J R Calabrese

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. ncbi request reprint A US perspective of the CANMAT bipolar guidelines
    Joseph R Calabrese
    Case Western Reserve University, Cleveland, OH 44106, USA
    Bipolar Disord 7:70-2. 2005
  2. ncbi request reprint New data on the use of lithium, divalproate, and lamotrigine in rapid cycling bipolar disorder
    J R Calabrese
    Case Western Reserve University School of Medicine, University Hospitals of Cleveland, 11400 Euclid Avenue, Suite 200, Cleveland, OH 44106, USA
    Eur Psychiatry 20:92-5. 2005
  3. ncbi request reprint Latest maintenance data on lamotrigine in bipolar disorder
    Joseph R Calabrese
    Case Western Reserve University School of Medicine, University Hospitals of Cleveland, Cleveland, OH, USA
    Eur Neuropsychopharmacol 13:S57-66. 2003
  4. ncbi request reprint Mood state at study entry as predictor of the polarity of relapse in bipolar disorder
    Joseph R Calabrese
    Case University School of Medicine, University Hospitals of Cleveland, 11400 Euclid Avenue, Suite 200, Cleveland, OH 44106, USA
    Biol Psychiatry 56:957-63. 2004
  5. ncbi request reprint A randomized, double-blind, placebo-controlled trial of quetiapine in the treatment of bipolar I or II depression
    Joseph R Calabrese
    University Hospitals of Cleveland and Case University School of Medicine, 11400 Euclid Ave, Suite 200, Cleveland, OH 44106, USA
    Am J Psychiatry 162:1351-60. 2005
  6. ncbi request reprint Clinical highlights in bipolar depression: focus on atypical antipsychotics
    Joseph R Calabrese
    University Hospitals of Cleveland Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    J Clin Psychiatry 66:26-33. 2005
  7. ncbi request reprint A 20-month, double-blind, maintenance trial of lithium versus divalproex in rapid-cycling bipolar disorder
    Joseph R Calabrese
    Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Am J Psychiatry 162:2152-61. 2005
  8. pmc Predictors of bipolar disorder risk among patients currently treated for major depression
    Joseph R Calabrese
    Mood Disorders Program, Department of Psychiatry, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, Ohio, USA
    MedGenMed 8:38. 2006
  9. ncbi request reprint Recurrence in bipolar I disorder: a post hoc analysis excluding relapses in two double-blind maintenance studies
    Joseph R Calabrese
    Department of Psychiatry, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    Biol Psychiatry 59:1061-4. 2006
  10. ncbi request reprint Impact of depressive symptoms compared with manic symptoms in bipolar disorder: results of a U.S. community-based sample
    Joseph R Calabrese
    University Hospitals of Cleveland Case Western Reserve School of Medicine, Cleveland, Ohio, USA
    J Clin Psychiatry 65:1499-504. 2004

Research Grants

Collaborators

Detail Information

Publications105 found, 100 shown here

  1. ncbi request reprint A US perspective of the CANMAT bipolar guidelines
    Joseph R Calabrese
    Case Western Reserve University, Cleveland, OH 44106, USA
    Bipolar Disord 7:70-2. 2005
  2. ncbi request reprint New data on the use of lithium, divalproate, and lamotrigine in rapid cycling bipolar disorder
    J R Calabrese
    Case Western Reserve University School of Medicine, University Hospitals of Cleveland, 11400 Euclid Avenue, Suite 200, Cleveland, OH 44106, USA
    Eur Psychiatry 20:92-5. 2005
    ..In addition, lamotrigine has the potential to complement the spectrum of lithium and divalproate through its greater efficacy for depressive symptoms...
  3. ncbi request reprint Latest maintenance data on lamotrigine in bipolar disorder
    Joseph R Calabrese
    Case Western Reserve University School of Medicine, University Hospitals of Cleveland, Cleveland, OH, USA
    Eur Neuropsychopharmacol 13:S57-66. 2003
    ..In summary, lamotrigine is an effective and well-tolerated maintenance treatment for bipolar I disorder, providing a spectrum of efficacy complementary to that of lithium...
  4. ncbi request reprint Mood state at study entry as predictor of the polarity of relapse in bipolar disorder
    Joseph R Calabrese
    Case University School of Medicine, University Hospitals of Cleveland, 11400 Euclid Avenue, Suite 200, Cleveland, OH 44106, USA
    Biol Psychiatry 56:957-63. 2004
    ..We conclude that putative mood stabilizers must be tested in recently manic and recently depressed patients to determine their spectrum of prophylactic efficacy...
  5. ncbi request reprint A randomized, double-blind, placebo-controlled trial of quetiapine in the treatment of bipolar I or II depression
    Joseph R Calabrese
    University Hospitals of Cleveland and Case University School of Medicine, 11400 Euclid Ave, Suite 200, Cleveland, OH 44106, USA
    Am J Psychiatry 162:1351-60. 2005
    ..There is a major unmet need for effective options in the treatment of bipolar depression...
  6. ncbi request reprint Clinical highlights in bipolar depression: focus on atypical antipsychotics
    Joseph R Calabrese
    University Hospitals of Cleveland Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    J Clin Psychiatry 66:26-33. 2005
    ..In addition, direct comparison of the regimens used in the current study should determine whether the differences evident between them can be confirmed...
