Research Topics
| J R CalabreseSummaryAffiliation: Case Western Reserve University Country: USA Publications
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Publications
Differentiating bipolar disorder from depression in primary careDavid J Muzina
Bipolar Disorders Research Unit, Department of Psychiatry and Psychology, Cleveland Clinic, OH 44195, USA
Cleve Clin J Med 74:89, 92, 95-9 passim. 2007..Greater diagnostic accuracy is needed...- A randomized, double-blind, placebo-controlled trial of quetiapine in the treatment of bipolar I or II depressionJoseph R Calabrese
University Hospitals of Cleveland and Case University School of Medicine, 11400 Euclid Ave, Suite 200, Cleveland, OH 44106, USA
Am J Psychiatry 162:1351-60. 2005..There is a major unmet need for effective options in the treatment of bipolar depression... - Latest maintenance data on lamotrigine in bipolar disorderJoseph R Calabrese
Case Western Reserve University School of Medicine, University Hospitals of Cleveland, Cleveland, OH, USA
Eur Neuropsychopharmacol 13:S57-66. 2003..In summary, lamotrigine is an effective and well-tolerated maintenance treatment for bipolar I disorder, providing a spectrum of efficacy complementary to that of lithium... - A 20-month, double-blind, maintenance trial of lithium versus divalproex in rapid-cycling bipolar disorderJoseph R Calabrese
Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH 44106, USA
Am J Psychiatry 162:2152-61. 2005..The authors tested the hypothesis that divalproex would be more effective than lithium in the long-term management of patients with recently stabilized rapid-cycling bipolar disorder... - Mood state at study entry as predictor of the polarity of relapse in bipolar disorderJoseph R Calabrese
Case University School of Medicine, University Hospitals of Cleveland, 11400 Euclid Avenue, Suite 200, Cleveland, OH 44106, USA
Biol Psychiatry 56:957-63. 2004..We conclude that putative mood stabilizers must be tested in recently manic and recently depressed patients to determine their spectrum of prophylactic efficacy... - New data on the use of lithium, divalproate, and lamotrigine in rapid cycling bipolar disorderJ R Calabrese
Case Western Reserve University School of Medicine, University Hospitals of Cleveland, 11400 Euclid Avenue, Suite 200, Cleveland, OH 44106, USA
Eur Psychiatry 20:92-5. 2005..In addition, lamotrigine has the potential to complement the spectrum of lithium and divalproate through its greater efficacy for depressive symptoms... - Clinical highlights in bipolar depression: focus on atypical antipsychoticsJoseph R Calabrese
University Hospitals of Cleveland Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
J Clin Psychiatry 66:26-33. 2005..In addition, direct comparison of the regimens used in the current study should determine whether the differences evident between them can be confirmed... 
Predictors of bipolar disorder risk among patients currently treated for major depressionJoseph R Calabrese
Mood Disorders Program, Department of Psychiatry, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, Ohio, USA
MedGenMed 8:38. 2006..PATIENTS, DESIGN, AND SETTING: Psychiatrists from community and private practice settings sequentially selected patients with unipolar depression who exhibited nonresponse to at least 1 antidepressant (AD) trial...- Impact of depressive symptoms compared with manic symptoms in bipolar disorder: results of a U.S. community-based sampleJoseph R Calabrese
University Hospitals of Cleveland Case Western Reserve School of Medicine, Cleveland, Ohio, USA
J Clin Psychiatry 65:1499-504. 2004..In the present study, we assessed the functional impact of depressive versus manic symptoms in bipolar disorder... - A US perspective of the CANMAT bipolar guidelinesJoseph R Calabrese
Case Western Reserve University, Cleveland, OH 44106, USA
Bipolar Disord 7:70-2. 2005 - Recurrence in bipolar I disorder: a post hoc analysis excluding relapses in two double-blind maintenance studiesJoseph R Calabrese
Department of Psychiatry, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
Biol Psychiatry 59:1061-4. 2006..To assess the efficacy of lamotrigine or lithium in preventing mood recurrence (i.e., a new mood episode) in bipolar disorder... - A randomized, placebo-controlled 12-month trial of divalproex and lithium in treatment of outpatients with bipolar I disorder. Divalproex Maintenance Study GroupC L Bowden
Department of Psychiatry, University of Texas Health Science Center at San Antonio, 78284 7792, USA
Arch Gen Psychiatry 57:481-9. 2000..This study compared the efficacy of divalproex, lithium, and placebo as prophylactic therapy... - Bipolar rapid cycling: focus on depression as its hallmarkJ R Calabrese
Department of Psychiatry at University Hospitals of Cleveland and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
J Clin Psychiatry 62:34-41. 2001..The results indicate that lamotrigine may be a useful treatment for patients with rapid-cycling bipolar II disorder and that this drug has begun to address this unmet need... 
