Alan E Jones

Summary

Affiliation: Carolinas Medical Center
Country: USA

Publications

  1. ncbi request reprint Emergency department hypotension predicts sudden unexpected in-hospital mortality: a prospective cohort study
    Alan E Jones
    Department of Emergency Medicine, 1000 Blythe Blvd, MEB 304D, Carolinas Medical Center, Charlotte, NC 28203, USA
    Chest 130:941-6. 2006
  2. pmc Prospective external validation of the clinical effectiveness of an emergency department-based early goal-directed therapy protocol for severe sepsis and septic shock
    Alan E Jones
    Assistant Director of Research, Department of Emergency Medicine, 1000 Blythe Blvd, MEB 304e, Carolinas Medical Center, Charlotte, NC 28203, USA
    Chest 132:425-32. 2007
  3. pmc Implementing early goal-directed therapy in the emergency setting: the challenges and experiences of translating research innovations into clinical reality in academic and community settings
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Acad Emerg Med 14:1072-8. 2007
  4. pmc The Sequential Organ Failure Assessment score for predicting outcome in patients with severe sepsis and evidence of hypoperfusion at the time of emergency department presentation
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Crit Care Med 37:1649-54. 2009
  5. pmc Performance of the Mortality in Emergency Department Sepsis score for predicting hospital mortality among patients with severe sepsis and septic shock
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28203, USA
    Am J Emerg Med 26:689-92. 2008
  6. pmc Cost-effectiveness of an emergency department-based early sepsis resuscitation protocol
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Crit Care Med 39:1306-12. 2011
  7. doi request reprint Sepsis-induced tissue hypoperfusion
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, 28203, USA
    Crit Care Nurs Clin North Am 23:115-25. 2011
  8. pmc The effect of a quantitative resuscitation strategy on mortality in patients with sepsis: a meta-analysis
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Crit Care Med 36:2734-9. 2008
  9. doi request reprint Sepsis-induced tissue hypoperfusion
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28203, USA
    Crit Care Clin 25:769-79, ix. 2009
  10. ncbi request reprint Procalcitonin test in the diagnosis of bacteremia: a meta-analysis
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28232 2861, USA
    Ann Emerg Med 50:34-41. 2007

Detail Information

Publications77

  1. ncbi request reprint Emergency department hypotension predicts sudden unexpected in-hospital mortality: a prospective cohort study
    Alan E Jones
    Department of Emergency Medicine, 1000 Blythe Blvd, MEB 304D, Carolinas Medical Center, Charlotte, NC 28203, USA
    Chest 130:941-6. 2006
    ..The prevalence and prognostic significance of nontraumatic hypotension measured in the emergency department (ED) have not been studied. We hypothesized that ED hypotension confers risk of in-hospital mortality...
  2. pmc Prospective external validation of the clinical effectiveness of an emergency department-based early goal-directed therapy protocol for severe sepsis and septic shock
    Alan E Jones
    Assistant Director of Research, Department of Emergency Medicine, 1000 Blythe Blvd, MEB 304e, Carolinas Medical Center, Charlotte, NC 28203, USA
    Chest 132:425-32. 2007
    ..To determine the clinical effectiveness of implementing early goal-directed therapy (EGDT) as a routine protocol in the emergency department (ED)...
  3. pmc Implementing early goal-directed therapy in the emergency setting: the challenges and experiences of translating research innovations into clinical reality in academic and community settings
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Acad Emerg Med 14:1072-8. 2007
    ....
  4. pmc The Sequential Organ Failure Assessment score for predicting outcome in patients with severe sepsis and evidence of hypoperfusion at the time of emergency department presentation
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Crit Care Med 37:1649-54. 2009
    ..We examined the utility of the SOFA score for assessing outcome of patients with severe sepsis with evidence of hypoperfusion at the time of emergency department (ED) presentation...
  5. pmc Performance of the Mortality in Emergency Department Sepsis score for predicting hospital mortality among patients with severe sepsis and septic shock
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28203, USA
    Am J Emerg Med 26:689-92. 2008
    ..The aim of the study was to test if the Mortality in Emergency Department Sepsis (MEDS) score accurately predicts death among emergency department (ED) patients with severe sepsis and septic shock...
