JEFFREY KLINE

Summary

Affiliation: Carolinas Medical Center
Country: USA

Publications

  1. pmc Derivation and validation of a multivariate model to predict mortality from pulmonary embolism with cancer: The POMPE-C tool
    Jeffrey A Kline
    Department of Emergency Medicine, 1000 Blythe Boulevard, MEB 3rd Floor, Room 306, Charlotte, NC 28203, USA
    Thromb Res 129:e194-9. 2012
  2. pmc D-dimer threshold increase with pretest probability unlikely for pulmonary embolism to decrease unnecessary computerized tomographic pulmonary angiography
    J A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    J Thromb Haemost 10:572-81. 2012
  3. pmc Prospective study of the frequency and outcomes of patients with suspected pulmonary embolism administered heparin prior to confirmatory imaging
    Jeffrey A Kline
    Emergency Medicine Research, Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
    Thromb Res 129:e25-8. 2012
  4. doi Normalization of vital signs does not reduce the probability of acute pulmonary embolism in symptomatic emergency department patients
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Acad Emerg Med 19:11-7. 2012
  5. pmc Development and comparison of a minimally-invasive model of autologous clot pulmonary embolism in Sprague-Dawley and Copenhagen rats
    Michael S Runyon
    Emergency Medicine Research, Carolinas Medical Center, Charlotte, NC, USA
    Thromb J 8:3. 2010
  6. pmc One year mortality of patients treated with an emergency department based early goal directed therapy protocol for severe sepsis and septic shock: a before and after study
    Michael A Puskarich
    Department of Emergency Medicine, Carolinas Medical Center, 1000 Blythe Blvd, Charlotte, North Carolina 28203, USA
    Crit Care 13:R167. 2009
  7. ncbi Prospective study of the diagnostic accuracy of the simplify D-dimer assay for pulmonary embolism in emergency department patients
    Jeffrey A Kline
    Director, Emergency Medicine Research, Department of Emergency Medicine, Carolinas Medical Center, PO Box 32861, Charlotte, NC 28323 2861, USA
    Chest 129:1417-23. 2006
  8. pmc Prospective evaluation of right ventricular function and functional status 6 months after acute submassive pulmonary embolism: frequency of persistent or subsequent elevation in estimated pulmonary artery pressure
    Jeffrey A Kline
    Department of Emergency Medicine, Emergency Medicine Research, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
    Chest 136:1202-10. 2009
  9. ncbi Prospective study of the clinical features and outcomes of emergency department patients with delayed diagnosis of pulmonary embolism
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Acad Emerg Med 14:592-8. 2007
  10. doi Prospective multicenter evaluation of the pulmonary embolism rule-out criteria
    J A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
    J Thromb Haemost 6:772-80. 2008

Research Grants

Collaborators

Detail Information

Publications95

  1. pmc Derivation and validation of a multivariate model to predict mortality from pulmonary embolism with cancer: The POMPE-C tool
    Jeffrey A Kline
    Department of Emergency Medicine, 1000 Blythe Boulevard, MEB 3rd Floor, Room 306, Charlotte, NC 28203, USA
    Thromb Res 129:e194-9. 2012
    ..No quantitative decision instrument has been derived specifically for patients with active cancer and PE...
  2. pmc D-dimer threshold increase with pretest probability unlikely for pulmonary embolism to decrease unnecessary computerized tomographic pulmonary angiography
    J A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    J Thromb Haemost 10:572-81. 2012
    ....
  3. pmc Prospective study of the frequency and outcomes of patients with suspected pulmonary embolism administered heparin prior to confirmatory imaging
    Jeffrey A Kline
    Emergency Medicine Research, Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
    Thromb Res 129:e25-8. 2012
    ..We describe the use of ESA in a large prospective cohort of emergency department (ED) patients and report the outcomes of those treated with ESA compared with patients not receiving ESA...
  4. doi Normalization of vital signs does not reduce the probability of acute pulmonary embolism in symptomatic emergency department patients
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Acad Emerg Med 19:11-7. 2012
    ..The objective of this study was to evaluate if normalization of an initially abnormal vital sign can be used as evidence to lower the suspicion for PE...
  5. pmc Development and comparison of a minimally-invasive model of autologous clot pulmonary embolism in Sprague-Dawley and Copenhagen rats
    Michael S Runyon
    Emergency Medicine Research, Carolinas Medical Center, Charlotte, NC, USA
    Thromb J 8:3. 2010
    ..Current literature lacks a simple, well-described rat model of autlogous PE. Objective: Test if moderate-severity autologous PE in Sprague-Dawley (SD) and Copenhagen (Cop) rats can produce persistent PH...