Treatment-emergent mania/hypomania during antidepressant monotherapy in patients with rapid cycling bipolar disorderKeming Gao
Department of Psychiatry, Bipolar Disorder Research Center at Mood Disorders Program, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, 10524 Euclid Avenue, Cleveland, OH 44106, USA
Bipolar Disord 10:907-15. 2008..To study treatment-emergent mania/hypomania (TEM) associated with second-generation antidepressant monotherapy in patients with rapid cycling bipolar disorder (RCBD)...- Current research on rapid cycling bipolar disorder and its treatmentJ R Calabrese
Mood Disorders Program, Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
J Affect Disord 67:241-55. 2001..Electroconvulsive therapy may also prove efficacious in selected cases. The present paper provides a critical review of the evidence for the foregoing clinical issues in rapid cycling... - A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently manic or hypomanic patients with bipolar I disorderCharles L Bowden
Department of Psychiatry, University of Texas Health Science Center at San Antonio, 78229, USA
Arch Gen Psychiatry 60:392-400. 2003.... - Controlled trials in bipolar I depression: focus on switch rates and efficacyJ R Calabrese
Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, OH, USA
Eur Neuropsychopharmacol 9:S109-12. 1999..At present there is no consensus over the optimal definition of switching. Standardising the definition may lead to improvements in the clinical management of bipolar disorder... - Clinical studies on the use of lamotrigine in bipolar disorderJ R Calabrese
Mood Disorder Program, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
Neuropsychobiology 38:185-91. 1998.... - A 6-month, double-blind, maintenance trial of lithium monotherapy versus the combination of lithium and divalproex for rapid-cycling bipolar disorder and Co-occurring substance abuse or dependenceDavid E Kemp
Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, Ohio, USA
J Clin Psychiatry 70:113-21. 2009.... - Differential interactions between comorbid anxiety disorders and substance use disorder in rapid cycling bipolar I or II disorderKeming Gao
Department of Psychiatry, Bipolar Disorder Research Center at Mood Disorders Program, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio, USA
J Affect Disord 110:167-73. 2008..Anxiety disorders (AD) and substance use disorders (SUD) commonly co-occur with bipolar disorder. This study was undertaken to assess AD-SUD-bipolar subtype interactions... - Medical and substance use comorbidity in bipolar disorderDavid E Kemp
Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH, USA
J Affect Disord 116:64-9. 2009.... - Current concepts in rapid cycling bipolar disorderM D Shelton
Mood Disorders Program, Department of Psychiatry, Case Western Reserve University School of Medicine, 11400 Euclid Avenue, Suite 200, Cleveland, Ohio 44106, USA
Curr Psychiatry Rep 2:310-5. 2000..Controlled trials in homogeneous cohorts of RCBD patients are needed. Preliminary data suggest that two or more mood stabilizers are required for adequate control... - Discriminative validity of parent report of hypomanic and depressive symptoms on the General Behavior InventoryE A Youngstrom
Department of Psychology, Case Western Reserve University, 11220 Bellflower Road, Cleveland, Ohio 44106, USA
Psychol Assess 13:267-76. 2001..80. Results indicate that clinicians can use the parent-completed GBI to derive clinically meaningful information about mood disorders in youths... - Does recovery from substance use disorder matter in patients with bipolar disorder?Roger D Weiss
Department of Psychiatry, Harvard Medical School, Boston, USA
J Clin Psychiatry 66:730-5; quiz 808-9. 2005..To examine the potential impact of recovery from substance use disorder (SUD) on the course of bipolar disorder among patients diagnosed with both bipolar and substance use disorders according to DSM-IV criteria... - Phenomenology of rapid-cycling bipolar disorder: data from the first 500 participants in the Systematic Treatment Enhancement ProgramChristopher D Schneck
Department of Psychiatry, University of Colorado Health Sciences Center, 4455 East 12th Ave, Box A011 15, Denver, CO 80220, USA
Am J Psychiatry 161:1902-8. 2004..This study compared demographic and phenomenological variables between bipolar patients with and without rapid cycling as a function of bipolar I versus bipolar II status... - Correlates of historical suicide attempt in rapid-cycling bipolar disorder: a cross-sectional assessmentKeming Gao
Department of Psychiatry, Case Western University School of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio, USA
J Clin Psychiatry 70:1032-40. 2009..A rapid-cycling course in bipolar disorder has previously been identified as a risk factor for attempted suicide. This study investigated factors associated with suicide attempts in patients with rapid-cycling bipolar I or II disorder... - Rapid, continuous cycling and psychiatric co-morbidity in pediatric bipolar I disorderR L Findling
