A I Caplan

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. pmc Defining human mesenchymal stem cell efficacy in vivo
    Tracey L Bonfield
    Department of Pediatrics, Case Western Reserve University, Cleveland, OH, USA
    J Inflamm (Lond) 7:51. 2010
  2. doi Why are MSCs therapeutic? New data: new insight
    A I Caplan
    Skeletal Research Center, Department of Biology, Case Western Reserve University, Cleveland, OH 44106, USA
    J Pathol 217:318-24. 2009
  3. pmc New era of cell-based orthopedic therapies
    Arnold I Caplan
    Department of Biology, Skeletal Research Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Tissue Eng Part B Rev 15:195-200. 2009
  4. ncbi Adult mesenchymal stem cells for tissue engineering versus regenerative medicine
    Arnold I Caplan
    Skeletal Research Center, Department of Biology, Case Western Reserve University, Cleveland, Ohio, USA
    J Cell Physiol 213:341-7. 2007
  5. ncbi Mesenchymal stem cells as trophic mediators
    Arnold I Caplan
    Department of Biology, Skeletal Research Center, Case Western Reserve University, 2080 Adelbert Road, Cleveland, OH 44106 7080, USA
    J Cell Biochem 98:1076-84. 2006
  6. ncbi All MSCs are pericytes?
    Arnold I Caplan
    Department of Biology, Skeletal Research Center, Case Western Reserve University, Cleveland, OH 44106 7080, USA
    Cell Stem Cell 3:229-30. 2008
  7. pmc The MSC: an injury drugstore
    Arnold I Caplan
    Skeletal Research Center, Department of Biology, Case Western Reserve University, Cleveland, OH 44106 7080, USA
    Cell Stem Cell 9:11-5. 2011
  8. doi PDGF in bone formation and regeneration: new insights into a novel mechanism involving MSCs
    Arnold I Caplan
    Skeletal Research Center, Department of Biology, Case Western Reserve University, 2080 Adelbert Road, Cleveland, Ohio 44106 7080, USA
    J Orthop Res 29:1795-803. 2011
  9. ncbi Versican in human fetal skin development
    J M Sorrell
    Department of Biology and Skeletal Research Center, Case Western Reserve University, Cleveland, OH 44106, USA
    Anat Embryol (Berl) 199:45-56. 1999
  10. ncbi In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells
    B Johnstone
    Skeletal Research Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Exp Cell Res 238:265-72. 1998

Collaborators

Detail Information

Publications74

  1. pmc Defining human mesenchymal stem cell efficacy in vivo
    Tracey L Bonfield
    Department of Pediatrics, Case Western Reserve University, Cleveland, OH, USA
    J Inflamm (Lond) 7:51. 2010
    ..Our data also support future directions toward exploring hMSCs as an alternative therapeutic for the treatment of airway inflammation associated with asthma...
  2. doi Why are MSCs therapeutic? New data: new insight
    A I Caplan
    Skeletal Research Center, Department of Biology, Case Western Reserve University, Cleveland, OH 44106, USA
    J Pathol 217:318-24. 2009
    ..Thus, a new, enlightened era of experimentation and clinical trials has been initiated with xenogenic and allogeneic MSCs...
  3. pmc New era of cell-based orthopedic therapies
    Arnold I Caplan
    Department of Biology, Skeletal Research Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Tissue Eng Part B Rev 15:195-200. 2009
    ..Such infused MSCs trophically establish microenvironments that support the regeneration of the injured tissue. These new functions usher in a new era of cell-based therapies...
  4. ncbi Adult mesenchymal stem cells for tissue engineering versus regenerative medicine
    Arnold I Caplan
    Skeletal Research Center, Department of Biology, Case Western Reserve University, Cleveland, Ohio, USA
    J Cell Physiol 213:341-7. 2007
    ..This review summarizes the biological basis for the in vivo functioning of MSCs through development and aging...
  5. ncbi Mesenchymal stem cells as trophic mediators
    Arnold I Caplan
    Department of Biology, Skeletal Research Center, Case Western Reserve University, 2080 Adelbert Road, Cleveland, OH 44106 7080, USA
    J Cell Biochem 98:1076-84. 2006
    ..Several studies which tested the use of MSCs in models of infarct (injured heart), stroke (brain), or meniscus regeneration models are reviewed within the context of MSC-mediated trophic effects in tissue repair...