  6. pmc One year mortality of patients treated with an emergency department based early goal directed therapy protocol for severe sepsis and septic shock: a before and after study
    Michael A Puskarich
    Department of Emergency Medicine, Carolinas Medical Center, 1000 Blythe Blvd, Charlotte, North Carolina 28203, USA
    Crit Care 13:R167. 2009
    ..We sought to determine one year outcomes associated with implementation of early goal directed therapy (EGDT) in the emergency department (ED) care of sepsis...
  7. ncbi Prospective study of the diagnostic accuracy of the simplify D-dimer assay for pulmonary embolism in emergency department patients
    Jeffrey A Kline
    Director, Emergency Medicine Research, Department of Emergency Medicine, Carolinas Medical Center, PO Box 32861, Charlotte, NC 28323 2861, USA
    Chest 129:1417-23. 2006
    ....
  8. pmc Prospective evaluation of right ventricular function and functional status 6 months after acute submassive pulmonary embolism: frequency of persistent or subsequent elevation in estimated pulmonary artery pressure
    Jeffrey A Kline
    Department of Emergency Medicine, Emergency Medicine Research, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
    Chest 136:1202-10. 2009
    ..The aim of this work was to document the rate of pulmonary hypertension, as assessed noninvasively by estimated right ventricular systolic pressure (RVSP) of >or= 40 mm Hg 6 months after the diagnosis of submassive PE...
  9. ncbi Prospective study of the clinical features and outcomes of emergency department patients with delayed diagnosis of pulmonary embolism
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Acad Emerg Med 14:592-8. 2007
    ....
  10. doi Prospective multicenter evaluation of the pulmonary embolism rule-out criteria
    J A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
    J Thromb Haemost 6:772-80. 2008
    ..We hypothesized that low suspicion and PERC(-) would predict a post-test probability of VTE(+) or death below 2.0%...
  11. doi Emergency clinician-performed compression ultrasonography for deep venous thrombosis of the lower extremity
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
    Ann Emerg Med 52:437-45. 2008
    ..However, the diagnostic accuracy of emergency clinician-performed ultrasonography performed by a heterogenous group of clinicians remains undefined...
  12. doi Accuracy of very low pretest probability estimates for pulmonary embolism using the method of attribute matching compared with the Wells score
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Acad Emerg Med 17:133-41. 2010
    ..The authors tested the accuracy of this method for forecasting a very low probability of venous thromboembolism (VTE) in symptomatic emergency department (ED) patients...
  13. doi Randomized trial of computerized quantitative pretest probability in low-risk chest pain patients: effect on safety and resource use
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
    Ann Emerg Med 53:727-35.e1. 2009
    ..We hypothesize that the presentation of a quantitative pretest probability of acute coronary syndrome would safely reduce unnecessary resource use in low-risk emergency department (ED) chest pain patients...
  14. doi Incidence and predictors of repeated computed tomographic pulmonary angiography in emergency department patients
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
    Ann Emerg Med 54:41-8. 2009
    ..We sought to measure the frequency of repeat CT pulmonary angiography in emergency department (ED) patients...
  15. pmc D-dimer and exhaled CO2/O2 to detect segmental pulmonary embolism in moderate-risk patients
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, 1000 Blythe Boulevard, Charlotte, NC 28203, USA
    Am J Respir Crit Care Med 182:669-75. 2010
    ..Pulmonary embolism (PE) decreases the exhaled end-tidal ratio of carbon dioxide to oxygen (etCO(2)/O(2))...
  16. pmc Patient Protection and Affordable Care Act of 2010: summary, analysis, and opportunities for advocacy for the academic emergency physician
    Jeffrey A Kline
    Department of Emergency Medicine at Carolinas Medical Center, Charlotte, NC, USA
    Acad Emerg Med 17:e69-74. 2010
    ..The authors conclude that this Act can be expected to have a profound influence on research and training in emergency care...
  17. ncbi New diagnostic tests for pulmonary embolism
    J A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28232 2861, USA
    Ann Emerg Med 35:168-80. 2000
    ..For comparison, recent data on the diagnostic utility of the alveolar-arterial oxygen gradient and the V/Q scan are included. The potential application of these new tests to a hypothetical ED population is described...
  18. ncbi Risk stratification for acute pulmonary embolism
    Jeffrey A Kline
    Department of Emergency Medicine, Mecklenburg Medical Group, Carolinas Medical Center, Charlotte, North Carolina
    J Natl Compr Canc Netw 9:800-10. 2011
    ..Patients with cancer with an incidentally discovered PE should be risk stratified the same as those who have clinically suspected PE...
  19. ncbi Diagnostic accuracy of a bedside D-dimer assay and alveolar dead-space measurement for rapid exclusion of pulmonary embolism: a multicenter study
    J A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28232 2816, USA
    JAMA 285:761-8. 2001
    ..A previous study suggested that the combination of a normal D-dimer assay and normal alveolar dead-space fraction is a highly sensitive screening test for pulmonary embolism (PE)...