Department of Psychiatry, University Hospitals of Cleveland Case Western Reserve University School of Medicine, Case Western Reserve University, Cleveland, OH 44106 5080, USA
Bipolar Disord 3:202-10. 2001..The primary purpose of this study was to describe the clinical presentation of bipolar I disorder (BP-I) as it occurs in children and adolescents and to assess whether the manifestations of BP-I were similar in both age groups... - A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently depressed patients with bipolar I disorderJoseph R Calabrese
University Hospitals of Cleveland Case Western Reserve School of Medicine, Department of Psychiatry, 11400 Euclid Ave, Ste 200, Cleveland, OH 44106, USA
J Clin Psychiatry 64:1013-24. 2003..This study assessed the efficacy and tolerability of lamotrigine and lithium compared with placebo for the prevention of mood episodes in bipolar disorder... - Relationship of mania symptomatology to maintenance treatment response with divalproex, lithium, or placeboCharles L Bowden
Department of Psychiatry, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
Neuropsychopharmacology 30:1932-9. 2005..Dysphoric mania appeared to predispose patients to more side effects when treated with either divalproex or lithium during maintenance therapy... - A randomized, placebo-controlled, multicenter study of divalproex sodium extended release in the treatment of acute maniaCharles L Bowden
Department of Psychiatry, University of Texas Health Science Center, San Antonio 78284 7792, USA
J Clin Psychiatry 67:1501-10. 2006..The efficacy and safety of divalproex sodium extended release (divalproex ER) were evaluated in patients hospitalized for acute mania associated with bipolar I disorder, manic or mixed type (DSM-IV-TR criteria)... - Maintenance efficacy of divalproex in the prevention of bipolar depressionLaszlo Gyulai
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Neuropsychopharmacology 28:1374-82. 2003.... - Clinical correlates of patients with rapid-cycling bipolar disorder and a recent history of substance use disorder: a subtype comparison from baseline data of 2 randomized, placebo-controlled trialsKeming Gao
Department of Psychiatry, Bipolar Disorder Research Center at the Mood Disorders Program, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
J Clin Psychiatry 69:1057-63. 2008..To compare clinical variables in patients with rapid-cycling bipolar I or II disorder and a recent history of substance use disorder (SUD)... - International Consensus Group on Bipolar I Depression Treatment GuidelinesJoseph R Calabrese
Department of Psychiatry, Case Western Reserve University, Cleveland, OH, USA
J Clin Psychiatry 65:571-9. 2004 - Aripiprazole monotherapy for maintenance therapy in bipolar I disorder: a 100-week, double-blind study versus placeboPaul E Keck
Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
J Clin Psychiatry 68:1480-91. 2007..Efficacy and tolerability of aripiprazole for relapse prevention in bipolar I disorder was, therefore, evaluated for 100 weeks... - Evolving methodologies in bipolar disorder maintenance researchJ R Calabrese
Mood Disorders Program, Department of Psychiatry, Case Western Reserve University, Cleveland, Ohio, USA
Br J Psychiatry Suppl 41:s157-63. 2001..Comparisons with the early bipolar disorder maintenance studies indicate that the methodologies of recent trials have evolved substantially... - Employing parent, teacher, and youth self-report checklists in identifying pediatric bipolar spectrum disorders: an examination of diagnostic accuracy and clinical utilityShoshana Y Kahana
Case Western Reserve University, Cleveland, Ohio 44106, USA
J Child Adolesc Psychopharmacol 13:471-88. 2003..Results indicate that the Child Behavior Checklist has limited utility when attempting to derive clinically meaningful information about the presentation of juvenile BPSD... - Rash in multicenter trials of lamotrigine in mood disorders: clinical relevance and managementJoseph R Calabrese
Department of Psychiatry, Case Western Reserve University University Hospitals of Cleveland, Cleveland, Ohio, USA
J Clin Psychiatry 63:1012-9. 2002..The objective of this report was to determine rash rates in clinical trials of lamotrigine in DSM-IV unipolar depression or bipolar disorder... - Evaluation and comparison of psychometric instruments for pediatric bipolar spectrum disorders in four age groupsThomas W Frazier
Department of Psychiatry, University Hospitals Case Medical Center, Cleveland, OH, USA
J Child Adolesc Psychopharmacol 17:853-66. 2007..The CDRS-R may be better conceptualized as a two-factor measure in older adolescents. The semistructured K-SADS interview can be used to generate reliable diagnoses across a broad age range... - Impact of lamotrigine and lithium on weight in obese and nonobese patients with bipolar I disorderCharles L Bowden
Department of Psychiatry, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