  7. ncbi request reprint A 20-month, double-blind, maintenance trial of lithium versus divalproex in rapid-cycling bipolar disorder
    Joseph R Calabrese
    Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Am J Psychiatry 162:2152-61. 2005
    ..The authors tested the hypothesis that divalproex would be more effective than lithium in the long-term management of patients with recently stabilized rapid-cycling bipolar disorder...
  8. pmc Predictors of bipolar disorder risk among patients currently treated for major depression
    Joseph R Calabrese
    Mood Disorders Program, Department of Psychiatry, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, Ohio, USA
    MedGenMed 8:38. 2006
    ..The primary objective of this study was to assess the rate of bipolar disorder (BPD) risk among patients unsuccessfully treated for major depression and to identify predictors of bipolarity...
  9. ncbi request reprint Recurrence in bipolar I disorder: a post hoc analysis excluding relapses in two double-blind maintenance studies
    Joseph R Calabrese
    Department of Psychiatry, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    Biol Psychiatry 59:1061-4. 2006
    ..To assess the efficacy of lamotrigine or lithium in preventing mood recurrence (i.e., a new mood episode) in bipolar disorder...
  10. ncbi request reprint Impact of depressive symptoms compared with manic symptoms in bipolar disorder: results of a U.S. community-based sample
    Joseph R Calabrese
    University Hospitals of Cleveland Case Western Reserve School of Medicine, Cleveland, Ohio, USA
    J Clin Psychiatry 65:1499-504. 2004
    ..In the present study, we assessed the functional impact of depressive versus manic symptoms in bipolar disorder...
  11. ncbi request reprint A randomized, placebo-controlled 12-month trial of divalproex and lithium in treatment of outpatients with bipolar I disorder. Divalproex Maintenance Study Group
    C L Bowden
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, 78284 7792, USA
    Arch Gen Psychiatry 57:481-9. 2000
    ..This study compared the efficacy of divalproex, lithium, and placebo as prophylactic therapy...
  12. ncbi request reprint Bipolar rapid cycling: focus on depression as its hallmark
    J R Calabrese
    Department of Psychiatry at University Hospitals of Cleveland and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    J Clin Psychiatry 62:34-41. 2001
    ..The results indicate that lamotrigine may be a useful treatment for patients with rapid-cycling bipolar II disorder and that this drug has begun to address this unmet need...
  13. doi request reprint Treatment-emergent mania/hypomania during antidepressant monotherapy in patients with rapid cycling bipolar disorder
    Keming Gao
    Department of Psychiatry, Bipolar Disorder Research Center at Mood Disorders Program, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, 10524 Euclid Avenue, Cleveland, OH 44106, USA
    Bipolar Disord 10:907-15. 2008
    ..To study treatment-emergent mania/hypomania (TEM) associated with second-generation antidepressant monotherapy in patients with rapid cycling bipolar disorder (RCBD)...
  14. ncbi request reprint Current research on rapid cycling bipolar disorder and its treatment
    J R Calabrese
    Mood Disorders Program, Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    J Affect Disord 67:241-55. 2001
    ..Electroconvulsive therapy may also prove efficacious in selected cases. The present paper provides a critical review of the evidence for the foregoing clinical issues in rapid cycling...
  15. ncbi request reprint A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently manic or hypomanic patients with bipolar I disorder
    Charles L Bowden
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, 78229, USA
    Arch Gen Psychiatry 60:392-400. 2003
    ....
  16. ncbi request reprint Clinical studies on the use of lamotrigine in bipolar disorder
    J R Calabrese
    Mood Disorder Program, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Neuropsychobiology 38:185-91. 1998
    ....
  17. ncbi request reprint Controlled trials in bipolar I depression: focus on switch rates and efficacy
    J R Calabrese
    Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, OH, USA
    Eur Neuropsychopharmacol 9:S109-12. 1999
    ..At present there is no consensus over the optimal definition of switching. Standardising the definition may lead to improvements in the clinical management of bipolar disorder...
  18. pmc A 6-month, double-blind, maintenance trial of lithium monotherapy versus the combination of lithium and divalproex for rapid-cycling bipolar disorder and Co-occurring substance abuse or dependence
    David E Kemp
    Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, Ohio, USA
    J Clin Psychiatry 70:113-21. 2009
    ....
  19. pmc Medical and substance use comorbidity in bipolar disorder
    David E Kemp
    Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH, USA
    J Affect Disord 116:64-9. 2009
    ....
  20. pmc Differential interactions between comorbid anxiety disorders and substance use disorder in rapid cycling bipolar I or II disorder
    Keming Gao
    Department of Psychiatry, Bipolar Disorder Research Center at Mood Disorders Program, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio, USA
    J Affect Disord 110:167-73. 2008
    ..Anxiety disorders (AD) and substance use disorders (SUD) commonly co-occur with bipolar disorder. This study was undertaken to assess AD-SUD-bipolar subtype interactions...
  21. ncbi request reprint Current concepts in rapid cycling bipolar disorder
    M D Shelton
    Mood Disorders Program, Department of Psychiatry, Case Western Reserve University School of Medicine, 11400 Euclid Avenue, Suite 200, Cleveland, Ohio 44106, USA
    Curr Psychiatry Rep 2:310-5. 2000
    ..Controlled trials in homogeneous cohorts of RCBD patients are needed. Preliminary data suggest that two or more mood stabilizers are required for adequate control...
