Research Topics
| J R CalabreseSummaryAffiliation: Case Western Reserve University Country: USA Publications
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Publications
Long-term treatment of bipolar disorder with lamotrigineJoseph R Calabrese
J Clin Psychiatry 63:18-22. 2002....- Citalopram treatment of fluoxetine-intolerant depressed patientsJoseph R Calabrese
Mood Disorders Program, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
J Clin Psychiatry 64:562-7. 2003..We assessed the tolerability of and response to citalopram in depressed patients who had discontinued fluoxetine treatment due to adverse events... - Current research on rapid cycling bipolar disorder and its treatmentJ R Calabrese
Mood Disorders Program, Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
J Affect Disord 67:241-55. 2001..Electroconvulsive therapy may also prove efficacious in selected cases. The present paper provides a critical review of the evidence for the foregoing clinical issues in rapid cycling... - Bipolar rapid cycling: focus on depression as its hallmarkJ R Calabrese
Department of Psychiatry at University Hospitals of Cleveland and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
J Clin Psychiatry 62:34-41. 2001..The results indicate that lamotrigine may be a useful treatment for patients with rapid-cycling bipolar II disorder and that this drug has begun to address this unmet need... - Evolving methodologies in bipolar disorder maintenance researchJ R Calabrese
Mood Disorders Program, Department of Psychiatry, Case Western Reserve University, Cleveland, Ohio, USA
Br J Psychiatry Suppl 41:s157-63. 2001..Comparisons with the early bipolar disorder maintenance studies indicate that the methodologies of recent trials have evolved substantially... - Bipolar disorders and the effectiveness of novel anticonvulsantsJoseph R Calabrese
Mood Disorders Program, Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
J Clin Psychiatry 63:5-9. 2002..The new anticonvulsants are promising agents for the treatment of bipolar disorders, but they are heterogeneous with regard to their efficacy, target symptoms, and adverse event profiles... - A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently depressed patients with bipolar I disorderJoseph R Calabrese
University Hospitals of Cleveland Case Western Reserve School of Medicine, Department of Psychiatry, 11400 Euclid Ave, Ste 200, Cleveland, OH 44106, USA
J Clin Psychiatry 64:1013-24. 2003..This study assessed the efficacy and tolerability of lamotrigine and lithium compared with placebo for the prevention of mood episodes in bipolar disorder... - Rash in multicenter trials of lamotrigine in mood disorders: clinical relevance and managementJoseph R Calabrese
Department of Psychiatry, Case Western Reserve University University Hospitals of Cleveland, Cleveland, Ohio, USA
J Clin Psychiatry 63:1012-9. 2002..The objective of this report was to determine rash rates in clinical trials of lamotrigine in DSM-IV unipolar depression or bipolar disorder... - Controlled trials in bipolar I depression: focus on switch rates and efficacyJ R Calabrese
Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, OH, USA
Eur Neuropsychopharmacol 9:S109-12. 1999..At present there is no consensus over the optimal definition of switching. Standardising the definition may lead to improvements in the clinical management of bipolar disorder... - Impact of bipolar disorder on a U.S. community sampleJoseph R Calabrese
Department of Psychiatry, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