Am J Psychiatry 163:1199-201. 2006..This study assessed weight changes in a large cohort of patients with bipolar disorder who were treated with randomly assigned maintenance monotherapies... - Predictive value of early improvement in bipolar depression trials: a post-hoc pooled analysis of two 8-week aripiprazole studiesD E Kemp
Case Western Reserve University, Cleveland, OH, USA
Psychopharmacol Bull 43:5-27. 2010..To evaluate the value of early improvement to predict treatment outcome in patients with bipolar depression... - A pilot pharmacotherapy trial for depressed youths at high genetic risk for bipolarityRobert L Findling
Department of Psychiatry, University Hospitals Case Medical Center Case Western Reserve University, Cleveland, Ohio 44106, USA
J Child Adolesc Psychopharmacol 18:615-21. 2008..As a result, future treatment studies in this population appear to be warranted, not only due to the putative impending risk of developing bipolar disorder, but also the manifest risk of current depressive episodes... - Metabolic syndrome in patients enrolled in a clinical trial of aripiprazole in the maintenance treatment of bipolar I disorder: a post hoc analysis of a randomized, double-blind, placebo-controlled trialDavid E Kemp
Case Western Reserve University School of Medicine, 10524 Euclid Ave, 12th Floor, Cleveland, OH 44106, USA
J Clin Psychiatry 71:1138-44. 2010..To compare the effects of maintenance treatment with aripiprazole or placebo on the incidence of metabolic syndrome in bipolar disorder... - Lithium treatment -- moderate dose use study (LiTMUS) for bipolar disorder: rationale and designAndrew A Nierenberg
Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
Clin Trials 6:637-48. 2009..Recent data indicate that lithium use for bipolar disorder has declined over the last decade and that lithium largely has been replaced with alternate, commercially promoted medications that may or may not result in better outcomes... - Relationship of open acute mania treatment to blinded maintenance outcome in bipolar I disorderSusan L McElroy
Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
J Affect Disord 107:127-33. 2008..No published studies have statistically evaluated the relationship between the outcomes in maintenance treatment and the principal acute agent... - A randomized, double-blind, placebo-controlled 26-week trial of aripiprazole in recently manic patients with bipolar I disorderPaul E Keck
Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
J Clin Psychiatry 67:626-37. 2006..To investigate the safety and efficacy of aripiprazole in preventing relapse of a mood episode in recently manic- or mixed-episode patients with bipolar I disorder stabilized on aripiprazole... - Lamotrigine in the acute treatment of bipolar depression: results of five double-blind, placebo-controlled clinical trialsJoseph R Calabrese
Case Western Reserve University School of Medicine University Hospitals of Cleveland, Cleveland, OH, USA
Bipolar Disord 10:323-33. 2008..This paper reports the results of five randomized, double-blind, placebo-controlled trials of lamotrigine monotherapy for the acute treatment of bipolar depression... - Suicidal ideation and depressive symptoms among bipolar patients as predictors of the health and well-being of caregiversCheryl A Chessick
Department of Psychiatry, University of Colorado Denver School of Medicine, Denver, CO 80045, USA
Bipolar Disord 11:876-84. 2009..This study examined whether caregivers' health is associated with changes in suicidal ideation and depressive symptoms among bipolar patients observed over one year... - Agomelatine adjunctive therapy for acute bipolar depression: preliminary open dataJoseph R Calabrese
University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH 44106, USA
Bipolar Disord 9:628-35. 2007..The aim of this study was to gather preliminary data regarding the antidepressant efficacy of agomelatine in patients with bipolar I disorder experiencing a major depressive episode... - Retrospective age at onset of bipolar disorder and outcome during two-year follow-up: results from the STEP-BD studyRoy H Perlis
Bipolar Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, ACC 812 15 Parkman Street, Boston, MA 02114, USA
Bipolar Disord 11:391-400. 2009..Symptoms of bipolar disorder are increasingly recognized among children and adolescents, but little is known about the course of bipolar disorder among adults who experience childhood onset of symptoms... - A review of sensitivity and tolerability of antipsychotics in patients with bipolar disorder or schizophrenia: focus on somnolenceKeming Gao
Department of Psychiatry, Bipolar Disorder Research Center at Mood Disorders Program, University Hospitals Case Medical Center Case Western Reserve University, School of Medicine, Cleveland, Ohio, USA
J Clin Psychiatry 69:302-9. 2008..This study compared the sensitivity and tolerability of antipsychotics in patients with bipolar disorder or schizophrenia... - Recent placebo-controlled acute trials in bipolar depression: focus on methodologyDavid J Muzina