  22. ncbi request reprint Discriminative validity of parent report of hypomanic and depressive symptoms on the General Behavior Inventory
    E A Youngstrom
    Department of Psychology, Case Western Reserve University, 11220 Bellflower Road, Cleveland, Ohio 44106, USA
    Psychol Assess 13:267-76. 2001
    ..80. Results indicate that clinicians can use the parent-completed GBI to derive clinically meaningful information about mood disorders in youths...
  23. ncbi request reprint Phenomenology of rapid-cycling bipolar disorder: data from the first 500 participants in the Systematic Treatment Enhancement Program
    Christopher D Schneck
    Department of Psychiatry, University of Colorado Health Sciences Center, 4455 East 12th Ave, Box A011 15, Denver, CO 80220, USA
    Am J Psychiatry 161:1902-8. 2004
    ..This study compared demographic and phenomenological variables between bipolar patients with and without rapid cycling as a function of bipolar I versus bipolar II status...
  24. ncbi request reprint Does recovery from substance use disorder matter in patients with bipolar disorder?
    Roger D Weiss
    Department of Psychiatry, Harvard Medical School, Boston, USA
    J Clin Psychiatry 66:730-5; quiz 808-9. 2005
    ..To examine the potential impact of recovery from substance use disorder (SUD) on the course of bipolar disorder among patients diagnosed with both bipolar and substance use disorders according to DSM-IV criteria...
  25. pmc Correlates of historical suicide attempt in rapid-cycling bipolar disorder: a cross-sectional assessment
    Keming Gao
    Department of Psychiatry, Case Western University School of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio, USA
    J Clin Psychiatry 70:1032-40. 2009
    ..A rapid-cycling course in bipolar disorder has previously been identified as a risk factor for attempted suicide. This study investigated factors associated with suicide attempts in patients with rapid-cycling bipolar I or II disorder...
  26. ncbi request reprint Rapid, continuous cycling and psychiatric co-morbidity in pediatric bipolar I disorder
    R L Findling
    Department of Psychiatry, University Hospitals of Cleveland Case Western Reserve University School of Medicine, Case Western Reserve University, Cleveland, OH 44106 5080, USA
    Bipolar Disord 3:202-10. 2001
    ..The primary purpose of this study was to describe the clinical presentation of bipolar I disorder (BP-I) as it occurs in children and adolescents and to assess whether the manifestations of BP-I were similar in both age groups...
  27. ncbi request reprint Relationship of mania symptomatology to maintenance treatment response with divalproex, lithium, or placebo
    Charles L Bowden
    Department of Psychiatry, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Neuropsychopharmacology 30:1932-9. 2005
    ..Dysphoric mania appeared to predispose patients to more side effects when treated with either divalproex or lithium during maintenance therapy...
  28. ncbi request reprint Aripiprazole monotherapy for maintenance therapy in bipolar I disorder: a 100-week, double-blind study versus placebo
    Paul E Keck
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    J Clin Psychiatry 68:1480-91. 2007
    ..Efficacy and tolerability of aripiprazole for relapse prevention in bipolar I disorder was, therefore, evaluated for 100 weeks...
  29. ncbi request reprint Clinical correlates of patients with rapid-cycling bipolar disorder and a recent history of substance use disorder: a subtype comparison from baseline data of 2 randomized, placebo-controlled trials
    Keming Gao
    Department of Psychiatry, Bipolar Disorder Research Center at the Mood Disorders Program, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
    J Clin Psychiatry 69:1057-63. 2008
    ..To compare clinical variables in patients with rapid-cycling bipolar I or II disorder and a recent history of substance use disorder (SUD)...
  30. ncbi request reprint A randomized, placebo-controlled, multicenter study of divalproex sodium extended release in the treatment of acute mania
    Charles L Bowden
    Department of Psychiatry, University of Texas Health Science Center, San Antonio 78284 7792, USA
    J Clin Psychiatry 67:1501-10. 2006
    ..The efficacy and safety of divalproex sodium extended release (divalproex ER) were evaluated in patients hospitalized for acute mania associated with bipolar I disorder, manic or mixed type (DSM-IV-TR criteria)...
  31. ncbi request reprint International Consensus Group on Bipolar I Depression Treatment Guidelines
    Joseph R Calabrese
    Department of Psychiatry, Case Western Reserve University, Cleveland, OH, USA
    J Clin Psychiatry 65:571-9. 2004
  32. ncbi request reprint Maintenance efficacy of divalproex in the prevention of bipolar depression
    Laszlo Gyulai
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 28:1374-82. 2003
    ....
  33. ncbi request reprint A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently depressed patients with bipolar I disorder
    Joseph R Calabrese
    University Hospitals of Cleveland Case Western Reserve School of Medicine, Department of Psychiatry, 11400 Euclid Ave, Ste 200, Cleveland, OH 44106, USA
    J Clin Psychiatry 64:1013-24. 2003
    ..This study assessed the efficacy and tolerability of lamotrigine and lithium compared with placebo for the prevention of mood episodes in bipolar disorder...
  34. ncbi request reprint Evolving methodologies in bipolar disorder maintenance research
    J R Calabrese
    Mood Disorders Program, Department of Psychiatry, Case Western Reserve University, Cleveland, Ohio, USA
    Br J Psychiatry Suppl 41:s157-63. 2001
    ..Comparisons with the early bipolar disorder maintenance studies indicate that the methodologies of recent trials have evolved substantially...
  35. ncbi request reprint Employing parent, teacher, and youth self-report checklists in identifying pediatric bipolar spectrum disorders: an examination of diagnostic accuracy and clinical utility
    Shoshana Y Kahana
    Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Child Adolesc Psychopharmacol 13:471-88. 2003
    ..Results indicate that the Child Behavior Checklist has limited utility when attempting to derive clinically meaningful information about the presentation of juvenile BPSD...