  6. ncbi All MSCs are pericytes?
    Arnold I Caplan
    Department of Biology, Skeletal Research Center, Case Western Reserve University, Cleveland, OH 44106 7080, USA
    Cell Stem Cell 3:229-30. 2008
  7. pmc The MSC: an injury drugstore
    Arnold I Caplan
    Skeletal Research Center, Department of Biology, Case Western Reserve University, Cleveland, OH 44106 7080, USA
    Cell Stem Cell 9:11-5. 2011
    ..These trophic and immunomodulatory activities suggest that MSCs may serve as site-regulated "drugstores" in vivo...
  8. doi PDGF in bone formation and regeneration: new insights into a novel mechanism involving MSCs
    Arnold I Caplan
    Skeletal Research Center, Department of Biology, Case Western Reserve University, 2080 Adelbert Road, Cleveland, Ohio 44106 7080, USA
    J Orthop Res 29:1795-803. 2011
    ..This thesis explains how PDGF functions as a powerful therapeutic agent for bone formation and repair...
  9. ncbi Versican in human fetal skin development
    J M Sorrell
    Department of Biology and Skeletal Research Center, Case Western Reserve University, Cleveland, OH 44106, USA
    Anat Embryol (Berl) 199:45-56. 1999
    ..The results of these studies indicate that human fetal skin is structurally different from adult skin in terms of both the distribution and the composition of the large, aggregating chondroitin sulfate proteoglycan versican...
  10. ncbi In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells
    B Johnstone
    Skeletal Research Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Exp Cell Res 238:265-72. 1998
    ..These results provide histological, immunohistochemical, and molecular evidence for the in vitro chondrogenic differentiation of adult mammalian progenitor cells derived from bone marrow...
  11. ncbi Comparison of the cartilage proteoglycan core protein synthesized by chondrocytes of different ages
    S E Haynesworth
    Department of Biology, Case Western Reserve University, Cleveland, Ohio 44106
    Connect Tissue Res 25:311-20. 1991
    ..e., the core protein)...
  12. ncbi Generation of a monoclonal antibody against avian small dermatan sulfate proteoglycan: immunolocalization and tissue distribution of PG-II (decorin) in embryonic tissues
    D P Lennon
    Department of Biology, Case Western Reserve University, Cleveland, OH 44106
    Matrix 11:412-27. 1991
    ..This antibody, which has been designated CB-1, reveals developmental stage-specific changes in the deposition of PG-II in embryonic limb bud and skeletal muscle...
  13. ncbi Cultivation of rat marrow-derived mesenchymal stem cells in reduced oxygen tension: effects on in vitro and in vivo osteochondrogenesis
    D P Lennon
    Skeletal Research Center, Case Western Reserve University, Cleveland, Ohio 44106-7080, USA
    J Cell Physiol 187:345-55. 2001
    ..We conclude that rMSCs in culture function optimally in an atmosphere of reduced oxygen that more closely approximates documented in vivo oxygen tension...
  14. ncbi Regulated expression of chondroitin sulfates at sites of epithelial-mesenchymal interaction: spatio-temporal patterning identified with anti-chondroitin sulfate monoclonal antibodies
    J M Sorreli
    Skeletal Research Center and Biology Department, Case Western Reserve University, Cleveland, OH 44106, USA
    Int J Dev Neurosci 14:233-48. 1996
    ..The highly organized expression of chondroitin sulfate proteoglycans in the development of the central nervous system strongly argues for a similar role for these molecules in the organs that comprise this system...
  15. doi Fibroblasts-a diverse population at the center of it all
    J Michael Sorrell
    Department of Biology, Case Western Reserve University, Cleveland, OH 44106, USA
    Int Rev Cell Mol Biol 276:161-214. 2009
    ..In short, fibroblasts represent a multifaceted, complex group of cells...
  16. ncbi BMP-2 induction and TGF-beta 1 modulation of rat periosteal cell chondrogenesis
    K Hanada
    Skeletal Research Center and the Department of Biology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Cell Biochem 81:284-94. 2001
    ..Collectively, our results suggest that BMP-2 induces neochondrogenesis of rat periosteum-derived cells, and that TGF-beta 1 modulates the terminal differentiation in BMP-2 induced chondrogenesis...