Cleveland Clinic Foundation, Cleveland, Ohio, USA
Int J Neuropsychopharmacol 6:285-91. 2003..Moclobemide monotherapy was similar in efficacy to imipramine (n=156), but had a lower rate of switching (4% vs. 11%)... - Combination lithium and divalproex sodium in pediatric bipolarityRobert L Findling
Department of Psychiatry, Case Western Reserve University School of Medicine, USA
J Am Acad Child Adolesc Psychiatry 42:895-901. 2003..Many youths with bipolar disorder do not respond to DVPX or Li monotherapy. An open-label study was conducted to examine the effectiveness of combination DVPX and Li therapy with youths diagnosed with bipolar disorder... - Anticonvulsants in bipolar disorderVivek Singh
Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive Mail Code 7792, San Antonio, TX 78229, USA
Psychiatr Clin North Am 28:301-23. 2005.... - Acute treatment of mania: an update on new medicationsPrashant Gajwani
Case School of Medicine, Mood Disorders Program, University Hospitals Case Medical Center, 11400 Euclid Avenue, Suite 200, Cleveland, OH 44106, USA
Curr Psychiatry Rep 8:504-9. 2006.... - Quetiapine for the treatment of bipolar mania in older adultsMartha Sajatovic
Department of Psychiatry, Case Western Reserve University School of Medicine, University Hospitals of Cleveland, Cleveland, OH 44106, USA
Bipolar Disord 10:662-71. 2008..The primary efficacy endpoint was the change from baseline in Young Mania Rating Scale (YMRS) total score at Day 21. A secondary endpoint was change from baseline in YMRS score at Day 84... - Newer treatment studies for bipolar depressionKeming Gao
NIMH Bipolar Research Center, Mood Disorders Program, University Hospitals of Cleveland Case Western Reserve University School of Medicine, Cleveland, OH, USA
Bipolar Disord 7:13-23. 2005..Depressive symptoms of bipolar disorder have more negative impact on a patient's life than manic symptoms. This review focused on the emerging efficacy data for treatments in bipolar depression... - Initiation of stimulant and antidepressant medication and clinical presentation in juvenile bipolar I disorderMaria E Pagano
Department of Psychiatry, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, OH 44106 5080, USA
Bipolar Disord 10:334-41. 2008..Another aim was to investigate differences in clinical presentation between youths prescribed stimulant or antidepressant medication before and after the onset of juvenile BP I disorder... - Depression mood stabilisation: novel concepts and clinical managementJoseph R Calabrese
Case Western Reserve University, MD 11400 Euclid Avenue, Suite 200, Cleveland, OH 44106, USA
Eur Neuropsychopharmacol 14:S100-7. 2004..Lamotrigine represents a valuable addition to the current therapeutic armamentarium for bipolar disorder, allowing a therapeutic balance between the treatment of mania and depression... - Double-blind, placebo-controlled trial of divalproex monotherapy in the treatment of symptomatic youth at high risk for developing bipolar disorderRobert L Findling
Department of Psychiatry, Case Western Reserve University, and the University Hospitals of Cleveland, Cleveland, Ohio 44106 5080, USA
J Clin Psychiatry 68:781-8. 2007..To determine if divalproex sodium was superior to placebo in the treatment of symptomatic youths who suffer from a bipolar spectrum disorder and who also have a parent with a diagnosis of a bipolar illness... - Personal and societal construction of illness among individuals with rapid-cycling bipolar disorder: a life-trajectory perspectiveMartha Sajatovic
Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, OH, USA
Am J Geriatr Psychiatry 16:718-26. 2008..The purpose of this study was to examine the subjective experience of illness among 19 men and women with rapid cycling bipolar disorder receiving treatment at an academic psychiatry clinic... - Adherence to pharmacological treatment for juvenile bipolar disorderDennis Drotar
Department of Psychiatry, Case Western Reserve University, USA
J Am Acad Child Adolesc Psychiatry 46:831-9. 2007..The objective of this study was to describe the prevalence and correlates of adherence to divalproex sodium (DVPX) and lithium carbonate (Li) combination treatment during the initial stabilization treatment phase... - Efficacy of typical and atypical antipsychotics for primary and comorbid anxiety symptoms or disorders: a reviewKeming Gao
Department of Psychiatry, the Bipolar Disorders Research Center, University Hospitals of Cleveland Case Western Reserve University, School of Medicine, Cleveland, Ohio, USA
J Clin Psychiatry 67:1327-40. 2006..The efficacy of antipsychotics in the treatment of primary or comorbid anxiety disorders or anxiety symptoms in major depressive disorder or bipolar disorder was reviewed... - Double-blind 18-month trial of lithium versus divalproex maintenance treatment in pediatric bipolar disorderRobert L Findling
Department of Psychiatry, Case Western Reserve University, USA