  36. ncbi request reprint Rash in multicenter trials of lamotrigine in mood disorders: clinical relevance and management
    Joseph R Calabrese
    Department of Psychiatry, Case Western Reserve University University Hospitals of Cleveland, Cleveland, Ohio, USA
    J Clin Psychiatry 63:1012-9. 2002
    ..The objective of this report was to determine rash rates in clinical trials of lamotrigine in DSM-IV unipolar depression or bipolar disorder...
  37. ncbi request reprint Impact of lamotrigine and lithium on weight in obese and nonobese patients with bipolar I disorder
    Charles L Bowden
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
    Am J Psychiatry 163:1199-201. 2006
    ..This study assessed weight changes in a large cohort of patients with bipolar disorder who were treated with randomly assigned maintenance monotherapies...
  38. doi request reprint Evaluation and comparison of psychometric instruments for pediatric bipolar spectrum disorders in four age groups
    Thomas W Frazier
    Department of Psychiatry, University Hospitals Case Medical Center, Cleveland, OH, USA
    J Child Adolesc Psychopharmacol 17:853-66. 2007
    ..The CDRS-R may be better conceptualized as a two-factor measure in older adolescents. The semistructured K-SADS interview can be used to generate reliable diagnoses across a broad age range...
  39. pmc General medical burden in bipolar disorder: findings from the LiTMUS comparative effectiveness trial
    D E Kemp
    University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA
    Acta Psychiatr Scand 129:24-34. 2014
    ..This study examined general medical illnesses and their association with clinical features of bipolar disorder...
  40. ncbi request reprint Predictive value of early improvement in bipolar depression trials: a post-hoc pooled analysis of two 8-week aripiprazole studies
    D E Kemp
    Case Western Reserve University, Cleveland, OH, USA
    Psychopharmacol Bull 43:5-27. 2010
    ..To evaluate the value of early improvement to predict treatment outcome in patients with bipolar depression...
  41. doi request reprint Lithium treatment -- moderate dose use study (LiTMUS) for bipolar disorder: rationale and design
    Andrew A Nierenberg
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin Trials 6:637-48. 2009
    ..Recent data indicate that lithium use for bipolar disorder has declined over the last decade and that lithium largely has been replaced with alternate, commercially promoted medications that may or may not result in better outcomes...
  42. ncbi request reprint Agomelatine adjunctive therapy for acute bipolar depression: preliminary open data
    Joseph R Calabrese
    University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH 44106, USA
    Bipolar Disord 9:628-35. 2007
    ..The aim of this study was to gather preliminary data regarding the antidepressant efficacy of agomelatine in patients with bipolar I disorder experiencing a major depressive episode...
  43. pmc Suicidal ideation and depressive symptoms among bipolar patients as predictors of the health and well-being of caregivers
    Cheryl A Chessick
    Department of Psychiatry, University of Colorado Denver School of Medicine, Denver, CO 80045, USA
    Bipolar Disord 11:876-84. 2009
    ..This study examined whether caregivers' health is associated with changes in suicidal ideation and depressive symptoms among bipolar patients observed over one year...
  44. ncbi request reprint A randomized, double-blind, placebo-controlled 26-week trial of aripiprazole in recently manic patients with bipolar I disorder
    Paul E Keck
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Clin Psychiatry 67:626-37. 2006
    ..To investigate the safety and efficacy of aripiprazole in preventing relapse of a mood episode in recently manic- or mixed-episode patients with bipolar I disorder stabilized on aripiprazole...
  45. ncbi request reprint Relationship of open acute mania treatment to blinded maintenance outcome in bipolar I disorder
    Susan L McElroy
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    J Affect Disord 107:127-33. 2008
    ..No published studies have statistically evaluated the relationship between the outcomes in maintenance treatment and the principal acute agent...
  46. pmc Metabolic syndrome in patients enrolled in a clinical trial of aripiprazole in the maintenance treatment of bipolar I disorder: a post hoc analysis of a randomized, double-blind, placebo-controlled trial
    David E Kemp
    Case Western Reserve University School of Medicine, 10524 Euclid Ave, 12th Floor, Cleveland, OH 44106, USA
    J Clin Psychiatry 71:1138-44. 2010
    ..To compare the effects of maintenance treatment with aripiprazole or placebo on the incidence of metabolic syndrome in bipolar disorder...
  47. pmc Retrospective age at onset of bipolar disorder and outcome during two-year follow-up: results from the STEP-BD study
    Roy H Perlis
    Bipolar Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, ACC 812 15 Parkman Street, Boston, MA 02114, USA
    Bipolar Disord 11:391-400. 2009
    ..Symptoms of bipolar disorder are increasingly recognized among children and adolescents, but little is known about the course of bipolar disorder among adults who experience childhood onset of symptoms...
  48. doi request reprint Lamotrigine in the acute treatment of bipolar depression: results of five double-blind, placebo-controlled clinical trials
    Joseph R Calabrese
    Case Western Reserve University School of Medicine University Hospitals of Cleveland, Cleveland, OH, USA
    Bipolar Disord 10:323-33. 2008
    ..This paper reports the results of five randomized, double-blind, placebo-controlled trials of lamotrigine monotherapy for the acute treatment of bipolar depression...