  17. ncbi Use of mesenchymal stem cells in a collagen matrix for Achilles tendon repair
    R G Young
    Osiris Therapeutics, Cleveland, Ohio, USA
    J Orthop Res 16:406-13. 1998
    ..The results indicate that delivering mesenchymal stem cell-contracted, organized collagen implants to large tendon defects can significantly improve the biomechanics, structure, and probably the function of the tendon after injury...
  18. ncbi Generation of pluripotent stem cells and their differentiation to the chondrocytic phenotype
    Luis A Solchaga
    Department of Orthopedics, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH, USA
    Methods Mol Med 100:53-68. 2004
    ..Although we have the technology to accomplish chondrogenic differentiation of stem cells, much is still to be learned regarding the regulatory mechanisms controlling the lineage transitions and maturation of the cartilaginous tissue...
  19. ncbi Sustained Wnt protein expression in chondral constructs from mesenchymal stem cells
    Katsuhiro Nishioka
    Skeletal Research Center, Department of Biology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Cell Physiol 203:6-14. 2005
    ..Their different spatial expression patterns suggest that Wnt4 and Wnt5a proteins are not functionally linked to type II collagen and type X collagen synthesis in in vitro chondrogenic models of hMSCs...
  20. pmc Low oxygen tension during incubation periods of chondrocyte expansion is sufficient to enhance postexpansion chondrogenesis
    James H Henderson
    Department of Biology Skeletal Research Center, Case Western Reserve University, Cleveland, OH, USA
    Tissue Eng Part A 16:1585-93. 2010
    ..The application of low O(2) tension during incubation periods of chondrocyte expansion enhances the ultimate cartilage matrix density and quantity, and this enhancement can be achieved through the use of an O(2) control incubator...
  21. ncbi Tissue-engineered fabrication of an osteochondral composite graft using rat bone marrow-derived mesenchymal stem cells
    J Gao
    Skeletal Research Center, Department of Biology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Tissue Eng 7:363-71. 2001
    ..These data suggest that the construction of a tissue-engineered composite osteochondral graft is possible with MSCs and different biomaterials and bioactive factors that support either chondrogenic or osteogenic differentiation...
  22. ncbi In vivo osteogenesis assay: a rapid method for quantitative analysis
    J E Dennis
    Skeletal Research Center, Biology Department, Case Western Reserve University, Cleveland, OH 44106 7080, USA
    Biomaterials 19:1323-8. 1998
    ..Thus, the Percentage Bone method of scoring is an accurate and relatively quick scoring method for in vivo bone formation...
  23. ncbi Clonal characterization of fibroblasts in the superficial layer of the adult human dermis
    J Michael Sorrell
    Skeletal Research Center, Biology Department, Case Western Reserve University, Cleveland, OH 44106, USA
    Cell Tissue Res 327:499-510. 2007
    ..This heterogeneity might indicate that diverse subpopulations of fibroblasts are required to interact in both homeostatic and pathological situations in skin...
  24. ncbi A self-assembled fibroblast-endothelial cell co-culture system that supports in vitro vasculogenesis by both human umbilical vein endothelial cells and human dermal microvascular endothelial cells
    J Michael Sorrell
    Skeletal Research Center and Biology Department, Case Western Reserve University, Cleveland, Ohio, USA
    Cells Tissues Organs 186:157-68. 2007
    ..This system also provides an experimental basis for developing vascularized tissue-engineered connective tissue...
  25. doi Human dermal fibroblast subpopulations; differential interactions with vascular endothelial cells in coculture: nonsoluble factors in the extracellular matrix influence interactions
    J Michael Sorrell
    Department of Biology, Skeletal Research Centre, Case Western Reserve University, Cleveland, Ohio, USA
    Wound Repair Regen 16:300-9. 2008
    ..Furthermore, these studies have important implications for wound repair and may help to explain how fibroblasts contribute to the etiology of nonhealing wounds...
  26. ncbi FGF-2 enhances the mitotic and chondrogenic potentials of human adult bone marrow-derived mesenchymal stem cells
    Luis A Solchaga
    Department of Orthopaedics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    J Cell Physiol 203:398-409. 2005
    ..With the generation of gene expression profiles of FGF-treated and control cells we have taken the first steps in the elucidation of the molecular mechanism(s) behind these phenomena...
