Jill S Barnholtz-Sloan

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. pmc Replication of GWAS "Hits" by Race for Breast and Prostate Cancers in European Americans and African Americans
    Jill S Barnholtz-Sloan
    Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine Cleveland, OH, USA
    Front Genet 2:37. 2011
  2. pmc Splitting random forest (SRF) for determining compact sets of genes that distinguish between cancer subtypes
    Xiaowei Guan
    Case Comprehensive Cancer Center, 11100 Euclid Avenue, Cleveland, OH, USA
    J Clin Bioinforma 2:13. 2012
  3. pmc A nomogram for individualized estimation of survival among patients with brain metastasis
    Jill S Barnholtz-Sloan
    Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106 5065, USA
    Neuro Oncol 14:910-8. 2012
  4. pmc Assessing the impact of global versus local ancestry in association studies
    Sun Jung Kang
    Department of Epidemiology and Biostatistics, Division of Genetic and Molecular Epidemiology, Case Western Reserve University School of Medicine, Wolstein Research Building, 2103 Cornell Road, Cleveland, Ohio 44106 USA
    BMC Proc 3:S107. 2009
  5. doi request reprint Ancestry estimation and correction for population stratification in molecular epidemiologic association studies
    Jill S Barnholtz-Sloan
    Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Cleveland, OH 44106 5065, USA
    Cancer Epidemiol Biomarkers Prev 17:471-7. 2008
  6. pmc FGFR2 and other loci identified in genome-wide association studies are associated with breast cancer in African-American and younger women
    Jill S Barnholtz-Sloan
    Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106 5065, USA
    Carcinogenesis 31:1417-23. 2010
  7. doi request reprint Incidence trends of invasive cervical cancer in the United States by combined race and ethnicity
    Jill Barnholtz-Sloan
    Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106 5065, USA
    Cancer Causes Control 20:1129-38. 2009
  8. ncbi request reprint Racial/ethnic differences in survival among elderly patients with a primary glioblastoma
    Jill S Barnholtz-Sloan
    Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Cleveland, OH 44106 5065, USA
    J Neurooncol 85:171-80. 2007
  9. ncbi request reprint Meningiomas: causes and risk factors
    Jill S Barnholtz-Sloan
    Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 5065, USA
    Neurosurg Focus 23:E2. 2007
  10. pmc Decision tree-based modeling of androgen pathway genes and prostate cancer risk
    Jill S Barnholtz-Sloan
    Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106 5065, USA
    Cancer Epidemiol Biomarkers Prev 20:1146-55. 2011

