Henry W Boom

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. pmc Modulation of pulmonary dendritic cell function during mycobacterial infection
    Mursalin M Anis
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106 4984, USA
    Infect Immun 76:671-7. 2008
  2. pmc TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis
    Michael G Drage
    Department of Pathology, Case Western Reserve University School of Medicine University Hospitals Case Medical Center, Cleveland, OH 44106, USA
    Cell Immunol 258:29-37. 2009
  3. pmc Rhomboid homologs in mycobacteria: insights from phylogeny and genomic analysis
    David P Kateete
    Department of Medical Microbiology, School of Biomedical Sciences, Makerere University College of Health Sciences, Kampala, Uganda
    BMC Microbiol 10:272. 2010
  4. pmc New TB vaccines: is there a requirement for CD8 T cells?
    W Henry Boom
    Tuberculosis Research Unit, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio 44106 4984, USA
    J Clin Invest 117:2092-4. 2007
  5. ncbi request reprint Alternate class I MHC antigen processing is inhibited by Toll-like receptor signaling pathogen-associated molecular patterns: Mycobacterium tuberculosis 19-kDa lipoprotein, CpG DNA, and lipopolysaccharide
    Aaron A R Tobian
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    J Immunol 171:1413-22. 2003
  6. pmc Prolonged toll-like receptor signaling by Mycobacterium tuberculosis and its 19-kilodalton lipoprotein inhibits gamma interferon-induced regulation of selected genes in macrophages
    Rish K Pai
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106 4943, USA
    Infect Immun 72:6603-14. 2004
  7. pmc Mycobacterium tuberculosis and TLR2 agonists inhibit induction of type I IFN and class I MHC antigen cross processing by TLR9
    Daimon P Simmons
    Department of Pathology, Case Western Reserve University University Hospitals Case Medical Center, Cleveland, OH 44106, USA
    J Immunol 185:2405-15. 2010
  8. pmc Mycobacterium tuberculosis synergizes with ATP to induce release of microvesicles and exosomes containing major histocompatibility complex class II molecules capable of antigen presentation
    Lakshmi Ramachandra
    Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106 4943, USA
    Infect Immun 78:5116-25. 2010
  9. pmc Tuberculosis treatment in HIV infected Ugandans with CD4 counts>350 cells/mm reduces immune activation with no effect on HIV load or CD4 count
    C Scott Mahan
    Tuberculosis Research Unit, Case Western Reserve University School of Medicine, and University Hospitals Case Medical Center, Cleveland, Ohio, United States of America
    PLoS ONE 5:e9138. 2010
  10. pmc Mycobacterium bovis BCG decreases MHC-II expression in vivo on murine lung macrophages and dendritic cells during aerosol infection
    Nicole D Pecora
    Department of Pathology, Case Western Reserve University, Wolstein 6534, 10900 Euclid Avenue, Cleveland, OH 44106 7288, USA
    Cell Immunol 254:94-104. 2009

Collaborators

Detail Information

Publications46

  1. pmc Modulation of pulmonary dendritic cell function during mycobacterial infection
    Mursalin M Anis
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106 4984, USA
    Infect Immun 76:671-7. 2008
    ..These findings suggest that during BCG infection, the inflammation and sustained expression of CCL19 result in the recruitment, activation, and retention in the lung of DCs that can activate naïve CD4(+) T cells in situ...
  2. pmc TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis
    Michael G Drage
    Department of Pathology, Case Western Reserve University School of Medicine University Hospitals Case Medical Center, Cleveland, OH 44106, USA
    Cell Immunol 258:29-37. 2009
    ..Thus, lung APC subsets differ in TLR expression, which may determine differences in responses to Mtb...
