... - The neuronal expression of MYC causes a neurodegenerative phenotype in a novel transgenic mouseHyoung gon Lee
Department of Pathology, Case Western Reserve University, 2103 Cornell Rd, Cleveland, OH 44106, USA
Am J Pathol 174:891-7. 2009.... - The cell cycle in Alzheimer disease: a unique target for neuropharmacologyKate M Webber
Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
Mech Ageing Dev 126:1019-25. 2005..Therefore, therapeutic interventions targeted toward ameliorating mitotic changes would be predicted to have a profound and positive impact on Alzheimer disease progression... - The effect of mGluR2 activation on signal transduction pathways and neuronal cell survivalHyoung gon Lee
Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA
Brain Res 1249:244-50. 2009..Additionally, our findings lend support to the notion that tau phosphorylation is a neuroprotective antioxidant response to cellular insults... - Neuronal cell cycle re-entry markers are altered in the senescence accelerated mouse P8 (SAMP8)Gemma Casadesus
Departments of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA
J Alzheimers Dis 30:573-83. 2012.... - Antioxidant approaches for the treatment of Alzheimer's diseaseHyun Pil Lee
Case Western Reserve University, OH, USA
Expert Rev Neurother 10:1201-8. 2010..In this article, we discuss the multiple pathogenic mechanisms of oxidative stress in AD and the potential targeting approaches... - Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteinsXinglong Wang
Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
Proc Natl Acad Sci U S A 105:19318-23. 2008.... - Gonadotropins: a cohesive gender-based etiology of Alzheimer diseaseKate M Webber
Department of Pathology, Case Western Reserve University, Cleveland, OH, USA
Mol Cell Endocrinol 260:271-5. 2007..In this review, we examine how the gonadotropins may play a central and determining role in modulating the susceptibility to, and progression of, Alzheimer disease... - LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1Xinglong Wang
Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
Hum Mol Genet 21:1931-44. 2012..We concluded that LRRK2 regulates mitochondrial dynamics by increasing mitochondrial DLP1 through its direct interaction with DLP1, and LRRK2 kinase activity plays a critical role in this process... - Increases in luteinizing hormone are associated with declines in cognitive performanceGemma Casadesus
Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio, United States
Mol Cell Endocrinol 269:107-11. 2007..As such, modulation of luteinizing hormone or its receptor levels may prove to be useful therapeutic strategies for cognitive decline associated with aging and age-related neurodegenerative diseases such as Alzheimer disease... - Menopause, estrogen, and gonadotropins in Alzheimer's diseaseGemma Casadesus
Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106, USA
Adv Clin Chem 45:139-53. 2008..Moreover, targeting gonadotropins appears to have beneficial actions as a therapeutic regimen... - The estrogen myth: potential use of gonadotropin-releasing hormone agonists for the treatment of Alzheimer's diseaseGemma Casadesus
Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
Drugs R D 7:187-93. 2006.... - The cell cycle and hormonal fluxes in Alzheimer disease: a novel therapeutic targetKate M Webber
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106. USA
Curr Pharm Des 12:691-7. 2006..Therapeutic interventions targeted at gonadotropins, if they are indeed the driving mitogenic force, could both prevent disease in those patients currently asymptomatic or halt, and even reverse, disease in those currently afflicted... - Activation of the extracellular signal-regulated kinase pathway contributes to the behavioral deficit of fragile x-syndromeXinglong Wang
Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA
J Neurochem 121:672-9. 2012..These findings suggest that activation of the ERK pathway results in some cardinal cognitive and clinical features in FXS patients and likely have profound translational implications... - Perspectives on the amyloid-beta cascade hypothesisHyoung-Gon Lee
Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
J Alzheimers Dis 6:137-45. 2004..These findings bring into serious doubt the validity of the Amyloid Cascade Hypothesis as the central cause of Alzheimer disease and, consequently, the potential usefulness of therapeutic targets against amyloid-beta... - Oxidative imbalance in Alzheimer's diseaseXiongwei Zhu
Institute of Pathology, Case Western Reserve University, Cleveland, OH, USA
