Cynthia M Beall

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. pmc The genetic architecture of adaptations to high altitude in Ethiopia
    Gorka Alkorta-Aranburu
    Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America
    PLoS Genet 8:e1003110. 2012
  2. pmc Nitric oxide in adaptation to altitude
    Cynthia M Beall
    Department of Anthropology, Case Western Reserve University, Cleveland, OH 44106, USA
    Free Radic Biol Med 52:1123-34. 2012
  3. pmc Two routes to functional adaptation: Tibetan and Andean high-altitude natives
    Cynthia M Beall
    Department of Anthropology, Case Western Reserve University, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 104:8655-60. 2007
  4. ncbi request reprint Detecting natural selection in high-altitude human populations
    Cynthia M Beall
    Case Western Reserve University, Department of Anthropology, Cleveland, OH 44106 7125, United States
    Respir Physiol Neurobiol 158:161-71. 2007
  5. ncbi request reprint Nitric oxide and cardiopulmonary hemodynamics in Tibetan highlanders
    Brian D Hoit
    Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, OH 44106 5038, USA
    J Appl Physiol (1985) 99:1796-801. 2005
  6. pmc Elevated pulmonary artery pressure among Amhara highlanders in Ethiopia
    Brian D Hoit
    Department of Medicine, Case Western Reserve University, Cleveland, OH 44106 7125, USA
    Am J Hum Biol 23:168-76. 2011
  7. pmc Adaptations to climate-mediated selective pressures in humans
    Angela M Hancock
    Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America
    PLoS Genet 7:e1001375. 2011
  8. ncbi request reprint High-altitude adaptations
    Cynthia M Beall
    Department of Anthropology, Case Western Reserve University, Cleveland, OH 44106 7125, USA
    Lancet 362:s14-5. 2003
  9. pmc An Ethiopian pattern of human adaptation to high-altitude hypoxia
    Cynthia M Beall
    Department of Anthropology, Case Western Reserve University, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 99:17215-8. 2002
  10. pmc Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders
    Cynthia M Beall
    Department of Anthropology, Case Western Reserve University, Cleveland, OH 44106 7125, USA
    Proc Natl Acad Sci U S A 107:11459-64. 2010

Collaborators

Detail Information

Publications14

  1. pmc The genetic architecture of adaptations to high altitude in Ethiopia
    Gorka Alkorta-Aranburu
    Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America
    PLoS Genet 8:e1003110. 2012
    ..Finally, a comparison of CpG methylation levels between high- and lowlanders found several significant signals at individual genes in the Oromo...
  2. pmc Nitric oxide in adaptation to altitude
    Cynthia M Beall
    Department of Anthropology, Case Western Reserve University, Cleveland, OH 44106, USA
    Free Radic Biol Med 52:1123-34. 2012
    ..Gains in understanding will require integrating appropriate methods and measurement techniques with indicators of adaptive function under hypoxic stress...
  3. pmc Two routes to functional adaptation: Tibetan and Andean high-altitude natives
    Cynthia M Beall
    Department of Anthropology, Case Western Reserve University, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 104:8655-60. 2007
    ..Identifying the genetic bases of these traits is crucial to discovering the steps along the Tibetan and Andean routes to functional adaptation...
  4. ncbi request reprint Detecting natural selection in high-altitude human populations
    Cynthia M Beall
    Case Western Reserve University, Department of Anthropology, Cleveland, OH 44106 7125, United States
    Respir Physiol Neurobiol 158:161-71. 2007
    ..New approaches use candidate gene and genomic analyses. Conclusive evidence about population genetic differences and associations with phenotypes remains to be discovered...
  5. ncbi request reprint Nitric oxide and cardiopulmonary hemodynamics in Tibetan highlanders
    Brian D Hoit
    Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, OH 44106 5038, USA
    J Appl Physiol (1985) 99:1796-801. 2005
    ....
  6. pmc Elevated pulmonary artery pressure among Amhara highlanders in Ethiopia
    Brian D Hoit
    Department of Medicine, Case Western Reserve University, Cleveland, OH 44106 7125, USA
    Am J Hum Biol 23:168-76. 2011
    ..The objective of this study was to identify the consequences of lifelong hypoxia exposure for the pulmonary vasculature among Amhara high-altitude natives from Ethiopia...
  7. pmc Adaptations to climate-mediated selective pressures in humans
    Angela M Hancock
    Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America
    PLoS Genet 7:e1001375. 2011
    ..Further, we find an enrichment of strong signals in gene sets related to UV radiation, infection and immunity, and cancer. Our results imply that adaptations to climate shaped the spatial distribution of variation in humans...
  8. ncbi request reprint High-altitude adaptations
    Cynthia M Beall
    Department of Anthropology, Case Western Reserve University, Cleveland, OH 44106 7125, USA
    Lancet 362:s14-5. 2003
  9. pmc An Ethiopian pattern of human adaptation to high-altitude hypoxia
    Cynthia M Beall
    Department of Anthropology, Case Western Reserve University, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 99:17215-8. 2002
    ..Thus, Ethiopian highlanders maintain venous hemoglobin concentrations and arterial oxygen saturation within the ranges of sea level populations, despite the unavoidable, universal decrease in the ambient oxygen tension at high altitude...
  10. pmc Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders
    Cynthia M Beall
    Department of Anthropology, Case Western Reserve University, Cleveland, OH 44106 7125, USA
    Proc Natl Acad Sci U S A 107:11459-64. 2010
    ..Whichever of these explanations is correct, the evidence for genetic selection at the EPAS1 locus from the GWADS study is supported by the replicated studies associating function with the allelic variants...
  11. doi request reprint Admixture facilitates genetic adaptations to high altitude in Tibet
    Choongwon Jeong
    Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA
    Nat Commun 5:3281. 2014
    ..Therefore, we identify a novel mechanism, beyond selection on new mutations or on standing variation, through which populations can adapt to local environments. ..
  12. doi request reprint Human adaptability studies at high altitude: research designs and major concepts during fifty years of discovery
    Cynthia M Beall
    Department of Anthropology, Case Western Reserve University, Cleveland, Ohio, 44106 7125
    Am J Hum Biol 25:141-7. 2013
    ..A focus is on the research that has occurred over the past 50 years of anthropological fieldwork on the Andean, Tibetan, and, to a lesser extent, the East African plateaus...
  13. pmc Higher offspring survival among Tibetan women with high oxygen saturation genotypes residing at 4,000 m
    Cynthia M Beall
    Department of Anthropology, Case Western Reserve University, 238 Mather Memorial Building, 11220 Bellflower Road, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 101:14300-4. 2004
    ....
  14. ncbi request reprint Exhaled nitric oxide decreases upon acute exposure to high-altitude hypoxia
    Daniel E Brown
    Department of Anthropology, University of Hawaii at Hilo, Hilo, HI 96720
    Am J Hum Biol 18:196-202. 2006
    ..There was no significant association between the level of NO exhaled and the number of self-reported symptoms of AMS during this brief exposure...