Eric J Arts

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. pmc HIV-1 antiretroviral drug therapy
    Eric J Arts
    Ugandan CFAR Laboratories, Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Cold Spring Harb Perspect Med 2:a007161. 2012
  2. pmc Commentary on the role of treatment-related HIV compensatory mutations on increasing virulence: new discoveries twenty years since the clinical testing of protease inhibitors to block HIV-1 replication
    Eric J Arts
    Division of Infectious Diseases and HIV Medicine, Department of Medicine, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    BMC Med 10:114. 2012
  3. pmc Effect of natural polymorphisms in the HIV-1 CRF02_AG protease on protease inhibitor hypersusceptibility
    André F A Santos
    Laboratório de Virologia Humana, Departamento de Genetica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Antimicrob Agents Chemother 56:2719-25. 2012
  4. doi request reprint A radiolabeled oligonucleotide ligation assay demonstrates the high frequency of nevirapine resistance mutations in HIV type 1 quasispecies of NVP-treated and untreated mother-infant pairs from Uganda
    Ryan M Troyer
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    AIDS Res Hum Retroviruses 24:235-50. 2008
  5. pmc Changes in human immunodeficiency virus type 1 fitness and genetic diversity during disease progression
    Ryan M Troyer
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
    J Virol 79:9006-18. 2005
  6. doi request reprint A novel yeast-based recombination method to clone and propagate diverse HIV-1 isolates
    Dawn M Dudley
    Department of Molecular Biology and Microbiology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Biotechniques 46:458-67. 2009
  7. pmc Divergent evolution in reverse transcriptase (RT) of HIV-1 group O and M lineages: impact on structure, fitness, and sensitivity to nonnucleoside RT inhibitors
    Denis M Tebit
    Division of Infectious Diseases, Case Western Reserve University, Cleveland, OH 44106, USA
    J Virol 84:9817-30. 2010
  8. pmc Influence of sequence identity and unique breakpoints on the frequency of intersubtype HIV-1 recombination
    Heather A Baird
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Retrovirology 3:91. 2006
  9. pmc Natural variation in the V3 crown of human immunodeficiency virus type 1 affects replicative fitness and entry inhibitor sensitivity
    Michael A Lobritz
    Department of Molecular Biology and Microbiology, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
    J Virol 81:8258-69. 2007
  10. pmc Targets of small interfering RNA restriction during human immunodeficiency virus type 1 replication
    Yong Gao
    Division of Infectious Diseases, BRB 1034, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
    J Virol 82:2938-51. 2008

Collaborators

Detail Information

Publications40

  1. pmc HIV-1 antiretroviral drug therapy
    Eric J Arts
    Ugandan CFAR Laboratories, Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Cold Spring Harb Perspect Med 2:a007161. 2012
    ..In this article, we will review the basic principles of antiretroviral drug therapy, the mode of drug action, and the factors leading to treatment failure (i.e., drug resistance)...
  2. pmc Commentary on the role of treatment-related HIV compensatory mutations on increasing virulence: new discoveries twenty years since the clinical testing of protease inhibitors to block HIV-1 replication
    Eric J Arts
    Division of Infectious Diseases and HIV Medicine, Department of Medicine, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    BMC Med 10:114. 2012
    ..The modeled fitness scores increased with an accumulation of these secondary protease inhibitors mutations, and not because of any one specific polymorphism...
  3. pmc Effect of natural polymorphisms in the HIV-1 CRF02_AG protease on protease inhibitor hypersusceptibility
    André F A Santos
    Laboratório de Virologia Humana, Departamento de Genetica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Antimicrob Agents Chemother 56:2719-25. 2012
    ....
  4. doi request reprint A radiolabeled oligonucleotide ligation assay demonstrates the high frequency of nevirapine resistance mutations in HIV type 1 quasispecies of NVP-treated and untreated mother-infant pairs from Uganda
    Ryan M Troyer
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    AIDS Res Hum Retroviruses 24:235-50. 2008
    ..The persistence of these mutations may reduce the effectiveness of subsequent NVP use in treatment or prevention of perinatal transmission...
  5. pmc Changes in human immunodeficiency virus type 1 fitness and genetic diversity during disease progression
    Ryan M Troyer
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
    J Virol 79:9006-18. 2005
    ..These data provide in vivo evidence that increasing HIV-1 replication efficiency may be related to a concomitant increase in HIV-1 diversity, which in turn may be a determining factor in disease progression...