  20. ncbi The clinical features of acute pulmonary embolism in ambulatory patients
    O Susec
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28232 2861, USA
    Acad Emerg Med 4:891-7. 1997
    ..To identify clinical findings and predisposing conditions associated with acute pulmonary embolism (PE) in ambulatory patients being evaluated for PE...
  21. ncbi Alveolar dead space as a predictor of severity of pulmonary embolism
    J A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28203, USA
    Acad Emerg Med 7:611-7. 2000
    ..To determine whether the alveolar dead space volume (V(D)alv), expressed as a percentage of the alveolar tidal volume (V(D)alv/V(T)alv), can predict the degree of vascular occlusion caused by pulmonary embolism (PE)...
  22. doi Prospective evaluation of real-time use of the pulmonary embolism rule-out criteria in an academic emergency department
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Acad Emerg Med 17:1016-9. 2010
    ..This study examined whether clinicians who document PERC negative also document results of all nine components of the PERC rule...
  23. ncbi Preliminary study of the capnogram waveform area to screen for pulmonary embolism
    J A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28232, USA
    Ann Emerg Med 32:289-96. 1998
    ....
  24. ncbi Use of the alveolar dead space fraction (Vd/Vt) and plasma D-dimers to exclude acute pulmonary embolism in ambulatory patients
    J A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28232 2861, USA
    Acad Emerg Med 4:856-63. 1997
    ..To evaluate the utility of a modified calculation of the alveolar dead space fraction (Vd/Vt), combined with plasma D-dimers, to aid in the exclusion of acute pulmonary embolism (PE)...
  25. ncbi Impact of a rapid rule-out protocol for pulmonary embolism on the rate of screening, missed cases, and pulmonary vascular imaging in an urban US emergency department
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
    Ann Emerg Med 44:490-502. 2004
    ..0% of patients with a negative protocol would have an adverse outcome...
  26. pmc Clinical features from the history and physical examination that predict the presence or absence of pulmonary embolism in symptomatic emergency department patients: results of a prospective, multicenter study
    D Mark Courtney
    Department of Emergency Medicine, Northwestern University, Chicago, IL, USA
    Ann Emerg Med 55:307-315.e1. 2010
    ..The objective of this study is to measure the predictive value of 13 implicit variables...
  27. ncbi Emergency department hypotension predicts sudden unexpected in-hospital mortality: a prospective cohort study
    Alan E Jones
    Department of Emergency Medicine, 1000 Blythe Blvd, MEB 304D, Carolinas Medical Center, Charlotte, NC 28203, USA
    Chest 130:941-6. 2006
    ..The prevalence and prognostic significance of nontraumatic hypotension measured in the emergency department (ED) have not been studied. We hypothesized that ED hypotension confers risk of in-hospital mortality...
  28. ncbi Interobserver agreement for the diagnosis of venous thromboembolism on computed tomography chest angiography and indirect venography of the lower extremities in emergency department patients
    Peter B Richman
    Department of Emergency Medicine, Mayo Clinic Hospital, Charlotte, NC, USA
    Acad Emerg Med 13:295-301. 2006
    ..CT venography of the lower extremities combined with standard CT angiography of the chest may result in an increased overall diagnosis rate of venous thromboembolism (pulmonary embolism or deep venous thrombosis)...
  29. ncbi Surrogate markers for adverse outcomes in normotensive patients with pulmonary embolism
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Crit Care Med 34:2773-80. 2006
    ..Although echocardiography has proven utility in risk stratifying normotensive patients with pulmonary embolism, echocardiography is not always available...
  30. ncbi Measurement of expired carbon dioxide, oxygen and volume in conjunction with pretest probability estimation as a method to diagnose and exclude pulmonary venous thromboembolism
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Centre, Charlotte, NC 28232, USA
    Clin Physiol Funct Imaging 26:212-9. 2006
    ..Expired pCO(2), pO(2) and breath volume were measured. All patients underwent standardized objective testing for PE including 90-day follow-up. Diagnosis (PE+) required anticoagulation for image-proven PE within 90 days...
  31. ncbi Prospective multicenter study of quantitative pretest probability assessment to exclude acute coronary syndrome for patients evaluated in emergency department chest pain units
    Alice M Mitchell
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
    Ann Emerg Med 47:447. 2006
    ....
  32. ncbi Inhibition of CINC-1 decreases right ventricular damage caused by experimental pulmonary embolism in rats
    John Zagorski
    Department of Emergency Medicine, James G Cannon Research Center, Carolinas Medical Center, Charlotte, NC 28203, USA
    J Immunol 179:7820-6. 2007
    ..These results suggest that selective anti-inflammatory therapies targeted at neutrophil chemoattractants will reduce cardiac inflammation and reduce RV damage in the setting of PE...