J Clin Psychiatry 64:425-32. 2003..Bipolar symptoms have been associated with significant functional impairment. We conducted a study to determine the psychosocial impact of bipolar disorder in a U.S. community sample... - A randomized, placebo-controlled 12-month trial of divalproex and lithium in treatment of outpatients with bipolar I disorder. Divalproex Maintenance Study GroupC L Bowden
Department of Psychiatry, University of Texas Health Science Center at San Antonio, 78284 7792, USA
Arch Gen Psychiatry 57:481-9. 2000..This study compared the efficacy of divalproex, lithium, and placebo as prophylactic therapy... - Clinical studies on the use of lamotrigine in bipolar disorderJ R Calabrese
Mood Disorder Program, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
Neuropsychobiology 38:185-91. 1998.... - Current concepts in rapid cycling bipolar disorderM D Shelton
Mood Disorders Program, Department of Psychiatry, Case Western Reserve University School of Medicine, 11400 Euclid Avenue, Suite 200, Cleveland, Ohio 44106, USA
Curr Psychiatry Rep 2:310-5. 2000..Controlled trials in homogeneous cohorts of RCBD patients are needed. Preliminary data suggest that two or more mood stabilizers are required for adequate control... - Rapid, continuous cycling and psychiatric co-morbidity in pediatric bipolar I disorderR L Findling
Department of Psychiatry, University Hospitals of Cleveland Case Western Reserve University School of Medicine, Case Western Reserve University, Cleveland, OH 44106 5080, USA
Bipolar Disord 3:202-10. 2001..The primary purpose of this study was to describe the clinical presentation of bipolar I disorder (BP-I) as it occurs in children and adolescents and to assess whether the manifestations of BP-I were similar in both age groups... - New data on the use of lithium, divalproate, and lamotrigine in rapid cycling bipolar disorderJ R Calabrese
Case Western Reserve University School of Medicine, University Hospitals of Cleveland, 11400 Euclid Avenue, Suite 200, Cleveland, OH 44106, USA
Eur Psychiatry 20:92-5. 2005..In addition, lamotrigine has the potential to complement the spectrum of lithium and divalproate through its greater efficacy for depressive symptoms... - Discriminative validity of parent report of hypomanic and depressive symptoms on the General Behavior InventoryE A Youngstrom
Department of Psychology, Case Western Reserve University, 11220 Bellflower Road, Cleveland, Ohio 44106, USA
Psychol Assess 13:267-76. 2001..80. Results indicate that clinicians can use the parent-completed GBI to derive clinically meaningful information about mood disorders in youths... - Predictive value of early improvement in bipolar depression trials: a post-hoc pooled analysis of two 8-week aripiprazole studiesD E Kemp
Case Western Reserve University, Cleveland, OH, USA
Psychopharmacol Bull 43:5-27. 2010..To evaluate the value of early improvement to predict treatment outcome in patients with bipolar depression... - Structure of mania: depressive, irritable, and psychotic clusters with different retrospectively-assessed course patterns of illness in randomized clinical trial participantsA C Swann
Department of Psychiatry, University of Texas Houston Health Science Center, 1300 Moursund Street, Room 270, Houston, TX 77030, USA
J Affect Disord 67:123-32. 2001..We investigated the structure of manic episodes by determining whether there was evidence for distinct groups of patients differing in clinical characteristics and course of illness... 
Aims and results of the NIMH systematic treatment enhancement program for bipolar disorder (STEP-BD)C L Bowden
Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
CNS Neurosci Ther 18:243-9. 2012..STEP-BD has established procedures that are relevant to future collaborative research programs aimed at the systematic study of the complex, intrinsically important elements of bipolar disorders...