  3. pmc Rhomboid homologs in mycobacteria: insights from phylogeny and genomic analysis
    David P Kateete
    Department of Medical Microbiology, School of Biomedical Sciences, Makerere University College of Health Sciences, Kampala, Uganda
    BMC Microbiol 10:272. 2010
    ..We report detailed phylogenetic and genomic analyses devoted to prokaryotic rhomboids of an important genus, Mycobacterium...
  4. pmc New TB vaccines: is there a requirement for CD8 T cells?
    W Henry Boom
    Tuberculosis Research Unit, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio 44106 4984, USA
    J Clin Invest 117:2092-4. 2007
    ..M. tuberculosis genetically modified to induce apoptosis is shown to be more effective in priming CD8(+) T cells in vivo and therefore may be a more effective vaccine against tuberculosis than the currently utilized M. bovis BCG vaccine...
  5. ncbi request reprint Alternate class I MHC antigen processing is inhibited by Toll-like receptor signaling pathogen-associated molecular patterns: Mycobacterium tuberculosis 19-kDa lipoprotein, CpG DNA, and lipopolysaccharide
    Aaron A R Tobian
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    J Immunol 171:1413-22. 2003
    ..g., MTB, may immunologically silence macrophages and evade surveillance by both CD4(+) and CD8(+) T cells, promoting chronic infection...
  6. pmc Prolonged toll-like receptor signaling by Mycobacterium tuberculosis and its 19-kilodalton lipoprotein inhibits gamma interferon-induced regulation of selected genes in macrophages
    Rish K Pai
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106 4943, USA
    Infect Immun 72:6603-14. 2004
    ..tuberculosis inhibits certain macrophage responses to IFN-gamma, particularly those related to MHC-II Ag presentation. This inhibition may promote M. tuberculosis evasion of T-cell responses and persistence of infection in tuberculosis...
  7. pmc Mycobacterium tuberculosis and TLR2 agonists inhibit induction of type I IFN and class I MHC antigen cross processing by TLR9
    Daimon P Simmons
    Department of Pathology, Case Western Reserve University University Hospitals Case Medical Center, Cleveland, OH 44106, USA
    J Immunol 185:2405-15. 2010
    ..tuberculosis. However, downregulation of certain TLR responses may benefit the host by preventing detrimental excessive inflammation that may occur in the presence of persistent infection...
  8. pmc Mycobacterium tuberculosis synergizes with ATP to induce release of microvesicles and exosomes containing major histocompatibility complex class II molecules capable of antigen presentation
    Lakshmi Ramachandra
    Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106 4943, USA
    Infect Immun 78:5116-25. 2010
    ..Thus, infection with M. tuberculosis primes macrophages for the increased release of exosomes and microvesicles bearing M. tuberculosis peptide-MHC-II complexes that may generate antimicrobial T-cell responses...
  9. pmc Tuberculosis treatment in HIV infected Ugandans with CD4 counts>350 cells/mm reduces immune activation with no effect on HIV load or CD4 count
    C Scott Mahan
    Tuberculosis Research Unit, Case Western Reserve University School of Medicine, and University Hospitals Case Medical Center, Cleveland, Ohio, United States of America
    PLoS ONE 5:e9138. 2010
    ..Immune activation in HIV is associated with progression to AIDS. Prior studies, focusing on persons with advanced HIV, have shown no decline in markers of cellular activation in response to TB therapy alone...
  10. pmc Mycobacterium bovis BCG decreases MHC-II expression in vivo on murine lung macrophages and dendritic cells during aerosol infection
    Nicole D Pecora
    Department of Pathology, Case Western Reserve University, Wolstein 6534, 10900 Euclid Avenue, Cleveland, OH 44106 7288, USA
    Cell Immunol 254:94-104. 2009
    ..Thus, lung APCs that harbor mycobacteria in vivo have decreased MHC-II expression relative to uninfected APCs from the same lung, possibly contributing to evasion of T cell responses...