  6. pmc Cost-effectiveness of an emergency department-based early sepsis resuscitation protocol
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Crit Care Med 39:1306-12. 2011
    ..Guidelines recommend that sepsis be treated with an early resuscitation protocol such as early goal-directed therapy. Our objective was to assess the cost-effectiveness of implementing early goal-directed therapy as a routine protocol...
  7. doi request reprint Sepsis-induced tissue hypoperfusion
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, 28203, USA
    Crit Care Nurs Clin North Am 23:115-25. 2011
    ..Once detected, aggressive and endpoint-directed resuscitation should be implemented to reverse the hypoperfusion and to prevent further deterioration, organ dysfunction, and death...
  8. pmc The effect of a quantitative resuscitation strategy on mortality in patients with sepsis: a meta-analysis
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Crit Care Med 36:2734-9. 2008
    ..Quantitative resuscitation consists of structured cardiovascular intervention targeting predefined hemodynamic end points. We sought to measure the treatment effect of quantitative resuscitation on mortality from sepsis...
  9. doi request reprint Sepsis-induced tissue hypoperfusion
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28203, USA
    Crit Care Clin 25:769-79, ix. 2009
    ..Therefore, it is critical for the clinician to understand the pathophysiology, recognition, and treatment of sepsis-induced hypoperfusion...
  10. ncbi request reprint Procalcitonin test in the diagnosis of bacteremia: a meta-analysis
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28232 2861, USA
    Ann Emerg Med 50:34-41. 2007
    ..We seek to evaluate the diagnostic performance of the procalcitonin test for the diagnosis of bacteremia in the emergency department (ED) population...
  11. pmc Whole blood lactate kinetics in patients undergoing quantitative resuscitation for severe sepsis and septic shock
    Michael A Puskarich
    Department of Emergency Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Chest 143:1548-53. 2013
    ..We sought to compare the association of whole-blood lactate kinetics with survival in patients with septic shock undergoing early quantitative resuscitation...
  12. pmc Prognostic value and agreement of achieving lactate clearance or central venous oxygen saturation goals during early sepsis resuscitation
    Michael A Puskarich
    Department of Emergency Medicine Carolinas Medical Center, Charlotte, NC, USA
    Acad Emerg Med 19:252-8. 2012
    ..The authors sought to determine the agreement and prognostic value of achieving ScvO(2) or LC goals in septic shock patients undergoing emergency department (ED)-based early resuscitation...
  13. doi request reprint Relationship between supranormal oxygen tension and outcome after resuscitation from cardiac arrest
    J Hope Kilgannon
    Department of Emergency Medicine, Cooper University Hospital, Camden, NJ 08103, USA
    Circulation 123:2717-22. 2011
    ..We aimed to define the relationship between supranormal oxygen tension and outcome in postresuscitation patients...
  14. pmc Association between timing of antibiotic administration and mortality from septic shock in patients treated with a quantitative resuscitation protocol
    Michael A Puskarich
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Crit Care Med 39:2066-71. 2011
    ..We sought to determine the association between time to initial antibiotics and mortality of patients with septic shock treated with an emergency department-based early resuscitation protocol...
  15. doi request reprint Predictors of the complication of postintubation hypotension during emergency airway management
    Alan C Heffner
    Division of Critical Care Medicine, Department of Internal Medicine, Carolinas Medical Center, Charlotte, NC 28203, USA
    J Crit Care 27:587-93. 2012
    ..Our aim was to identify factors associated with postintubation hypotension after emergency intubation...
  16. pmc Diabetes is not associated with increased mortality in emergency department patients with sepsis
    Philipp Schuetz
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Ann Emerg Med 58:438-44. 2011
    ..Our aim is to investigate the association of diabetes and initial glucose level with mortality in patients with suspected infection from the ED...
  17. doi request reprint Multicenter observational study of the development of progressive organ dysfunction and therapeutic interventions in normotensive sepsis patients in the emergency department
    Ryan C Arnold
    Department of Emergency Medicine, Cooper University Hospital, Camden, NJ, USA
    Acad Emerg Med 20:433-40. 2013
    ....
  18. pmc One year mortality of patients treated with an emergency department based early goal directed therapy protocol for severe sepsis and septic shock: a before and after study
    Michael A Puskarich
    Department of Emergency Medicine, Carolinas Medical Center, 1000 Blythe Blvd, Charlotte, North Carolina 28203, USA
    Crit Care 13:R167. 2009
    ..We sought to determine one year outcomes associated with implementation of early goal directed therapy (EGDT) in the emergency department (ED) care of sepsis...
