E J Arts

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. pmc 3'-Azido-3'-deoxythymidine (AZT) mediates cross-resistance to nucleoside analogs in the case of AZT-resistant human immunodeficiency virus type 1 variants
    E J Arts
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Virol 72:4858-65. 1998
  2. ncbi request reprint High prevalence of antiretroviral resistance in treated Ugandans infected with non-subtype B human immunodeficiency virus type 1
    Nathalie Richard
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    AIDS Res Hum Retroviruses 20:355-64. 2004
  3. pmc Mechanisms involved in stimulation of human immunodeficiency virus type 1 replication by aminooxypentane RANTES
    A J Marozsan
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Virol 75:8624-38. 2001
  4. doi request reprint A radiolabeled oligonucleotide ligation assay demonstrates the high frequency of nevirapine resistance mutations in HIV type 1 quasispecies of NVP-treated and untreated mother-infant pairs from Uganda
    Ryan M Troyer
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    AIDS Res Hum Retroviruses 24:235-50. 2008
  5. pmc Variable sensitivity of CCR5-tropic human immunodeficiency virus type 1 isolates to inhibition by RANTES analogs
    V S Torre
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Virol 74:4868-76. 2000
  6. ncbi request reprint Virus fitness: concept, quantification, and application to HIV population dynamics
    M E Quiñones-Mateu
    Department of Molecular Genetics, Section Virology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue NN10, Cleveland, OH 44195, USA
    Curr Top Microbiol Immunol 299:83-140. 2006
  7. pmc Sensitive oligonucleotide ligation assay for low-level detection of nevirapine resistance mutations in human immunodeficiency virus type 1 quasispecies
    Matthew S Lalonde
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Clin Microbiol 45:2604-15. 2007
  8. pmc CCR5- and CXCR4-tropic subtype C human immunodeficiency virus type 1 isolates have a lower level of pathogenic fitness than other dominant group M subtypes: implications for the epidemic
    Awet Abraha
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Virol 83:5592-605. 2009
  9. pmc Selection of a simian-human immunodeficiency virus strain resistant to a vaginal microbicide in macaques
    Dawn M Dudley
    Department of Molecular Biology and Microbiology, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
    J Virol 83:5067-76. 2009
  10. pmc Divergent evolution in reverse transcriptase (RT) of HIV-1 group O and M lineages: impact on structure, fitness, and sensitivity to nonnucleoside RT inhibitors
    Denis M Tebit
    Division of Infectious Diseases, Case Western Reserve University, Cleveland, OH 44106, USA
    J Virol 84:9817-30. 2010

Collaborators

Detail Information

Publications42

  1. pmc 3'-Azido-3'-deoxythymidine (AZT) mediates cross-resistance to nucleoside analogs in the case of AZT-resistant human immunodeficiency virus type 1 variants
    E J Arts
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Virol 72:4858-65. 1998
    ..Tedder, J. Weber, and G. J. Weverling, Lancet 350:983-990, 1997). Our results suggest that the use of AZT may be contraindicated in those patients for whom resistance to this compound (M41L and/or T215Y) has been demonstrated...
  2. ncbi request reprint High prevalence of antiretroviral resistance in treated Ugandans infected with non-subtype B human immunodeficiency virus type 1
    Nathalie Richard
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    AIDS Res Hum Retroviruses 20:355-64. 2004
    ..Overall, this observational study suggests that ARV-resistant HIV-1 isolates are emerging rapidly in ARV-treated individual in Uganda and possibly other developing countries...
  3. pmc Mechanisms involved in stimulation of human immunodeficiency virus type 1 replication by aminooxypentane RANTES
    A J Marozsan
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Virol 75:8624-38. 2001
    ..MAPK/ERK1 and -2 appear to phosphorylate the HIV-1 preintegration complex, a step necessary for nuclear translocation and successful integration...
  4. doi request reprint A radiolabeled oligonucleotide ligation assay demonstrates the high frequency of nevirapine resistance mutations in HIV type 1 quasispecies of NVP-treated and untreated mother-infant pairs from Uganda
    Ryan M Troyer
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    AIDS Res Hum Retroviruses 24:235-50. 2008
    ..The persistence of these mutations may reduce the effectiveness of subsequent NVP use in treatment or prevention of perinatal transmission...
  5. pmc Variable sensitivity of CCR5-tropic human immunodeficiency virus type 1 isolates to inhibition by RANTES analogs
    V S Torre
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Virol 74:4868-76. 2000
    ..Distribution of AOP-RANTES IC(50) values with these isolates has promoted ongoing screens for new CCR5 agonists that show broad inhibition of HIV-1 variants...
