Susann M Brady-Kalnay

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. pmc PTPmu regulates N-cadherin-dependent neurite outgrowth
    S M Burden-Gulley
    Department of Molecular Biology and Microbiology, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106 4960, USA
    J Cell Biol 144:1323-36. 1999
  2. ncbi request reprint Protein tyrosine phosphatase-mu differentially regulates neurite outgrowth of nasal and temporal neurons in the retina
    Susan M Burden-Gulley
    Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4960, USA
    J Neurosci 22:3615-27. 2002
  3. pmc Single cell molecular recognition of migrating and invading tumor cells using a targeted fluorescent probe to receptor PTPmu
    Susan M Burden-Gulley
    Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH, USA
    Int J Cancer 132:1624-32. 2013
  4. pmc A novel molecular diagnostic of glioblastomas: detection of an extracellular fragment of protein tyrosine phosphatase mu
    Susan M Burden-Gulley
    Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106 4960, USA
    Neoplasia 12:305-16. 2010
  5. ncbi request reprint PTPmu signaling via PKCdelta is instructive for retinal ganglion cell guidance
    Sonya E Ensslen
    Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106 4960, USA
    Mol Cell Neurosci 25:558-71. 2004
  6. pmc Cryo-image analysis of tumor cell migration, invasion, and dispersal in a mouse xenograft model of human glioblastoma multiforme
    Mohammed Q Qutaish
    Department of Biomedical Engineering, Case Western Reserve University, Room 319 Wickenden Bldg, 2071 Martin Luther King Jr Drive, Cleveland, OH 44106 7207, USA
    Mol Imaging Biol 14:572-83. 2012
  7. pmc E-cadherin promotes retinal ganglion cell neurite outgrowth in a protein tyrosine phosphatase-mu-dependent manner
    Samantha A Oblander
    Department of Molecular Biology and Microbiology, Case Western Reserve University, School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106 4960, USA
    Mol Cell Neurosci 34:481-92. 2007
  8. pmc Cadherin-11, a marker of the mesenchymal phenotype, regulates glioblastoma cell migration and survival in vivo
    Harpreet Kaur
    Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Mol Cancer Res 10:293-304. 2012
  9. ncbi request reprint The receptor protein-tyrosine phosphatase PTPmu interacts with IQGAP1
    Polly J Phillips-Mason
    Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4960, USA
    J Biol Chem 281:4903-10. 2006
  10. pmc Rho GTPases regulate PTPmu-mediated nasal neurite outgrowth and temporal repulsion of retinal ganglion cell neurons
    Denice L Major
    Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, OH 44106 4960, USA
    Mol Cell Neurosci 34:453-67. 2007

Collaborators

Detail Information

Publications37

  1. pmc PTPmu regulates N-cadherin-dependent neurite outgrowth
    S M Burden-Gulley
    Department of Molecular Biology and Microbiology, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106 4960, USA
    J Cell Biol 144:1323-36. 1999
    ..Together, these results suggest that PTPmu plays a dual role in the regulation of neurite outgrowth...
  2. ncbi request reprint Protein tyrosine phosphatase-mu differentially regulates neurite outgrowth of nasal and temporal neurons in the retina
    Susan M Burden-Gulley
    Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4960, USA
    J Neurosci 22:3615-27. 2002
    ..Therefore, PTPmu may specifically signal to temporal RGC axons to cease their forward growth after reaching the anterior tectum, thus allowing for subsequent innervation of deeper tectal layers...
  3. pmc Single cell molecular recognition of migrating and invading tumor cells using a targeted fluorescent probe to receptor PTPmu
    Susan M Burden-Gulley
    Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH, USA
    Int J Cancer 132:1624-32. 2013
    ....
  4. pmc A novel molecular diagnostic of glioblastomas: detection of an extracellular fragment of protein tyrosine phosphatase mu
    Susan M Burden-Gulley
    Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106 4960, USA
    Neoplasia 12:305-16. 2010
    ..Such a tool has clear translational applications and may lead to improved surgical resections and prognosis for patients with this devastating disease...
  5. ncbi request reprint PTPmu signaling via PKCdelta is instructive for retinal ganglion cell guidance
    Sonya E Ensslen
    Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106 4960, USA
    Mol Cell Neurosci 25:558-71. 2004
    ....
