Research Topics
| Marina V BackerSummaryAffiliation: Case Western Reserve University School of Medicine Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Vascular endothelial growth factor selectively targets boronated dendrimers to tumor vasculatureMarina V Backer
SibTech, Inc, Newington, CT 06111, USA
Mol Cancer Ther 4:1423-9. 2005..Our data lay the groundwork for future studies using the VEGF-BD/Cy5 bioconjugate as a targeting agent for BNCT of tumor neovasculature...- Overexpression of NM23-1 enhances responsiveness of IMR-32 human neuroblastoma cells to differentiation stimuliM V Backer
SibTech, Inc, Newington, CT 06111, USA
Anticancer Res 20:1743-9. 2000..These genes encode nucleoside diphosphate kinases A and B that form free or bound homo- and heteromers, which are distributed between soluble and particulate fractions of cells and display catalytic and non-catalytic activities... 
Chaperone-targeting cytotoxin and endoplasmic reticulum stress-inducing drug synergize to kill cancer cellsJoseph M Backer
SibTech, Inc, Brookfield, CT 06804, USA
Neoplasia 11:1165-73. 2009....- Self-assembled "dock and lock" system for linking payloads to targeting proteinsMarina V Backer
SibTech, Inc, Newington, Connecticut 06111, USA
Bioconjug Chem 17:912-9. 2006..We expect that this self-assembled "dock and lock" system will provide new opportunities for using functionally active proteins for biomedical purposes... - Surface immobilization of active vascular endothelial growth factor via a cysteine-containing tagMarina V Backer
SibTech, Inc, Newington, CT 06111, USA
Biomaterials 27:5452-8. 2006.... - Adapter protein for site-specific conjugation of payloads for targeted drug deliveryMarina V Backer
Rammelkamp Center for Research, Case Western Reserve University School of Medicine, Cleveland, Ohio 44109, USA
Bioconjug Chem 15:1021-9. 2004..Targeting proteins, Hu-tagged vascular endothelial growth factor or Hu-tagged annexin V, were docked to liposomes decorated with HuS, and the assembled complexes delivered liposomes selectively to target cells... - Assembly of targeting complexes driven by a single-chain antibodyMarina V Backer
SibTech, Inc, Newington, CT 06111, USA
J Immunol Methods 289:37-45. 2004.... - Humanized docking system for assembly of targeting drug delivery complexesMarina V Backer
SibTech, Inc, 705 North Mountain Road, Newington, CT 06111, USA
J Control Release 89:499-511. 2003..Targeting DNA delivery complexes were assembled, characterized by dynamic light scattering, and found to be very effective in receptor-mediated DNA delivery... - Engineering S-protein fragments of bovine ribonuclease A for targeted drug deliveryMarina V Backer
SibTech Inc, 705 North Mountain Road, Newington, CT 06111, USA
Protein Expr Purif 26:455-61. 2002..After the removal of S-peptide, both fragments retain the ability to bind S-peptide and S-peptide-tagged proteins. The 122cys residue in the mutant fragment is available for site-specific conjugation... - Molecular vehicles for targeted drug deliveryMarina V Backer
SibTech, Inc, Newington, Connecticut 06111, USA
Bioconjug Chem 13:462-7. 2002..We expect that our strategy can be employed for targeted delivery of many therapeutic or imaging agents by different recombinant targeting proteins... - Shiga-like toxin-VEGF fusion proteins are selectively cytotoxic to endothelial cells overexpressing VEGFR-2M V Backer
SibTech Inc, 705 North Mountain Road, Newington, CT 06111, USA
J Control Release 74:349-55. 2001..The selective cytotoxicity of SLT-VEGF proteins against growing endothelial cells overexpressing VEGFR-2 suggests that they may be useful in targeting similar cells at sites of angiogenesis... - Targeting endothelial cells overexpressing VEGFR-2: selective toxicity of Shiga-like toxin-VEGF fusion proteinsM V Backer
SibTech, Inc, Newington, Connecticut 06111, USA
Bioconjug Chem 12:1066-73. 2001..Selective cytotoxicity of SLT-VEGF/L against growing endothelial cells overexpressing VEGFR-2 suggests that it may be useful in targeting similar cells at the sites of angiogenesis... - Functionally active VEGF fusion proteinsM V Backer
Sib Tech, Incorporated, 705 North Mountain Road, Newington, Connecticut 06111, USA
Protein Expr Purif 23:1-7. 2001..We hypothesize that VEGF fusion proteins may be employed for targeting endothelial cells at the sites of angiogenesis... - Chimeric ribonuclease as a source of human adapter protein for targeted drug deliveryTimur I Gaynutdinov
SibTech, Inc, Newington, CT 06111, USA
Protein Eng 16:771-5. 2003..The affinity of HuS obtained from BH-RNase to Hu-tag is approximately five times higher than that for recombinant HuS, reflecting a higher percentage of properly folded proteins... 