  27. ncbi Fibroblast heterogeneity: more than skin deep
    J Michael Sorrell
    Skeletal Research Center, Biology Department, Case Western Reserve University, Cleveland, OH 44106, USA
    J Cell Sci 117:667-75. 2004
    ..Bioengineered skin currently performs important roles in providing (1) a basic understanding of skin biology, (2) a vehicle for testing topically applied products and (3) a resource for skin replacement...
  28. ncbi Production of a monoclonal antibody, DF-5, that identifies cells at the epithelial-mesenchymal interface in normal human skin. APN/CD13 is an epithelial-mesenchymal marker in skin
    J Michael Sorrell
    Department of Biology, Case Western Reserve University, Cleveland, OH, 44106 USA
    Exp Dermatol 12:315-23. 2003
    ..It may play a role in regulating the activity of neuropeptides or other signaling peptides that are released in this region of skin or it may have an as yet undefined role in mediating communication between dermal and epidermal cells...
  29. doi Mesenchymal stem cells: mechanisms of inflammation
    Nora G Singer
    MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio 44109, USA
    Annu Rev Pathol 6:457-78. 2011
    ....
  30. pmc Age-related differences in human skin proteoglycans
    David A Carrino
    Department of Biology, Skeletal Research Center, Case Western Reserve University, Cleveland, OH 44106, USA
    Glycobiology 21:257-68. 2011
    ..These age-related differences in proteoglycan patterns and catabolism may play a role in the age-related changes in the physical properties and injury response of human skin...
  31. pmc Topical delivery of mesenchymal stem cells and their function in wounds
    J Michael Sorrell
    Department of Biology, Skeletal Research Center, Case Western Reserve University, 2080 Adelbert Road, Cleveland, OH 44106, USA
    Stem Cell Res Ther 1:30. 2010
    ....
  32. doi Human mesenchymal stem cells suppress chronic airway inflammation in the murine ovalbumin asthma model
    Tracey L Bonfield
    Dept of Pediatrics, Case Western Reserve Univ, Cleveland, OH 44106 4948, USA
    Am J Physiol Lung Cell Mol Physiol 299:L760-70. 2010
    ..In addition, the results from these studies verify the in vivo immunoeffectiveness of hMSCs in rodents and support the potential therapeutic use of hMSCs for the treatment of airway inflammation associated with chronic asthma...
  33. ncbi Adult mesenchymal stem cells: an innovative therapeutic for lung diseases
    Tracey L Bonfield
    Division of Pediatric Pulmonology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Discov Med 9:337-45. 2010
    ..This review highlights current concepts of such functions with a focus on the clinical utility of hMSCs in the treatment of lung diseases...
  34. ncbi The potential of mesenchymal stem cells for neural repair
    Robert H Miller
    Centers for Stem Cells and Regenerative Medicine, Translational Neuroscience, Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Discov Med 9:236-42. 2010
    ..In each situation, treatment with MSCs results in substantial functional benefit and these pre-clinical studies have led to the initiation of a number of clinical trials worldwide in neural repair...
  35. pmc Fibroblast growth factor-2 enhances proliferation and delays loss of chondrogenic potential in human adult bone-marrow-derived mesenchymal stem cells
    Luis A Solchaga
    Division of Hematology and Oncology, Department of General Medical Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106 7080, USA
    Tissue Eng Part A 16:1009-19. 2010
    ..Supplementation with FGF-2 allows reaching target cell numbers more rapidly and extends the level of expansion within which these cells are useful for tissue-engineered cartilage repair...
  36. pmc Influence of adult mesenchymal stem cells on in vitro vascular formation
    J Michael Sorrell
    Department of Biology, Skeletal Research Center, Case Western Reserve University, Cleveland, OH 44106, USA
    Tissue Eng Part A 15:1751-61. 2009
    ..This in vitro system provides a means for assessing the function of BM-MSCs in aspects of the angiogenic component of wound repair...
  37. ncbi Review: mesenchymal stem cells: cell-based reconstructive therapy in orthopedics
    Arnold I Caplan
    Skeletal Research Center, Department of Biology, Case Western Reserve University, Cleveland, OH 44106, USA
    Tissue Eng 11:1198-211. 2005
    ....