  33. ncbi Inhibition of prostaglandin synthesis during polystyrene microsphere-induced pulmonary embolism in the rat
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, North Carolina 28203, USA
    Am J Physiol Lung Cell Mol Physiol 284:L1072-81. 2003
    ..Experimental PE increased lung and systemic production of TxB(2). Inhibition at the COX-1/2 enzyme was equally as effective as inhibition of thromboxane synthase at reducing alveolar dead space and improving heart function after PE...
  34. ncbi Prevalence and significance of nonthromboembolic findings on chest computed tomography angiography performed to rule out pulmonary embolism: a multicenter study of 1,025 emergency department patients
    Peter B Richman
    Department of Emergency Medicine, Mayo Clinic Hospital, Scottsdale, AZ, USA
    Acad Emerg Med 11:642-7. 2004
    ..To evaluate the hypothesis that computed tomography (CT) angiography often yields a result interpreted as an alternative diagnosis to pulmonary embolism (PE) in emergency department (ED) patients...
  35. pmc The significance of non-sustained hypotension in emergency department patients with sepsis
    Michael R Marchick
    Emergency Medicine Research, Department of Emergency Medicine, Carolinas Medical Center, PO Box 32861, Charlotte, NC 28232 2861, USA
    Intensive Care Med 35:1261-4. 2009
    ..We hypothesized that ED non-sustained hypotension increases risk of in-hospital mortality in patients with sepsis...
  36. ncbi Methodology for a rapid protocol to rule out pulmonary embolism in the emergency department
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28203, USA
    Ann Emerg Med 42:266-75. 2003
    ..Finally, we assess the potential effect of the proposed pulmonary embolism rule-out protocol on use of imaging resources and ED throughput...
  37. doi Comparison of 8 biomarkers for prediction of right ventricular hypokinesis 6 months after submassive pulmonary embolism
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
    Am Heart J 156:308-14. 2008
    ..We compare the prognostic use of BNP, troponin I, D-dimer, monocyte chemoattractant protein-1, matrix metalloproteinase, myeloperoxidase, C-reactive protein, and caspase 3 as biomarkers of RV damage and adverse outcomes in submassive PE...
  38. ncbi Comparison of the unstructured clinician estimate of pretest probability for pulmonary embolism to the Canadian score and the Charlotte rule: a prospective observational study
    Michael S Runyon
    Department of Emergency Medicine, Carolinas Medical Center, P O Box 32861, Charlotte, NC 28232 2861, USA
    Acad Emerg Med 12:587-93. 2005
    ..However, many clinicians prefer to use clinical gestalt for this purpose. The authors compared the unstructured clinical estimate of pretest probability for PE with two clinical decision rules...
  39. ncbi Cardiac UCP2 expression and myocardial oxidative metabolism during acute septic shock in the rat
    Michael J Roshon
    Division of Research, Department of Emergency Medicine, Carolinas Medical Center, Charlotte, North Carolina 28323 2861, USA
    Shock 19:570-6. 2003
    ..These data argue against the hypothesis that UCP-2 causes decreased cardiac mechanical efficiency in septic shock...
  40. pmc Performance of the Mortality in Emergency Department Sepsis score for predicting hospital mortality among patients with severe sepsis and septic shock
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28203, USA
    Am J Emerg Med 26:689-92. 2008
    ..The aim of the study was to test if the Mortality in Emergency Department Sepsis (MEDS) score accurately predicts death among emergency department (ED) patients with severe sepsis and septic shock...
  41. pmc Prospective external validation of the clinical effectiveness of an emergency department-based early goal-directed therapy protocol for severe sepsis and septic shock
    Alan E Jones
    Assistant Director of Research, Department of Emergency Medicine, 1000 Blythe Blvd, MEB 304e, Carolinas Medical Center, Charlotte, NC 28203, USA
    Chest 132:425-32. 2007
    ..To determine the clinical effectiveness of implementing early goal-directed therapy (EGDT) as a routine protocol in the emergency department (ED)...
  42. pmc Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial
    Alan E Jones
    Department of Emergency Medicine, 1000 Blythe Blvd, Carolinas Medical Center, Charlotte, NC 28203, USA
    JAMA 303:739-46. 2010
    ..Goal-directed resuscitation for severe sepsis and septic shock has been reported to reduce mortality when applied in the emergency department...
  43. doi Indirect computed tomography venography: a report of vascular opacification
    Patrick R Burnside
    Carolinas Medical Center, Charlotte, NC, USA
    Emerg Radiol 17:195-201. 2010
    ..5% for DVT thrombus. CTV imaging produces a very small HU gradient between clot and blood in leg veins. These findings highlight the importance of ancillary radiological findings in assessing presence of DVT on CTV...