  6. ncbi request reprint Virus fitness: concept, quantification, and application to HIV population dynamics
    M E Quiñones-Mateu
    Department of Molecular Genetics, Section Virology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue NN10, Cleveland, OH 44195, USA
    Curr Top Microbiol Immunol 299:83-140. 2006
    ....
  7. pmc Sensitive oligonucleotide ligation assay for low-level detection of nevirapine resistance mutations in human immunodeficiency virus type 1 quasispecies
    Matthew S Lalonde
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Clin Microbiol 45:2604-15. 2007
    ..These findings suggest that OLA is a robust, sensitive, and specific method for the detection of low-frequency drug resistance mutations in an intrapatient HIV-1 population...
  8. pmc CCR5- and CXCR4-tropic subtype C human immunodeficiency virus type 1 isolates have a lower level of pathogenic fitness than other dominant group M subtypes: implications for the epidemic
    Awet Abraha
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Virol 83:5592-605. 2009
    ..These findings suggest that subtype C HIV-1 isolates might have equal transmission fitness but reduced pathogenic fitness relative to other group M HIV-1 isolates...
  9. pmc Selection of a simian-human immunodeficiency virus strain resistant to a vaginal microbicide in macaques
    Dawn M Dudley
    Department of Molecular Biology and Microbiology, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
    J Virol 83:5067-76. 2009
    ..This rhesus CCR5-specific/PSC- RANTES resistance selection is particularly alarming given the relative homogeneity of the SHIV(SF162-p3) stock compared to the potential exposure to a heterogeneous HIV-1 population in human transmission...
  10. pmc Divergent evolution in reverse transcriptase (RT) of HIV-1 group O and M lineages: impact on structure, fitness, and sensitivity to nonnucleoside RT inhibitors
    Denis M Tebit
    Division of Infectious Diseases, Case Western Reserve University, Cleveland, OH 44106, USA
    J Virol 84:9817-30. 2010
    ....
  11. pmc Human immunodeficiency virus type 1 (HIV-1) quasispecies at the sites of Mycobacterium tuberculosis infection contribute to systemic HIV-1 heterogeneity
    Kalonji R Collins
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Virol 76:1697-706. 2002
    ..Collectively, these findings suggest that HIV-1 quasispecies in the M. tuberculosis-infected pleural space may leak into the systemic circulation and lead to increased systemic HIV-1 heterogeneity during TB...
  12. doi request reprint A novel yeast-based recombination method to clone and propagate diverse HIV-1 isolates
    Dawn M Dudley
    Department of Molecular Biology and Microbiology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Biotechniques 46:458-67. 2009
    ..Although HIV-1 served as the prototype, this cloning strategy is now being developed for other diverse virus species such as hepatitis C virus and influenza virus...
  13. pmc Natural variation in the V3 crown of human immunodeficiency virus type 1 affects replicative fitness and entry inhibitor sensitivity
    Michael A Lobritz
    Department of Molecular Biology and Microbiology, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
    J Virol 81:8258-69. 2007
    ..These findings suggest that differences in coreceptor affinity and/or avidity may underlie these phenotypic characteristics...
  14. pmc Characterization of a subtype D human immunodeficiency virus type 1 isolate that was obtained from an untreated individual and that is highly resistant to nonnucleoside reverse transcriptase inhibitors
    Yong Gao
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    J Virol 78:5390-401. 2004
    ..Finally, ex vivo fitness analyses suggested that NNRTI-resistant sites 135L and 245T in wild-type isolate D14-UG may reduce RT fitness but do not have an impact on the fitness of the primary HIV-1 isolate...
  15. ncbi request reprint Impact of tuberculosis on HIV-1 replication, diversity, and disease progression
    Kalonji R Collins
    Molecular Virology Program, Case Western Reserve University, Biomedical Research Building 10th, 2109 Adelbert Rd, Cleveland, OH 44106 4984, USA
    AIDS Rev 4:165-76. 2002
    ..The HIV-1 found in blood following this TB-mediated burst in load and diversity appear to be phylogenetically-related to HIV-1 clones that have evolved independently in the lung or pleural compartments, now infected by M. tuberculosis...
  16. ncbi request reprint HIV diversity, recombination and disease progression: how does fitness "fit" into the puzzle?
    Denis M Tebit
    Division of Infectious Disease, Case Western Reserve University, Cleveland, OH 44106, USA
    AIDS Rev 9:75-87. 2007
    ..This review explores some of the important aspects relating to fitness during disease progression, during global distribution of different HIV subtypes, and related to circulation of recombinant forms in the epidemic...
  17. pmc Comparing the ex vivo fitness of CCR5-tropic human immunodeficiency virus type 1 isolates of subtypes B and C
    Sarah C Ball
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Virol 77:1021-38. 2003
    ....