  38. ncbi Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy
    O N Koc
    Departments of Medicine and Biology, Case Western Reserve University, Cleveland, OH 44106, USA
    J Clin Oncol 18:307-16. 2000
    ....
  39. ncbi Dynamic expression of proteoglycans during chicken skeletal muscle development and maturation
    D A Carrino
    Department of Biology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Poult Sci 78:769-77. 1999
    ....
  40. ncbi The dynamic in vivo distribution of bone marrow-derived mesenchymal stem cells after infusion
    J Gao
    Skeletal Research Center, Department of Biology, Case Western Reserve University, Cleveland, Ohio, USA
    Cells Tissues Organs 169:12-20. 2001
    ..These results indicate multiple homing sites for injected MSCs and that the distribution of MSCs can be influenced by administration of vasodilator...
  41. ncbi The STRO-1+ marrow cell population is multipotential
    James E Dennis
    Skeletal Research Center, Department of Biology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Cells Tissues Organs 170:73-82. 2002
    ....
  42. pmc Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis
    Lianhua Bai
    Case Western Reserve University, Centers for Stem Cells and Regenerative Medicine, Translational Neuroscience, Department of Neurosciences, Case School of Medicine, Cleveland, Ohio 44106, USA
    Glia 57:1192-203. 2009
    ..Together, these data suggest that the BM-hMSCs represent a viable option for therapeutic approaches...
  43. ncbi Embryonic development and the principles of tissue engineering
    Arnold I Caplan
    Skeletal Research Center, Department of Biology, Case Western Reserve University, 2080 Adelbert Road, Cleveland, OH 44106 7080, USA
    Novartis Found Symp 249:17-25; discussion 25-33, 170-4, 239-41. 2003
    ..Several tissue-engineering principles based on the details of embryonic events provide guides for the development of scientific logics for new reparative strategies for the regeneration of skeletal tissues...
  44. doi Dexamethasone inhibition of confluence-induced apoptosis in human mesenchymal stem cells
    In Hwan Song
    Department of Orthopaedics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Orthop Res 27:216-21. 2009
    ..These results may impact how MSCs should be cultured for clinical applications...
  45. ncbi Isolation of rat marrow-derived mesenchymal stem cells
    Donald P Lennon
    Skeletal Research Center, Department of Biology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Exp Hematol 34:1606-7. 2006
  46. ncbi Targeted delivery of progenitor cells for cartilage repair
    James E Dennis
    Skeletal Research Center, Department of Biology, Case Western Reserve University and University Hospitals of Cleveland, 2080 Adelbert Road, Cleveland, OH 44106 7080, USA
    J Orthop Res 22:735-41. 2004
    ..These results demonstrate that painting cell membranes with antibodies to matrix molecules is an effective method for promoting the adherence of stem or progenitor cells to a cartilage injury site...
  47. ncbi Isolation of human marrow-derived mesenchymal stem cells
    Donald P Lennon
    Skeletal Research Center, Department of Biology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Exp Hematol 34:1604-5. 2006
  48. ncbi Age-related changes in the proteoglycans of human skin
    D A Carrino
    Department of Biology, Case Western Reserve University, Cleveland, Ohio, 44106 7080, USA
    Arch Biochem Biophys 373:91-101. 2000
    ..The observation that proteoglycans in skin show dramatic age-related differences suggests that these changes may be involved in the age-related changes in the physical properties of skin...
  49. ncbi Mesenchymal stem cells: building blocks for molecular medicine in the 21st century
    A I Caplan
    Dept of Biology, Skeletal Research Center, Case Western Reserve University, Cleveland, OH, USA
    Trends Mol Med 7:259-64. 2001
    ....
  50. doi In vitro dexamethasone pretreatment enhances bone formation of human mesenchymal stem cells in vivo
    In Hwan Song
    Department of Orthopedics, Case Western Reserve University, Cleveland, Ohio, USA
    J Orthop Res 27:916-21. 2009
    ..These results indicate that pretreatment of MSCs with dex results in greater bone formation than in untreated controls...
  51. pmc Cartilage tissue engineering for laryngotracheal reconstruction: comparison of chondrocytes from three anatomic locations in the rabbit
    James H Henderson
    Departments of Biology and Orthopaedics, Skeletal Research Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Tissue Eng 13:843-53. 2007
    ..The results also suggest that this and similar tissue engineering approaches must be optimized for each potential source of chondrocytes...
