Kumar N Alagramam

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. pmc Characterization of vestibular dysfunction in the mouse model for Usher syndrome 1F
    Kumar N Alagramam
    Department of Otolaryngology Head and Neck Surgery, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH 44106, USA
    J Assoc Res Otolaryngol 6:106-18. 2005
  2. pmc A mouse model with postnatal endolymphatic hydrops and hearing loss
    Cliff A Megerian
    Department of Otolaryngology Head and Neck Surgery, Case Western Reserve University, University Hospitals Case Medical Center, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    Hear Res 237:90-105. 2008
  3. pmc Noddy, a mouse harboring a missense mutation in protocadherin-15, reveals the impact of disrupting a critical interaction site between tip-link cadherins in inner ear hair cells
    Ruishuang Geng
    Otolaryngology Head and Neck Surgery, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Neurosci 33:4395-404. 2013
  4. pmc The mechanosensory structure of the hair cell requires clarin-1, a protein encoded by Usher syndrome III causative gene
    Ruishuang Geng
    Otolaryngology Head and Neck Surgery, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Neurosci 32:9485-98. 2012
  5. ncbi request reprint Development of outer hair cells in Ames waltzer mice: mutation in protocadherin 15 affects development of cuticular plate and associated structures
    Yayoi S Kikkawa
    Department of Otolaryngology Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9035, USA
    Anat Rec (Hoboken) 291:224-32. 2008
  6. ncbi request reprint Molecular changes associated with the endolymphatic hydrops model
    Samantha Anne
    Otolaryngology Head and Neck Surgery, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    Otol Neurotol 28:834-41. 2007
  7. ncbi request reprint Identification and characterization of mouse cochlear stem cells
    Michael V Yerukhimovich
    Department of Otolaryngology, Head and Neck Surgery, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Dev Neurosci 29:251-60. 2007
  8. pmc Progression of inner ear pathology in Ames waltzer mice and the role of protocadherin 15 in hair cell development
    Karen S Pawlowski
    Department of Otolaryngology Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390 9035, USA
    J Assoc Res Otolaryngol 7:83-94. 2006
  9. doi request reprint Spiral ganglion degeneration patterns in endolymphatic hydrops
    Paul J Bixenstine
    Department of Otolaryngology Head and Neck Surgery, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    Laryngoscope 118:1217-23. 2008
  10. doi request reprint Pharmacological protection of hearing loss in the mouse model of endolymphatic hydrops
    Sami J Melki
    Department of Otolaryngology Head and Neck Surgery, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, USA
    Laryngoscope 120:1637-45. 2010