  18. pmc Influence of sequence identity and unique breakpoints on the frequency of intersubtype HIV-1 recombination
    Heather A Baird
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Retrovirology 3:91. 2006
    ..Ugandan subtypes A and D HIV-1 env sequences (115-A, 120-A, 89-D, 122-D, 126-D) were employed in all three assay systems. These subtypes co-circulate in East Africa and frequently recombine in this human population...
  19. pmc Sequence determinants of breakpoint location during HIV-1 intersubtype recombination
    Heather A Baird
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Nucleic Acids Res 34:5203-16. 2006
    ..A significant preference for recombination was also observed for regions containing homopolymeric stretches. These results define, for the first time, local sequence determinants for recombination between divergent HIV-1 isolates...
  20. pmc Elite suppressor-derived HIV-1 envelope glycoproteins exhibit reduced entry efficiency and kinetics
    Kara G Lassen
    Department of Molecular Biology and Microbiology, Department of Medicine, Case Western Reserve University, Cleveland, OH, USA
    PLoS Pathog 5:e1000377. 2009
    ..These results imply that lower env fitness may be established early and may directly contribute to viral suppression in ES individuals...
  21. pmc Targets of small interfering RNA restriction during human immunodeficiency virus type 1 replication
    Yong Gao
    Division of Infectious Diseases, BRB 1034, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
    J Virol 82:2938-51. 2008
    ..Protection of HIV-1 RNA within the core following virus entry, during encapsidation/virus assembly, or within the nucleus may reflect virus evolution in response to siRNA, TRIM5alpha, or other host restriction factors...
  22. pmc Changes in human immunodeficiency virus type 1 fitness and genetic diversity during disease progression
    Ryan M Troyer
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
    J Virol 79:9006-18. 2005
    ..These data provide in vivo evidence that increasing HIV-1 replication efficiency may be related to a concomitant increase in HIV-1 diversity, which in turn may be a determining factor in disease progression...
  23. pmc Differences in the fitness of two diverse wild-type human immunodeficiency virus type 1 isolates are related to the efficiency of cell binding and entry
    Andre J Marozsan
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
    J Virol 79:7121-34. 2005
    ..This increased avidity of an HIV-1 isolate for its cell receptors may be a significant factor influencing overall replicative capacity or fitness...
  24. pmc Relationships between infectious titer, capsid protein levels, and reverse transcriptase activities of diverse human immunodeficiency virus type 1 isolates
    Andre J Marozsan
    Division of Infectious Diseases, BRB 1029, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    J Virol 78:11130-41. 2004
    ..Finally, the replication efficiency or fitness of both the NSI/R5 and SI/X4 HIV-1 isolates was not linked to the titers of the virus stocks...
  25. ncbi request reprint Development of a yeast-based recombination cloning/system for the analysis of gene products from diverse human immunodeficiency virus type 1 isolates
    Andre J Marozsan
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, BRB 1029, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    J Virol Methods 111:111-20. 2003
    ..These diverse HIV-1 genes have also been introduced into an infectious clone to produce chimeric viruses that are useful for studies on drug susceptibility, receptor binding and fitness...
  26. doi request reprint Calculating HIV-1 infectious titre using a virtual TCID(50) method
    Yong Gao
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, OH, USA
    Methods Mol Biol 485:27-35. 2009
    ..This method greatly simplifies the process of accurate HIV-1 titration and is particularly beneficial for studies which require titration of large number of HIV-1 isolates...
  27. pmc The replicative fitness of primary human immunodeficiency virus type 1 (HIV-1) group M, HIV-1 group O, and HIV-2 isolates
    Kevin K Ariën
    Centre for AIDS Research, Case Western Reserve University, Cleveland, OH, USA
    J Virol 79:8979-90. 2005
    ..These results suggest that reduced replicative and transmission fitness may be contributing to the low prevalence and limited geographical spread of HIV-2 and group O HIV-1 in the human population...
  28. ncbi request reprint The impact of viral and host elements on HIV fitness and disease progression
    Kenneth R Henry
    Division of Infectious Diseases, BRB 1029, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Curr HIV/AIDS Rep 4:36-41. 2007
    ..Therefore, in this review, we will discuss host and viral factors that affect viral fitness and its relationship on HIV pathogenesis...
  29. pmc Variable fitness impact of HIV-1 escape mutations to cytotoxic T lymphocyte (CTL) response
    Ryan M Troyer
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, OH, USA
    PLoS Pathog 5:e1000365. 2009
    ....