J Am Acad Child Adolesc Psychiatry 44:409-17. 2005.... - Maintenance treatment outcomes in older patients with bipolar I disorderMartha Sajatovic
Department of Psychiatry, Case University School of Medicine and University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106, USA
Am J Geriatr Psychiatry 13:305-11. 2005.... - Medical comorbidity in bipolar disorder: relationship between illnesses of the endocrine/metabolic system and treatment outcomeDavid E Kemp
Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH 44106, USA
Bipolar Disord 12:404-13. 2010..It was hypothesized that illnesses of the endocrine/metabolic system would be associated with greater psychiatric symptom burden and would impact the response to treatment with lithium and valproate... - Gender differences in criminality: bipolar disorder with co-occurring substance abuseSusan Hatters Friedman
Department of Psychiatry, University Hospitals of Cleveland, Hanna Pavilion, 11100 Euclid Avenue, Cleveland, OH 44106, USA
J Am Acad Psychiatry Law 33:188-95. 2005..Implications from this pilot study include the need for earlier identification of bipolar disorder and for the increased availability of psychiatric and substance abuse services within correctional facilities... - Comparing diagnostic checklists for pediatric bipolar disorder in academic and community mental health settingsEric Youngstrom
Department of Psychology, Case Western Reserve University, Cleveland, OH 44106, USA
Bipolar Disord 7:507-17. 2005.... - Early symptoms of mania and the role of parental riskRobert L Findling
Department of Psychiatry, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH 44106, USA
Bipolar Disord 7:623-34. 2005.... - Typical and atypical antipsychotics in bipolar depressionKeming Gao
Mood Disorders Program, Department of Psychiatry, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, 11400 Euclid Avenue, Cleveland, OH 44106, USA
J Clin Psychiatry 66:1376-85. 2005..Since the antipsychotic agents have been shown to diminish depressive symptoms during the treatment of mania, atypical agents are now being studied for use in bipolar depression... - Combination lithium and divalproex sodium in pediatric bipolar symptom re-stabilizationRobert L Findling
Department of Psychiatry, Case Western Reserve University, University Hospitals, Cleveland, OH 44106, USA
J Am Acad Child Adolesc Psychiatry 45:142-8. 2006..The primary goal of this study was to assess the rate of re-stabilization after the resumption of lithium (Li) plus divalproex (DVPX) following relapse on either agent as monotherapy... - Clinical decision-making using the General Behavior Inventory in juvenile bipolarityRobert L Findling
Department of Psychiatry, University Hospitals of Cleveland Case Western Reserve University School of Medicine, Cleveland, OH 44106 5080, USA
Bipolar Disord 4:34-42. 2002..The General Behavior Inventory (GBI) is a questionnaire that has utility in the assessment of mood disorders in adults. The purpose of this study was to examine how the GBI might optimally be used in the assessment of youths... - Citalopram treatment of fluoxetine-intolerant depressed patientsJoseph R Calabrese
Mood Disorders Program, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
J Clin Psychiatry 64:562-7. 2003..We assessed the tolerability of and response to citalopram in depressed patients who had discontinued fluoxetine treatment due to adverse events... - Effects of lamotrigine and lithium on body weight during maintenance treatment of bipolar I disorderGary Sachs
Department of Psychiatry, Harvard University, Harvard Bipolar Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
Bipolar Disord 8:175-81. 2006.... - Antiepileptic drugs in mood-disordered patientsPrashant Gajwani
NIMH Bipolar Research Center, Case Western Reserve University School of Medicine, Mood Disorders Program, University Hospitals of Cleveland, OH, USA
Epilepsia 46:38-44. 2005..LTG seems to be effective against depression and mania, with a more robust activity against depression. No firm evidence supports a role for vigabatrin, tiagabine, topiramate, or levetiracetam in these disorders... - Aims and results of the NIMH systematic treatment enhancement program for bipolar disorder (STEP-BD)C L Bowden
Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
CNS Neurosci Ther 18:243-9. 2012..STEP-BD has established procedures that are relevant to future collaborative research programs aimed at the systematic study of the complex, intrinsically important elements of bipolar disorders... - Comorbid anxiety and substance use disorders associated with a lower use of mood stabilisers in patients with rapid cycling bipolar disorder: a descriptive analysis of the cross-sectional data of 566 patientsK Gao
Department of Psychiatry, Mood and Anxiety Clinic at Mood Disorders Program, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, OH, USA
Int J Clin Pract 64:336-44. 2010..To study mood stabiliser treatment in patients with bipolar disorder with or without anxiety disorders (ADs) and/or substance use disorders (SUDs)... - A pilot study of topiramate as monotherapy in the treatment of acute maniaJ R Calabrese
Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
J Clin Psychopharmacol 21:340-2. 2001..The preliminary findings of this small series suggest that topiramate may be effective in acute mania. Double-blind controlled trials are now needed to further investigate the efficacy and safety of topiramate in bipolar disorder... - Structure of mania: depressive, irritable, and psychotic clusters with different retrospectively-assessed course patterns of illness in randomized clinical trial participantsA C Swann
Department of Psychiatry, University of Texas Houston Health Science Center, 1300 Moursund Street, Room 270, Houston, TX 77030, USA
J Affect Disord 67:123-32. 2001..We investigated the structure of manic episodes by determining whether there was evidence for distinct groups of patients differing in clinical characteristics and course of illness... - The empirical redefinition of the psychometric criteria for remission in bipolar disorderMichael Berk
Barwon Health and The Geelong Clinic, Geelong, Victoria, Australia
J Affect Disord 106:153-8. 2008.... - Efficacy of quetiapine monotherapy in bipolar I and II depression: a double-blind, placebo-controlled study (the BOLDER II study)Michael E Thase
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 2593, USA
J Clin Psychopharmacol 26:600-9. 2006..This study demonstrates that quetiapine monotherapy is an effective and well-tolerated treatment for depressive episodes in bipolar disorder, confirming the results observed from a previous study (BipOLar DEpRession [BOLDER] I)... - Suicidal ideation and pharmacotherapy among STEP-BD patientsJoseph F Goldberg
Affective Disorders Program, Silver Hill Hospital, 208 Valley Road, New Canaan, Connecticut 06840, and Department of Psychiatry, University of Colorado School of Medicine, Denver, USA
Psychiatr Serv 56:1534-40. 2005..Little is known about the effects of lithium on suicidal ideation or about the possible antisuicidal effects of divalproex, second-generation antipsychotics, or antidepressants among persons with bipolar disorder... - Randomized, placebo-controlled trial of olanzapine as maintenance therapy in patients with bipolar I disorder responding to acute treatment with olanzapineMauricio Tohen
Lilly Research Laboratories, Indianapolis, IN 46285, USA
Am J Psychiatry 163:247-56. 2006..In a placebo-controlled, double-blind study, the authors investigated the efficacy and safety of olanzapine as monotherapy in relapse prevention in bipolar I disorder... - Bipolar depression: criteria for treatment selection, definition of refractoriness, and treatment optionsLakshmi N Yatham
Department of Psychiatry, The University of British Columbia, Vancouver, British Columbia, Canada
Bipolar Disord 5:85-97. 2003..This paper reviews controlled studies of bipolar depression, outlines criteria for choosing treatment, defines refractoriness in bipolar depression, and provides options for treatment of refractory bipolar depression... - Long-term treatment of bipolar disorder with lamotrigineJoseph R Calabrese
J Clin Psychiatry 63:18-22. 2002.... - Treatment-resistant bipolar depression: a STEP-BD equipoise randomized effectiveness trial of antidepressant augmentation with lamotrigine, inositol, or risperidoneAndrew A Nierenberg
Massachusetts General Hospital Bipolar Clinic and Research Program, Suite 580, 50 Staniford Street, Boston, MA 02114, USA
Am J Psychiatry 163:210-6. 2006..This study represents the first randomized trial of competing options for treatment-resistant bipolar depression and assesses the effectiveness and safety of antidepressant augmentation with lamotrigine, inositol, and risperidone... - Adjunctive antidepressant use and symptomatic recovery among bipolar depressed patients with concomitant manic symptoms: findings from the STEP-BDJoseph F Goldberg
Affective Disorders Program, Silver Hill Hospital, New Canaan, Connecticut, USA
Am J Psychiatry 164:1348-55. 2007..However, few studies have examined the outcomes of patients with co-occurring manic and depressive symptoms who are treated with antidepressants plus mood stabilizing drugs... - Efficacy of olanzapine in combination with valproate or lithium in the treatment of mania in patients partially nonresponsive to valproate or lithium monotherapyMauricio Tohen
Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, IN 46285, USA
Arch Gen Psychiatry 59:62-9. 2002..CONCLUSION: Compared with the use of valproate or lithium alone, the addition of olanzapine provided superior efficacy in the treatment of manic and mixed bipolar episodes... - Olanzapine versus lithium in the maintenance treatment of bipolar disorder: a 12-month, randomized, double-blind, controlled clinical trialMauricio Tohen
Lilly Research Laboratories, Indianapolis, IN 46285, USA
Am J Psychiatry 162:1281-90. 2005..The authors compared the efficacy of olanzapine and lithium in the prevention of mood episode relapse/recurrence... - Influence of sub-syndromal symptoms after remission from manic or mixed episodesMauricio Tohen
