Weihong Hou

Summary

Affiliation: Carolinas Medical Center
Country: USA

Publications

  1. pmc The let-7 microRNA enhances heme oxygenase-1 by suppressing Bach1 and attenuates oxidant injury in human hepatocytes
    Weihong Hou
    The Liver Biliary Pancreatic Center, Carolinas Medical Center, Charlotte, NC, USA
    Biochim Biophys Acta 1819:1113-22. 2012
  2. pmc Zinc mesoporphyrin induces rapid proteasomal degradation of hepatitis C nonstructural 5A protein in human hepatoma cells
    Weihong Hou
    Liver Biliary Pancreatic Center and the Liver, Digestive Disease and Metabolism Laboratory, Carolinas Medical Center, Charlotte, North Carolina 28232 2861, USA
    Gastroenterology 138:1909-19. 2010
  3. pmc MicroRNA-196 represses Bach1 protein and hepatitis C virus gene expression in human hepatoma cells expressing hepatitis C viral proteins
    Weihong Hou
    Liver Biliary Pancreatic Center and the Liver, Digestive Diseases, and Metabolism Laboratory, Carolinas Medical Center, Charlotte, NC 28232 2861, USA
    Hepatology 51:1494-504. 2010
  4. pmc Lon peptidase 1 (LONP1)-dependent breakdown of mitochondrial 5-aminolevulinic acid synthase protein by heme in human liver cells
    Qing Tian
    Liver, Digestive, and Metabolic Disorders Laboratory, Carolinas Medical Center, Charlotte, North Carolina 28203, USA
    J Biol Chem 286:26424-30. 2011
  5. pmc Heme status affects human hepatic messenger RNA and microRNA expression
    Herbert L Bonkovsky
    Liver, Digestive and Metabolic Disorders Laboratory, Cannon Research Center, Carolinas Medical Center, 1542 Garden Terrace, Charlotte, NC 28203, USA
    World J Gastroenterol 19:1593-601. 2013
  6. pmc Zinc mesoporphyrin induces rapid and marked degradation of the transcription factor Bach1 and up-regulates HO-1
    Weihong Hou
    The Liver Biliary Pancreatic Center, Carolinas Medical Center, Charlotte, NC 28232 2861, USA
    Biochim Biophys Acta 1779:195-203. 2008
  7. doi request reprint Tissue-specific expression of ALA synthase-1 and heme oxygenase-1 and their expression in livers of rats chronically exposed to ethanol
    Jianyu Zheng
    Liver Biliary Pancreatic Center, Carolinas Medical Center, 1000 Blythe Boulevard, Charlotte, NC 28203, USA
    FEBS Lett 582:1829-34. 2008
  8. doi request reprint Porphyrin and heme metabolism and the porphyrias
    Herbert L Bonkovsky
    Department of Medicine and The Liver Biliary Pancreatic Center, Carolinas Medical Center, Charlotte, North Carolina, USA
    Compr Physiol 3:365-401. 2013
  9. doi request reprint Non-coding RNAs in hepatitis C-induced hepatocellular carcinoma: dysregulation and implications for early detection, diagnosis and therapy
    Weihong Hou
    Weihong Hou, Herbert L Bonkovsky, The Liver, Digestive and Metabolic Disorders Laboratory, and The Liver Biliary Pancreatic Center, Cannon Research Center, Carolinas Medical Center, Charlotte, NC 28203, United States
    World J Gastroenterol 19:7836-45. 2013
  10. pmc Contemporary clinical research of traditional Chinese medicines for chronic hepatitis B in China: an analytical review
    Lingyi Zhang
    Liver Biliary Pancreatic Center and the Liver, Digestive Diseases, and Metabolism Laboratory, NC, USA
    Hepatology 51:690-8. 2010