  44. doi Proinflammatory events in right ventricular damage during pulmonary embolism: effects of treatment with ketorolac in rats
    John A Watts
    Emergency Medicine Research, Carolinas Medical Center, Charlotte, NC 28232 2861, USA
    J Cardiovasc Pharmacol 54:246-52. 2009
    ..Ketorolac reduced CINC-1 stimulated chemotaxis of isolated neutrophils. PE converted cardiac tissue into a proinflammatory phenotype. Ketorolac reduced RV inflammatory genes, reduced neutrophil influx, and improved RV function in rat PE...
  45. doi 12-lead ECG findings of pulmonary hypertension occur more frequently in emergency department patients with pulmonary embolism than in patients without pulmonary embolism
    Michael R Marchick
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
    Ann Emerg Med 55:331-5. 2010
    ..We hypothesize that ECG findings consistent with pulmonary hypertension would be observed more frequently in patients with pulmonary embolism...
  46. doi Right ventricular heart failure from pulmonary embolism: key distinctions from chronic pulmonary hypertension
    John A Watts
    Emergency Medicine Research, Carolinas Medical Center, 1542 Garden Terrace, Charlotte, NC 28203, USA
    J Card Fail 16:250-9. 2010
    ....
  47. doi Tandem measurement of D-dimer and myeloperoxidase or C-reactive protein to effectively screen for pulmonary embolism in the emergency department
    Alice M Mitchell
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Acad Emerg Med 15:800-5. 2008
    ....
  48. pmc The effect of a quantitative resuscitation strategy on mortality in patients with sepsis: a meta-analysis
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Crit Care Med 36:2734-9. 2008
    ..Quantitative resuscitation consists of structured cardiovascular intervention targeting predefined hemodynamic end points. We sought to measure the treatment effect of quantitative resuscitation on mortality from sepsis...
  49. pmc Factors associated with positive D-dimer results in patients evaluated for pulmonary embolism
    Christopher Kabrhel
    Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Acad Emerg Med 17:589-97. 2010
    ..To help clinicians better target testing, this study sought to quantify the effect of risk factors for a positive quantitative D-dimer in patients evaluated for PE...
  50. ncbi Operational performance of validated physiologic scoring systems for predicting in-hospital mortality among critically ill emergency department patients
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Crit Care Med 33:974-8. 2005
    ..We tested the prognostic accuracy of these instruments for predicting mortality among a cohort of critically ill emergency department patients...
  51. ncbi Chemokines accumulate in the lungs of rats with severe pulmonary embolism induced by polystyrene microspheres
    John Zagorski
    Department of Emergency Medicine, James G Cannon Research Center, Carolinas Medical Center, Charlotte, NC 28203, USA
    J Immunol 171:5529-36. 2003
    ....
  52. doi Impact of anaesthesia-surgery on D-dimer concentration and end-tidal CO2 and O2 in patients undergoing surgery associated with high risk for pulmonary embolism
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28232 2861, USA
    Clin Physiol Funct Imaging 28:161-8. 2008
    ..The exhaled end-tidal CO2/O2 ratio and the D-dimer concentration are diagnostic markers of pulmonary embolism (PE)...
  53. ncbi Randomized, controlled trial of immediate versus delayed goal-directed ultrasound to identify the cause of nontraumatic hypotension in emergency department patients
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, 1000 Blythe Boulevard, Charlotte, NC 28203, USA
    Crit Care Med 32:1703-8. 2004
    ..We examined a physician-performed, goal-directed ultrasound protocol for the emergency department management of nontraumatic, symptomatic, undifferentiated hypotension...
  54. ncbi Bench to bedside: the role of mitochondrial medicine in the pathogenesis and treatment of cellular injury
    John A Watts
    Emergency Medicine Research, Carolinas Medical Center, Charlotte, NC 28232, USA
    Acad Emerg Med 10:985-97. 2003
    ..For individuals interested in the biochemistry of mitochondria, knowledge of this fundamental organelle is expanding at a rapid rate...
  55. ncbi Use of pulse oximetry to predict in-hospital complications in normotensive patients with pulmonary embolism
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, North Carolina 28323 2861, USA
    Am J Med 115:203-8. 2003
    ..A simple method is needed to risk stratify normotensive patients with pulmonary embolism. We studied whether bedside clinical data can predict in-hospital complications from pulmonary embolism...
  56. ncbi Cardiac inflammation contributes to right ventricular dysfunction following experimental pulmonary embolism in rats
    John A Watts
    Emergency Medicine Research, Carolinas Medical Center, Cannon Research Center, Charlotte, NC 28232 2861, USA
    J Mol Cell Cardiol 41:296-307. 2006
    ..Experimental agranulocytosis reduced RV, suggesting that neutrophil influx contributed to RV damage...