  19. doi request reprint Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality
    J Hope Kilgannon
    Department of Emergency Medicine, Cooper University Hospital, One Cooper Plaza, Camden, NJ 08103, USA
    JAMA 303:2165-71. 2010
    ..Laboratory investigations suggest that exposure to hyperoxia after resuscitation from cardiac arrest may worsen anoxic brain injury; however, clinical data are lacking...
  20. pmc Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial
    Alan E Jones
    Department of Emergency Medicine, 1000 Blythe Blvd, Carolinas Medical Center, Charlotte, NC 28203, USA
    JAMA 303:739-46. 2010
    ..Goal-directed resuscitation for severe sepsis and septic shock has been reported to reduce mortality when applied in the emergency department...
  21. ncbi request reprint Comparison of the unstructured clinician estimate of pretest probability for pulmonary embolism to the Canadian score and the Charlotte rule: a prospective observational study
    Michael S Runyon
    Department of Emergency Medicine, Carolinas Medical Center, P O Box 32861, Charlotte, NC 28232 2861, USA
    Acad Emerg Med 12:587-93. 2005
    ..However, many clinicians prefer to use clinical gestalt for this purpose. The authors compared the unstructured clinical estimate of pretest probability for PE with two clinical decision rules...
  22. pmc Derivation and validation of a multivariate model to predict mortality from pulmonary embolism with cancer: The POMPE-C tool
    Jeffrey A Kline
    Department of Emergency Medicine, 1000 Blythe Boulevard, MEB 3rd Floor, Room 306, Charlotte, NC 28203, USA
    Thromb Res 129:e194-9. 2012
    ..No quantitative decision instrument has been derived specifically for patients with active cancer and PE...
  23. ncbi request reprint Randomized, controlled trial of immediate versus delayed goal-directed ultrasound to identify the cause of nontraumatic hypotension in emergency department patients
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, 1000 Blythe Boulevard, Charlotte, NC 28203, USA
    Crit Care Med 32:1703-8. 2004
    ..We examined a physician-performed, goal-directed ultrasound protocol for the emergency department management of nontraumatic, symptomatic, undifferentiated hypotension...
  24. ncbi request reprint Impact of a rapid rule-out protocol for pulmonary embolism on the rate of screening, missed cases, and pulmonary vascular imaging in an urban US emergency department
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
    Ann Emerg Med 44:490-502. 2004
    ..0% of patients with a negative protocol would have an adverse outcome...
  25. pmc The significance of non-sustained hypotension in emergency department patients with sepsis
    Michael R Marchick
    Emergency Medicine Research, Department of Emergency Medicine, Carolinas Medical Center, PO Box 32861, Charlotte, NC 28232 2861, USA
    Intensive Care Med 35:1261-4. 2009
    ..We hypothesized that ED non-sustained hypotension increases risk of in-hospital mortality in patients with sepsis...
  26. pmc Complement activation in emergency department patients with severe sepsis
    John G Younger
    Department of Emergency Medicine, Center for Computational Medicine and Biology, University of Michigan, Ann Arbor, MI, USA
    Acad Emerg Med 17:353-9. 2010
    ..This study assessed the extent and mechanism of complement activation in community-acquired sepsis at presentation to the emergency department (ED) and following 24 hours of quantitative resuscitation...
  27. doi request reprint Characteristics and outcomes of patients with vasoplegic versus tissue dysoxic septic shock
    Sarah A Sterling
    Department of Emergency Medicine, University of Mississippi School of Medicine, Jackson, Mississippi 39216, USA
    Shock 40:11-4. 2013
    ..Some patients with septic shock present with hypotension and hyperlactatemia greater than 2 mmol/L (tissue dysoxic shock), whereas others have hypotension alone with normal lactate (vasoplegic shock)...
  28. doi request reprint Discordance between microcirculatory alterations and arterial pressure in patients with hemodynamic instability
    Ryan C Arnold
    Department of Emergency Medicine, Division of Critical Care Medicine, Cooper University Hospital, Camden, NJ 08103, USA
    J Crit Care 27:531.e1-7. 2012
    ..We selected cardiopulmonary bypass (CPB) patients with expected and rapidly reversible hemodynamic instability to test the hypothesis that microcirculatory alterations can occur independent of mean arterial pressure (MAP)...