Comorbid anxiety and substance use disorders associated with a lower use of mood stabilisers in patients with rapid cycling bipolar disorder: a descriptive analysis of the cross-sectional data of 566 patientsK Gao
Department of Psychiatry, Mood and Anxiety Clinic at Mood Disorders Program, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, OH, USA
Int J Clin Pract 64:336-44. 2010..To study mood stabiliser treatment in patients with bipolar disorder with or without anxiety disorders (ADs) and/or substance use disorders (SUDs)...- A pilot study of topiramate as monotherapy in the treatment of acute maniaJ R Calabrese
Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
J Clin Psychopharmacol 21:340-2. 2001..The preliminary findings of this small series suggest that topiramate may be effective in acute mania. Double-blind controlled trials are now needed to further investigate the efficacy and safety of topiramate in bipolar disorder... - Incidence and time course of subsyndromal symptoms in patients with bipolar I disorder: an evaluation of 2 placebo-controlled maintenance trialsMark A Frye
Mood Disorders Research Program, University of California at Los Angeles, USA
J Clin Psychiatry 67:1721-8. 2006..Subsyndromal symptoms in bipolar disorder can cause significant functional impairment and are associated with relapse... - Efficacy of quetiapine monotherapy in bipolar I and II depression: a double-blind, placebo-controlled study (the BOLDER II study)Michael E Thase
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 2593, USA
J Clin Psychopharmacol 26:600-9. 2006..This study demonstrates that quetiapine monotherapy is an effective and well-tolerated treatment for depressive episodes in bipolar disorder, confirming the results observed from a previous study (BipOLar DEpRession [BOLDER] I)... - Six-month prospective life charting of mood symptoms with lamotrigine monotherapy versus placebo in rapid cycling bipolar disorderJoseph F Goldberg
Affective Disorders Program, Silver Hill Hospital, New Canaan, Connecticut 06840, USA
Biol Psychiatry 63:125-30. 2008..The anticonvulsant lamotrigine has demonstrated efficacy for relapse prevention in bipolar disorder, but its possible mood-stabilizing properties on a day-to-day or week-to-week basis have not previously been investigated... - A randomized, placebo-controlled, multicenter study of divalproex sodium extended release in the treatment of acute maniaCharles L Bowden
Department of Psychiatry, University of Texas Health Science Center, San Antonio 78284 7792, USA
J Clin Psychiatry 67:1501-10. 2006..The efficacy and safety of divalproex sodium extended release (divalproex ER) were evaluated in patients hospitalized for acute mania associated with bipolar I disorder, manic or mixed type (DSM-IV-TR criteria)... - Comparing the effects of sampling designs on the diagnostic accuracy of eight promising screening algorithms for pediatric bipolar disorderEric Youngstrom
Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3270, USA
Biol Psychiatry 60:1013-9. 2006..The present investigation compared eight screening algorithms in the same sample but under two different design strategies... - Efficacy of typical and atypical antipsychotics for primary and comorbid anxiety symptoms or disorders: a reviewKeming Gao
Department of Psychiatry, the Bipolar Disorders Research Center, University Hospitals of Cleveland Case Western Reserve University, School of Medicine, Cleveland, Ohio, USA
J Clin Psychiatry 67:1327-40. 2006..The efficacy of antipsychotics in the treatment of primary or comorbid anxiety disorders or anxiety symptoms in major depressive disorder or bipolar disorder was reviewed... - Impact of lamotrigine and lithium on weight in obese and nonobese patients with bipolar I disorderCharles L Bowden
Department of Psychiatry, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
Am J Psychiatry 163:1199-201. 2006..This study assessed weight changes in a large cohort of patients with bipolar disorder who were treated with randomly assigned maintenance monotherapies... - Recurrence in bipolar I disorder: a post hoc analysis excluding relapses in two double-blind maintenance studiesJoseph R Calabrese
Department of Psychiatry, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
Biol Psychiatry 59:1061-4. 2006..To assess the efficacy of lamotrigine or lithium in preventing mood recurrence (i.e., a new mood episode) in bipolar disorder... - A randomized, double-blind, placebo-controlled 26-week trial of aripiprazole in recently manic patients with bipolar I disorderPaul E Keck
Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
J Clin Psychiatry 67:626-37. 2006..To investigate the safety and efficacy of aripiprazole in preventing relapse of a mood episode in recently manic- or mixed-episode patients with bipolar I disorder stabilized on aripiprazole... - Effects of lamotrigine and lithium on body weight during maintenance treatment of bipolar I disorderGary Sachs
Department of Psychiatry, Harvard University, Harvard Bipolar Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
Bipolar Disord 8:175-81. 2006.... - Treatment-resistant bipolar depression: a STEP-BD equipoise randomized effectiveness trial of antidepressant augmentation with lamotrigine, inositol, or risperidoneAndrew A Nierenberg
Massachusetts General Hospital Bipolar Clinic and Research Program, Suite 580, 50 Staniford Street, Boston, MA 02114, USA
Am J Psychiatry 163:210-6. 2006..This study represents the first randomized trial of competing options for treatment-resistant bipolar depression and assesses the effectiveness and safety of antidepressant augmentation with lamotrigine, inositol, and risperidone... - Adherence to pharmacological treatment for juvenile bipolar disorderDennis Drotar
Department of Psychiatry, Case Western Reserve University, USA
J Am Acad Child Adolesc Psychiatry 46:831-9. 2007..The objective of this study was to describe the prevalence and correlates of adherence to divalproex sodium (DVPX) and lithium carbonate (Li) combination treatment during the initial stabilization treatment phase... - Treatment adherence in individuals with rapid cycling bipolar disorder: results from a clinical-trial settingMartha Sajatovic
J Clin Psychopharmacol 27:412-4. 2007 - Clinical correlates of patients with rapid-cycling bipolar disorder and a recent history of substance use disorder: a subtype comparison from baseline data of 2 randomized, placebo-controlled trialsKeming Gao
Department of Psychiatry, Bipolar Disorder Research Center at the Mood Disorders Program, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
J Clin Psychiatry 69:1057-63. 2008..To compare clinical variables in patients with rapid-cycling bipolar I or II disorder and a recent history of substance use disorder (SUD)... - Efficacy of quetiapine monotherapy for the treatment of depressive episodes in bipolar I disorder: a post hoc analysis of combined results from 2 double-blind, randomized, placebo-controlled studiesRichard H Weisler
Department of Psychiatry and Behavioral Science, Duke University Medical Center, University of North Carolina at Chapel Hill, Raleigh, NC 27609, USA
J Clin Psychiatry 69:769-82. 2008.... - Evaluation and comparison of psychometric instruments for pediatric bipolar spectrum disorders in four age groupsThomas W Frazier
Department of Psychiatry, University Hospitals Case Medical Center, Cleveland, OH, USA
J Child Adolesc Psychopharmacol 17:853-66. 2007..The CDRS-R may be better conceptualized as a two-factor measure in older adolescents. The semistructured K-SADS interview can be used to generate reliable diagnoses across a broad age range... - Initiation of stimulant and antidepressant medication and clinical presentation in juvenile bipolar I disorderMaria E Pagano
Department of Psychiatry, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, OH 44106 5080, USA
Bipolar Disord 10:334-41. 2008..Another aim was to investigate differences in clinical presentation between youths prescribed stimulant or antidepressant medication before and after the onset of juvenile BP I disorder... - Lamotrigine in the acute treatment of bipolar depression: results of five double-blind, placebo-controlled clinical trialsJoseph R Calabrese
Case Western Reserve University School of Medicine University Hospitals of Cleveland, Cleveland, OH, USA
Bipolar Disord 10:323-33. 2008..This paper reports the results of five randomized, double-blind, placebo-controlled trials of lamotrigine monotherapy for the acute treatment of bipolar depression... - Differential interactions between comorbid anxiety disorders and substance use disorder in rapid cycling bipolar I or II disorderKeming Gao
Department of Psychiatry, Bipolar Disorder Research Center at Mood Disorders Program, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio, USA
J Affect Disord 110:167-73. 2008..Anxiety disorders (AD) and substance use disorders (SUD) commonly co-occur with bipolar disorder. This study was undertaken to assess AD-SUD-bipolar subtype interactions... - Discovery and development of lamotrigine for bipolar disorder: a story of serendipity, clinical observations, risk taking, and persistenceRichard H Weisler