  6. doi request reprint A novel yeast-based recombination method to clone and propagate diverse HIV-1 isolates
    Dawn M Dudley
    Department of Molecular Biology and Microbiology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Biotechniques 46:458-67. 2009
    ..Although HIV-1 served as the prototype, this cloning strategy is now being developed for other diverse virus species such as hepatitis C virus and influenza virus...
  7. pmc Divergent evolution in reverse transcriptase (RT) of HIV-1 group O and M lineages: impact on structure, fitness, and sensitivity to nonnucleoside RT inhibitors
    Denis M Tebit
    Division of Infectious Diseases, Case Western Reserve University, Cleveland, OH 44106, USA
    J Virol 84:9817-30. 2010
    ....
  8. pmc Influence of sequence identity and unique breakpoints on the frequency of intersubtype HIV-1 recombination
    Heather A Baird
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Retrovirology 3:91. 2006
    ..Ugandan subtypes A and D HIV-1 env sequences (115-A, 120-A, 89-D, 122-D, 126-D) were employed in all three assay systems. These subtypes co-circulate in East Africa and frequently recombine in this human population...
  9. pmc Natural variation in the V3 crown of human immunodeficiency virus type 1 affects replicative fitness and entry inhibitor sensitivity
    Michael A Lobritz
    Department of Molecular Biology and Microbiology, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
    J Virol 81:8258-69. 2007
    ..These findings suggest that differences in coreceptor affinity and/or avidity may underlie these phenotypic characteristics...
  10. pmc Targets of small interfering RNA restriction during human immunodeficiency virus type 1 replication
    Yong Gao
    Division of Infectious Diseases, BRB 1034, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
    J Virol 82:2938-51. 2008
    ..Protection of HIV-1 RNA within the core following virus entry, during encapsidation/virus assembly, or within the nucleus may reflect virus evolution in response to siRNA, TRIM5alpha, or other host restriction factors...
  11. ncbi request reprint A yeast recombination-based cloning system to produce chimeric HIV-1 viruses and express HIV-1 genes
    Dawn M Moore
    Molecular and Cellular Biology Program, Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH, USA
    Methods Mol Biol 304:369-85. 2005
    ....
  12. pmc CCR5- and CXCR4-tropic subtype C human immunodeficiency virus type 1 isolates have a lower level of pathogenic fitness than other dominant group M subtypes: implications for the epidemic
    Awet Abraha
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Virol 83:5592-605. 2009
    ..These findings suggest that subtype C HIV-1 isolates might have equal transmission fitness but reduced pathogenic fitness relative to other group M HIV-1 isolates...
  13. pmc Elite suppressor-derived HIV-1 envelope glycoproteins exhibit reduced entry efficiency and kinetics
    Kara G Lassen
    Department of Molecular Biology and Microbiology, Department of Medicine, Case Western Reserve University, Cleveland, OH, USA
    PLoS Pathog 5:e1000377. 2009
    ..These results imply that lower env fitness may be established early and may directly contribute to viral suppression in ES individuals...
  14. pmc Selection of a simian-human immunodeficiency virus strain resistant to a vaginal microbicide in macaques
    Dawn M Dudley
    Department of Molecular Biology and Microbiology, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
    J Virol 83:5067-76. 2009
    ..This rhesus CCR5-specific/PSC- RANTES resistance selection is particularly alarming given the relative homogeneity of the SHIV(SF162-p3) stock compared to the potential exposure to a heterogeneous HIV-1 population in human transmission...
  15. pmc Enrichment of intersubtype HIV-1 recombinants in a dual infection system using HIV-1 strain-specific siRNAs
    Yong Gao
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, Ohio 44106, USA
    Retrovirology 8:5. 2011
    ..This study describes the use of HIV-1 isolate-specific siRNAs to enrich intersubtype HIV-1 recombinants and inhibit the parental HIV-1 isolates from a dual infection...
  16. pmc Relationships between infectious titer, capsid protein levels, and reverse transcriptase activities of diverse human immunodeficiency virus type 1 isolates
    Andre J Marozsan
    Division of Infectious Diseases, BRB 1029, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    J Virol 78:11130-41. 2004
    ..Finally, the replication efficiency or fitness of both the NSI/R5 and SI/X4 HIV-1 isolates was not linked to the titers of the virus stocks...