  29. ncbi request reprint Prospective study of the diagnostic accuracy of the simplify D-dimer assay for pulmonary embolism in emergency department patients
    Jeffrey A Kline
    Director, Emergency Medicine Research, Department of Emergency Medicine, Carolinas Medical Center, PO Box 32861, Charlotte, NC 28323 2861, USA
    Chest 129:1417-23. 2006
    ....
  30. ncbi request reprint Nontraumatic out-of-hospital hypotension predicts inhospital mortality
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Ann Emerg Med 43:106-13. 2004
    ..Out-of-hospital hypotension may signify need for intensive resuscitation and rapid diagnosis on emergency department (ED) arrival. We hypothesized that nontraumatic out-of-hospital hypotension confers risk of inhospital mortality...
  31. pmc The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsis
    Nathan I Shapiro
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, 1 Deaconess Road CC2 W, Boston, MA 02215, USA
    Crit Care 14:R182. 2010
    ..We investigated the association between biomarkers of endothelial cell activation and sepsis severity, organ dysfunction sequential organ failure assessment (SOFA) score, and death...
  32. doi request reprint Prospective study of the incidence of contrast-induced nephropathy among patients evaluated for pulmonary embolism by contrast-enhanced computed tomography
    Alice M Mitchell
    Department of Emergency Medicine, Carolinas HealthCare System, Charlotte, NC, USA
    Acad Emerg Med 19:618-25. 2012
    ..While contrast-induced nephropathy (CIN) is a known complication, this risk is not well defined in the ED or other ambulatory setting. The aim of this study was to define the risk of CIN following CTPA...
  33. pmc Plasma levels of mitochondrial DNA in patients presenting to the emergency department with sepsis
    Michael A Puskarich
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, North Carolina, USA
    Shock 38:337-40. 2012
    ..Mitochondrial DNA levels were negatively associated with organ dysfunction, suggesting that plasma mtDNA does not significantly contribute to the pathophysiology of sepsis...
  34. pmc Endothelial cell activation in emergency department patients with sepsis-related and non-sepsis-related hypotension
    Philipp Schuetz
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Shock 36:104-8. 2011
    ..4; CI, 0.8-2.3; P = 0.2) did not reach statistical significance. This study found a sepsis-specific activation of endothelium activation markers, particularly E-selectin and sFLT-1, in emergency department patients with hypotension...
  35. pmc Effect of glucose-insulin-potassium infusion on mortality in critical care settings: a systematic review and meta-analysis
    Michael A Puskarich
    Department of Emergency Medicine, Carolinas Medical Center, PO Box 32861, Charlotte, NC 28232 2861, USA
    J Clin Pharmacol 49:758-67. 2009
    ..No studies are identified using GIK in patients with septic shock or other forms of circulatory shock, providing an absence of evidence regarding the effect of GIK as a therapy in patients with shock...
  36. pmc Early arterial hypotension is common in the post-cardiac arrest syndrome and associated with increased in-hospital mortality
    J Hope Kilgannon
    Department of Emergency Medicine, UMDNJ Robert Wood Johnson Medical School at Camden, Cooper University Hospital, One Cooper Plaza, 114 Kelemen, Camden, NJ 08103, USA
    Resuscitation 79:410-6. 2008
    ..We tested the hypothesis that exposure to arterial hypotension after ROSC occurs commonly (>50%) and is an independent predictor of death...
  37. pmc Multicenter study of central venous oxygen saturation (ScvO(2)) as a predictor of mortality in patients with sepsis
    Jennifer V Pope
    Harvard Affiliated Emergency Medicine Residency, Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Ann Emerg Med 55:40-46.e1. 2010
    ..Abnormal (both low and high) central venous saturation (ScvO(2)) is associated with increased mortality in emergency department (ED) patients with suspected sepsis...
  38. doi request reprint The frequency and significance of postintubation hypotension during emergency airway management
    Alan C Heffner
    Division of Critical Care Medicine, Department of Internal Medicine, Carolinas Medical Center, Charlotte, NC, USA
    J Crit Care 27:417.e9-13. 2012
    ..Our aim was to identify the incidence of postintubation hypotension (PIH) after emergency intubation and to determine its association with inhospital mortality...