Collaborators

Detail Information

Publications23

  1. pmc Characterization of vestibular dysfunction in the mouse model for Usher syndrome 1F
    Kumar N Alagramam
    Department of Otolaryngology Head and Neck Surgery, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH 44106, USA
    J Assoc Res Otolaryngol 6:106-18. 2005
    ....
  2. pmc A mouse model with postnatal endolymphatic hydrops and hearing loss
    Cliff A Megerian
    Department of Otolaryngology Head and Neck Surgery, Case Western Reserve University, University Hospitals Case Medical Center, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    Hear Res 237:90-105. 2008
    ....
  3. pmc Noddy, a mouse harboring a missense mutation in protocadherin-15, reveals the impact of disrupting a critical interaction site between tip-link cadherins in inner ear hair cells
    Ruishuang Geng
    Otolaryngology Head and Neck Surgery, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Neurosci 33:4395-404. 2013
    ..These results offer new insights into the interaction between PCDH15 and CDH23 and help explain the etiology of human deafness linked to mutations in the tip-link interface...
  4. pmc The mechanosensory structure of the hair cell requires clarin-1, a protein encoded by Usher syndrome III causative gene
    Ruishuang Geng
    Otolaryngology Head and Neck Surgery, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Neurosci 32:9485-98. 2012
    ..Furthermore, the ear phenotype in the Clrn1(N48K) mouse suggests that it is a valuable model for ear disease in CLRN1(N48K), the most prevalent Usher syndrome III mutation in North America...
  5. ncbi request reprint Development of outer hair cells in Ames waltzer mice: mutation in protocadherin 15 affects development of cuticular plate and associated structures
    Yayoi S Kikkawa
    Department of Otolaryngology Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9035, USA
    Anat Rec (Hoboken) 291:224-32. 2008
    ..These observations support the hypothesis that mutations in Pcdh15 in av3J mice adversely affect coordinated maturation of apical cell components, resulting in disturbed stereocilia bundle polarity in av mice...
  6. ncbi request reprint Molecular changes associated with the endolymphatic hydrops model
    Samantha Anne
    Otolaryngology Head and Neck Surgery, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    Otol Neurotol 28:834-41. 2007
    ....
  7. ncbi request reprint Identification and characterization of mouse cochlear stem cells
    Michael V Yerukhimovich
    Department of Otolaryngology, Head and Neck Surgery, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Dev Neurosci 29:251-60. 2007
    ..Our results show that cochleae from neonatal mice harbor cells capable of forming spheres and cells from these spheres appear to be better endowed to become hair cells...
  8. pmc Progression of inner ear pathology in Ames waltzer mice and the role of protocadherin 15 in hair cell development
    Karen S Pawlowski
    Department of Otolaryngology Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390 9035, USA
    J Assoc Res Otolaryngol 7:83-94. 2006
    ..The positive correlation of severity of effects with extent of mutation can be seen well into adulthood...
  9. doi request reprint Spiral ganglion degeneration patterns in endolymphatic hydrops
    Paul J Bixenstine
    Department of Otolaryngology Head and Neck Surgery, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    Laryngoscope 118:1217-23. 2008
    ..The goal of this study is to evaluate the hypothesis that spiral ganglion cell degeneration is the principle pathologic site of ELH-related cochlear injury, correlates with ELH severity, and is most profound in the apical region...
  10. doi request reprint Pharmacological protection of hearing loss in the mouse model of endolymphatic hydrops
    Sami J Melki
    Department of Otolaryngology Head and Neck Surgery, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, USA
    Laryngoscope 120:1637-45. 2010
    ..This study tests the hypothesis that interruption of the initial and/or downstream aspects of excitotoxicity should provide hearing protection in ELH-associated hearing loss...
  11. doi request reprint Spiral ganglion loss outpaces inner hair cell loss in endolymphatic hydrops
    Suhael R Momin
    Department of Otolaryngology Head and Neck Surgery, Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
    Laryngoscope 120:159-65. 2010
    ....
  12. ncbi request reprint Optimization of ribonucleic acid detection from archival Guinea pig temporal bone specimens
    Kathryn L Hall
    Department of Otolaryngology Head and Neck Surgery, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Otol Neurotol 28:116-23. 2007
    ..The choice of ribonucleic acid (RNA) isolation protocol coupled with modifications to RNA extraction and detection procedures may result in a more reliable method to detect gene expression in archived temporal bones...
  13. ncbi request reprint Assessment of retinal structure and function in Ames waltzer mice
    Sherry L Ball
    Research Service, Cleveland VA Medical Center, Cleveland, Ohio, USA
    Invest Ophthalmol Vis Sci 44:3986-92. 2003
    ..To determine whether the Ames waltzer is a model for retinopathy in USH1F, retinal structure and function were assessed in all four available alleles of the mouse...
  14. pmc Mutations in protocadherin 15 and cadherin 23 affect tip links and mechanotransduction in mammalian sensory hair cells
    Kumar N Alagramam
    Otolaryngology Head and Neck Surgery, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS ONE 6:e19183. 2011
    ..These results therefore provide genetic evidence consistent with PCDH15 and CDH23 being part of the tip-link complex and necessary for normal mechanotransduction...
  15. pmc Usher syndrome IIIA gene clarin-1 is essential for hair cell function and associated neural activation
    Ruishuang Geng
    Department of Otolaryngology Head and Neck Surgery, Case Western Reserve University, Cleveland, OH 44106, USA
    Hum Mol Genet 18:2748-60. 2009
    ..In sum, hair cell dysfunction and prolonged peak latencies in vestibular and cochlear evoked potentials in Clrn1(-/-) mice strongly indicate that Clrn1 is necessary for hair cell function and associated neural activation...
  16. pmc Promoter, alternative splice forms, and genomic structure of protocadherin 15
    Kumar N Alagramam
    Department of Otolaryngology Head and Neck Surgery, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH 44106, USA
    Genomics 90:482-92. 2007
    ..Results from our study show that both mouse and human protocadherin 15 genes have complex genomic structures and transcription control mechanisms...
  17. pmc Tympanometry assessment of 61 inbred strains of mice
    Qing Yin Zheng
    Department of Otolaryngology Head and Neck Surgery, Case Western Reserve University, 11100 Euclid Avenue, LKS 5045, Cleveland, OH 44106, USA
    Hear Res 231:23-31. 2007
    ..This is the first report to successfully use tympanometry to measure mouse middle ear function, which has been a challenge for the hearing research field because of the mouse's tiny ear size...
  18. ncbi request reprint Gene expression analysis of distinct populations of cells isolated from mouse and human inner ear FFPE tissue using laser capture microdissection--a technical report based on preliminary findings
    Nitin A Pagedar
    Department of Otolaryngology Head and Neck Surgery, University Hospitals of Cleveland, Lakeside 4500, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    Brain Res 1091:289-99. 2006
    ..Also, this method can be applied for analysis of human archival ear tissue...
  19. ncbi request reprint The basic science of Meniere's disease and endolymphatic hydrops
    Maroun T Semaan
    Department of Otolaryngology Head and Neck Surgery, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Curr Opin Otolaryngol Head Neck Surg 13:301-7. 2005
    ..Emphasis is placed on reviewing the newly described animal models that exhibit endolymphatic hydrops...
  20. ncbi request reprint Interactions in the network of Usher syndrome type 1 proteins
    Avital Adato
    Unité de Génétique des Déficits Sensoriels, INSERM U587, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Hum Mol Genet 14:347-56. 2005
    ..We propose that via its binding to myosin VIIa and/or harmonin, sans controls the hair bundle cohesion and proper development by regulating the traffic of USH1 proteins en route to the stereocilia...
  21. pmc A quantitative survey of gravity receptor function in mutant mouse strains
    Sherri M Jones
    Department of Communication Sciences and Disorders, East Carolina University, Greenville, NC 27858, USA
    J Assoc Res Otolaryngol 6:297-310. 2005
    ..Interestingly, some heterozygote groups also showed abnormalities in one or more VsEP response parameters, suggesting that vestibular dysfunction, although less severe, may be present in some heterozygous animals...
  22. ncbi request reprint A new spontaneous mutation in the mouse Ames waltzer gene, Pcdh15
    Lori L Hampton
    G Protein Coupled Receptors Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Hear Res 180:67-75. 2003
    ..The new allele of Ames waltzer, designated Pcdh15(av-Jfb), may aid in studying the histopathology associated with Usher syndrome type 1F, which is caused by a functional null allele of PCDH15...
  23. pmc Inner ear proteomics of mouse models for deafness, a discovery strategy
    Qing Yin Zheng
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609 1500, USA
    Brain Res 1091:113-21. 2006
    ..In this short technical report, we also discuss protein-profiling approaches suitable for SSUMM and briefly discuss other approaches used in the field of proteomics...