A "dock and lock" approach to preparation of targeted liposomesMarina V Backer
SibTech, Inc, Brookfield, CT, USA
Methods Mol Biol 605:257-66. 2010..We expect that our "dock and lock" strategy will open new opportunities for development of targeted therapeutic liposomes for research and clinical use...- Inhibition of anthrax protective antigen outside and inside the cellMarina V Backer
SibTech, Inc, 705 North Mountain Road, Newington, CT 06111, USA
Antimicrob Agents Chemother 51:245-51. 2007..These data suggest the potential for the use of beta-cyclodextrins in combination with LFn-Lip loaded with antianthrax drugs against intracellular targets... - Cysteine-containing fusion tag for site-specific conjugation of therapeutic and imaging agents to targeting proteinsMarina V Backer
SibTech Inc, Brookfield, CT, USA
Methods Mol Biol 494:275-94. 2008..We expect that Cys-tag would provide new opportunities for development of targeted therapeutic and imaging agents for research and clinical use... - Molecular imaging of VEGF receptors in angiogenic vasculature with single-chain VEGF-based probesMarina V Backer
SibTech, Inc, 705 North Mountain Road, Newington, Connecticut 06111, USA
Nat Med 13:504-9. 2007..We expect that multimodal imaging of VEGF receptors with these probes will be useful for clinical diagnosis and therapeutic monitoring, and will help to accelerate the development of new angiogenesis-directed drugs and treatments... - Inhibition of vascular endothelial growth factor receptor signaling in angiogenic tumor vasculatureMarina V Backer
SibTech, Inc, Brookfield, Connecticut 06804, USA
Adv Genet 67:1-27. 2009..We describe here one such molecule, SLT-VEGF, a fusion protein containing VEGF121 and the highly cytotoxic catalytic subunit of Shiga-like toxin... - Targeting the unfolded protein response in cancer therapyMarina V Backer
SibTech, Inc, Brookfield, Connecticut, USA
Methods Enzymol 491:37-56. 2011..In this chapter, we provide experimental protocols for the assessment of the effects of EGF-SubA on EGFR-positive cancer cells, either alone or in combination with UPR-inducing drugs... - Imaging key biomarkers of tumor angiogenesisMarina V Backer
SibTech, Inc Brookfield, CT 06804, USA
Theranostics 2:502-15. 2012..Further work will define the competitiveness of targeted imaging of key angiogenesis markers for early diagnostic and image-guided therapy... - Receptor-targeted liposomal delivery of boron-containing cholesterol mimics for boron neutron capture therapy (BNCT)B T S Thirumamagal
Division of Medicinal Chemistry and Pharmacognosy, The Ohio State University, Columbus, 43210, USA
Bioconjug Chem 17:1141-50. 2006.... - Boron containing macromolecules and nanovehicles as delivery agents for neutron capture therapyGong Wu
Department of Pathology, The Ohio State University, 165 Hamilton Hall, 1645 Neil Avenue, Columbus, Ohio 43210, USA
Anticancer Agents Med Chem 6:167-84. 2006..Finally, we will conclude with a discussion relating to issues that must be addressed if these HMW agents are to be used clinically... - Tumor imaging using a standardized radiolabeled adapter protein docked to vascular endothelial growth factorFrancis G Blankenberg
Department of Pediatrics, Stanford University, Stanford, California 94304, USA
J Nucl Med 45:1373-80. 2004..The assembly of this complex is based on interactions between human 109-amino acid (HuS) and 15-amino acid (Hu-tag) fragments of ribonuclease I, which serve as an "Adapter protein" and a Docking tag, respectively... - In vivo tumor angiogenesis imaging with site-specific labeled (99m)Tc-HYNIC-VEGFFrancis G Blankenberg
Division of Nuclear Medicine Department of Radiology and MIPS Molecular Imaging Program at Stanford, Stanford University, Stanford, CA 94304, USA
Eur J Nucl Med Mol Imaging 33:841-8. 2006..We wished to test (99m)Tc-HYNIC-C-tagged VEGF ((99m)Tc-HYNIC-VEGF) for the imaging of tumor vasculature before and after antiangiogenic (low continuous dosing, metronomic) and tumoricidal (high-dose) cyclophosphamide treatment... - VEGF receptors and neuropilins are expressed in the urothelial and neuronal cells in normal mouse urinary bladder and are upregulated in inflammationMarcia R Saban
Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Am J Physiol Renal Physiol 295:F60-72. 2008....
Research Grants
- Targeted Delivery of Anthrax InhibitorsMarina Backer; Fiscal Year: 2007..In Phase II we will develop LFn-liposomes with combination of LF and EF inhibitors, validate these liposomes in animal models of anthrax infection, and pre-clinical steps required for IND filing. ..