  52. ncbi Repair of osteochondral defects with hyaluronan- and polyester-based scaffolds
    Luis A Solchaga
    Department of Orthopaedics, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, OH, USA
    Osteoarthritis Cartilage 13:297-309. 2005
    ....
  53. ncbi Cytokines and glucocorticoids differentially regulate APN/CD13 and DPPIV/CD26 enzyme activities in cultured human dermal fibroblasts
    J Michael Sorrell
    Department of Biology, Case Western Reserve University, Cleveland, OH 44106, USA
    Arch Dermatol Res 295:160-8. 2003
    ..This finding, along with their differential distribution in normal skin, suggests that APN/CD13 and DPPIV/CD26 have different functions in the skin...
  54. ncbi Treatment of osteochondral defects with autologous bone marrow in a hyaluronan-based delivery vehicle
    Luis A Solchaga
    Skeletal Research Center, Department of Biology, Case Western Reserve University, Cleveland, Ohio, USA
    Tissue Eng 8:333-47. 2002
    ..The fundamental tissue engineering principles derived from this study should provide guidelines for the development of comparable clinical reconstructive therapies...
  55. ncbi Mesenchymal stem cells and tissue engineering for orthopaedic surgery
    J Gao
    Skeletal Research Center, Department of Biology, Case Western Reserve University, Cleveland, Ohio, USA
    Chir Organi Mov 88:305-16. 2003
    ..Future efforts should be made to establish reliable and standardized full-scale clinical approaches using MSCs for orthopaedic surgery...
  56. ncbi Monoclonal antibodies to mineralized matrix molecules of the avian eggshell
    J E Dennis
    Skeletal Research Center, Department of Biology, Case Western Reserve University, 2080 Adelbert Rd, Cleveland, OH 44106 7080, USA
    Matrix Biol 19:683-92. 2000
    ....
  57. ncbi Age-related changes in the proteoglycans of human skin. Specific cleavage of decorin to yield a major catabolic fragment in adult skin
    David A Carrino
    Department of Biology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 278:17566-72. 2003
    ..Because of the capacity of decorin to influence collagen fibrillogenesis, catabolism of decorin may have important functional implications with respect to the dermal collagen network...
  58. ncbi Effect of transforming growth factor beta 2 on marrow-infused foam poly(propylene fumarate) tissue-engineered constructs for the repair of critical-size cranial defects in rabbits
    David Dean
    Department of Neurological Surgery and Research Institute, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Tissue Eng 11:923-39. 2005
    ..These results support the use of PPF as an osteogenic substrate and future research into preoperative fabrication of critical size and supercritical-size cranial prosthetic implants...
  59. ncbi In vivo remodeling
    Arnold I Caplan
    Case Western Reserve University, 2080 Adelbert Road, Cleveland, OH 44106, USA
    Ann N Y Acad Sci 961:307-8. 2002
  60. ncbi Toxic effects of gentamicin on marrow-derived human mesenchymal stem cells
    Yuhan Chang
    Skeletal Research Center, Case Western Reserve University, Cleveland, OH 44106 7080, USA
    Clin Orthop Relat Res 452:242-9. 2006
    ..At a high concentration, gentamicin inhibits proliferation and differentiation of human bone marrow mesenchymal stem cells and could compromise the bone-healing process...
  61. doi Optimizing mesenchymal stem cell-based therapeutics
    Joseph Wagner
    Cell Targeting, Inc, 11000 Cedar Ave, Cleveland, OH 44106, USA
    Curr Opin Biotechnol 20:531-6. 2009
    ..Each of these strategies has its own set of distinct advantages and disadvantages when viewed with a mindset of ultimate commercialization and clinical utility...
  62. ncbi Repair of osteochondral defect with tissue-engineered two-phase composite material of injectable calcium phosphate and hyaluronan sponge
    Jizong Gao
    Skeletal Research Center, Department of Biology, Case Western Reserve University, 2080 Adelbert Road, Cleveland, OH 44106, USA
    Tissue Eng 8:827-37. 2002
    ....
  63. pmc A rapid seeding technique for the assembly of large cell/scaffold composite constructs
    Luis A Solchaga
    Department of Orthopaedics, Case Western Reserve University Cleveland, Ohio 44106 7080, USA
    Tissue Eng 12:1851-63. 2006
    ..The vacuum seeding technique is safe, rapid, reproducible, and results in controlled quantitative cell loading, high retention, and uniform distribution...
