Affiliation: Carnegie Institution
Wan Y, Zheng X, Chen H, Guo Y, Jiang H, He X, et al
. Splicing function of mitotic regulators links R-loop-mediated DNA damage to tumor cell killing. J Cell Biol. 2015;209:235-46 pubmed publisher
..This demonstrates the importance of understanding the full range of functions of mitotic regulators to develop antitumor drugs. ..
Jiang H, He X, Feng D, Zhu X, Zheng Y. RanGTP aids anaphase entry through Ubr5-mediated protein turnover. J Cell Biol. 2015;211:7-18 pubmed publisher
..We propose that elevated metaphase RanGTP levels use Ubr5 to couple overall chromosome congression to SAC silencing. ..
Zhang L, Keating T, Wilde A, Borisy G, Zheng Y. The role of Xgrip210 in gamma-tubulin ring complex assembly and centrosome recruitment. J Cell Biol. 2000;151:1525-36 pubmed
..These results suggest that Xgrip210 is a component of the gammaTuRC cap structure that is required for the assembly of the gammaTuRC. ..
Zheng X, Yue S, Chen H, Weber B, Jia J, Zheng Y. Low-Cell-Number Epigenome Profiling Aids the Study of Lens Aging and Hematopoiesis. Cell Rep. 2015;13:1505-1518 pubmed publisher
..These datasets not only highlight genes that may be involved in lens aging but also indicate a lack of H3K4me3/H3K27me3 bivalency on hematopoietic genes in HSCs. ..
Guo Y, Zheng Y. Lamins position the nuclear pores and centrosomes by modulating dynein. Mol Biol Cell. 2015;26:3379-89 pubmed publisher
..Therefore lamins regulate microtubule-based motor forces in vivo to ensure proper NPC distribution in interphase and centrosome separation in the mitotic prophase. ..
Tran J, Chen H, Zheng X, Zheng Y. Lamin in inflammation and aging. Curr Opin Cell Biol. 2016;40:124-130 pubmed publisher
..This inflammatory response perturbs the local immune response of the neighboring gut tissue and leads to hyperplasia. Here, we will discuss the literature connecting lamins to aging and inflammation. ..
Chen H, Zheng X, Zheng Y. Age-associated loss of lamin-B leads to systemic inflammation and gut hyperplasia. Cell. 2014;159:829-43 pubmed publisher
Jiang H, Wang S, Huang Y, He X, Cui H, Zhu X, et al
. Phase transition of spindle-associated protein regulate spindle apparatus assembly. Cell. 2015;163:108-22 pubmed publisher
Tran J, Zheng X, Zheng Y. Lamin-B1 contributes to the proper timing of epicardial cell migration and function during embryonic heart development. Mol Biol Cell. 2016;27:3956-3963 pubmed
..These findings suggest that Lb1 contributes to nuclear shape maintenance and migration of epicardial cells and highlights the use of these cells for in vitro and in vivo study of these classic cell biological phenomena. ..