Research Grants

  1. Analysis of Ethnic Admixture in Lung Cancer
    Jill Barnholtz Sloan; Fiscal Year: 2006

Detail Information

Publications41

  1. pmc Replication of GWAS "Hits" by Race for Breast and Prostate Cancers in European Americans and African Americans
    Jill S Barnholtz-Sloan
    Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine Cleveland, OH, USA
    Front Genet 2:37. 2011
    ..We show that genetic associations by race are modified by interaction between individual SNPs and PS...
  2. pmc Splitting random forest (SRF) for determining compact sets of genes that distinguish between cancer subtypes
    Xiaowei Guan
    Case Comprehensive Cancer Center, 11100 Euclid Avenue, Cleveland, OH, USA
    J Clin Bioinforma 2:13. 2012
    ..abstract:..
  3. pmc A nomogram for individualized estimation of survival among patients with brain metastasis
    Jill S Barnholtz-Sloan
    Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106 5065, USA
    Neuro Oncol 14:910-8. 2012
    ..An estimated 24%-45% of patients with cancer develop brain metastases. Individualized estimation of survival for patients with brain metastasis could be useful for counseling patients on clinical outcomes and prognosis...
  4. pmc Assessing the impact of global versus local ancestry in association studies
    Sun Jung Kang
    Department of Epidemiology and Biostatistics, Division of Genetic and Molecular Epidemiology, Case Western Reserve University School of Medicine, Wolstein Research Building, 2103 Cornell Road, Cleveland, Ohio 44106 USA
    BMC Proc 3:S107. 2009
    ....
  5. doi request reprint Ancestry estimation and correction for population stratification in molecular epidemiologic association studies
    Jill S Barnholtz-Sloan
    Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Cleveland, OH 44106 5065, USA
    Cancer Epidemiol Biomarkers Prev 17:471-7. 2008
  6. pmc FGFR2 and other loci identified in genome-wide association studies are associated with breast cancer in African-American and younger women
    Jill S Barnholtz-Sloan
    Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106 5065, USA
    Carcinogenesis 31:1417-23. 2010
    ..Several new haplotypes were associated with breast cancer in AA and younger women, particularly the FGFR2 GTGT haplotype. These results highlight the need to conduct GWAS among younger women and in a variety of racial-ethnic populations...
  7. doi request reprint Incidence trends of invasive cervical cancer in the United States by combined race and ethnicity
    Jill Barnholtz-Sloan
    Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106 5065, USA
    Cancer Causes Control 20:1129-38. 2009
    ..To better understand national patterns of invasive cervical cancer (ICC) incidence by race and ethnicity in order to develop appropriate ICC prevention policies...
  8. ncbi request reprint Racial/ethnic differences in survival among elderly patients with a primary glioblastoma
    Jill S Barnholtz-Sloan
    Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Cleveland, OH 44106 5065, USA
    J Neurooncol 85:171-80. 2007
    ....
  9. ncbi request reprint Meningiomas: causes and risk factors
    Jill S Barnholtz-Sloan
    Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 5065, USA
    Neurosurg Focus 23:E2. 2007
    ..Gaining a better understanding of the origin of this disease is essential so that treatments and outcomes can be improved and prevention strategies can be developed...
  10. pmc Decision tree-based modeling of androgen pathway genes and prostate cancer risk
    Jill S Barnholtz-Sloan
    Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106 5065, USA
    Cancer Epidemiol Biomarkers Prev 20:1146-55. 2011
    ..e., decision trees), and to evaluate whether these interactive effects add information about prostate cancer risk prediction beyond that of "traditional" risk factors...
  11. doi request reprint Risk of subsequent primary malignancies after dermatofibrosarcoma protuberans diagnosis: a national study
    David E Kurlander
    Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Am Acad Dermatol 68:790-6. 2013
    ..Patients frequently live many years after diagnosis of dermatofibrosarcoma protuberans (DFSP)...
  12. pmc A variable age of onset segregation model for linkage analysis, with correction for ascertainment, applied to glioma
    Xiangqing Sun
    Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    Cancer Epidemiol Biomarkers Prev 21:2242-51. 2012
    ..We propose a 2-step model-based approach, with correction for ascertainment, to linkage analysis of a binary trait with variable age of onset and apply it to a set of multiplex pedigrees segregating for adult glioma...
  13. pmc Aberrant vimentin methylation is characteristic of upper gastrointestinal pathologies
    Helen Moinova
    Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Cancer Epidemiol Biomarkers Prev 21:594-600. 2012
    ..We now examine vimentin methylation in neoplasia of the upper gastrointestinal tract...
  14. pmc Variation in age at cancer diagnosis in familial versus nonfamilial Barrett's esophagus
    Amitabh Chak
    Division of Gastroenterology, University Hospitals Case Medical Center, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    Cancer Epidemiol Biomarkers Prev 21:376-83. 2012
    ..In this study, we determine whether cancers develop at an earlier age in multiplex Familial Barrett's Esophagus (FBE) kindreds, defined by 3 or more members affected by Barrett's esophagus (BE) or esophageal adenocarcinoma (EAC)...