  39. doi request reprint Regionalization of post-cardiac arrest care: implementation of a cardiac resuscitation center
    Alan C Heffner
    Department of Internal Medicine, PO Box 32861, Carolinas Medical Center, Charlotte, NC 28232 2861, USA
    Am Heart J 164:493-501.e2. 2012
    ..Given that regionalization of time-dependent high-acuity illness is an emerging paradigm, the aim of the present study was to develop and implement a regionalized approach to post-cardiac arrest care...
  40. doi request reprint Normalization of vital signs does not reduce the probability of acute pulmonary embolism in symptomatic emergency department patients
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Acad Emerg Med 19:11-7. 2012
    ..The objective of this study was to evaluate if normalization of an initially abnormal vital sign can be used as evidence to lower the suspicion for PE...
  41. pmc Outcomes of patients undergoing early sepsis resuscitation for cryptic shock compared with overt shock
    Michael A Puskarich
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Resuscitation 82:1289-93. 2011
    ..We sought to compare the outcomes of patients with cryptic versus overt shock treated with an emergency department (ED) based early sepsis resuscitation protocol...
  42. doi request reprint Immediate complications of intravenous contrast for computed tomography imaging in the outpatient setting are rare
    Alice M Mitchell
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Acad Emerg Med 18:1005-9. 2011
    ..Thus, this study sought to define the risk of these immediate complications with the overall aim of improving institutional guidelines and patient consent procedures...
  43. ncbi request reprint Prospective study of the clinical features and outcomes of emergency department patients with delayed diagnosis of pulmonary embolism
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Acad Emerg Med 14:592-8. 2007
    ....
  44. ncbi request reprint Diagnostic accuracy of left ventricular function for identifying sepsis among emergency department patients with nontraumatic symptomatic undifferentiated hypotension
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, North Carolina 28203, USA
    Shock 24:513-7. 2005
    ..5 (95% CI 1.1-45). Among ED patients with non-traumatic undifferentiated symptomatic hypotension, the presence of hyperdynamic LVF on focused echo is highly specific for sepsis as the etiology of shock...
  45. ncbi request reprint Electronic medical record review as a surrogate to telephone follow-up to establish outcome for diagnostic research studies in the emergency department
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
    Acad Emerg Med 12:1127-33. 2005
    ..Follow-up for diagnostic research studies might be facilitated if medical record review (MRR) could be used instead of telephone calls...
  46. pmc Etiology of illness in patients with severe sepsis admitted to the hospital from the emergency department
    Alan C Heffner
    Division of Critical Care Medicine, Department of Internal Medicine, Carolinas Medical Center, Charlotte, North Carolina 28203, USA
    Clin Infect Dis 50:814-20. 2010
    ..Our aim was to describe the etiology of illness in patients identified and treated for severe sepsis in the emergency department...
  47. ncbi request reprint Operational performance of validated physiologic scoring systems for predicting in-hospital mortality among critically ill emergency department patients
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Crit Care Med 33:974-8. 2005
    ..We tested the prognostic accuracy of these instruments for predicting mortality among a cohort of critically ill emergency department patients...
  48. ncbi request reprint Early goal-directed therapy: improving mortality and morbidity of sepsis in the emergency department
    Anne Focht
    Pulmonary and Critical Care Medicine, Carolinas Medical Center, Charlotte, North Carolina, USA
    Jt Comm J Qual Patient Saf 35:186-91. 2009
    ..Before implementing the EDGT protocol, the ED did not follow a written management protocol for septic patients...
  49. doi request reprint Prognostic value of incremental lactate elevations in emergency department patients with suspected infection
    Michael A Puskarich
    Department of Emergency Medicine, University of Mississippi Medical Center, Jackson, MS, USA
    Acad Emerg Med 19:983-5. 2012
    ..This study sought to evaluate the association between blood lactate concentrations along an incremental continuum up to a maximum value of 20 mmol/L and mortality...
  50. ncbi request reprint Severity of emergency department hypotension predicts adverse hospital outcome
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28203, USA
    Shock 22:410-4. 2004
    ..1; 95% CI 1.5-7.1). Mortality among patients who present to the ED with undifferentiated shock is high. The depth and duration of systolic blood pressure appears to have a dose-response relationship to adverse hospital outcome...