  49. ncbi request reprint A review of sensitivity and tolerability of antipsychotics in patients with bipolar disorder or schizophrenia: focus on somnolence
    Keming Gao
    Department of Psychiatry, Bipolar Disorder Research Center at Mood Disorders Program, University Hospitals Case Medical Center Case Western Reserve University, School of Medicine, Cleveland, Ohio, USA
    J Clin Psychiatry 69:302-9. 2008
    ..This study compared the sensitivity and tolerability of antipsychotics in patients with bipolar disorder or schizophrenia...
  50. doi request reprint A pilot pharmacotherapy trial for depressed youths at high genetic risk for bipolarity
    Robert L Findling
    Department of Psychiatry, University Hospitals Case Medical Center Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Child Adolesc Psychopharmacol 18:615-21. 2008
    ..As a result, future treatment studies in this population appear to be warranted, not only due to the putative impending risk of developing bipolar disorder, but also the manifest risk of current depressive episodes...
  51. ncbi request reprint Recent placebo-controlled acute trials in bipolar depression: focus on methodology
    David J Muzina
    Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Int J Neuropsychopharmacol 6:285-91. 2003
    ..Moclobemide monotherapy was similar in efficacy to imipramine (n=156), but had a lower rate of switching (4% vs. 11%)...
  52. ncbi request reprint Adherence to pharmacological treatment for juvenile bipolar disorder
    Dennis Drotar
    Department of Psychiatry, Case Western Reserve University, USA
    J Am Acad Child Adolesc Psychiatry 46:831-9. 2007
    ..The objective of this study was to describe the prevalence and correlates of adherence to divalproex sodium (DVPX) and lithium carbonate (Li) combination treatment during the initial stabilization treatment phase...
  53. pmc Initiation of stimulant and antidepressant medication and clinical presentation in juvenile bipolar I disorder
    Maria E Pagano
    Department of Psychiatry, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, OH 44106 5080, USA
    Bipolar Disord 10:334-41. 2008
    ..Another aim was to investigate differences in clinical presentation between youths prescribed stimulant or antidepressant medication before and after the onset of juvenile BP I disorder...
  54. ncbi request reprint Efficacy of typical and atypical antipsychotics for primary and comorbid anxiety symptoms or disorders: a review
    Keming Gao
    Department of Psychiatry, the Bipolar Disorders Research Center, University Hospitals of Cleveland Case Western Reserve University, School of Medicine, Cleveland, Ohio, USA
    J Clin Psychiatry 67:1327-40. 2006
    ..The efficacy of antipsychotics in the treatment of primary or comorbid anxiety disorders or anxiety symptoms in major depressive disorder or bipolar disorder was reviewed...
  55. ncbi request reprint Acute treatment of mania: an update on new medications
    Prashant Gajwani
    Case School of Medicine, Mood Disorders Program, University Hospitals Case Medical Center, 11400 Euclid Avenue, Suite 200, Cleveland, OH 44106, USA
    Curr Psychiatry Rep 8:504-9. 2006
    ....
  56. pmc Medical comorbidity in bipolar disorder: relationship between illnesses of the endocrine/metabolic system and treatment outcome
    David E Kemp
    Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH 44106, USA
    Bipolar Disord 12:404-13. 2010
    ..It was hypothesized that illnesses of the endocrine/metabolic system would be associated with greater psychiatric symptom burden and would impact the response to treatment with lithium and valproate...
  57. doi request reprint Quetiapine for the treatment of bipolar mania in older adults
    Martha Sajatovic
    Department of Psychiatry, Case Western Reserve University School of Medicine, University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Bipolar Disord 10:662-71. 2008
    ..The primary efficacy endpoint was the change from baseline in Young Mania Rating Scale (YMRS) total score at Day 21. A secondary endpoint was change from baseline in YMRS score at Day 84...
  58. pmc Personal and societal construction of illness among individuals with rapid-cycling bipolar disorder: a life-trajectory perspective
    Martha Sajatovic
    Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, OH, USA
    Am J Geriatr Psychiatry 16:718-26. 2008
    ..The purpose of this study was to examine the subjective experience of illness among 19 men and women with rapid cycling bipolar disorder receiving treatment at an academic psychiatry clinic...
  59. ncbi request reprint Double-blind, placebo-controlled trial of divalproex monotherapy in the treatment of symptomatic youth at high risk for developing bipolar disorder
    Robert L Findling
    Department of Psychiatry, Case Western Reserve University, and the University Hospitals of Cleveland, Cleveland, Ohio 44106 5080, USA
    J Clin Psychiatry 68:781-8. 2007
    ..To determine if divalproex sodium was superior to placebo in the treatment of symptomatic youths who suffer from a bipolar spectrum disorder and who also have a parent with a diagnosis of a bipolar illness...
  60. ncbi request reprint Effects of lamotrigine and lithium on body weight during maintenance treatment of bipolar I disorder
    Gary Sachs
    Department of Psychiatry, Harvard University, Harvard Bipolar Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    Bipolar Disord 8:175-81. 2006
    ....
  61. ncbi request reprint Gender differences in criminality: bipolar disorder with co-occurring substance abuse
    Susan Hatters Friedman
    Department of Psychiatry, University Hospitals of Cleveland, Hanna Pavilion, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    J Am Acad Psychiatry Law 33:188-95. 2005
    ..Implications from this pilot study include the need for earlier identification of bipolar disorder and for the increased availability of psychiatric and substance abuse services within correctional facilities...