  6. pmc Cryo-image analysis of tumor cell migration, invasion, and dispersal in a mouse xenograft model of human glioblastoma multiforme
    Mohammed Q Qutaish
    Department of Biomedical Engineering, Case Western Reserve University, Room 319 Wickenden Bldg, 2071 Martin Luther King Jr Drive, Cleveland, OH 44106 7207, USA
    Mol Imaging Biol 14:572-83. 2012
    ....
  7. pmc E-cadherin promotes retinal ganglion cell neurite outgrowth in a protein tyrosine phosphatase-mu-dependent manner
    Samantha A Oblander
    Department of Molecular Biology and Microbiology, Case Western Reserve University, School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106 4960, USA
    Mol Cell Neurosci 34:481-92. 2007
    ..Taken together, these findings demonstrate that E-cadherin is an important adhesion molecule for chick RGC neurite outgrowth and suggest that PTPmu expression and catalytic activity are required for outgrowth on an E-cadherin substrate...
  8. pmc Cadherin-11, a marker of the mesenchymal phenotype, regulates glioblastoma cell migration and survival in vivo
    Harpreet Kaur
    Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Mol Cancer Res 10:293-304. 2012
    ..Thus, our studies suggest cadherin-11 is a viable molecular target for therapeutic intervention in GBM...
  9. ncbi request reprint The receptor protein-tyrosine phosphatase PTPmu interacts with IQGAP1
    Polly J Phillips-Mason
    Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4960, USA
    J Biol Chem 281:4903-10. 2006
    ..In support of this, we show that a peptide that competes IQGAP1 binding to Rho GTPases blocks PTPmu-mediated neurite outgrowth...
  10. pmc Rho GTPases regulate PTPmu-mediated nasal neurite outgrowth and temporal repulsion of retinal ganglion cell neurons
    Denice L Major
    Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, OH 44106 4960, USA
    Mol Cell Neurosci 34:453-67. 2007
    ..Together these data suggest that Cdc42 activity is required for both permissive and repulsive responses to PTPmu. However, the key to PTPmu-dependent repulsion is inhibition of Rac1 activity in temporal RGC neurons...
  11. doi request reprint Novel peptide mimetic small molecules of the HAV motif in N-cadherin inhibit N-cadherin-mediated neurite outgrowth and cell adhesion
    Susan M Burden-Gulley
    Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH 44106, USA
    Peptides 30:2380-7. 2009
    ..5 to 30 microM. Given the efficacy of ADH-1 for treating cancer, these small molecule antagonists will be highly effective in treatment of cancer metastasis and conditions of aberrant neurite outgrowth, such as neuropathic pain...
  12. ncbi request reprint Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth
    Jullia A Rosdahl
    Department of Molecular Biology and Microbiology, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106 4960, USA
    Mol Cell Neurosci 19:292-306. 2002
    ..These results suggest that PTPmu signaling via RACK1 requires PKCdelta activity to promote neurite outgrowth...
  13. pmc Protein tyrosine phosphatase mu regulates glioblastoma cell growth and survival in vivo
    Harpreet Kaur
    Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4960, USA
    Neuro Oncol 14:561-73. 2012
    ..c. tumor models. Inhibitors of PTPµ could be used to reduce the growth and survival of GBM cells in the brain, representing a promising therapeutic target for GBM...
  14. pmc Characterization of the adhesive properties of the type IIb subfamily receptor protein tyrosine phosphatases
    Scott Becka
    Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA
    Cell Commun Adhes 17:34-47. 2010
    ..The authors conclude from these experiments that PCP-2 is likely to have a distinct biological function other than cell-cell aggregation...
  15. pmc Distinct PTPmu-associated signaling molecules differentially regulate neurite outgrowth on E-, N-, and R-cadherin
    Samantha A Oblander
    Department of Molecular Biology and Microbiology, Case Western Reserve University, School of Medicine, Cleveland, OH 44106, USA
    Mol Cell Neurosci 44:78-93. 2010
    ..In summary, distinct PTPmicro-associated signaling proteins are required to promote neurite outgrowth on cadherins...
  16. ncbi request reprint Expression of the receptor protein-tyrosine phosphatase, PTPmu, restores E-cadherin-dependent adhesion in human prostate carcinoma cells
    Carina B Hellberg
    Department of Molecular Biology and Microbiology, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106 4960, USA
    J Biol Chem 277:11165-73. 2002
    ..Together, these studies suggest that PTPmu regulates the PKC pathway to restore E-cadherin-dependent adhesion via its interaction with RACK1...