  57. ncbi Nontraumatic out-of-hospital hypotension predicts inhospital mortality
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Ann Emerg Med 43:106-13. 2004
    ..Out-of-hospital hypotension may signify need for intensive resuscitation and rapid diagnosis on emergency department (ED) arrival. We hypothesized that nontraumatic out-of-hospital hypotension confers risk of inhospital mortality...
  58. pmc Pretest probability assessment derived from attribute matching
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    BMC Med Inform Decis Mak 5:26. 2005
    ..This report compares a novel attribute-matching method to generate a PTP for acute coronary syndrome (ACS). We compare the new method with a validated logistic regression equation (LRE)...
  59. ncbi Severity of emergency department hypotension predicts adverse hospital outcome
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28203, USA
    Shock 22:410-4. 2004
    ..1; 95% CI 1.5-7.1). Mortality among patients who present to the ED with undifferentiated shock is high. The depth and duration of systolic blood pressure appears to have a dose-response relationship to adverse hospital outcome...
  60. pmc The Sequential Organ Failure Assessment score for predicting outcome in patients with severe sepsis and evidence of hypoperfusion at the time of emergency department presentation
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Crit Care Med 37:1649-54. 2009
    ..We examined the utility of the SOFA score for assessing outcome of patients with severe sepsis with evidence of hypoperfusion at the time of emergency department (ED) presentation...
  61. ncbi Procalcitonin test in the diagnosis of bacteremia: a meta-analysis
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28232 2861, USA
    Ann Emerg Med 50:34-41. 2007
    ..We seek to evaluate the diagnostic performance of the procalcitonin test for the diagnosis of bacteremia in the emergency department (ED) population...
  62. ncbi Criteria for the safe use of D-dimer testing in emergency department patients with suspected pulmonary embolism: a multicenter US study
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Ann Emerg Med 39:144-52. 2002
    ....
  63. ncbi Emergency echocardiography to detect pericardial effusion in patients in PEA and near-PEA states
    Vivek S Tayal
    Department of Emergency Medicine, P O Box 32861, Charlotte, NC 28232, USA
    Resuscitation 59:315-8. 2003
    ..We observed the value of EM echo by emergency physicians in detecting pericardial effusion in patients in PEA and near PEA states...
  64. doi Systematic review of emergency physician-performed ultrasonography for lower-extremity deep vein thrombosis
    Patrick R Burnside
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Acad Emerg Med 15:493-8. 2008
    ..The authors performed a systematic review to evaluate published literature on diagnostic performance of emergency physician-performed ultrasonography (EPPU) for the diagnosis and exclusion of deep venous thrombosis (DVT)...
  65. ncbi Diagnostic accuracy of left ventricular function for identifying sepsis among emergency department patients with nontraumatic symptomatic undifferentiated hypotension
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, North Carolina 28203, USA
    Shock 24:513-7. 2005
    ..5 (95% CI 1.1-45). Among ED patients with non-traumatic undifferentiated symptomatic hypotension, the presence of hyperdynamic LVF on focused echo is highly specific for sepsis as the etiology of shock...
  66. ncbi Electronic medical record review as a surrogate to telephone follow-up to establish outcome for diagnostic research studies in the emergency department
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
    Acad Emerg Med 12:1127-33. 2005
    ..Follow-up for diagnostic research studies might be facilitated if medical record review (MRR) could be used instead of telephone calls...
  67. pmc Prospective study of clinician-entered research data in the Emergency Department using an Internet-based system after the HIPAA Privacy Rule
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    BMC Med Inform Decis Mak 4:17. 2004
    ..Design and test the reliability of a web-based system for multicenter, real-time collection of data in the emergency department (ED), under waiver of authorization, in compliance with HIPAA...
  68. ncbi Derivation and validation of a Bayesian network to predict pretest probability of venous thromboembolism
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
    Ann Emerg Med 45:282-90. 2005
    ..We determine the accuracy with which a Bayesian network can identify patients with a low pretest probability of venous thromboembolism, defined as less than or equal to 2%...
  69. doi Summary of NIH Medical-Surgical Emergency Research Roundtable held on April 30 to May 1, 2009
    Amy H Kaji
    Department of Emergency Medicine, Harbor UCLA Medical Center, 1000 W Carson Street, Box 21, Torrance, CA 90509 2910, USA
    Ann Emerg Med 56:522-37. 2010
    ....
  70. ncbi Prospective use of a clinical decision rule to identify pulmonary embolism as likely cause of outpatient cardiac arrest
    D Mark Courtney
    Department of Emergency Medicine, Feinberg School of Medicine, Northwestern University, Emergency Medicine, 259 E Erie Suite 100, Chicago, IL 60611, USA
    Resuscitation 65:57-64. 2005
    ..These retrospectively studied patients also had significant frequency of pre-arrest respiratory distress, altered mental status, and shock...
