Research Topics
| P B LockhartSummaryAffiliation: Carolinas Medical Center Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Decision-making on the use of antimicrobial prophylaxis for dental procedures: a survey of infectious disease consultants and reviewPeter B Lockhart
Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC, 28232, USA
Clin Infect Dis 34:1621-6. 2002..These differences underscore the need for definitive studies to delineate appropriate candidates for antimicrobial prophylaxis in dental practice...
Drug cost implications for antibiotic prophylaxis for dental proceduresPeter B Lockhart
Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC 28232 2861, USA
Oral Surg Oral Med Oral Pathol Oral Radiol 115:345-53. 2013..To determine the potential economic impact from the practice of antibiotic prophylaxis for dental procedures...
Poor oral hygiene as a risk factor for infective endocarditis-related bacteremiaPeter B Lockhart
Department of Oral Medicine, Carolinas Medical Center, P O Box 32861, Charlotte, NC 28232 2861, USA
J Am Dent Assoc 140:1238-44. 2009..The authors conducted a study to determine if poor oral hygiene or dental disease are risk factors for developing bacteremia after toothbrushing or single-tooth extraction...
Bacteremia associated with toothbrushing and dental extractionPeter B Lockhart
Department of Oral Medicine, Carolinas Medical Center, PO Box 32861, Charlotte, NC 28232 2861, USA
Circulation 117:3118-25. 2008....
The evidence base for the efficacy of antibiotic prophylaxis in dental practicePeter B Lockhart
Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC 28232 2861, USA
J Am Dent Assoc 138:458-74; quiz 534-5, 437. 2007..The authors conducted a qualitative, systematic review to determine the level of evidence for this practice and whether antibiotic prophylaxis prevents distant site infections in these patients...
Concomitant surgical treatment of dental and valvular heart diseasesPeter B Lockhart
Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC 28232 2861, USA
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 107:71-6. 2009..Invasive dental procedures are often indicated before cardiac valve surgery. The purpose of this case-control study was to determine the risks and benefits of concomitant dental and thoracic surgery...
Randomized controlled trial of pilocarpine hydrochloride for the moderation of oral mucositis during autologous blood stem cell transplantationP B Lockhart
Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC, USA
Bone Marrow Transplant 35:713-20. 2005..Pilocarpine has no benefit for the moderation of the incidence, severity, or duration of mucositis in patients receiving autologous blood stem cell transplantation...
Impact of amoxicillin prophylaxis on the incidence, nature, and duration of bacteremia in children after intubation and dental proceduresPeter B Lockhart
Department of Oral Medicine, Carolinas Medical Center, 1000 Blythe Blvd, PO Box 32861, Charlotte, NC 28232 2861, USA
Circulation 109:2878-84. 2004....
Dental management considerations for the patient with an acquired coagulopathy. Part 2: Coagulopathies from drugsP B Lockhart
Department of Oral Medicine, Carolinas Medical Center, Charlotte, North Carolina 28232, USA
Br Dent J 195:495-501. 2003..The vast majority of these patients can be managed in the community setting without risk and without alteration of anticoagulant drug regimes...
Dental management considerations for the patient with an acquired coagulopathy. Part 1: Coagulopathies from systemic diseaseP B Lockhart
Glasgow Dental Hospital and School, 387 Sauchiehall Street, University of Glasgow, Glasgow G2 3JZ, Scotland, UK
Br Dent J 195:439-45. 2003
Aspirin use and post-operative bleeding from dental extractionsM T Brennan
Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC 28232, USA
J Dent Res 87:740-4. 2008..Whole-blood aggregation results were significantly different between the aspirin and placebo groups. These findings suggest that there is no indication to discontinue aspirin for persons requiring single-tooth extraction...
Dental postoperative bleeding complications in patients with suspected and documented liver diseaseC H Hong
Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC, USA
Oral Dis 18:661-6. 2012....
The oral mucosa as a therapeutic target for xerostomiaW R Thelin
Parion Sciences, Durham, NC, USA
Oral Dis 14:683-9. 2008..This review discusses the current understanding of oral fluid balance and how these processes may be manipulated to provide relief for those suffering from dry mouth...
Incidence of acute oral sequelae in pediatric patients undergoing chemotherapyC H Hong
Pediatric Dentistry, Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC, USA
Pediatr Dent 31:420-5. 2009..The purpose of this literature review was to assess the incidence of acute oral sequelae in children receiving cytotoxic therapy...
Oral health needs and barriers to dental care in hospitalized childrenMartine Nicopoulos
Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC, USA
Spec Care Dentist 27:206-11. 2007..A high prevalance of unmet oral health needs and soft tissue abnormalities was identified in a hospitalized pediatric population. Children with chronic medical conditions were more likely to experience barriers to obtaining dental care...
Radiation-induced trismus in head and neck cancer patientsM Louise Kent
Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC 28203, USA
Support Care Cancer 16:305-9. 2008..In addition, we assessed if trismus was associated with quality of life deficits and radiation toxicity...