  30. ncbi request reprint Methods to determine HIV-1 ex vivo fitness
    Awet Abraha
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, OH, USA
    Methods Mol Biol 304:355-68. 2005
    ..HTA is used to evaluate the production of HIV-1 variants in a competition, which can then be used to estimate ex vivo viral fitness...
  31. ncbi request reprint A yeast recombination-based cloning system to produce chimeric HIV-1 viruses and express HIV-1 genes
    Dawn M Moore
    Molecular and Cellular Biology Program, Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH, USA
    Methods Mol Biol 304:369-85. 2005
    ....
  32. pmc In vitro intersubtype recombinants of human immunodeficiency virus type 1: comparison to recent and circulating in vivo recombinant forms
    Miguel E Quinones-Mateu
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Virol 76:9600-13. 2002
    ..Based on these findings, HIV-1 recombinants generated from these dual infections may be used as a model for in vivo intersubtype recombination and for the design of various diagnostic assays and vaccine constructs...
  33. ncbi request reprint Fitness of drug resistant HIV-1: methodology and clinical implications
    Miguel E Quinones-Mateu
    Department of Virology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue NN10, OH 44195, USA
    Drug Resist Updat 5:224-33. 2002
    ..Characterization of the relative viral fitness of drug-resistant HIV-1 strains may lead to a better understanding of whether or not less fit viruses pose a clinical benefit to the patient...
  34. ncbi request reprint Sorting out the complexities of HIV-1 fitness
    Eric J Arts
    AIDS 17:780-1. 2003
  35. pmc Effectiveness of nevirapine and zidovudine in a pilot program for the prevention of mother-to-child transmission of HIV-1 in Uganda
    Francis Bajunirwe
    Department of Community Health, Mbarara University of Science and Technology, P O Box 1410, Mbarara, Uganda
    Afr Health Sci 4:146-54. 2004
    ..The effectiveness of these antiretroviral (ARV) regimens has been shown in the clinical trials but has not been demonstrated outside the clinical trials setting in this country...
  36. pmc Escape of HIV-1 from a small molecule CCR5 inhibitor is not associated with a fitness loss
    Cleo G Anastassopoulou
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, United States of America
    PLoS Pathog 3:e79. 2007
    ..These in vitro studies may have implications for the development and management of resistance to other CCR5 inhibitors that are being evaluated clinically for the treatment of HIV-1 infection...
  37. ncbi request reprint Is HIV-1 evolving to a less virulent form in humans?
    Kevin K Ariën
    HIV and Retrovirology Research Unit, Department of Microbiology, Institute of Tropical Medicine, Nationalestraat 155, B2000 Antwerp, Belgium
    Nat Rev Microbiol 5:141-51. 2007
    ..Here, we explore whether HIV-1 has reached peak virulence or has already started the slow path to attenuation...
  38. pmc PSC-RANTES blocks R5 human immunodeficiency virus infection of Langerhans cells isolated from individuals with a variety of CCR5 diplotypes
    Tatsuyoshi Kawamura
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
    J Virol 78:7602-9. 2004
    ..In summary, PSC-RANTES is a potent inhibitor of R5 HIV infection in immature LC, suggesting that it may be useful as a topical microbicide to block sexual transmission of HIV...
  39. ncbi request reprint Replicative fitness of historical and recent HIV-1 isolates suggests HIV-1 attenuation over time
    Kevin K Ariën
    Department of Microbiology, HIV and Retrovirology Research Unit, Institute of Tropical Medicine, Antwerp, Belgium
    AIDS 19:1555-64. 2005
    ..Here we used primary human cells to study the replicative fitness of primary HIV-1 isolates from untreated patients, comparing historical (1986-1989) and recent samples (2002-2003)...
  40. pmc Molecular characterization of human immunodeficiency virus type 1 (HIV-1) and HIV-2 in Yaounde, Cameroon: evidence of major drug resistance mutations in newly diagnosed patients infected with subtypes other than subtype B
    Nicaise Ndembi
    Laboratory of Hematology and Virology, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon
    J Clin Microbiol 46:177-84. 2008
    ..3%) group M samples. None of the patients had any history of ART exposure. Population surveillance of transmitted HIV drug resistance is required and should be included to aid in the development of appropriate guidelines...
  41. pmc Identifying the important HIV-1 recombination breakpoints
    John Archer
    Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    PLoS Comput Biol 4:e1000178. 2008
    ..This suggests that, despite the wide diversity of recombinant forms seen in the viral population, only a minority of recombination events appear to be of significance to the evolution of HIV-1...
  42. pmc Evolution of human immunodeficiency virus type 1 cytotoxic T-lymphocyte epitopes: fitness-balanced escape
    Yi Liu
    Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98195 8070, USA
    J Virol 81:12179-88. 2007
    ....