  71. ncbi Tenecteplase to treat pulmonary embolism in the emergency department
    Jeffrey A Kline
    Emergency Medicine Research, Department of Emergency Medicine, Carolinas Medical Center, PO Box 32861, Charlotte, NC 28323 2861, USA
    J Thromb Thrombolysis 23:101-5. 2007
    ..Taken together, we submit that the present case report and prior case reports are sufficient to comprise a phase I study of the safety and efficacy of tenecteplase to treat acute pulmonary embolism...
  72. doi Transcriptional profile of right ventricular tissue during acute pulmonary embolism in rats
    John Zagorski
    Department of Emergency Medicine, James G Cannon Research Center, Carolinas Medical Center, Charlotte, NC 28203, USA
    Physiol Genomics 34:101-11. 2008
    ..This pattern suggests an extensive shift in cardiac physiology favoring the expression of the "fetal gene program."..
  73. ncbi Emergency department resuscitative procedures: animal laboratory training improves procedural competency and speed
    Catherine B Custalow
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Acad Emerg Med 9:575-86. 2002
    ..Certain resuscitative procedures can be lifesaving, but are performed infrequently by emergency medicine (EM) residents on human subjects. Alternative training methods for gaining procedural proficiency must be explored and tested...
  74. ncbi Determination of left ventricular function by emergency physician echocardiography of hypotensive patients
    Christopher L Moore
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28232, USA
    Acad Emerg Med 9:186-93. 2002
    ..To determine whether emergency physicians (EPs) with goal-directed training can use echocardiography to accurately assess left ventricular function (LVF) in hypotensive emergency department (ED) patients...
  75. doi Transcriptional changes in right ventricular tissues are enriched in the outflow tract compared with the apex during chronic pulmonary embolism in rats
    John Zagorski
    Department of Emergency Medicine, James G Cannon Research Center, Carolinas Medical Center, Charlotte, North Carolina 28203, USA
    Physiol Genomics 39:61-71. 2009
    ..The apex region of the RV had few compensating adaptations...
  76. doi Risk stratification and treatment strategy of pulmonary embolism
    Andrea Penaloza
    Emergency Department, Cliniques Universitaires St Luc, Universite Catholique de Louvain, Brussels, Belgium
    Curr Opin Crit Care 18:318-25. 2012
    ..Optimizing risk stratification to prognose pulmonary embolism patients appears to be important to improve management, treatment and clinical outcome...
  77. ncbi Risk stratification of community-acquired pneumonia: what does all of this mean?
    Alan E Jones
    Ann Emerg Med 52:61-2. 2008
  78. ncbi Use of goal-directed therapy for severe sepsis and septic shock in academic emergency departments
    Alan E Jones
    Crit Care Med 33:1888-9; author reply 1889-90. 2005
  79. ncbi Pleural effusions in the critically ill: the evolving role of bedside ultrasound
    Alan E Jones
    Crit Care Med 33:1874-5. 2005
  80. ncbi Frequency of thrombophilia-related genetic variations in patients with idiopathic pulmonary embolism in an urban emergency department
    Lori Kruse
    Department of Emergency Medicine, James G Cannon Research Center, Carolinas Medical Center, Charlotte, NC 28203, USA
    Clin Chem 52:1026-32. 2006
    ....
  81. ncbi The beneficial effects of dichloroacetate in acute limb ischemia
    Timothy A Platz
    Department of Vascular and Endovascular Surgery, Naval Medical Center Portsmouth, 620 John Paul Jones Circle, Portsmouth, VA 23708, USA
    Mil Med 172:628-33. 2007
    ..The purpose of this study was to determine the effects of dichloroacetate (DCA) in acute limb ischemia...
  82. ncbi End tidal CO(2) is reduced during hypotension and cardiac arrest in a rat model of massive pulmonary embolism
    D Mark Courtney
    Division of Emergency Medicine, Northwestern Memorial Hospital, Chicago, IL, USA
    Resuscitation 53:83-91. 2002
    ....
  83. ncbi Frequency of thromboprophylaxis and incidence of in-hospital venous thromboembolism in a cohort of emergency department patients
    Alan E Jones
    Department of Emergency Medicine, Emergency Medicine Research, Carolinas Medical Center, PO Box 32861, Charlotte, NC 28232 2861, USA
    J Thromb Thrombolysis 25:160-4. 2008
    ..Our objective was to quantify the rate of thromboprophylaxis and incidence of in-hospital VTE, based upon risk of VTE, in a cohort of patients admitted through the emergency department (ED)...