University of North Carolina at Chapel Hill and Duke University Medical Center, United States
J Affect Disord 108:1-9. 2008..The development of lamotrigine provides one example of the importance of prescience, patience and persistence in bringing a novel idea to clinical fruition... - Aripiprazole monotherapy for maintenance therapy in bipolar I disorder: a 100-week, double-blind study versus placeboPaul E Keck
Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
J Clin Psychiatry 68:1480-91. 2007..Efficacy and tolerability of aripiprazole for relapse prevention in bipolar I disorder was, therefore, evaluated for 100 weeks... - Relationship of open acute mania treatment to blinded maintenance outcome in bipolar I disorderSusan L McElroy
Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
J Affect Disord 107:127-33. 2008..No published studies have statistically evaluated the relationship between the outcomes in maintenance treatment and the principal acute agent... - Adjunctive antidepressant use and symptomatic recovery among bipolar depressed patients with concomitant manic symptoms: findings from the STEP-BDJoseph F Goldberg
Affective Disorders Program, Silver Hill Hospital, New Canaan, Connecticut, USA
Am J Psychiatry 164:1348-55. 2007..However, few studies have examined the outcomes of patients with co-occurring manic and depressive symptoms who are treated with antidepressants plus mood stabilizing drugs... - Intensive psychosocial intervention enhances functioning in patients with bipolar depression: results from a 9-month randomized controlled trialDavid J Miklowitz
Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
Am J Psychiatry 164:1340-7. 2007..In a randomized trial, the authors examined the impact of intensive psychosocial treatment plus pharmacotherapy on the functional outcomes of patients with bipolar disorder over the 9 months following a depressive episode... - The empirical redefinition of the psychometric criteria for remission in bipolar disorderMichael Berk
Barwon Health and The Geelong Clinic, Geelong, Victoria, Australia
J Affect Disord 106:153-8. 2008.... - The relationship of personality traits to substance abuse in patients with bipolar disorderGonzalo Haro
Dual Pathology Unit, Psychiatry Department, Hospital de la Ribera, C Onda s n, 46600 Alzira, Valencia, Spain
Eur Psychiatry 22:305-8. 2007..Patients filled out the TCI, the differences were analyzed by ANOVA and the likelihood was obtained by Multinomial Logistic Regression... - Typical and atypical antipsychotics in bipolar depressionKeming Gao
Mood Disorders Program, Department of Psychiatry, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, 11400 Euclid Avenue, Cleveland, OH 44106, USA
J Clin Psychiatry 66:1376-85. 2005..Since the antipsychotic agents have been shown to diminish depressive symptoms during the treatment of mania, atypical agents are now being studied for use in bipolar depression... - A 20-month, double-blind, maintenance trial of lithium versus divalproex in rapid-cycling bipolar disorderJoseph R Calabrese
Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH 44106, USA
Am J Psychiatry 162:2152-61. 2005..The authors tested the hypothesis that divalproex would be more effective than lithium in the long-term management of patients with recently stabilized rapid-cycling bipolar disorder... - Depression mood stabilisation: novel concepts and clinical managementJoseph R Calabrese
Case Western Reserve University, MD 11400 Euclid Avenue, Suite 200, Cleveland, OH 44106, USA
Eur Neuropsychopharmacol 14:S100-7. 2004..Lamotrigine represents a valuable addition to the current therapeutic armamentarium for bipolar disorder, allowing a therapeutic balance between the treatment of mania and depression... - International Consensus Group on Bipolar I Depression Treatment GuidelinesJoseph R Calabrese
Department of Psychiatry, Case Western Reserve University, Cleveland, OH, USA
J Clin Psychiatry 65:571-9. 2004 - A pooled analysis of 2 placebo-controlled 18-month trials of lamotrigine and lithium maintenance in bipolar I disorderGuy M Goodwin
Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, England, UK
J Clin Psychiatry 65:432-41. 2004..Two clinical trials, prospectively designed for combined analysis, compared placebo, lithium, and lamotrigine for treatment of bipolar I disorder in recently depressed or manic patients... - Recent placebo-controlled acute trials in bipolar depression: focus on methodologyDavid J Muzina