  17. pmc Differences in the fitness of two diverse wild-type human immunodeficiency virus type 1 isolates are related to the efficiency of cell binding and entry
    Andre J Marozsan
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
    J Virol 79:7121-34. 2005
    ..This increased avidity of an HIV-1 isolate for its cell receptors may be a significant factor influencing overall replicative capacity or fitness...
  18. pmc Variable fitness impact of HIV-1 escape mutations to cytotoxic T lymphocyte (CTL) response
    Ryan M Troyer
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, OH, USA
    PLoS Pathog 5:e1000365. 2009
    ....
  19. ncbi request reprint High prevalence of antiretroviral resistance in treated Ugandans infected with non-subtype B human immunodeficiency virus type 1
    Nathalie Richard
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    AIDS Res Hum Retroviruses 20:355-64. 2004
    ..Overall, this observational study suggests that ARV-resistant HIV-1 isolates are emerging rapidly in ARV-treated individual in Uganda and possibly other developing countries...
  20. ncbi request reprint Methods to determine HIV-1 ex vivo fitness
    Awet Abraha
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, OH, USA
    Methods Mol Biol 304:355-68. 2005
    ..HTA is used to evaluate the production of HIV-1 variants in a competition, which can then be used to estimate ex vivo viral fitness...
  21. pmc Sequence determinants of breakpoint location during HIV-1 intersubtype recombination
    Heather A Baird
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Nucleic Acids Res 34:5203-16. 2006
    ..A significant preference for recombination was also observed for regions containing homopolymeric stretches. These results define, for the first time, local sequence determinants for recombination between divergent HIV-1 isolates...
  22. pmc Sensitive oligonucleotide ligation assay for low-level detection of nevirapine resistance mutations in human immunodeficiency virus type 1 quasispecies
    Matthew S Lalonde
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Clin Microbiol 45:2604-15. 2007
    ..These findings suggest that OLA is a robust, sensitive, and specific method for the detection of low-frequency drug resistance mutations in an intrapatient HIV-1 population...
  23. doi request reprint Calculating HIV-1 infectious titre using a virtual TCID(50) method
    Yong Gao
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, OH, USA
    Methods Mol Biol 485:27-35. 2009
    ..This method greatly simplifies the process of accurate HIV-1 titration and is particularly beneficial for studies which require titration of large number of HIV-1 isolates...
  24. pmc Novel method for simultaneous quantification of phenotypic resistance to maturation, protease, reverse transcriptase, and integrase HIV inhibitors based on 3'Gag(p2/p7/p1/p6)/PR/RT/INT-recombinant viruses: a useful tool in the multitarget era of antiretro
    Jan Weber
    Diagnostic Hybrids, Inc, Cleveland, Ohio, USA
    Antimicrob Agents Chemother 55:3729-42. 2011
    ....
  25. ncbi request reprint HIV diversity, recombination and disease progression: how does fitness "fit" into the puzzle?
    Denis M Tebit
    Division of Infectious Disease, Case Western Reserve University, Cleveland, OH 44106, USA
    AIDS Rev 9:75-87. 2007
    ..This review explores some of the important aspects relating to fitness during disease progression, during global distribution of different HIV subtypes, and related to circulation of recombinant forms in the epidemic...
  26. doi request reprint HIV-1 replicative fitness in elite controllers
    Michael A Lobritz
    Department of Medicine, Stanford University Hospital and Clinics, Palo Alto, USA
    Curr Opin HIV AIDS 6:214-20. 2011
    ..Whether this poor virus replication is the cause of elite suppression or the consequence of a strong immune response remains a leading question in the field...
  27. pmc The replicative fitness of primary human immunodeficiency virus type 1 (HIV-1) group M, HIV-1 group O, and HIV-2 isolates
    Kevin K Ariën
    Centre for AIDS Research, Case Western Reserve University, Cleveland, OH, USA
    J Virol 79:8979-90. 2005
    ..These results suggest that reduced replicative and transmission fitness may be contributing to the low prevalence and limited geographical spread of HIV-2 and group O HIV-1 in the human population...
  28. ncbi request reprint The impact of viral and host elements on HIV fitness and disease progression
    Kenneth R Henry
    Division of Infectious Diseases, BRB 1029, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Curr HIV/AIDS Rep 4:36-41. 2007
    ..Therefore, in this review, we will discuss host and viral factors that affect viral fitness and its relationship on HIV pathogenesis...
