C M Beall

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. ncbi An Ethiopian pattern of human adaptation to high-altitude hypoxia
    Cynthia M Beall
    Department of Anthropology, Case Western Reserve University, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 99:17215-8. 2002
  2. ncbi Ventilation and hypoxic ventilatory response of Tibetan and Aymara high altitude natives
    C M Beall
    Case Western Reserve University, Cleveland, Ohio 44106 7125, USA
    Am J Phys Anthropol 104:427-47. 1997
  3. ncbi Higher offspring survival among Tibetan women with high oxygen saturation genotypes residing at 4,000 m
    Cynthia M Beall
    Department of Anthropology, Case Western Reserve University, 238 Mather Memorial Building, 11220 Bellflower Road, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 101:14300-4. 2004
  4. ncbi High-altitude adaptations
    Cynthia M Beall
    Department of Anthropology, Case Western Reserve University, Cleveland, OH 44106-7125, USA
    Lancet 362:s14-5. 2003
  5. ncbi Oxygen saturation increases during childhood and decreases during adulthood among high altitude native Tibetians residing at 3,800-4,200m
    C M Beall
    Department of Anthropology, Case Western Reserve University, Cleveland, OH 44106 7125, USA
    High Alt Med Biol 1:25-32. 2000
  6. ncbi Percent of oxygen saturation of arterial hemoglobin among Bolivian Aymara at 3,900-4,000 m
    C M Beall
    Department of Anthropology, Case Western Reserve University, Cleveland, Ohio 44106 7125, USA
    Am J Phys Anthropol 108:41-51. 1999
  7. ncbi Hemoglobin concentration of high-altitude Tibetans and Bolivian Aymara
    C M Beall
    Case Western Reserve University, Cleveland, Ohio 44106 7125, USA
    Am J Phys Anthropol 106:385-400. 1998
  8. ncbi Two routes to functional adaptation: Tibetan and Andean high-altitude natives
    Cynthia M Beall
    Department of Anthropology, Case Western Reserve University, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 104:8655-60. 2007
  9. ncbi Nitric oxide and cardiopulmonary hemodynamics in Tibetan highlanders
    Brian D Hoit
    Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, OH 44106 5038, USA
    J Appl Physiol 99:1796-801. 2005
  10. ncbi Higher blood flow and circulating NO products offset high-altitude hypoxia among Tibetans
    S C Erzurum
    Department of Pathobiology, Allergy, and Critical Care, Cleveland Clinic, Cleveland, OH 44195, USA
    Proc Natl Acad Sci U S A 104:17593-8. 2007

Collaborators

Detail Information

Publications13

  1. ncbi An Ethiopian pattern of human adaptation to high-altitude hypoxia
    Cynthia M Beall
    Department of Anthropology, Case Western Reserve University, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 99:17215-8. 2002
    ..Thus, Ethiopian highlanders maintain venous hemoglobin concentrations and arterial oxygen saturation within the ranges of sea level populations, despite the unavoidable, universal decrease in the ambient oxygen tension at high altitude...
  2. ncbi Ventilation and hypoxic ventilatory response of Tibetan and Aymara high altitude natives
    C M Beall
    Case Western Reserve University, Cleveland, Ohio 44106 7125, USA
    Am J Phys Anthropol 104:427-47. 1997
    ....
  3. ncbi Higher offspring survival among Tibetan women with high oxygen saturation genotypes residing at 4,000 m
    Cynthia M Beall
    Department of Anthropology, Case Western Reserve University, 238 Mather Memorial Building, 11220 Bellflower Road, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 101:14300-4. 2004
    ....
  4. ncbi High-altitude adaptations
    Cynthia M Beall
    Department of Anthropology, Case Western Reserve University, Cleveland, OH 44106-7125, USA
    Lancet 362:s14-5. 2003
  5. ncbi Oxygen saturation increases during childhood and decreases during adulthood among high altitude native Tibetians residing at 3,800-4,200m
    C M Beall
    Department of Anthropology, Case Western Reserve University, Cleveland, OH 44106 7125, USA
    High Alt Med Biol 1:25-32. 2000
    ..The age of onset of aging processes detrimental to oxygen transfer differed for females and males...
  6. ncbi Percent of oxygen saturation of arterial hemoglobin among Bolivian Aymara at 3,900-4,000 m
    C M Beall
    Department of Anthropology, Case Western Reserve University, Cleveland, Ohio 44106 7125, USA
    Am J Phys Anthropol 108:41-51. 1999
    ..The presence of genetic variance in SaO2 in the Tibetan sample and its absence in the Aymara sample indicate there is potential for natural selection on this trait in the Tibetan but not the Aymara population...
  7. ncbi Hemoglobin concentration of high-altitude Tibetans and Bolivian Aymara
    C M Beall
    Case Western Reserve University, Cleveland, Ohio 44106 7125, USA
    Am J Phys Anthropol 106:385-400. 1998
    ..87 in the Aymara sample). The presence of significant genetic variance means that there is the potential for natural selection and genetic adaptation of hemoglobin concentration in Tibetan and Aymara high-altitude populations...
  8. ncbi Two routes to functional adaptation: Tibetan and Andean high-altitude natives
    Cynthia M Beall
    Department of Anthropology, Case Western Reserve University, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 104:8655-60. 2007
    ..Identifying the genetic bases of these traits is crucial to discovering the steps along the Tibetan and Andean routes to functional adaptation...
  9. ncbi Nitric oxide and cardiopulmonary hemodynamics in Tibetan highlanders
    Brian D Hoit
    Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, OH 44106 5038, USA
    J Appl Physiol 99:1796-801. 2005
    ....
  10. ncbi Higher blood flow and circulating NO products offset high-altitude hypoxia among Tibetans
    S C Erzurum
    Department of Pathobiology, Allergy, and Critical Care, Cleveland Clinic, Cleveland, OH 44195, USA
    Proc Natl Acad Sci U S A 104:17593-8. 2007
    ..These findings shift attention from the traditional focus on pulmonary and hematological systems to vascular factors contributing to adaptation to high-altitude hypoxia...
  11. ncbi Detecting natural selection in high-altitude human populations
    Cynthia M Beall
    Case Western Reserve University, Department of Anthropology, Cleveland, OH 44106 7125, United States
    Respir Physiol Neurobiol 158:161-71. 2007
    ..New approaches use candidate gene and genomic analyses. Conclusive evidence about population genetic differences and associations with phenotypes remains to be discovered...
  12. ncbi Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders
    Cynthia M Beall
    Department of Anthropology, Case Western Reserve University, Cleveland, OH 44106 7125, USA
    Proc Natl Acad Sci U S A 107:11459-64. 2010
    ..Whichever of these explanations is correct, the evidence for genetic selection at the EPAS1 locus from the GWADS study is supported by the replicated studies associating function with the allelic variants...
  13. ncbi Exhaled nitric oxide decreases upon acute exposure to high-altitude hypoxia
    Daniel E Brown
    Department of Anthropology, University of Hawaii at Hilo, Hilo, HI 96720
    Am J Hum Biol 18:196-202. 2006
    ..There was no significant association between the level of NO exhaled and the number of self-reported symptoms of AMS during this brief exposure...