  84. ncbi Evaluation of capnography using a genetic algorithm to predict PaCO2
    Milo Engoren
    Department of Anesthesiology, St Vincent Mercy Medical Center, 2213 Cherry St, Toledo, OH 43608, USA
    Chest 127:579-84. 2005
    ..A genetic algorithm is a computer technique for discovering relationships between variables. The purpose of this study was to use a genetic algorithm to improve the precision of Paco(2) prediction in comparison to Petco(2)...
  85. ncbi Fatal pulmonary embolism immediately after transatlantic air travel to the United States: less than one in a million
    Jeffrey A Kline
    Thromb Haemost 87:342. 2002
  86. ncbi Determination of the effect of in vitro time, temperature, and tourniquet use on whole blood venous point-of-care lactate concentrations
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Acad Emerg Med 14:587-91. 2007
    ..The authors sought to determine the effect of in vitro time, temperature, and removable tourniquet use on changes in venous point-of-care lactate concentrations...
  87. ncbi Echocardiographic and functional cardiopulmonary problems 6 months after first-time pulmonary embolism in previously healthy patients
    Brad G Stevinson
    MS4, School of Medicine, Georgetown University, Washington DC, USA
    Eur Heart J 28:2517-24. 2007
    ....
  88. ncbi Dichloroacetate increases skeletal muscle pyruvate dehydrogenase activity during acute limb ischemia
    Jeffrey S Wilson
    Division of Vascular and Endovascular Surgery, University of South Florida College of Medicine, Tampa, FL, USA
    Vasc Endovascular Surg 37:191-5. 2003
    ..Ischemic muscle function was also improved by DCA treatment. Further investigation of the potential beneficial effects of DCA treatment on muscle injury during ischemia and reperfusion is warranted...
  89. pmc Prospective, randomized evaluation of a personal digital assistant-based research tool in the emergency department
    Morris L Rivera
    Dept of Emergency Medicine, Hilo Medical Center, Hilo, HI, USA
    BMC Med Inform Decis Mak 8:3. 2008
    ..The aim of this study was to prospectively compare the performance of PDA and paper enrollment instruments with respect to time required and errors generated...
  90. ncbi Emergency medicine practitioner knowledge and use of decision rules for the evaluation of patients with suspected pulmonary embolism: variations by practice setting and training level
    Michael S Runyon
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Acad Emerg Med 14:53-7. 2007
    ..Several clinical decision rules (CDRs) have been validated for pretest probability assessment of pulmonary embolism (PE), but the authors are unaware of any data quantifying and characterizing their use in emergency departments...
  91. doi Systematic bias introduced by the informed consent process in a diagnostic research study
    Alice M Mitchell
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Acad Emerg Med 15:225-30. 2008
    ..The authors hypothesized that the prevalence of venous thromboembolism (VTE) would be lower among study participants and that medical acuity and refusal to provide a blood sample would be the most common reasons for nonparticipation...
  92. ncbi Elevated brain natriuretic peptide in septic patients without heart failure
    Alan E Jones
    Ann Emerg Med 42:714-5. 2003
  93. ncbi Estimating the pretest probability threshold to justify empiric administration of heparin prior to pulmonary vascular imaging for pulmonary embolism
    Kerstin E Hogg
    Department of Emergency Medicine, Hope Hospital, Manchester, UK
    Thromb Res 118:547-53. 2006
    ..For these three time points, we estimate the pretest probability of pulmonary embolism to justify the empiric administration of heparin...
  94. ncbi Crash course in decision making
    Jeffrey A Kline
    Acad Emerg Med 11:179-80. 2004
  95. ncbi Focused training of emergency medicine residents in goal-directed echocardiography: a prospective study
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28203, USA
    Acad Emerg Med 10:1054-8. 2003
    ..To determine if a focused transthoracic echocardiography (TTE) training course would improve the accuracy of completion and interpretation of a goal-directed TTE by emergency medicine residents...

Research Grants6

  1. Surrogate markers for Severe Pulmonary Embolism
    JEFFREY KLINE; Fiscal Year: 2005
    ..This study will determine if criteria that are widely and immediately available in most hospitals can be used to risk-stratify severity of PE and to clarify the role of nonmalignant thrombophilias on the prognosis of PE. ..
  2. Pretest Probability Assessment for Pulmonary Embolism
    JEFFREY KLINE; Fiscal Year: 2005
    ..In phase III, we will test the validity of the PE PREtest Consult TM and determine if the use of the PE PREtest ConsultTM will decrease unnecessary testing for PE. ..
  3. Expired CO2/O2 Analysis to Diagnose Pulmonary Embolism
    JEFFREY KLINE; Fiscal Year: 2007
    ..This project will fund a clinical study designed to test the diagnostic accuracy of a hand- held breath device that detects the altered gas exchange physiology caused by PE in post-surgical and other patients at high risk for PE. ..