  11. ncbi request reprint Mycobacterium tuberculosis 19-kDa lipoprotein inhibits IFN-gamma-induced chromatin remodeling of MHC2TA by TLR2 and MAPK signaling
    Meghan E Pennini
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    J Immunol 176:4323-30. 2006
    ..Chromatin remodeling at MHC2TA is a novel target of inhibition by Mtb. These mechanisms may diminish class II MHC expression by infected macrophages, contributing to immune evasion by Mtb...
  12. ncbi request reprint Linkage and association analysis of candidate genes for TB and TNFalpha cytokine expression: evidence for association with IFNGR1, IL-10, and TNF receptor 1 genes
    Catherine M Stein
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Wolstein Research Building Room 1303, 2103 Cornell Rd, Cleveland, OH 44106, USA
    Hum Genet 121:663-73. 2007
    ..This study further illustrates the utility of such a model for disentangling complex traits...
  13. ncbi request reprint Bacterial heat shock proteins promote CD91-dependent class I MHC cross-presentation of chaperoned peptide to CD8+ T cells by cytosolic mechanisms in dendritic cells versus vacuolar mechanisms in macrophages
    Aaron A R Tobian
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    J Immunol 172:5277-86. 2004
    ..Prokaryotic HSPs are a potential source of microbial peptide Ags during phagocytic processing of bacteria during infection and could potentially be incorporated in vaccines to enhance presentation of peptides to CD8(+) T cells...
  14. ncbi request reprint Mycobacterium tuberculosis LprA is a lipoprotein agonist of TLR2 that regulates innate immunity and APC function
    Nicole D Pecora
    Department of Pathology, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH 44106 7288, USA
    J Immunol 177:422-9. 2006
    ..Thus, Mtb LprA is a TLR2 agonist that induces cytokine responses and regulates APC function...
  15. pmc Effects of antiretroviral therapy on immune function of HIV-infected adults with pulmonary tuberculosis and CD4+ >350 cells/mm3
    Christina L Lancioni
    Division of Pediatric Infectious Disease, Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    J Infect Dis 203:992-1001. 2011
    ..We compared changes in T cell activation and function between patients receiving concurrent treatment for HIV-tuberculosis coinfection and those receiving treatment for tuberculosis alone...
  16. pmc CCAAT/enhancer-binding protein beta and delta binding to CIITA promoters is associated with the inhibition of CIITA expression in response to Mycobacterium tuberculosis 19-kDa lipoprotein
    Meghan E Pennini
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    J Immunol 179:6910-8. 2007
    ....
  17. pmc Modulation of naive CD4+ T-cell responses to an airway antigen during pulmonary mycobacterial infection
    Mursalin M Anis
    Department of Pathology, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106 4984, USA
    Infect Immun 75:2260-8. 2007
    ....
  18. pmc Genome scan of M. tuberculosis infection and disease in Ugandans
    Catherine M Stein
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA
    PLoS ONE 3:e4094. 2008
    ..Many of the genetic factors for each of these stages are part of the innate immune system...
  19. pmc Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) binds triacylated glycolipid agonists of Toll-like receptor 2
    Michael G Drage
    Department of Pathology, Case Western Reserve University University Hospitals Case Medical Center, Cleveland, Ohio, USA
    Nat Struct Mol Biol 17:1088-95. 2010
    ..In conclusion, we demonstrate a glycolipid binding function of LprG that enhances recognition of triacylated MTB glycolipids by TLR2 and may affect glycolipid assembly or transport for bacterial cell wall biogenesis...
  20. pmc Mycobacterium tuberculosis lipoproteins directly regulate human memory CD4(+) T cell activation via Toll-like receptors 1 and 2
    Christina L Lancioni
    Department of Pediatrics, Case Western Reserve School of Medicine, Cleveland, Ohio 44106, USA
    Infect Immun 79:663-73. 2011
    ....