  62. ncbi request reprint Antiepileptic drugs in mood-disordered patients
    Prashant Gajwani
    NIMH Bipolar Research Center, Case Western Reserve University School of Medicine, Mood Disorders Program, University Hospitals of Cleveland, OH, USA
    Epilepsia 46:38-44. 2005
    ..LTG seems to be effective against depression and mania, with a more robust activity against depression. No firm evidence supports a role for vigabatrin, tiagabine, topiramate, or levetiracetam in these disorders...
  63. ncbi request reprint Maintenance treatment outcomes in older patients with bipolar I disorder
    Martha Sajatovic
    Department of Psychiatry, Case University School of Medicine and University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    Am J Geriatr Psychiatry 13:305-11. 2005
    ....
  64. ncbi request reprint Newer treatment studies for bipolar depression
    Keming Gao
    NIMH Bipolar Research Center, Mood Disorders Program, University Hospitals of Cleveland Case Western Reserve University School of Medicine, Cleveland, OH, USA
    Bipolar Disord 7:13-23. 2005
    ..Depressive symptoms of bipolar disorder have more negative impact on a patient's life than manic symptoms. This review focused on the emerging efficacy data for treatments in bipolar depression...
  65. ncbi request reprint Double-blind 18-month trial of lithium versus divalproex maintenance treatment in pediatric bipolar disorder
    Robert L Findling
    Department of Psychiatry, Case Western Reserve University, USA
    J Am Acad Child Adolesc Psychiatry 44:409-17. 2005
    ....
  66. ncbi request reprint Comparing diagnostic checklists for pediatric bipolar disorder in academic and community mental health settings
    Eric Youngstrom
    Department of Psychology, Case Western Reserve University, Cleveland, OH 44106, USA
    Bipolar Disord 7:507-17. 2005
    ....
  67. ncbi request reprint Depression mood stabilisation: novel concepts and clinical management
    Joseph R Calabrese
    Case Western Reserve University, MD 11400 Euclid Avenue, Suite 200, Cleveland, OH 44106, USA
    Eur Neuropsychopharmacol 14:S100-7. 2004
    ..Lamotrigine represents a valuable addition to the current therapeutic armamentarium for bipolar disorder, allowing a therapeutic balance between the treatment of mania and depression...
  68. ncbi request reprint Combination lithium and divalproex sodium in pediatric bipolarity
    Robert L Findling
    Department of Psychiatry, Case Western Reserve University School of Medicine, USA
    J Am Acad Child Adolesc Psychiatry 42:895-901. 2003
    ..Many youths with bipolar disorder do not respond to DVPX or Li monotherapy. An open-label study was conducted to examine the effectiveness of combination DVPX and Li therapy with youths diagnosed with bipolar disorder...
  69. ncbi request reprint Citalopram treatment of fluoxetine-intolerant depressed patients
    Joseph R Calabrese
    Mood Disorders Program, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Clin Psychiatry 64:562-7. 2003
    ..We assessed the tolerability of and response to citalopram in depressed patients who had discontinued fluoxetine treatment due to adverse events...
  70. ncbi request reprint Clinical decision-making using the General Behavior Inventory in juvenile bipolarity
    Robert L Findling
    Department of Psychiatry, University Hospitals of Cleveland Case Western Reserve University School of Medicine, Cleveland, OH 44106 5080, USA
    Bipolar Disord 4:34-42. 2002
    ..The General Behavior Inventory (GBI) is a questionnaire that has utility in the assessment of mood disorders in adults. The purpose of this study was to examine how the GBI might optimally be used in the assessment of youths...
  71. ncbi request reprint Early symptoms of mania and the role of parental risk
    Robert L Findling
    Department of Psychiatry, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH 44106, USA
    Bipolar Disord 7:623-34. 2005
    ....
  72. ncbi request reprint Typical and atypical antipsychotics in bipolar depression
    Keming Gao
    Mood Disorders Program, Department of Psychiatry, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, 11400 Euclid Avenue, Cleveland, OH 44106, USA
    J Clin Psychiatry 66:1376-85. 2005
    ..Since the antipsychotic agents have been shown to diminish depressive symptoms during the treatment of mania, atypical agents are now being studied for use in bipolar depression...
  73. ncbi request reprint Combination lithium and divalproex sodium in pediatric bipolar symptom re-stabilization
    Robert L Findling
    Department of Psychiatry, Case Western Reserve University, University Hospitals, Cleveland, OH 44106, USA
    J Am Acad Child Adolesc Psychiatry 45:142-8. 2006
    ..The primary goal of this study was to assess the rate of re-stabilization after the resumption of lithium (Li) plus divalproex (DVPX) following relapse on either agent as monotherapy...
  74. ncbi request reprint Anticonvulsants in bipolar disorder
    Vivek Singh
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive Mail Code 7792, San Antonio, TX 78229, USA
    Psychiatr Clin North Am 28:301-23. 2005
    ....
  75. doi request reprint Aims and results of the NIMH systematic treatment enhancement program for bipolar disorder (STEP-BD)
    C L Bowden
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    CNS Neurosci Ther 18:243-9. 2012
    ..STEP-BD has established procedures that are relevant to future collaborative research programs aimed at the systematic study of the complex, intrinsically important elements of bipolar disorders...