  29. pmc Multifaceted Mechanisms of HIV Inhibition and Resistance to CCR5 Inhibitors PSC-RANTES and Maraviroc
    Michael A Lobritz
    Department of Molecular Biology and Microbiology
    Antimicrob Agents Chemother 57:2640-50. 2013
    ..MVC could also mediate inhibition and possibly resistance through competitive mechanisms...
  30. pmc Inhibition of both HIV-1 reverse transcription and gene expression by a cyclic peptide that binds the Tat-transactivating response element (TAR) RNA
    Matthew S Lalonde
    Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS Pathog 7:e1002038. 2011
    ..Our results suggest that antiviral drugs targeting TAR RNA might be highly effective due to a dual inhibitory mechanism...
  31. pmc A cis-acting element in retroviral genomic RNA links Gag-Pol ribosomal frameshifting to selective viral RNA encapsidation
    Mastooreh Chamanian
    Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH 44106, USA
    Cell Host Microbe 13:181-92. 2013
    ..Thus, only the HIV-1 RNAs employed for Gag-Pol translation may be specifically selected for encapsidation, possibly explaining the limitation of two gRNAs per virion...
  32. pmc Characterization of a subtype D human immunodeficiency virus type 1 isolate that was obtained from an untreated individual and that is highly resistant to nonnucleoside reverse transcriptase inhibitors
    Yong Gao
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    J Virol 78:5390-401. 2004
    ..Finally, ex vivo fitness analyses suggested that NNRTI-resistant sites 135L and 245T in wild-type isolate D14-UG may reduce RT fitness but do not have an impact on the fitness of the primary HIV-1 isolate...
  33. pmc Comparing the ex vivo fitness of CCR5-tropic human immunodeficiency virus type 1 isolates of subtypes B and C
    Sarah C Ball
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Virol 77:1021-38. 2003
    ....
  34. ncbi request reprint Impact of tuberculosis on HIV-1 replication, diversity, and disease progression
    Kalonji R Collins
    Molecular Virology Program, Case Western Reserve University, Biomedical Research Building 10th, 2109 Adelbert Rd, Cleveland, OH 44106 4984, USA
    AIDS Rev 4:165-76. 2002
    ..The HIV-1 found in blood following this TB-mediated burst in load and diversity appear to be phylogenetically-related to HIV-1 clones that have evolved independently in the lung or pleural compartments, now infected by M. tuberculosis...
  35. ncbi request reprint Past, present, and future of entry inhibitors as HIV microbicides
    Richard M Gibson
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Curr HIV Res 10:19-26. 2012
    ..The outcome of continued research and potential efficacy trials on the next generation of entry inhibitors might reveal whether or not an effective entry microbicide can be developed...
  36. ncbi request reprint Development of a yeast-based recombination cloning/system for the analysis of gene products from diverse human immunodeficiency virus type 1 isolates
    Andre J Marozsan
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, BRB 1029, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    J Virol Methods 111:111-20. 2003
    ..These diverse HIV-1 genes have also been introduced into an infectious clone to produce chimeric viruses that are useful for studies on drug susceptibility, receptor binding and fitness...
  37. pmc HIV-1 resistance to maraviroc conferred by a CD4 binding site mutation in the envelope glycoprotein gp120
    Annette N Ratcliff
    Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH, USA
    J Virol 87:923-34. 2013
    ..In contrast, our structural models on K425 gp120 suggest that this resistant mutation impacts CD4 interactions and highlights a novel pathway for MVC resistance...
  38. pmc DNA suspension arrays: silencing discrete artifacts for high-sensitivity applications
    Matthew S Lalonde
    Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS ONE 5:e15476. 2010
    ....
  39. doi request reprint Tracking a century of global expansion and evolution of HIV to drive understanding and to combat disease
    Denis M Tebit
    Case Western Reserve University, Cleveland, OH 44106, USA
    Lancet Infect Dis 11:45-56. 2011
    ..Research over the past 25 years and advances in genomic sequencing methods, such as deep DNA sequencing, have greatly improved understanding and analysis of the thousands to millions of full infectious HIV-1 genomes...
  40. pmc HIV-1 Entry, Inhibitors, and Resistance
    Michael A Lobritz
    Department of Molecular Biology and Microbiology and Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA E Mails M A L A N R
    Viruses 2:1069-105. 2010
    ..In this review we will address the development of attachment, fusion, and coreceptor entry inhibitors and explore recent studies describing potential mechanisms of resistance...