  21. pmc Role of phagosomes and major histocompatibility complex class II (MHC-II) compartment in MHC-II antigen processing of Mycobacterium tuberculosis in human macrophages
    Martha Torres
    Division of Infectious Diseases, Dept of Pediatrics, Rainbow Babies and Children s Hospital, Rm 4007, 2101 Adelbert Rd, Cleveland, OH 44106 6008, USA
    Infect Immun 74:1621-30. 2006
    ..Thus, M. tuberculosis phagosomes with high levels of MHC-II and LAMP-1 and MIIC both have the potential to form peptide-MHC-II complexes from M. tuberculosis antigens in human macrophages...
  22. pmc The Mycobacterium tuberculosis 19-kilodalton lipoprotein inhibits gamma interferon-regulated HLA-DR and Fc gamma R1 on human macrophages through Toll-like receptor 2
    Adam J Gehring
    Department of Pathology, Division of Infectious Disease, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio 44106 4984, USA
    Infect Immun 71:4487-97. 2003
    ..These findings provide a mechanism for M. tuberculosis persistence in macrophages...
  23. doi request reprint Class II MHC antigen processing in phagosomes
    Lakshmi Ramachandra
    Department of Pediatrics, Division of Infectious Diseases, Case Western Reserve University and Rainbow Babies and Children s Hospital University, Cleveland, OH, USA
    Methods Mol Biol 445:353-77. 2008
    ..Using these techniques, we have demonstrated that phagosomes containing latex beads or Mycobacterium tuberculosis (MTB) contain components of the MHC II processing pathway and support the formation of peptide-MHC II complexes...
  24. pmc Immune correlates of acute Mycobacterium tuberculosis infection in household contacts in Kampala, Uganda
    Christopher C Whalen
    Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Am J Trop Med Hyg 75:55-61. 2006
    ....
  25. pmc Phagosomal processing of Mycobacterium tuberculosis antigen 85B is modulated independently of mycobacterial viability and phagosome maturation
    Lakshmi Ramachandra
    Department of Pediatrics, Case Western Reserve University and Rainbow Babies and Children s Hospital, Room 4007, 11100 Euclid Avenue, Cleveland, OH 44106 6008B, USA
    Infect Immun 73:1097-105. 2005
    ..tuberculosis. These findings suggest that the mechanisms used by M. tuberculosis to inhibit phagosomal maturation differ from the mechanisms involved in modulating phagosome Ag processing...
  26. pmc CD4+ CD25(high) Foxp3+ regulatory T cells downregulate human Vdelta2+ T-lymphocyte function triggered by anti-CD3 or phosphoantigen
    C Scott Mahan
    Department of Medicine, Division of Infectious Diseases, MetroHealth Medical Center, MetroHealth Drive, Cleveland, OH 44109, USA
    Immunology 127:398-407. 2009
    ..Our study provides evidence that Tregs suppress both anti-CD3 and antigen-driven Vdelta2+ T-cell activation. Antigen-specific Tregs may therefore contribute to the Vdelta2+ T-cell functional deficiencies observed in TB...
  27. pmc Mycobacterium tuberculosis cell wall glycolipids directly inhibit CD4+ T-cell activation by interfering with proximal T-cell-receptor signaling
    Robert N Mahon
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University and University Hospitals, Case Medical Center, 10900 Euclid Avenue, BRB 1010B, Cleveland, OH 44106 4984, USA
    Infect Immun 77:4574-83. 2009
    ..ZAP-70 phosphorylation was decreased in the presence of M. tuberculosis glycolipids, indicating that M. tuberculosis glycolipids directly inhibited CD4(+) T-cell activation by interfering with proximal T-cell-receptor signaling...
  28. pmc Regulation of antigen presentation by Mycobacterium tuberculosis: a role for Toll-like receptors
    Clifford V Harding
    Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106 7288, USA
    Nat Rev Microbiol 8:296-307. 2010
    ..tuberculosis has subverted to create a niche for survival in infected macrophages and evasion of recognition by CD4(+) T cells...