  76. pmc Comorbid anxiety and substance use disorders associated with a lower use of mood stabilisers in patients with rapid cycling bipolar disorder: a descriptive analysis of the cross-sectional data of 566 patients
    K Gao
    Department of Psychiatry, Mood and Anxiety Clinic at Mood Disorders Program, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, OH, USA
    Int J Clin Pract 64:336-44. 2010
    ..To study mood stabiliser treatment in patients with bipolar disorder with or without anxiety disorders (ADs) and/or substance use disorders (SUDs)...
  77. doi request reprint Gene-expression differences in peripheral blood between lithium responders and non-responders in the Lithium Treatment-Moderate dose Use Study (LiTMUS)
    R D Beech
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Pharmacogenomics J 14:182-91. 2014
    ..These changes were specific to Li responders (n=9), and were not seen in Li non-responders or patients treated without Li, suggesting that they may have specific roles in treatment response to Li...
  78. ncbi request reprint A pilot study of topiramate as monotherapy in the treatment of acute mania
    J R Calabrese
    Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    J Clin Psychopharmacol 21:340-2. 2001
    ..The preliminary findings of this small series suggest that topiramate may be effective in acute mania. Double-blind controlled trials are now needed to further investigate the efficacy and safety of topiramate in bipolar disorder...
  79. ncbi request reprint Structure of mania: depressive, irritable, and psychotic clusters with different retrospectively-assessed course patterns of illness in randomized clinical trial participants
    A C Swann
    Department of Psychiatry, University of Texas Houston Health Science Center, 1300 Moursund Street, Room 270, Houston, TX 77030, USA
    J Affect Disord 67:123-32. 2001
    ..We investigated the structure of manic episodes by determining whether there was evidence for distinct groups of patients differing in clinical characteristics and course of illness...
  80. ncbi request reprint Adjunctive antidepressant use and symptomatic recovery among bipolar depressed patients with concomitant manic symptoms: findings from the STEP-BD
    Joseph F Goldberg
    Affective Disorders Program, Silver Hill Hospital, New Canaan, Connecticut, USA
    Am J Psychiatry 164:1348-55. 2007
    ..However, few studies have examined the outcomes of patients with co-occurring manic and depressive symptoms who are treated with antidepressants plus mood stabilizing drugs...
  81. ncbi request reprint Relapse prevention in bipolar I disorder: 18-month comparison of olanzapine plus mood stabiliser v. mood stabiliser alone
    Mauricio Tohen
    Lilly Research Laboratories, Indianapolis, Indiana 46285, USA
    Br J Psychiatry 184:337-45. 2004
    ..Aims To evaluate whether olanzapine plus either lithium or valproate reduces the rate of relapse, compared with lithium or valproate alone...
  82. ncbi request reprint Incidence and time course of subsyndromal symptoms in patients with bipolar I disorder: an evaluation of 2 placebo-controlled maintenance trials
    Mark A Frye
    Mood Disorders Research Program, University of California at Los Angeles, USA
    J Clin Psychiatry 67:1721-8. 2006
    ..Subsyndromal symptoms in bipolar disorder can cause significant functional impairment and are associated with relapse...
  83. ncbi request reprint Influence of sub-syndromal symptoms after remission from manic or mixed episodes
    Mauricio Tohen
    Lilly Research Laboratories, Indianapolis, IN 46285, USA
    Br J Psychiatry 189:515-9. 2006
    ..Sub-syndromal symptoms in bipolar disorder impair functioning and diminish quality of life...
  84. ncbi request reprint Bipolar depression: criteria for treatment selection, definition of refractoriness, and treatment options
    Lakshmi N Yatham
    Department of Psychiatry, The University of British Columbia, Vancouver, British Columbia, Canada
    Bipolar Disord 5:85-97. 2003
    ..This paper reviews controlled studies of bipolar depression, outlines criteria for choosing treatment, defines refractoriness in bipolar depression, and provides options for treatment of refractory bipolar depression...
  85. ncbi request reprint Long-term treatment of bipolar disorder with lamotrigine
    Joseph R Calabrese
    J Clin Psychiatry 63:18-22. 2002
    ....
  86. ncbi request reprint Efficacy of quetiapine monotherapy in bipolar I and II depression: a double-blind, placebo-controlled study (the BOLDER II study)
    Michael E Thase
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 2593, USA
    J Clin Psychopharmacol 26:600-9. 2006
    ..This study demonstrates that quetiapine monotherapy is an effective and well-tolerated treatment for depressive episodes in bipolar disorder, confirming the results observed from a previous study (BipOLar DEpRession [BOLDER] I)...
  87. ncbi request reprint Treatment-resistant bipolar depression: a STEP-BD equipoise randomized effectiveness trial of antidepressant augmentation with lamotrigine, inositol, or risperidone
    Andrew A Nierenberg
    Massachusetts General Hospital Bipolar Clinic and Research Program, Suite 580, 50 Staniford Street, Boston, MA 02114, USA
    Am J Psychiatry 163:210-6. 2006
    ..This study represents the first randomized trial of competing options for treatment-resistant bipolar depression and assesses the effectiveness and safety of antidepressant augmentation with lamotrigine, inositol, and risperidone...
  88. ncbi request reprint Olanzapine versus lithium in the maintenance treatment of bipolar disorder: a 12-month, randomized, double-blind, controlled clinical trial
    Mauricio Tohen
    Lilly Research Laboratories, Indianapolis, IN 46285, USA
    Am J Psychiatry 162:1281-90. 2005
    ..The authors compared the efficacy of olanzapine and lithium in the prevention of mood episode relapse/recurrence...