Statistical analysis used in "A prospective placebo-controlled double-blind trial of antibiotic prophylaxis in intraoral bone grafting procedures: a pliot study"Michael T Brennan
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 97:664; author reply 664-5. 2004
Dental treatment planning and management in the patient who has cancerMichael T Brennan
Department of Oral Medicine, Carolinas Medical Center, PO Box 32861, Charlotte, NC 28232, USA
Dent Clin North Am 52:19-37, vii. 2008....
Prevention of infective endocarditis: guidelines from the American Heart Association: a guideline from the American Heart Association Rheumatic Fever, Endocarditis and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the CouWalter Wilson
J Am Dent Assoc 139:3S-24S. 2008..These changes are intended to define more clearly when IE prophylaxis is or is not recommended and to provide more uniform and consistent global recommendations...
Relationship between bleeding time test and postextraction bleeding in a healthy control populationMichael T Brennan
Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC 28232, USA
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 94:439-43. 2002..We sought to determine whether cutaneous bleeding time (BT) is related to bleeding outcome measures after a single tooth extraction...
Identification of oral bacteria in blood cultures by conventional versus molecular methodsFarah K Bahrani-Mougeot
Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC 28232, USA
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105:720-4. 2008..The purpose of this study was to compare two different methods of identifying oral bacteria from blood samples after dental extractions...
Utility of an international normalized ratio testing device in a hospital-based dental practiceMichael T Brennan
Department of Oral Medicine, Carolinas Medical Center, P O Box 32861, Charlotte, N C 28232, USA
J Am Dent Assoc 139:697-703. 2008..The authors aimed to evaluate the utility of an in-office international normalized ratio (INR) testing device in identifying patients with INR test values considered out of the normal range for dental procedures...
Cevimeline for the treatment of xerostomia in patients with Sjögren syndrome: a randomized trialRose S Fife
Department of Medicine, Indiana University School of Medicine, 535 Barnhill Dr, Room 150, Indianapolis, IN 46202, USA
Arch Intern Med 162:1293-300. 2002..Use of 30 mg of cevimeline provides a new option for the treatment of xerostomia in Sjögren syndrome...
Diverse and novel oral bacterial species in blood following dental proceduresFarah K Bahrani-Mougeot
Department of Oral Medicine, Carolinas Medical Center, Charlotte, North Carolina 28203, USA
J Clin Microbiol 46:2129-32. 2008..Of interest, 48 of the isolates represented 19 novel species of Prevotella, Fusobacterium, Streptococcus, Actinomyces, Capnocytophaga, Selenomonas, and Veillonella...
Prevention of infective endocarditis: guidelines from the American Heart Association: a guideline from the American Heart Association Rheumatic Fever, Endocarditis and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the CouWalter Wilson
Mayo Clinic, Rochester, MN, USA
J Am Dent Assoc 138:739-45, 747-60. 2007..The purpose of this statement is to update the recommendations by the American Heart Association (AHA) for the prevention of infective endocarditis, which were last published in 1997...
Relationship between mucositis and changes in oral microflora during cancer chemotherapyJoel J Napenas
Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC, USA
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103:48-59. 2007..More detailed studies are required to understand the relationship between chemotherapy, alterations in the nature and magnitude of the oral microflora, and the presence of mucositis...
Modified Child-Pugh score as a marker for postoperative bleeding from invasive dental proceduresManuel A Valerin
Carolina Medical Center, Charlotte, NC, USA
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 104:56-60. 2007..The objective of this study was to determine if the modified Child-Pugh score (MCP) is associated with peri- and postoperative bleeding complications from invasive dental procedures in patients with advanced liver disease...
Odontogenic signs and symptoms as predictors of odontogenic infection: a clinical trialMichael T Brennan
Oral Medicine Residency, Carolinas Medical Center, Department of Oral Medicine, 1000 Blythe Blvd, MEB 409, Charlotte, NC 28232, USA
J Am Dent Assoc 137:62-6. 2006..The authors conducted a study to determine if odontogenic signs and symptoms in the emergency department predicted the development of overt odontogenic infection at a follow-up dental visit...
The impact of oral disease and nonsurgical treatment on bacteremia in childrenMichael T Brennan
Department of Oral Medicine, Carolinas Medical Center, P O Box 32861, Charlotte, NC 28232, USA
J Am Dent Assoc 138:80-5. 2007..The authors examine the role of dental disease and nonsurgical dental procedures in the incidence and duration of bacteremia in children...
Efficacy of penicillin for dental pain without overt infectionMichael S Runyon
Department of Emergency Medicine, Carolinas Medical Center, P O Box 32861, Charlotte, NC 28232 2861, USA
Acad Emerg Med 11:1268-71. 2004..The authors sought to test the hypothesis that penicillin is not necessary or beneficial in the treatment of undifferentiated dental pain without overt infection...
Salivary dysfunction associated with systemic diseases: systematic review and clinical management recommendationsInger von Bültzingslöwen
Department of Oral Medicine, Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103:S57.e1-15. 2007..The objective of this study was to identify systemic diseases associated with hyposalivation and xerostomia and develop evidence-based management recommendations for hyposalivation/xerostomia...