  29. pmc Interferon-alphabeta mediates partial control of early pulmonary Mycobacterium bovis bacillus Calmette-Guérin infection
    John Kuchtey
    Institute of Pathology, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio 44106 4984, USA
    Immunology 118:39-49. 2006
    ..These findings suggest that IFN-alphabeta contributes to innate immunity to pulmonary mycobacterial infection by augmenting production of nitric oxide...
  30. ncbi request reprint T-cell hybridomas from HLA-transgenic mice as tools for analysis of human antigen processing
    David H Canaday
    Division of Infectious Disease, Case Western Reserve University and University Hospitals, Cleveland, OH 44106 4984, USA
    J Immunol Methods 281:129-42. 2003
    ..T hybridomas restricted by human MHC represent convenient and powerful tools for the study of antigen processing by human APC...
  31. pmc Genetic susceptibility to tuberculosis associated with cathepsin Z haplotype in a Ugandan household contact study
    Allison R Baker
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA
    Hum Immunol 72:426-30. 2011
    ..05). Haplotype analyses identified a significant risk haplotype in cathepsin X (CTSZ; p = 0.0281, odds ratio = 1.5493, 95% confidence interval [1.039, 2.320])...
  32. pmc Shortening treatment in adults with noncavitary tuberculosis and 2-month culture conversion
    John L Johnson
    Tuberculosis Research Unit, Department of Medicine, Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, Ohio 44106 5083, USA
    Am J Respir Crit Care Med 180:558-63. 2009
    ..Cavitary disease and delayed culture conversion have been associated with relapse. Combining patient characteristics and measures of bacteriologic response might allow treatment shortening with current drugs in some patients...
  33. ncbi request reprint Randomized trial of adjunctive interleukin-2 in adults with pulmonary tuberculosis
    John L Johnson
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Room E 202, Tuberculosis Research Unit, 10900 Euclid Avenue, Cleveland, OH 44106 4984, USA
    Am J Respir Crit Care Med 168:185-91. 2003
    ..One patient in each arm relapsed. IL-2 did not enhance bacillary clearance or improvement in symptoms in human immunodeficiency virus-seronegative adults with drug-susceptible tuberculosis...
  34. ncbi request reprint Inhibition of IFN-gamma-induced class II transactivator expression by a 19-kDa lipoprotein from Mycobacterium tuberculosis: a potential mechanism for immune evasion
    Rish K Pai
    Department of Pathology, Division of Infectious Diseases and Tuberculosis Research Unit, Case Western Reserve University and University of Hospitals of Cleveland, Cleveland, OH 44106, USA
    J Immunol 171:175-84. 2003
    ..Inhibition of IFN-gamma-induced CIITA by MTB 19-kDa lipoprotein may allow MTB to evade detection by CD4(+) T cells...
  35. ncbi request reprint Evidence for a major gene influence on tumor necrosis factor-alpha expression in tuberculosis: path and segregation analysis
    Catherine M Stein
    Department of Epidemiology and Biostatistics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Hum Hered 60:109-18. 2005
    ..Furthermore, these studies have not accounted for the influence of shared environment within households on TB risk, which may spuriously inflate estimates of heritability...
  36. ncbi request reprint Regulation of class II MHC expression in APCs: roles of types I, III, and IV class II transactivator
    Rish K Pai
    Department of Pathology and Division of Infectious Disease, Case Western Reserve University, Cleveland, OH 44106, USA
    J Immunol 169:1326-33. 2002
    ..CIITA types differ in regulation in various APCs under different stimuli, and the predominant type of CIITA varies at different stages of APC activation...
  37. pmc ATP and control of intracellular growth of mycobacteria by T cells
    David H Canaday
    Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, Ohio 44109, USA
    Infect Immun 70:6456-9. 2002
    ..Whether T cells can produce sufficient ATP is unknown. CD4(+) and CD8(+) T cells did not release sufficient ATP through either degranulation or lysis of bystander cells to restrict growth of Mycobacterium bovis BCG in monocytes...