  89. ncbi request reprint Efficacy of olanzapine in combination with valproate or lithium in the treatment of mania in patients partially nonresponsive to valproate or lithium monotherapy
    Mauricio Tohen
    Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, IN 46285, USA
    Arch Gen Psychiatry 59:62-9. 2002
    ....
  90. ncbi request reprint Randomized, placebo-controlled trial of olanzapine as maintenance therapy in patients with bipolar I disorder responding to acute treatment with olanzapine
    Mauricio Tohen
    Lilly Research Laboratories, Indianapolis, IN 46285, USA
    Am J Psychiatry 163:247-56. 2006
    ..In a placebo-controlled, double-blind study, the authors investigated the efficacy and safety of olanzapine as monotherapy in relapse prevention in bipolar I disorder...
  91. ncbi request reprint Pattern of response to divalproex, lithium, or placebo in four naturalistic subtypes of mania
    Alan C Swann
    University of Texas Houston Health Science Center, P O Box 20708, Houston, TX 77225, USA
    Neuropsychopharmacology 26:530-6. 2002
    ..These data suggest that there are naturalistic subtypes of manic episodes with different responses to treatment...
  92. ncbi request reprint A pooled analysis of 2 placebo-controlled 18-month trials of lamotrigine and lithium maintenance in bipolar I disorder
    Guy M Goodwin
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, England, UK
    J Clin Psychiatry 65:432-41. 2004
    ..Two clinical trials, prospectively designed for combined analysis, compared placebo, lithium, and lamotrigine for treatment of bipolar I disorder in recently depressed or manic patients...
  93. pmc Intensive psychosocial intervention enhances functioning in patients with bipolar depression: results from a 9-month randomized controlled trial
    David J Miklowitz
    Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
    Am J Psychiatry 164:1340-7. 2007
    ..In a randomized trial, the authors examined the impact of intensive psychosocial treatment plus pharmacotherapy on the functional outcomes of patients with bipolar disorder over the 9 months following a depressive episode...
  94. ncbi request reprint The empirical redefinition of the psychometric criteria for remission in bipolar disorder
    Michael Berk
    Barwon Health and The Geelong Clinic, Geelong, Victoria, Australia
    J Affect Disord 106:153-8. 2008
    ....
  95. ncbi request reprint Treatment adherence in individuals with rapid cycling bipolar disorder: results from a clinical-trial setting
    Martha Sajatovic
    J Clin Psychopharmacol 27:412-4. 2007
  96. ncbi request reprint Six-month prospective life charting of mood symptoms with lamotrigine monotherapy versus placebo in rapid cycling bipolar disorder
    Joseph F Goldberg
    Affective Disorders Program, Silver Hill Hospital, New Canaan, Connecticut 06840, USA
    Biol Psychiatry 63:125-30. 2008
    ..The anticonvulsant lamotrigine has demonstrated efficacy for relapse prevention in bipolar disorder, but its possible mood-stabilizing properties on a day-to-day or week-to-week basis have not previously been investigated...
  97. ncbi request reprint Suicidal ideation and pharmacotherapy among STEP-BD patients
    Joseph F Goldberg
    Affective Disorders Program, Silver Hill Hospital, 208 Valley Road, New Canaan, Connecticut 06840, and Department of Psychiatry, University of Colorado School of Medicine, Denver, USA
    Psychiatr Serv 56:1534-40. 2005
    ..Little is known about the effects of lithium on suicidal ideation or about the possible antisuicidal effects of divalproex, second-generation antipsychotics, or antidepressants among persons with bipolar disorder...
  98. ncbi request reprint Efficacy of olanzapine combined with valproate or lithium in the treatment of dysphoric mania
    Robert W Baker
    Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Br J Psychiatry 185:472-8. 2004
    ..Few controlled studies examine the treatment of depressive features in mania...
  99. ncbi request reprint Comparison of rapid-cycling and non-rapid-cycling bipolar I manic patients during treatment with olanzapine: analysis of pooled data
    Eduard Vieta
    Bipolar Disorders Program, Department of Psychiatry, Hospital Clinic, University of Barcelona, IDIBAPS, Barcelona, Spain
    J Clin Psychiatry 65:1420-8. 2004
    ..We report on the first controlled study comparing acute and continuous clinical outcomes in RC and non-RC manic patients treated with olanzapine...
  100. ncbi request reprint Pharmacotherapy for bipolar disorder and comorbid conditions: baseline data from STEP-BD
    Naomi M Simon
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychopharmacol 24:512-20. 2004
    ..Our findings highlight the need for greater clinical guidance and treatment options for patients with bipolar disorder and comorbidity...
  101. ncbi request reprint Efficacy of quetiapine monotherapy for the treatment of depressive episodes in bipolar I disorder: a post hoc analysis of combined results from 2 double-blind, randomized, placebo-controlled studies
    Richard H Weisler
    Department of Psychiatry and Behavioral Science, Duke University Medical Center, University of North Carolina at Chapel Hill, Raleigh, NC 27609, USA
    J Clin Psychiatry 69:769-82. 2008
    ....

Research Grants2

  1. Combination Therapy in Bipolar Rapid Cycling
    Joseph Calabrese; Fiscal Year: 2004
    ....
  2. Combination Therapy in Dual Diagnosis Rapid Cycling BPD in Both the Tertiary Care
    Joseph Calabrese; Fiscal Year: 2007
    ..To date, there are no published randomized, controlled trials in adults with BPD who are currently abusing alcohol or drugs. ..