Cleveland Clinic Foundation, Cleveland, Ohio, USA
Int J Neuropsychopharmacol 6:285-91. 2003..Moclobemide monotherapy was similar in efficacy to imipramine (n=156), but had a lower rate of switching (4% vs. 11%)... - Maintenance efficacy of divalproex in the prevention of bipolar depressionLaszlo Gyulai
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Neuropsychopharmacology 28:1374-82. 2003.... - Who are the comorbid adolescents? Agreement between psychiatric diagnosis, youth, parent, and teacher reportEric A Youngstrom
Department of Psychology, Case Western Reserve University, Cleveland, Ohio 44106 7123, USA
J Abnorm Child Psychol 31:231-45. 2003..14-.40). Results also indicate that single DSM-IV disorders, such as bipolar disorder, can manifest "comorbid" patterns of behavior problems on checklists... - A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently manic or hypomanic patients with bipolar I disorderCharles L Bowden
Department of Psychiatry, University of Texas Health Science Center at San Antonio, 78229, USA
Arch Gen Psychiatry 60:392-400. 2003.... - Screening for bipolar disorder in the communityRobert M A Hirschfeld
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, 77555 188, USA
J Clin Psychiatry 64:53-9. 2003..Our goal was to estimate the rate of positive screens for bipolar I and bipolar II disorders in the general population of the United States... - Validity of the mood disorder questionnaire: a general population studyRobert M A Hirschfeld
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, 1 302 Rebecca Sealy, 301 University Blvd, Galveston, TX 77555 0188, USA
Am J Psychiatry 160:178-80. 2003..The Mood Disorder Questionnaire has been validated in a psychiatric outpatient study group... - Factor structure of the Young Mania Rating Scale for use with youths ages 5 to 17 yearsEric A Youngstrom
Case Western Reserve University, University Hospitals of Cleveland, USA
J Clin Child Adolesc Psychol 31:567-72. 2002..However, the young male group showed higher scores on several items as well as the total YMRS score. Results suggest that the YMRS total score can be meaningfully interpreted in child and adolescent samples... - Third generation anticonvulsants in bipolar disorder: a review of efficacy and summary of clinical recommendationsLakshmi N Yatham
Department of Psychiatry, University of British Columbia, Vancouver, Canada
J Clin Psychiatry 63:275-83. 2002..To review the literature on efficacy of third generation anticonvulsants for treatment of bipolar disorder and provide clinical recommendations... - Stabilization of mood from below versus above baseline in bipolar disorder: a new nomenclatureTerence A Ketter
Department of Psychiatry and Behavioral Science, Stanford University School of Medicine, Calif 94305 5723, USA
J Clin Psychiatry 63:146-51. 2002..In this article, the treatment options for bipolar disorder, with a focus on depression and rapid cycling, are discussed according to this new conceptualization of management from below and above baseline... - Comparing the diagnostic accuracy of six potential screening instruments for bipolar disorder in youths aged 5 to 17 yearsEric A Youngstrom
Department of Psychology, Case Western Reserve University, University Hospitals of Cleveland, Ohia 44106 7123, USA
J Am Acad Child Adolesc Psychiatry 43:847-58. 2004..To compare the diagnostic efficiency of six index tests as predictors of juvenile bipolar disorder in two large outpatient samples, aged 5 to 10 and 11 to 17 years, gathered from 1997 to 2002... - Psychosis in mania: specificity of its role in severity and treatment responseAlan C Swann
University of Texas Medical School, Houston 77030, USA
J Clin Psychiatry 65:825-9. 2004..Psychosis is a prominent characteristic of manic episodes. We investigated relationships between the presence of psychotic features, the severity of the manic syndrome, and syndrome severity's response to treatment... - Pharmacotherapy for bipolar disorder and comorbid conditions: baseline data from STEP-BDNaomi M Simon
Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
J Clin Psychopharmacol 24:512-20. 2004..Our findings highlight the need for greater clinical guidance and treatment options for patients with bipolar disorder and comorbidity... - Newer treatment studies for bipolar depressionKeming Gao
NIMH Bipolar Research Center, Mood Disorders Program, University Hospitals of Cleveland Case Western Reserve University School of Medicine, Cleveland, OH, USA