  38. pmc Phosphoantigen presentation by macrophages to mycobacterium tuberculosis--reactive Vgamma9Vdelta2+ T cells: modulation by chloroquine
    Roxana E Rojas
    Department of Medicine, Case Western Reserve University and University Hospitals of Cleveland, Ohio 44106, USA
    Infect Immun 70:4019-27. 2002
    ..Chloroquine, by inhibiting membrane traffic, may increase association and retention of phosphoantigens with cell surface membrane molecules on macrophages...
  39. pmc Mycobacteria lacking the RD1 region do not induce necrosis in the lungs of mice lacking interferon-gamma
    Ana Paula Junqueira-Kipnis
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Immunology 119:224-31. 2006
    ..These data support the hypothesis that proteins encoded in the RD1 region are a major cause of necrosis and contribute significantly to the pathogenesis of the disease...
  40. pmc Inhibition of major histocompatibility complex II expression and antigen processing in murine alveolar macrophages by Mycobacterium bovis BCG and the 19-kilodalton mycobacterial lipoprotein
    Scott A Fulton
    Division of Infectious Diseases Institute of Pathology, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio 44106 4984
    Infect Immun 72:2101-10. 2004
    ..Thus, susceptibility to tuberculosis may result from the ability of mycobacteria to interfere with MHC-II expression and antigen presentation by alveolar macrophages...
  41. pmc Vdelta2+ gammadelta T cell function in Mycobacterium tuberculosis- and HIV-1-positive patients in the United States and Uganda: application of a whole-blood assay
    Roxana E Rojas
    Department of Medicine, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, OH 44106, USA
    J Infect Dis 192:1806-14. 2005
    ..Vdelta 2(+) T cells recognize phosphoantigens, such as bromohydrin pyrophosphate (BrHPP), and link innate and adaptive immunity...
  42. ncbi request reprint Phosphatidylinositol mannoside from Mycobacterium tuberculosis binds alpha5beta1 integrin (VLA-5) on CD4+ T cells and induces adhesion to fibronectin
    Roxana E Rojas
    Department of Medicine, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, OH 44106, USA
    J Immunol 177:2959-68. 2006
    ..This is the first report of direct binding of a M. tuberculosis molecule to a receptor on human T cells resulting in a change in CD4+ T cell function...
  43. ncbi request reprint Mycobacterium tuberculosis LprG (Rv1411c): a novel TLR-2 ligand that inhibits human macrophage class II MHC antigen processing
    Adam J Gehring
    Division of Infectious Diseases, Case Western Reserve University and University Hospitals of Cleveland, OH 44106, USA
    J Immunol 173:2660-8. 2004
    ..Inhibition of MHC-II Ag processing by mycobacterial lipoproteins may allow M. tuberculosis, within infected macrophages, to avoid recognition by CD4(+) T cells...
  44. pmc Cavitary disease and quantitative sputum bacillary load in cases of pulmonary tuberculosis
    Moises Palaci
    Núcleo de Doenças Infecciosas Centro de Ciências da Saúde, Universidade Federal do Espirito Santo, Av Marechal Campos, 1468 Maruipe, Vitoria, Brazil
    J Clin Microbiol 45:4064-6. 2007
    ..Patients with cavitary disease had higher CFU levels than those without cavities and shorter DTPs. Within radiographic strata of moderately and far advanced tuberculosis, higher CFU counts were associated with cavitary disease...
  45. pmc Population pharmacokinetics of levofloxacin, gatifloxacin, and moxifloxacin in adults with pulmonary tuberculosis
    Charles A Peloquin
    Infectious Disease Pharmacokinetics Laboratory, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Antimicrob Agents Chemother 52:852-7. 2008
    ..All three quinolones showed favorable pharmacokinetic and pharmacodynamic indices, with the most favorable results in this population being seen with levofloxacin at the comparative doses used...