  64. pmc A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential
    Gesine Kogler
    Institute for Transplantation Diagnostics and Cell Therapeutics, Heinrich Heine University Medical Center, Moorenstrasse 5, 40225 Dusseldorf, Germany
    J Exp Med 200:123-35. 2004
    ..No tumor formation was observed in any of these animals...
  65. ncbi Isolation and characterization of a population of immature dental pulp stem cells expressing OCT-4 and other embryonic stem cell markers
    Irina Kerkis
    Laboratorio de Genetica, Instituto Butantan, Sao Paulo, Brasil
    Cells Tissues Organs 184:105-16. 2006
    ..The relative ease of recovery and the expression profiles of various markers justify further exploration of IDPSC for clinical therapy...
  66. ncbi Tissue engineering of autologous cartilage grafts in three-dimensional in vitro macroaggregate culture system
    Andreas Naumann
    Department of Otorhinolaryngology, Head and Neck Surgery, Ludwig Maximilian University, Munich, Germany
    Tissue Eng 10:1695-706. 2004
    ..Further long-term in vitro and in vivo studies must be done before this method can be applied to reconstructive surgery of the nose or auricle...
  67. ncbi Adult stem cell driven genesis of human-shaped articular condyle
    Adel Alhadlaq
    Tissue Engineering Laboratory, Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612, USA
    Ann Biomed Eng 32:911-23. 2004
    ..These findings may serve as a primitive proof of concept for ultimate tissue-engineered replacement of degenerated articular condyles via a single population of adult mesenchymal stem cells...
  68. pmc Injectable biodegradable hydrogel composites for rabbit marrow mesenchymal stem cell and growth factor delivery for cartilage tissue engineering
    Hansoo Park
    Department of Bioengineering, Rice University, MS 142, P O Box 1892, Houston, TX 77251 1892, USA
    Biomaterials 28:3217-27. 2007
    ....
  69. ncbi A simple method for stem cell labeling with fluorine 18
    Bing Ma
    Department of Radiology, Division of Nuclear Medicine, University of Michigan Medical School, Ann Arbor, 48109, USA
    Nucl Med Biol 32:701-5. 2005
    ..18)F]HFB is thus simple to prepare and uses labeling agent for short-term distribution studies of injected stem cells...
  70. ncbi Bioreactors mediate the effectiveness of tissue engineering scaffolds
    Ming Pei
    Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    FASEB J 16:1691-4. 2002
    ..The data imply that interactions between bioreactors and 3D tissue engineering scaffolds can be utilized to improve the structure, function, and molecular properties of in vitro-generated cartilage...
  71. ncbi In vivo remodeling: breakout session summary
    Stephen F Badylak
    Purdue University, 1296 Potter Building, Room 204, West Lafayette, IN 47907, USA
    Ann N Y Acad Sci 961:319-22. 2002
  72. ncbi Hyaluronan-based polymer scaffold modulates the expression of inflammatory and degradative factors in mesenchymal stem cells: Involvement of Cd44 and Cd54
    Gina Lisignoli
    Laboratorio di Immunologia e Genetica, Istituti Ortopedici Rizzoli, Bologna, Italy
    J Cell Physiol 207:364-73. 2006
    ..Our data clearly demonstrate that HA in this 3-D conformation acts as a signaling molecule for h-MSCs...
  73. ncbi Immunochemical and mechanical characterization of cartilage subtypes in rabbit
    Andreas Naumann
    Department of Otorhinolaryngology, Head and Neck Surgery, Ludwig Maximilians University, Munich, Germany
    J Histochem Cytochem 50:1049-58. 2002
    ..The results provide a baseline of data for generating and evaluating engineered repair cartilage tissue synthesized in vitro or for post-implantation analysis...
  74. ncbi Cellular interactions and bone healing responses to a novel porous tricalcium phosphate bone graft material
    Douglas C Fredericks
    Bone Healing Research Laboratory, University of lowa College of Medicine, Iowa City, Iowa, USA
    Orthopedics 27:s167-73. 2004
    ..Collectively, the tricalcium phosphate material properties, cell seeding capabilities, and in vivo biological responses give evidence of this implant's functionality as a potential alternative for autograft...