  51. doi request reprint Randomized trial of computerized quantitative pretest probability in low-risk chest pain patients: effect on safety and resource use
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
    Ann Emerg Med 53:727-35.e1. 2009
    ..We hypothesize that the presentation of a quantitative pretest probability of acute coronary syndrome would safely reduce unnecessary resource use in low-risk emergency department (ED) chest pain patients...
  52. ncbi request reprint Multicenter study of early lactate clearance as a determinant of survival in patients with presumed sepsis
    Ryan C Arnold
    Department of Emergency Medicine, UMDNJ Robert Wood Johnson Medical School at Camden, Cooper University Hospital, Camden, New Jersey 08103, USA
    Shock 32:35-9. 2009
    ..These data provide rationale for a clinical trial of lactate clearance as a distinct end point of early sepsis resuscitation...
  53. doi request reprint Characterization of the spectrum of hemodynamic profiles in trauma patients with acute neurogenic shock
    Richard L Summers
    Department of Emergency Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA
    J Crit Care 28:531.e1-5. 2013
    ..In this study, we examine the hemodynamic profiles of a series of trauma patients with a diagnosis of neurogenic shock...
  54. doi request reprint Rationale and methodology for a multicentre randomised trial of fibrinolysis for pulmonary embolism that includes quality of life outcomes
    Jeffrey A Kline
    Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Emerg Med Australas 25:515-26. 2013
    ..Submassive pulmonary embolism (PE) has a low mortality rate but can degrade functional capacity...
  55. ncbi request reprint Determination of the effect of in vitro time, temperature, and tourniquet use on whole blood venous point-of-care lactate concentrations
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Acad Emerg Med 14:587-91. 2007
    ..The authors sought to determine the effect of in vitro time, temperature, and removable tourniquet use on changes in venous point-of-care lactate concentrations...
  56. pmc The impact of emergency medical services on the ED care of severe sepsis
    Jonathan R Studnek
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28203, USA
    Am J Emerg Med 30:51-6. 2012
    ..We hypothesized that emergency department (ED) patients with severe sepsis who received EMS care had more rapid recognition and treatment compared to non-EMS patients...
  57. pmc D-dimer and exhaled CO2/O2 to detect segmental pulmonary embolism in moderate-risk patients
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, 1000 Blythe Boulevard, Charlotte, NC 28203, USA
    Am J Respir Crit Care Med 182:669-75. 2010
    ..Pulmonary embolism (PE) decreases the exhaled end-tidal ratio of carbon dioxide to oxygen (etCO(2)/O(2))...
  58. pmc Incidence of contrast-induced nephropathy after contrast-enhanced computed tomography in the outpatient setting
    Alice M Mitchell
    Department of Emergency Medicine, Carolinas Medical Center, P O Box 32861, Charlotte, NC 28232 2861, USA
    Clin J Am Soc Nephrol 5:4-9. 2010
    ..No prospective study has reported the incidence of contrast-induced nephropathy (CIN) or the associated morbidity and mortality after contrast-enhanced computed tomography (CECT) in the outpatient setting...
  59. ncbi request reprint Accuracy of trauma ultrasound in major pelvic injury
    Vivek S Tayal
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28232, USA
    J Trauma 61:1453-7. 2006
    ..We hypothesized that in patients with major pelvic injury (MPI) trauma ultrasound would perform with lower accuracy than has previously been reported...
  60. ncbi request reprint Tenecteplase to treat pulmonary embolism in the emergency department
    Jeffrey A Kline
    Emergency Medicine Research, Department of Emergency Medicine, Carolinas Medical Center, PO Box 32861, Charlotte, NC 28323 2861, USA
    J Thromb Thrombolysis 23:101-5. 2007
    ..Taken together, we submit that the present case report and prior case reports are sufficient to comprise a phase I study of the safety and efficacy of tenecteplase to treat acute pulmonary embolism...
  61. ncbi request reprint Frequency of thromboprophylaxis and incidence of in-hospital venous thromboembolism in a cohort of emergency department patients
    Alan E Jones
    Department of Emergency Medicine, Emergency Medicine Research, Carolinas Medical Center, PO Box 32861, Charlotte, NC 28232 2861, USA
    J Thromb Thrombolysis 25:160-4. 2008
    ..Our objective was to quantify the rate of thromboprophylaxis and incidence of in-hospital VTE, based upon risk of VTE, in a cohort of patients admitted through the emergency department (ED)...