Bipolar Disord 7:13-23. 2005..Depressive symptoms of bipolar disorder have more negative impact on a patient's life than manic symptoms. This review focused on the emerging efficacy data for treatments in bipolar depression... - Clinical highlights in bipolar depression: focus on atypical antipsychoticsJoseph R Calabrese
University Hospitals of Cleveland Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
J Clin Psychiatry 66:26-33. 2005..In addition, direct comparison of the regimens used in the current study should determine whether the differences evident between them can be confirmed... - A randomized, double-blind, placebo-controlled trial of quetiapine in the treatment of bipolar I or II depressionJoseph R Calabrese
University Hospitals of Cleveland and Case University School of Medicine, 11400 Euclid Ave, Suite 200, Cleveland, OH 44106, USA
Am J Psychiatry 162:1351-60. 2005..There is a major unmet need for effective options in the treatment of bipolar depression... - Olanzapine versus lithium in the maintenance treatment of bipolar disorder: a 12-month, randomized, double-blind, controlled clinical trialMauricio Tohen
Lilly Research Laboratories, Indianapolis, IN 46285, USA
Am J Psychiatry 162:1281-90. 2005..The authors compared the efficacy of olanzapine and lithium in the prevention of mood episode relapse/recurrence... - Does recovery from substance use disorder matter in patients with bipolar disorder?Roger D Weiss
Department of Psychiatry, Harvard Medical School, Boston, USA
J Clin Psychiatry 66:730-5; quiz 808-9. 2005..To examine the potential impact of recovery from substance use disorder (SUD) on the course of bipolar disorder among patients diagnosed with both bipolar and substance use disorders according to DSM-IV criteria... - Maintenance treatment outcomes in older patients with bipolar I disorderMartha Sajatovic
Department of Psychiatry, Case University School of Medicine and University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106, USA
Am J Geriatr Psychiatry 13:305-11. 2005.... - Double-blind 18-month trial of lithium versus divalproex maintenance treatment in pediatric bipolar disorderRobert L Findling
Department of Psychiatry, Case Western Reserve University, USA
J Am Acad Child Adolesc Psychiatry 44:409-17. 2005.... - Anticonvulsants in bipolar disorderVivek Singh
Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive Mail Code 7792, San Antonio, TX 78229, USA
Psychiatr Clin North Am 28:301-23. 2005.... - Mood state at study entry as predictor of the polarity of relapse in bipolar disorderJoseph R Calabrese
Case University School of Medicine, University Hospitals of Cleveland, 11400 Euclid Avenue, Suite 200, Cleveland, OH 44106, USA
Biol Psychiatry 56:957-63. 2004..We conclude that putative mood stabilizers must be tested in recently manic and recently depressed patients to determine their spectrum of prophylactic efficacy... - Efficacy of olanzapine combined with valproate or lithium in the treatment of dysphoric maniaRobert W Baker
Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, USA
Br J Psychiatry 185:472-8. 2004..Few controlled studies examine the treatment of depressive features in mania... - Comparison of rapid-cycling and non-rapid-cycling bipolar I manic patients during treatment with olanzapine: analysis of pooled dataEduard Vieta
Bipolar Disorders Program, Department of Psychiatry, Hospital Clinic, University of Barcelona, IDIBAPS, Barcelona, Spain
J Clin Psychiatry 65:1420-8. 2004..We report on the first controlled study comparing acute and continuous clinical outcomes in RC and non-RC manic patients treated with olanzapine... - Phenomenology of rapid-cycling bipolar disorder: data from the first 500 participants in the Systematic Treatment Enhancement ProgramChristopher D Schneck
Department of Psychiatry, University of Colorado Health Sciences Center, 4455 East 12th Ave, Box A011 15, Denver, CO 80220, USA
Am J Psychiatry 161:1902-8. 2004..This study compared demographic and phenomenological variables between bipolar patients with and without rapid cycling as a function of bipolar I versus bipolar II status... - Efficacy of olanzapine in combination with valproate or lithium in the treatment of mania in patients partially nonresponsive to valproate or lithium monotherapyMauricio Tohen
Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, IN 46285, USA
Arch Gen Psychiatry 59:62-9. 2002..CONCLUSION: Compared with the use of valproate or lithium alone, the addition of olanzapine provided superior efficacy in the treatment of manic and mixed bipolar episodes...