Mol Neurobiol 31:205-17. 2005..In this review, we present the evidence for oxidative stress in Alzheimer's disease and its likely sources and consequence in relation to other pathological changes... - Challenging the amyloid cascade hypothesis: senile plaques and amyloid-beta as protective adaptations to Alzheimer diseaseHyoung-Gon Lee
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
Ann N Y Acad Sci 1019:1-4. 2004..With this in mind, we suspect that current therapeutic efforts targeted toward lowering amyloid-beta production or removal of deposited amyloid-beta will only serve to exacerbate the disease process... - Oxidative stress and redox-active iron in Alzheimer's diseaseKazuhiro Honda
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
Ann N Y Acad Sci 1012:179-82. 2004..In this review, we consider the role of iron-induced oxidative stress as a key event in AD pathophysiology... - Beyond estrogen: targeting gonadotropin hormones in the treatment of Alzheimer's diseaseGemma Casadesus
Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
Curr Drug Targets CNS Neurol Disord 3:281-5. 2004..Therefore, the effects of agents that abolish LH, such as leuprolide acetate, which are currently being evaluated in Phase II clinical trials for the treatment of AD, are eagerly anticipated... - The contribution of luteinizing hormone to Alzheimer disease pathogenesisKate M Webber
Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
Clin Med Res 5:177-83. 2007..These promising findings support the importance of luteinizing hormone in AD and bring to the forefront an alternative, and much needed, therapeutic avenue for the treatment of this insidious disease... - Oxidative stress signalling in Alzheimer's diseaseXiongwei Zhu
Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
Brain Res 1000:32-9. 2004..In this paper, we review the evidence of oxidative stress and compensatory responses that occur in AD with a particular focus on the roles and mechanism of activation of SAPK pathways... - The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerationsDavid J Bonda
Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA
Lancet Neurol 10:275-9. 2011..Ultimately, further analysis into both aspects is necessary if any progress is to be made... - Amyloid-beta and tau serve antioxidant functions in the aging and Alzheimer brainMark A Smith
Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
Free Radic Biol Med 33:1194-9. 2002..The notion that amyloid-beta and tau function as protective components brings into serious question the rationale of current therapeutic efforts targeted toward lesion removal... - Reversing the deleterious effects of aging on neuronal communication and behavior: beneficial properties of fruit polyphenolic compoundsJames A Joseph
US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, and the Institute of Pathology, Case Western Reserve University, Cleveland, USA
Am J Clin Nutr 81:313S-316S. 2005.... - Gender differences in Alzheimer disease: the role of luteinizing hormone in disease pathogenesisKate M Webber
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
Alzheimer Dis Assoc Disord 19:95-9. 2005..Based on this, we suggest that therapeutic interventions targeted at gonadotropins may both prevent disease in those patients currently asymptomatic or may halt, and even reverse, disease in those currently afflicted... - Frontiers in Alzheimer's disease therapeuticsJeremy G Stone
Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA
Ther Adv Chronic Dis 2:9-23. 2011..In this review, we summarize novel AD therapeutics that are currently being explored, and also mechanisms of action of specific drugs within the context of current knowledge of AD pathologic pathways... - The role of metabotropic glutamate receptors in Alzheimer's diseaseHyoung-Gon Lee
Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, Ohio 44106, USA
Acta Neurobiol Exp (Wars) 64:89-98. 2004..Thus, we here discuss the possible role of mGluR in the pathogenesis of AD based on the results from other neurodegenerative diseases that may give us clues to solve the mysterious selective neurodegeneration evident in AD... - Pet-1 is required across different stages of life to regulate serotonergic functionChen Liu
Case Western Reserve University, School of Medicine, Department of Neurosciences, Cleveland, Ohio, USA
Nat Neurosci 13:1190-8. 2010..These findings indicate that Pet-1 is required across the lifespan of the mouse and that behavioral pathogenesis can result from both developmental and adult-onset alterations in serotonergic transcription... - Evidence for the role of luteinizing hormone in Alzheimer diseaseKate M Webber