  17. doi request reprint Stimulation of N-cadherin-dependent neurite outgrowth by small molecule peptide mimetic agonists of the N-cadherin HAV motif
    Susan M Burden-Gulley
    Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH 44106, United States
    Peptides 31:842-9. 2010
    ..Five of these agonists also stimulated retinal cell migration. These small molecule agonists may be effective reagents for promoting axon growth and remyelination after injury or disease...
  18. ncbi request reprint The receptor protein tyrosine phosphatase mu, PTPmu, regulates histogenesis of the chick retina
    Sonya E Ensslen
    Departments of Neurosciences and Molecular Biology and Microbiology, Case Western Reserve University, School of Medicine, Cleveland, OH 44106, USA
    Dev Biol 264:106-18. 2003
    ..To our knowledge, this is the first demonstration that an Ig superfamily RPTP regulates the lamination of any neural tissue...
  19. pmc PTPmu suppresses glioma cell migration and dispersal
    Adam M Burgoyne
    Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Neuro Oncol 11:767-78. 2009
    ..Together, these data suggest that loss of PTPmu in human GBMs contributes to tumor cell migration and dispersal, implicating loss of PTPmu in glioma progression...
  20. pmc Synthesis and evaluation of a peptide targeted small molecular Gd-DOTA monoamide conjugate for MR molecular imaging of prostate cancer
    Xueming Wu
    Department of Biomedical Engineering, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Bioconjug Chem 23:1548-56. 2012
    ..03 mmol Gd/kg. The peptide targeted MRI contrast agent is promising for high-resolution MR molecular imaging of prostate tumor...
  21. pmc Identification of phospholipase C gamma1 as a protein tyrosine phosphatase mu substrate that regulates cell migration
    Polly J Phillips-Mason
    Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH 44106 4960, USA
    J Cell Biochem 112:39-48. 2011
    ..These data suggest that PLCγ1 is downstream of PTPµ and that dephosphorylation of PLCγ1 is likely to be a major pathway through which PTPµ suppresses glioma cell migration...
  22. pmc Novel cryo-imaging of the glioma tumor microenvironment reveals migration and dispersal pathways in vivid three-dimensional detail
    Susan M Burden-Gulley
    Department of Molecular Biology and Microbiology, Biomedical Engineering, Neuroscience, NFCR Center for Molecular Imaging, and Radiology, Case Western Reserve University, Cleveland, Ohio, USA
    Cancer Res 71:5932-40. 2011
    ..This novel cryo-imaging technique provides a valuable tool to evaluate therapeutic interventions targeted at limiting tumor cell invasion and dispersal...
  23. pmc Cancer-derived mutations in the fibronectin III repeats of PTPRT/PTPrho inhibit cell-cell aggregation
    Peng Zhang
    Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Cell Commun Adhes 16:146-53. 2009
    ..These results further support the hypothesis that mutational inactivation of PTPrho may lead to cancer progression by disrupting cell-cell adhesion...
  24. ncbi request reprint PTP mu expression and catalytic activity are required for PTP mu-mediated neurite outgrowth and repulsion
    Sonya E Ensslen-Craig
    Department of Neurosciences, Case Western Reserve University, School of Medicine, Cleveland, OH 44106 7960, USA
    Mol Cell Neurosci 28:177-88. 2005
    ..In summary, these data demonstrate that PTP mu expression and catalytic activity are important in vertebrate axon guidance...
  25. pmc BCCIP associates with the receptor protein tyrosine phosphatase PTPmu
    Polly J Phillips-Mason
    Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4960, USA
    J Cell Biochem 105:1059-72. 2008
    ..Furthermore, we show that BCCIP is required for both the permissive and repulsive functions of PTPmu in neurite outgrowth assays, suggesting BCCIP and PTPmu are in a common signal transduction pathway...
  26. ncbi request reprint PTP mu-dependent growth cone rearrangement is regulated by Cdc42
    Jullia A Rosdahl
    Department of Molecular and Microbiology, Case Western Reserve University, School of Medicine, 10900 Euclid Ave, Cleveland, Ohio 44106 4960, USA
    J Neurobiol 56:199-208. 2003
    ....