Lilly Research Laboratories, Indianapolis, IN 46285, USA
Br J Psychiatry 189:515-9. 2006..Sub-syndromal symptoms in bipolar disorder impair functioning and diminish quality of life... - Bipolar drug development: are we getting closer to the real world?Joseph R Calabrese
Am J Psychiatry 165:1234-6. 2008 - Incidence and time course of subsyndromal symptoms in patients with bipolar I disorder: an evaluation of 2 placebo-controlled maintenance trialsMark A Frye
Mood Disorders Research Program, University of California at Los Angeles, USA
J Clin Psychiatry 67:1721-8. 2006..Subsyndromal symptoms in bipolar disorder can cause significant functional impairment and are associated with relapse... - Intensive psychosocial intervention enhances functioning in patients with bipolar depression: results from a 9-month randomized controlled trialDavid J Miklowitz
Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
Am J Psychiatry 164:1340-7. 2007..In a randomized trial, the authors examined the impact of intensive psychosocial treatment plus pharmacotherapy on the functional outcomes of patients with bipolar disorder over the 9 months following a depressive episode... - Treatment adherence in individuals with rapid cycling bipolar disorder: results from a clinical-trial settingMartha Sajatovic
J Clin Psychopharmacol 27:412-4. 2007 - Comparison of rapid-cycling and non-rapid-cycling bipolar I manic patients during treatment with olanzapine: analysis of pooled dataEduard Vieta
Bipolar Disorders Program, Department of Psychiatry, Hospital Clinic, University of Barcelona, IDIBAPS, Barcelona, Spain
J Clin Psychiatry 65:1420-8. 2004..We report on the first controlled study comparing acute and continuous clinical outcomes in RC and non-RC manic patients treated with olanzapine... - Pharmacotherapy for bipolar disorder and comorbid conditions: baseline data from STEP-BDNaomi M Simon
Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
J Clin Psychopharmacol 24:512-20. 2004..Our findings highlight the need for greater clinical guidance and treatment options for patients with bipolar disorder and comorbidity... - Psychosis in mania: specificity of its role in severity and treatment responseAlan C Swann
University of Texas Medical School, Houston 77030, USA
J Clin Psychiatry 65:825-9. 2004..Psychosis is a prominent characteristic of manic episodes. We investigated relationships between the presence of psychotic features, the severity of the manic syndrome, and syndrome severity's response to treatment... - Six-month prospective life charting of mood symptoms with lamotrigine monotherapy versus placebo in rapid cycling bipolar disorderJoseph F Goldberg
Affective Disorders Program, Silver Hill Hospital, New Canaan, Connecticut 06840, USA
Biol Psychiatry 63:125-30. 2008..The anticonvulsant lamotrigine has demonstrated efficacy for relapse prevention in bipolar disorder, but its possible mood-stabilizing properties on a day-to-day or week-to-week basis have not previously been investigated... - Efficacy of olanzapine combined with valproate or lithium in the treatment of dysphoric maniaRobert W Baker
Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, USA
Br J Psychiatry 185:472-8. 2004..Few controlled studies examine the treatment of depressive features in mania... - A pooled analysis of 2 placebo-controlled 18-month trials of lamotrigine and lithium maintenance in bipolar I disorderGuy M Goodwin
Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, England, UK
J Clin Psychiatry 65:432-41. 2004..Two clinical trials, prospectively designed for combined analysis, compared placebo, lithium, and lamotrigine for treatment of bipolar I disorder in recently depressed or manic patients... - Relapse prevention in bipolar I disorder: 18-month comparison of olanzapine plus mood stabiliser v. mood stabiliser aloneMauricio Tohen
Lilly Research Laboratories, Indianapolis, Indiana 46285, USA
Br J Psychiatry 184:337-45. 2004..Aims To evaluate whether olanzapine plus either lithium or valproate reduces the rate of relapse, compared with lithium or valproate alone... - Stabilization of mood from below versus above baseline in bipolar disorder: a new nomenclatureTerence A Ketter
Department of Psychiatry and Behavioral Science, Stanford University School of Medicine, Calif 94305 5723, USA
J Clin Psychiatry 63:146-51. 2002..In this article, the treatment options for bipolar disorder, with a focus on depression and rapid cycling, are discussed according to this new conceptualization of management from below and above baseline...
Research Grants
- Combination Therapy in Bipolar Rapid CyclingJoseph Calabrese; Fiscal Year: 2004....
- Combination Therapy in Dual Diagnosis Rapid Cycling BPD in Both the Tertiary CareJoseph Calabrese; Fiscal Year: 2007..To date, there are no published randomized, controlled trials in adults with BPD who are currently abusing alcohol or drugs. ..