Department of Pathology, Case Western Reserve University, 2103 Cornell Road, Cleveland, Ohio 44106, USA
Endocr Metab Immune Disord Drug Targets 7:300-3. 2007..These promising findings support the importance of luteinizing hormone in Alzheimer disease and bring to the forefront an alternative, and much needed therapeutic avenue for the treatment of this insidious disease... - All-trans retinoic acid as a novel therapeutic strategy for Alzheimer's diseaseHyun Pil Lee
Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
Expert Rev Neurother 9:1615-21. 2009..Here, we review the actions of retinoic acid that indicate that it may have therapeutic properties ideally served for the treatment of neurodegenerative diseases such as Alzheimer's disease... - Neuroendocrinology-based therapy for Alzheimer's diseaseRussell Palm
Department of Neurosciences, Case Western Reserve University, Cleveland, OH, USA
Biofactors 38:123-32. 2012.... - A metabolic basis for Alzheimer diseaseGeorge Perry
Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
Neurochem Res 28:1549-52. 2003..Here we present data indicating that metabolic rate, nutrition, and neuronal size are all early indicators of AD. Understanding the cellular and molecular basis for these changes may open a new dimension to understanding AD... - Expression of CD74 is increased in neurofibrillary tangles in Alzheimer's diseaseKathryn J Bryan
Department of Neurosciences, Case Western Reserve University, Cleveland Ohio, USA
Mol Neurodegener 3:13. 2008..This is the first finding to our knowledge that CD74 is increased in neurons of AD cases compared to age-matched control cases... - Estrogen-mediated effects on cognition and synaptic plasticity: what do estrogen receptor knockout models tell us?Hyun Jin Kim
Department of Neurosciences, Case Western Reserve University, Cleveland, OH 44106, USA
Biochim Biophys Acta 1800:1090-3. 2010..This review provides an overview of estrogen receptors in the brain and an update of knowledge gained from transgenic knockout models on cognition and synaptic plasticity... - Retinoids for treatment of Alzheimer's diseaseAlan J Lerner
Department of Neurology, University Hospitals Case Medical Center, Cleveland, OH, USA
Biofactors 38:84-9. 2012..These studies need to address safety issues of retinoids in older populations, and hold hope for demonstrating efficacy in translating these basic mechanisms to treatment of a widespread dementing illness... - Gonadotropins and Alzheimer's disease: the link between estrogen replacement therapy and neuroprotectionKate M Webber
Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, Ohio 44106, USA
Acta Neurobiol Exp (Wars) 64:113-8. 2004..Based on this, we suggest that therapeutic interventions targeted at gonadotropins could both prevent disease in those patients currently asymptomatic or halt, and even reverse, disease in those currently afflicted... - Transection of CA3 does not affect memory performance in ratsMohamad Z Koubeissi
Neurology Department, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH 44106 5040, USA
Epilepsy Behav 21:267-70. 2011.... - Overexpression of the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) in skeletal muscle repatterns energy metabolism in the mouseParvin Hakimi
Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH 44106 4935, USA
J Biol Chem 282:32844-55. 2007..5 years ran twice as fast as 6-12-month-old control animals. We conclude that overexpression of PEPCK-C repatterns energy metabolism and leads to greater longevity... - Qualitative versus quantitative caloric intake: are they equivalent paths to successful aging?Gemma Casadesus
USDA ARS, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Rm 919, Boston, MA 02111, USA
Neurobiol Aging 23:747-69. 2002..The two interventions will be compared and contrasted in terms of their effectiveness, safety, and generalization capacity for human treatment... - Klf15 orchestrates circadian nitrogen homeostasisDarwin Jeyaraj
Case Cardiovascular Research Institute, Harrington Heart and Vascular Institute, Department of Medicine, Western Reserve University, Cleveland, OH 44106, USA
Cell Metab 15:311-23. 2012..Thus, in mammals, nitrogen homeostasis exhibits circadian rhythmicity, and is orchestrated by Krüppel-like factor 15...
Research Grants
- Gonadotropin involvement in cognition and Alzheimer's disease: Therapeutic ImplicGemma Casadesus; Fiscal Year: 2010..Outcomes of the proposal are not only important from a scientific perspective but could lead to immediate novel therapeutic regimens. ..