Treatment of xerostomia: a systematic review of therapeutic trialsMichael T Brennan
Department of Oral Medicine, Carolinas Medical Center, Post Office Box 3280, Charlotte, NC 28232, USA
Dent Clin North Am 46:847-56. 2002..Minimizing bias in clinical studies will allow for easier interpretation and comparisons of different studies. Better clinical trial design is vital to provide maximal confidence in the efficacy of xerostomia interventions...
World Workshop on Oral Medicine IV: Process and methodology for systematic review and developing management recommendations. Reference manual for management recommendations writing committeesLorena Baccaglini
University of Florida, Gainesville, Florida, USA
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103:S3.e1-19. 2007
Relationship between oral bacteria and hemodialysis access infectionGalib Shariff
Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC, USA
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 98:418-22. 2004..The purpose of this study was to determine the extent to which oral bacteria are associated with vascular access site infections in a group of HD patients...
The role of oral microbial colonization in ventilator-associated pneumoniaMichael T Brennan
Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC, USA
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 98:665-72. 2004..We need a deeper understanding of the pathophysiology of VAP in order to reduce the morbidity, mortality, and cost from this common complication in ICU medicine and surgery...
Prevention of premature discontinuation of dual antiplatelet therapy in patients with coronary artery stents: a science advisory from the American Heart Association, American College of Cardiology, Society for Cardiovascular Angiography and Interventions,Cindy L Grines
William Beaumont Hospital
Circulation 115:813-8. 2007..It also recommends postponing elective surgery for 1 year, and if surgery cannot be deferred, considering the continuation of aspirin during the perioperative period in high-risk patients with drug-eluting stents...
Prevention of infective endocarditis: guidelines from the American Heart Association: a guideline from the American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the CoWalter Wilson
Mayo Clinic, USA
Circulation 116:1736-54. 2007..The purpose of this statement is to update the recommendations by the American Heart Association (AHA) for the prevention of infective endocarditis that were last published in 1997...
Prevention of premature discontinuation of dual antiplatelet therapy in patients with coronary artery stents: a science advisory from the American Heart Association, American College of Cardiology, Society for Cardiovascular Angiography and Interventions,Cindy L Grines
J Am Coll Cardiol 49:734-9. 2007..It also recommends postponing elective surgery for 1 year, and if surgery cannot be deferred, considering the continuation of aspirin during the perioperative period in high-risk patients with drug-eluting stents...
Guidelines for prevention of infective endocarditis: an explanation of the changesPeter B Lockhart
Departmentof Oral Medicine, Carolinas Medical Center, Charlotte, NC, USA
J Am Dent Assoc 139:2S. 2008
Prevention of premature discontinuation of dual antiplatelet therapy in patients with coronary artery stents: a science advisory from the American Heart Association, American College of Cardiology, Society for Cardiovascular Angiography and Interventions,Cindy L Grines
Catheter Cardiovasc Interv 69:334-40. 2007..It also recommends postponing elective surgery for 1 year, and if surgery cannot be deferred, considering the continuation of aspirin during the perioperative period in high-risk patients with drug-eluting stents...
Molecular analysis of oral and respiratory bacterial species associated with ventilator-associated pneumoniaFarah K Bahrani-Mougeot
Department of Oral Medicine, Carolinas Medical Center, P O Box 32861, Charlotte, NC 28232, USA
J Clin Microbiol 45:1588-93. 2007..Furthermore, it is clear that the diversity of bacterial pathogens for VAP is far more complex than the current literature suggests...
Management of oral epithelial dysplasia: a reviewMichael Brennan
Carolinas Medical Center, Charlotte, NC, USA
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103:S19.e1-12. 2007..Because of the lack of randomized controlled trials that have shown effectiveness in the prevention of malignant transformation, no recommendations can be provided for specific surgical interventions of dysplastic oral lesions either...
Prevention of premature discontinuation of dual antiplatelet therapy in patients with coronary artery stents: a science advisory from the American Heart Association, American College of Cardiology, Society for Cardiovascular Angiography and Interventions,Cindy L Grines
William Beaumont Hospital, Royal Oak, Michigan, USA
J Am Dent Assoc 138:652-5. 2007..It also recommends postponing elective surgery for one year, and if surgery cannot be deferred, considering the continuation of aspirin during the perioperative period in high-risk patients with drug-eluting stents...
Research Grants
- Bacteremia from Dental Extraction vs. Oral HygienePeter Lockhart; Fiscal Year: 2004..Additionally, we will have unique and critical data for the development of both future research and evidence-based guidelines concerning antibiotic prophylaxis for individuals currently felt to be at risk for DSI. ..
- World Workshop in Oral Medicine IVPeter Lockhart; Fiscal Year: 2005..The proceedings will be published as evidence-based recommendations for best clinical practice in Oral Medicine as well as providing suggestions for future basic science and clinical research. ..