  15. doi request reprint Risk and survival of cutaneous melanoma diagnosed subsequent to a previous cancer
    Geoffrey B Yang
    Comprehensive Cancer Center, Case Western Reserve School of Medicine, Cleveland, OH 44106, USA
    Arch Dermatol 147:1395-402. 2011
    ..To understand the risk of cutaneous melanoma (CM) following a previous cancer...
  16. pmc Molecular subtypes of glioblastoma are relevant to lower grade glioma
    Xiaowei Guan
    Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
    PLoS ONE 9:e91216. 2014
    ..The intent was to evaluate the relevance of known glioblastoma (GBM) expression and methylation based subtypes to grade II and III gliomas (ie. lower grade gliomas)...
  17. pmc Identifying stage-specific protein subnetworks for colorectal cancer
    Sinan Erten
    Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH, USA
    BMC Proc 6:S1. 2012
    ..These algorithms use protein-protein interaction (PPI) networks as an integrative framework and identify subnetworks that are coordinately dysregulated in the phenotype of interest...
  18. pmc Reproductive and hormonal risk factors for ductal carcinoma in situ of the breast
    Lynette S Phillips
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA
    Cancer Epidemiol Biomarkers Prev 18:1507-14. 2009
    ..51; 95% CI, 0.25-1.04). Our results support the theory that comedo-type DCIS may share hormonal and reproductive risk factors with IBC, whereas the etiology of non-comedo DCIS deserves further investigation...
  19. pmc Incidence patterns for primary malignant spinal cord gliomas: a Surveillance, Epidemiology, and End Results study
    Steven Hsu
    Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Neurosurg Spine 14:742-7. 2011
    ....
  20. pmc Colonic 15-PGDH levels are stable across distance and time and are not perturbed by aspirin intervention
    Stephen P Fink
    Department of Medicine, Case Western Reserve University and Case Medical Center, 10900 Euclid Ave, Wolstein Research Building, Rm 3 128, Cleveland, OH 44106 7285, USA
    Dig Dis Sci 58:2615-22. 2013
    ....
  21. pmc Gene interaction enrichment and network analysis to identify dysregulated pathways and their interactions in complex diseases
    Yu Liu
    Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, OH 44106, USA
    BMC Syst Biol 6:65. 2012
    ..However, the dynamics of the interactions with respect to disease have been less well studied (i.e., properties of components ii and iii)...
  22. pmc Family history of cancer in benign brain tumor subtypes versus gliomas
    Quinn T Ostrom
    Department of Anthropology, Case Western Reserve University Cleveland, OH, USA
    Front Oncol 2:19. 2012
    ..Conclusion: The results suggest that benign brain tumor may have an association with family history of cancer. More studies are warranted to disentangle the potential genetic and/or environmental causes for these diseases...
  23. doi request reprint Current state of our knowledge on brain tumor epidemiology
    Quinn T Ostrom
    Department of Anthropology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Curr Neurol Neurosci Rep 11:329-35. 2011
    ..Recently studies of genetic risk factors for brain tumors have expanded to genome-wide association studies. In addition, genome-wide studies of somatic genetic changes in tumors show correlation with clinical outcomes...
  24. ncbi request reprint Pediatric brain tumors in non-Hispanics, Hispanics, African Americans and Asians: differences in survival after diagnosis
    Jill S Barnholtz-Sloan
    H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, 33612, MRC CANCONT Tampa, FL 33612, USA
    Cancer Causes Control 16:587-92. 2005
    ..The objective of this study was to assess racial differences in survival of children with brain tumors, focusing on Hispanics, African Americans and Asians compared to Non-Hispanics...
  25. ncbi request reprint Informativeness of the CODIS STR loci for admixture analysis
    Jill S Barnholtz-Sloan
    H Lee Moffitt Cancer Center and Research Institute Tampa, FL 33612, USA
    J Forensic Sci 50:1322-6. 2005
    ..We conclude that the FBI CODIS Core STR set is valid for admixture analysis, but not the most precise. We recommend using a combination of the most informative markers from the HGDP-CEPH and Shriver loci sets...
  26. ncbi request reprint Incidence trends in primary malignant penile cancer
    Jill S Barnholtz-Sloan
    Division of Cancer Prevention and Control, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Urol Oncol 25:361-7. 2007
    ..To examine trends in the incidence of primary, malignant penile cancer in the United States...
  27. ncbi request reprint A population-based study of racial and ethnic differences in survival among women with invasive cervical cancer: analysis of Surveillance, Epidemiology, and End Results data
    Divya A Patel
    Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI 48201, USA
    Gynecol Oncol 97:550-8. 2005
    ....
  28. doi request reprint Patterns of care and outcomes among elderly individuals with primary malignant astrocytoma
    Jill S Barnholtz-Sloan
    H Lee Moffitt Cancer Center and Research Institute, College of Public Health, University of South Florida, Tampa, Florida, USA
    J Neurosurg 108:642-8. 2008
    ..The odds of undergoing various combinations of treatments and the associations with outcome were calculated by tumor type and age and adjusted by various predictors...
  29. ncbi request reprint Racial differences in survival after diagnosis with primary malignant brain tumor
    Jill S Barnholtz-Sloan