  46. pmc Sputum cytokine levels in patients with pulmonary tuberculosis as early markers of mycobacterial clearance
    Rodrigo Ribeiro-Rodrigues
    Universidade Federal do Espirito Santo, Núcleo Doenças Infecciosas, Vitoria, ES, Brazil
    Clin Diagn Lab Immunol 9:818-23. 2002
    ..These data indicate that sputum cytokines correlate with disease activity during active TB of the lung and may serve as potential early markers for sputum conversion and response to anti-TB therapy...

Research Grants40

  1. M. TUBERCULOSIS INFECTION IN THE LUNG
    W Boom; Fiscal Year: 2009
    ....
  2. PULMONARY PATHOGEN DEFENSE MECHANISMS
    W Boom; Fiscal Year: 2007
    ..abstract_text> ..
  3. Heterogeneity of T-cells in M. tuberculosis Infection
    W Boom; Fiscal Year: 2006
    ....
  4. M. TUBERCULOSIS INFECTION IN THE LUNG
    W Boom; Fiscal Year: 2005
    ..Aim 3: To determine the ability of chemokines, CpG and cholera toxin to enhance innate and acquired immune defenses to M. bovis-BCG and M. Tuberculosis within lung. ..
  5. M. TUBERCULOSIS INFECTION IN THE LUNG
    W Boom; Fiscal Year: 2007
    ....
  6. Heterogeneity of T-cells in M. tuberculosis Infection
    W Boom; Fiscal Year: 2007
    ..These studies will provide insight into how MTB can regulate T cell responses to mycobacterial antigens. ..
  7. Heterogeneity of T-cells in M. tuberculosis Infection
    W Boom; Fiscal Year: 2009
    ..These studies will provide insight into how MTB can regulate T cell responses to mycobacterial antigens. ..
  8. Heterogeneity of T-cells in M. tuberculosis Infection
    HENRY BOOM; Fiscal Year: 2010
    ..These studies will provide insight into how MTB can regulate T cell responses to mycobacterial antigens. ..
  9. M. TUBERCULOSIS INFECTION IN THE LUNG
    HENRY BOOM; Fiscal Year: 2010
    ....
  10. Heterogeneity of T-cells in M. tuberculosis Infection
    W Boom; Fiscal Year: 2009
    ..These studies will provide insight into how MTB can regulate T cell responses to mycobacterial antigens. ..
  11. PULMONARY PATHOGEN DEFENSE MECHANISMS
    W Boom; Fiscal Year: 2007
    ..abstract_text> ..
  12. HETEROGENEITY OF T CELLS IN M TUBERCULOSIS INFECTION
    W Boom; Fiscal Year: 2001
    ..These studies will provide insight into the regulation of human T cell subsets involved in protective immunity to M. tuberculosis, which is necessary for the design of improved vaccines, and immunotherapies for tuberculosis. ..
  13. MYCOBACTERIUM TUBERCULOSIS INFECTION IN THE LUNG
    W Boom; Fiscal Year: 1999
    ..Such information will not only increase our understanding of the host-pathogen relationship in tuberculosis but also is necessary for the design of vaccines and immunotherapeutic interventions for tuberculosis. ..
  14. HETEROGENEITY OF T CELLS IN M TUBERCULOSIS INFECTION
    W Boom; Fiscal Year: 1993
    ..tuberculosis. An understanding of the T cell response to this pathogen will contribute to the design of improved methods of prevention and diagnosis of tuberculosis. This is a health related project...
  15. CD4+ T-CELLS HETEROGENEITY IN M TUBERCULOSIS INFECTION
    W Boom; Fiscal Year: 1991
    ..tuberculosis, which is a major cause of morbidity and mortality worldwide. These studies are therefore, directly healthy-related...
  16. Proteogenomics of dysregulated protein interaction networks in MTB infection
    Mark R Chance; Fiscal Year: 2010
    ....