Collaborators

Detail Information

Publications10

  1. pmc The let-7 microRNA enhances heme oxygenase-1 by suppressing Bach1 and attenuates oxidant injury in human hepatocytes
    Weihong Hou
    The Liver Biliary Pancreatic Center, Carolinas Medical Center, Charlotte, NC, USA
    Biochim Biophys Acta 1819:1113-22. 2012
    ..Over-expression of the let-7 miRNA family members may represent a novel approach to protecting human hepatocytes from oxidant injury...
  2. pmc Zinc mesoporphyrin induces rapid proteasomal degradation of hepatitis C nonstructural 5A protein in human hepatoma cells
    Weihong Hou
    Liver Biliary Pancreatic Center and the Liver, Digestive Disease and Metabolism Laboratory, Carolinas Medical Center, Charlotte, North Carolina 28232 2861, USA
    Gastroenterology 138:1909-19. 2010
    ..Our objectives were to elucidate the down-regulation of NS5A protein and HCV RNA replication by zinc mesoporphyrin (ZnMP) and the mechanism by which this process occurs...
  3. pmc MicroRNA-196 represses Bach1 protein and hepatitis C virus gene expression in human hepatoma cells expressing hepatitis C viral proteins
    Weihong Hou
    Liver Biliary Pancreatic Center and the Liver, Digestive Diseases, and Metabolism Laboratory, Carolinas Medical Center, Charlotte, NC 28232 2861, USA
    Hepatology 51:1494-504. 2010
    ..Moreover, there was no detectable effect of mutant miR-196 on Bach1 3'-UTR-dependent luciferase activity...
  4. pmc Lon peptidase 1 (LONP1)-dependent breakdown of mitochondrial 5-aminolevulinic acid synthase protein by heme in human liver cells
    Qing Tian
    Liver, Digestive, and Metabolic Disorders Laboratory, Carolinas Medical Center, Charlotte, North Carolina 28203, USA
    J Biol Chem 286:26424-30. 2011
    ..Therefore, our data support the existence of a conserved heme feedback regulatory mechanism that functions on the mature form of ALAS-1 protein through the activity of a mitochondrial proteolytic system...
  5. pmc Heme status affects human hepatic messenger RNA and microRNA expression
    Herbert L Bonkovsky
    Liver, Digestive and Metabolic Disorders Laboratory, Cannon Research Center, Carolinas Medical Center, 1542 Garden Terrace, Charlotte, NC 28203, USA
    World J Gastroenterol 19:1593-601. 2013
    ..To assess effects of heme on messenger RNA (mRNA) and microRNA (miRNA) profiles of liver cells derived from humans...
  6. pmc Zinc mesoporphyrin induces rapid and marked degradation of the transcription factor Bach1 and up-regulates HO-1
    Weihong Hou
    The Liver Biliary Pancreatic Center, Carolinas Medical Center, Charlotte, NC 28232 2861, USA
    Biochim Biophys Acta 1779:195-203. 2008
    ..Our results indicate that ZnMP up-regulates HO-1 gene expression by markedly increasing Bach1 protein degradation in a proteasome-dependent manner...
  7. doi request reprint Tissue-specific expression of ALA synthase-1 and heme oxygenase-1 and their expression in livers of rats chronically exposed to ethanol
    Jianyu Zheng
    Liver Biliary Pancreatic Center, Carolinas Medical Center, 1000 Blythe Boulevard, Charlotte, NC 28203, USA
    FEBS Lett 582:1829-34. 2008
    ..These results provide novel insights into the effects of chronic ethanol consumption on hepatic heme biosynthesis and porphyrias...
  8. doi request reprint Porphyrin and heme metabolism and the porphyrias
    Herbert L Bonkovsky
    Department of Medicine and The Liver Biliary Pancreatic Center, Carolinas Medical Center, Charlotte, North Carolina, USA
    Compr Physiol 3:365-401. 2013
    ....
  9. doi request reprint Non-coding RNAs in hepatitis C-induced hepatocellular carcinoma: dysregulation and implications for early detection, diagnosis and therapy
    Weihong Hou
    Weihong Hou, Herbert L Bonkovsky, The Liver, Digestive and Metabolic Disorders Laboratory, and The Liver Biliary Pancreatic Center, Cannon Research Center, Carolinas Medical Center, Charlotte, NC 28203, United States
    World J Gastroenterol 19:7836-45. 2013
    ..Studies of the potential uses of miRNAs and lncRNAs as diagnostic tools or therapies are still in their infancy. ..
  10. pmc Contemporary clinical research of traditional Chinese medicines for chronic hepatitis B in China: an analytical review
    Lingyi Zhang
    Liver Biliary Pancreatic Center and the Liver, Digestive Diseases, and Metabolism Laboratory, NC, USA
    Hepatology 51:690-8. 2010
    ....