  62. pmc Arterial pressure optimization in the treatment of septic shock: a complex puzzle
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28203, USA
    Crit Care 14:102. 2010
    ..Although these data add important new evidence to our understanding of arterial pressure management, there are still many unanswered questions upon which future investigations should focus...
  63. pmc Dynamics of human complement-mediated killing of Klebsiella pneumoniae
    Christina M Nypaver
    Department of Emergency Medicine, University of Michigan, Ann Arbor, Michigan 48109 3300, USA
    Am J Respir Cell Mol Biol 43:585-90. 2010
    ..The use of luminescent bacteria allowed for the development of a novel and powerful tool for assessing complement immunology for the purposes of mechanistic study and patient evaluation...
  64. ncbi request reprint Focused training of emergency medicine residents in goal-directed echocardiography: a prospective study
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28203, USA
    Acad Emerg Med 10:1054-8. 2003
    ..To determine if a focused transthoracic echocardiography (TTE) training course would improve the accuracy of completion and interpretation of a goal-directed TTE by emergency medicine residents...
  65. doi request reprint Goal-directed hemodynamic optimization in the post-cardiac arrest syndrome: a systematic review
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, United States
    Resuscitation 77:26-9. 2008
    ....
  66. ncbi request reprint Sonographic intraperitoneal fluid in patients with pelvic fracture: two cases of traumatic intraperitoneal bladder rupture
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, North Carolina 28203, USA
    J Emerg Med 25:373-7. 2003
    ..This is a report of sonographic intraperitoneal fluid in the setting of major pelvic injury and hemodynamic instability found to be uroperitoneum and not hemoperitoneum...
  67. ncbi request reprint Inhibition of prostaglandin synthesis during polystyrene microsphere-induced pulmonary embolism in the rat
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, North Carolina 28203, USA
    Am J Physiol Lung Cell Mol Physiol 284:L1072-81. 2003
    ..Experimental PE increased lung and systemic production of TxB(2). Inhibition at the COX-1/2 enzyme was equally as effective as inhibition of thromboxane synthase at reducing alveolar dead space and improving heart function after PE...
  68. ncbi request reprint Risk stratification of community-acquired pneumonia: what does all of this mean?
    Alan E Jones
    Ann Emerg Med 52:61-2. 2008
  69. ncbi request reprint Use of goal-directed therapy for severe sepsis and septic shock in academic emergency departments
    Alan E Jones
    Crit Care Med 33:1888-9; author reply 1889-90. 2005
  70. doi request reprint Applying research findings at a patient's bedside: progressing clinical practice
    Alan E Jones
    Acad Emerg Med 15:86-7. 2008
  71. ncbi request reprint Evidence-based therapies for sepsis care in the emergency department: striking a balance between feasibility and necessity
    Alan E Jones
    Acad Emerg Med 13:82-3. 2006
  72. ncbi request reprint Simple triage scoring system predicting death and the need for critical care resources for use during epidemics
    Daniel Talmor
    Trauma Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Crit Care Med 35:1251-6. 2007
    ..To date, no standardized method for allocating scarce resources when the number of patients in need far exceeds capacity exists. We sought to derive and validate such a triage scheme...
  73. ncbi request reprint Pleural effusions in the critically ill: the evolving role of bedside ultrasound
    Alan E Jones
    Crit Care Med 33:1874-5. 2005
  74. doi request reprint Productivity and career paths of previous recipients of Society for Academic Emergency Medicine research grant awards
    Kelly D Young
    Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Acad Emerg Med 15:560-6. 2008
    ..The objective was to assess productivity of previous recipients of Society for Academic Emergency Medicine (SAEM) grant awards...
  75. ncbi request reprint The FAST scan: beyond free fluid
    James F Fiechtl
    Ann Emerg Med 47:293. 2006
  76. ncbi request reprint Elevated brain natriuretic peptide in septic patients without heart failure
    Alan E Jones
    Ann Emerg Med 42:714-5. 2003
  77. doi request reprint Hypothermia after cardiac arrest: we can do this
    Alan E Jones
    Acad Emerg Med 15:558-9. 2008

Research Grants2

  1. Randomized Clinical Trial of a Less-Invasive Resuscitation Protocol for Sepsis
    Alan Jones; Fiscal Year: 2007
    ..This will potentially result in saving thousands of lives per year and reduce the cost of care for septic patients. ..