  27. pmc Mapping the mechanome of live stem cells using a novel method to measure local strain fields in situ at the fluid-cell interface
    Min Jae Song
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS ONE 7:e43601. 2012
    ..The method presented here provides a novel means to probe the live stem cell's mechanome, enabling mechanistic studies of the role of mechanics in lineage commitment as it unfolds...
  28. doi request reprint MR molecular imaging of prostate cancer with a peptide-targeted contrast agent in a mouse orthotopic prostate cancer model
    Mingqian Tan
    Department of Biomedical Engineering, Case Western Reserve University, Wickenden Building, Room 427, 10900 Euclid Avenue, Cleveland, Ohio 44106 7207, USA
    Pharm Res 29:953-60. 2012
    ..To study the effectiveness of a peptide targeted nanoglobular Gd-DOTA complexes for MR molecular imaging of prostate cancer in a mouse orthotopic PC-3 prostate cancer model...
  29. pmc Tumor-derived extracellular fragments of receptor protein tyrosine phosphatases (RPTPs) as cancer molecular diagnostic tools
    Sonya E L Craig
    Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH 44106 4960, USA
    Anticancer Agents Med Chem 11:133-40. 2011
    ....
  30. pmc Cancer cells cut homophilic cell adhesion molecules and run
    Sonya E L Craig
    Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio 44106 4960, USA
    Cancer Res 71:303-9. 2011
    ..The study of cell-cell CAM cleavage will provide important and novel means of diagnosing, imaging, and treating tumor progression...
  31. pmc Proteolytic cleavage of protein tyrosine phosphatase mu regulates glioblastoma cell migration
    Adam M Burgoyne
    Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4960, USA
    Cancer Res 69:6960-8. 2009
    ..These data suggest that loss of cell surface PTPmu by proteolysis generates catalytically active PTPmu fragments that contribute to migration and survival of glioblastoma cells...
  32. ncbi request reprint Receptor protein tyrosine phosphatases regulate neural development and axon guidance
    Sonya E Ensslen-Craig
    Department of Neurosciences, Case Western Reserve University, School of Medicine, Cleveland, OH 44106 4960, USA
    Dev Biol 275:12-22. 2004
    ..This review focuses on the role of RPTPs in development of the nervous system in processes such as axon guidance, synapse formation, and neural tissue morphogenesis...
  33. ncbi request reprint Modulation of Rho GTPase activity alleviates chondroitin sulfate proteoglycan-dependent inhibition of neurite extension
    Anjana Jain
    Biomaterials, Cell and Tissue Engineering Laboratory, Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA
    J Neurosci Res 77:299-307. 2004
    ..Therefore, activation of Cdc42 and Rac, as well as inhibition of Rho, helps overcome the CSPG-dependent inhibition of neurite extension...
  34. pmc Molecular Magnetic Resonance Imaging of Tumors with a PTPµ Targeted Contrast Agent
    Susan M Burden-Gulley
    Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, OH
    Transl Oncol 6:329-37. 2013
    ..Consequently, the SBK2 probe may be more useful than the current gold standard reagent for MRI to identify tumors and to co-register tumor borders during surgical resection...
  35. pmc Tumor-derived extracellular mutations of PTPRT /PTPrho are defective in cell adhesion
    Jianshi Yu
    Department of Genetics and Case Comprehensive Cancer Center, Case Western Reserve University, Euclid Avenue, Cleveland, OH 44106, USA
    Mol Cancer Res 6:1106-13. 2008
    ..Our results suggest that PTPrho may play an important role in cell-cell adhesion and that mutational inactivation of this phosphatase could promote tumor migration and metastasis...
  36. pmc alpha3beta1 integrin-CD151, a component of the cadherin-catenin complex, regulates PTPmu expression and cell-cell adhesion
    Nibedita Chattopadhyay
    Division of Nephrology, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 163:1351-62. 2003
    ..These findings demonstrate how integrin-based signaling can regulate complex biological responses at multiple levels to determine cell morphology and behavior...
  37. ncbi request reprint Protein-tyrosine phosphatase (PTP) wedge domain peptides: a novel approach for inhibition of PTP function and augmentation of protein-tyrosine kinase function
    Youmei Xie
    Department of Neurology, University of North Carolina, Chapel Hill, NC 27599, USA
    J Biol Chem 281:16482-92. 2006
    ..PTP wedge domain peptides provide a unique PTP inhibition strategy and offer a novel approach for augmenting PTK function...