    Department of Internal Medicine, Division of Hematology Oncology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cancer 98:603-9. 2003
    ..The objective of this study was to examine racial differences in survival after diagnosis with primary malignant brain tumor in a population-based sample of patients while adjusting for prognostic variables that differ by race...
  30. ncbi request reprint Relative survival rates and patterns of diagnosis analyzed by time period for individuals with primary malignant brain tumor, 1973-1997
    Jill S Barnholtz-Sloan
    Department of Internal Medicine, Division of Hematology Oncology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, USA
    J Neurosurg 99:458-66. 2003
    ....
  31. ncbi request reprint Survival analysis of distant prostate cancer by decade (1973-1997) in the Detroit Metropolitan Surveillance, Epidemiology and End Results (SEER) Program registry: has outcome improved? (United States)
    Jill S Barnholtz-Sloan
    Division of Hematology Oncology, Department of Internal Medicine, Wayne State University School of Medicine and The Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, USA
    Cancer Causes Control 14:681-5. 2003
    ..The purpose of this study is to examine differences in survival after diagnosis with distant stage prostate cancer by decade of diagnosis...
  32. pmc Analysis of gene x environment interactions in sibships using mixed models
    Jill S Barnholtz-Sloan
    Department of Internal Medicine Oncology, Wayne State University School of Medicine and Karmanos Cancer Institute, 110 East Warren, Detroit, Michigan, USA
    BMC Genet 4:S18. 2003
    ....
  33. ncbi request reprint Admixture effects in the traditional linkage analysis of admixed families
    Jill S Barnholtz-Sloan
    Karmanos Cancer Institute, Population Studies and Prevention Program, Wayne State University, Detroit, Michigan 48201, USA
    Ethn Dis 12:411-9. 2002
    ..If one or both of these assumptions are violated, incorrect inference for linkage could result...
  34. ncbi request reprint Ethnic differences in survival among women with ovarian carcinoma
    Jill S Barnholtz-Sloan
    Epidemiology Section, Population Studies and Prevention Program, Karmanos Cancer Institute, Detroit, Michigan 48201, USA
    Cancer 94:1886-93. 2002
    ..The objective of this study was to examine ethnic differences in survival after ovarian carcinoma in a population-based sample of women...
  35. pmc Susceptibility scoring in family-based association testing
    Laila M Poisson
    Department of Biostatistics and Research Epidemiology, Henry Ford Health Sciences Center, Detroit, Michigan, USA
    BMC Genet 4:S49. 2003
    ..Tests are available to include multiple siblings, unaffected offspring, and to adjust for environmental covariates. We explore a susceptibility residual method of adjustment for covariates...
  36. ncbi request reprint Survival of women diagnosed with malignant, mixed mullerian tumors of the ovary (OMMMT)
    Jill S Barnholtz-Sloan
    Division of Hematology Oncology, Department of Internal Medicine, Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI 48201, USA
    Gynecol Oncol 93:506-12. 2004
    ..To analyze the survival of women with malignant, mixed mullerian tumors of the ovary (OMMMT) compared to women with epithelial ovarian cancer (EOC)...
  37. ncbi request reprint Incidence proportions of brain metastases in patients diagnosed (1973 to 2001) in the Metropolitan Detroit Cancer Surveillance System
    Jill S Barnholtz-Sloan
    Karmanos Cancer Institute, Wayne State University School of Medicine, 110 E Warren, Detroit, MI 48201, USA
    J Clin Oncol 22:2865-72. 2004
    ..The purpose of this study was to calculate population-based incidence proportions (IPs) of brain metastases from single primary lung, melanoma, breast, renal, or colorectal cancer...
  38. ncbi request reprint Examining population stratification via individual ancestry estimates versus self-reported race
    Jill S Barnholtz-Sloan
    Cancer Prevention and Control Program, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, Florida 33612, USA
    Cancer Epidemiol Biomarkers Prev 14:1545-51. 2005
    ..This study suggests that significant population substructure differences exist that self-reported race alone does not capture and that individual ancestry may be confounded with disease status and/or a candidate gene risk genotype...
  39. pmc Brain tumor epidemiology: consensus from the Brain Tumor Epidemiology Consortium
    Melissa L Bondy
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 113:1953-68. 2008
    ..In this report, BTEC epidemiologists reviewed the group's consensus on the current state of scientific findings, and they present a consensus on research priorities to identify which important areas the science should move to address...
  40. doi request reprint Issues of diagnostic review in brain tumor studies: from the Brain Tumor Epidemiology Consortium
    Faith G Davis
    Division of Epidemiology Biostatistics, School of Public Health, University of Illinois at Chicago, Chicago, IL 60612, USA
    Cancer Epidemiol Biomarkers Prev 17:484-9. 2008
    ..It is essential that epidemiologists and neuropathologists collaborate to develop appropriate study designs and protocols for specific hypothesis and populations...

Research Grants1

  1. Analysis of Ethnic Admixture in Lung Cancer
    Jill Barnholtz Sloan; Fiscal Year: 2006
    ..These projects will give me experience in developing methodology in statistical genetics and genetic epidemiology, while also helping me to better understand etiology of disease. ..