Yu li Wang

Summary

Affiliation: Carnegie Mellon University
Country: USA

Publications

  1. doi request reprint Traction forces and rigidity sensing of adherent cells
    Yu li Wang
    University of Massachusetts Medical School, Worcester, MA 01605, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:3339-40. 2009
  2. pmc Responses of fibroblasts to anchorage of dorsal extracellular matrix receptors
    Karen A Beningo
    Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 101:18024-9. 2004
  3. ncbi request reprint Regulation of mechanical interactions between fibroblasts and the substratum by stretch-activated Ca2+ entry
    Steven Munevar
    Department of Physiology, University of Massachusetts Medical School, 377 Plantation Street, Suite 327, Worcester, MA 01605, USA
    J Cell Sci 117:85-92. 2004
  4. ncbi request reprint The kinase activity of aurora B is required for kinetochore-microtubule interactions during mitosis
    Maki Murata-Hori
    Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Curr Biol 12:894-9. 2002
  5. ncbi request reprint Flexible polyacrylamide substrata for the analysis of mechanical interactions at cell-substratum adhesions
    Karen A Beningo
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Methods Cell Biol 69:325-39. 2002
  6. pmc Cellular responses to substrate topography: role of myosin II and focal adhesion kinase
    Margo T Frey
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Biophys J 90:3774-82. 2006
  7. ncbi request reprint Cortical actin turnover during cytokinesis requires myosin II
    Minakshi Guha
    Department of Physiology, University of Massachussetts Medical School, Worcester, 01605, USA
    Curr Biol 15:732-6. 2005
  8. ncbi request reprint Computational restoration of fluorescence images: noise reduction, deconvolution, and pattern recognition
    Yu li Wang
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Methods Cell Biol 72:337-48. 2003
  9. pmc Substrate rigidity regulates the formation and maintenance of tissues
    Wei hui Guo
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Biophys J 90:2213-20. 2006
  10. pmc Both midzone and astral microtubules are involved in the delivery of cytokinesis signals: insights from the mobility of aurora B
    Maki Murata-Hori
    University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Cell Biol 159:45-53. 2002

Research Grants

Collaborators

  • Micah Dembo
  • James H Keen
  • Denis B Buxton
  • Amjad Javed
  • Kris Noel Dahl
  • Maki Murata-Hori
  • Karen A Beningo
  • Wei hui Guo
  • Margo T Frey
  • Mian Zhou
  • Ian T Hoffecker
  • Chun Min Lo
  • Brian D Holt
  • Javier Satulovsky
  • Anne K Warner
  • Minakshi Guha
  • Steven Munevar
  • Kimberly S Harrington
  • Philip A Short
  • Mohammad F Islam
  • Andrew D Rape
  • Roger Lui
  • Adam Engler
  • Juliet Lee
  • Dennis E Discher
  • Nancy A Burnham
  • Steven K Hanks
  • Thomas P Russell
  • Irene Y Tsai
  • Robert S Adelstein
  • Gregory C H Chua
  • Sandra McNeil
  • Jane B Lian
  • Andre J Van Wijnen
  • Gary S Stein
  • Hicham Drissi
  • Janet L Stein

Detail Information

Publications27

  1. doi request reprint Traction forces and rigidity sensing of adherent cells
    Yu li Wang
    University of Massachusetts Medical School, Worcester, MA 01605, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:3339-40. 2009
    ..This article is a concise review of our efforts in understanding the biological functions of traction forces, particularly in relation to the detection of rigidity of adhesive materials by fibroblasts...
  2. pmc Responses of fibroblasts to anchorage of dorsal extracellular matrix receptors
    Karen A Beningo
    Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 101:18024-9. 2004
    ..Changes in cell shape may in turn affect diverse cellular activities, including gene expression, growth, and differentiation, as shown in numerous previous studies...
  3. ncbi request reprint Regulation of mechanical interactions between fibroblasts and the substratum by stretch-activated Ca2+ entry
    Steven Munevar
    Department of Physiology, University of Massachusetts Medical School, 377 Plantation Street, Suite 327, Worcester, MA 01605, USA
    J Cell Sci 117:85-92. 2004
    ..This mechanism probably plays an important role in sustaining cell migration and in mediating active and passive responses to mechanical signals...
  4. ncbi request reprint The kinase activity of aurora B is required for kinetochore-microtubule interactions during mitosis
    Maki Murata-Hori
    Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Curr Biol 12:894-9. 2002
    ..Interactions of kinetochore motors with microtubules may in turn regulate the organization of microtubules, the movement of prometaphase chromosomes, and the release of the spindle checkpoint...
  5. ncbi request reprint Flexible polyacrylamide substrata for the analysis of mechanical interactions at cell-substratum adhesions
    Karen A Beningo
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Methods Cell Biol 69:325-39. 2002
    ..The present approach, as well as other approaches capable of probing physical interactions, should fill in this important gap in the near future...
  6. pmc Cellular responses to substrate topography: role of myosin II and focal adhesion kinase
    Margo T Frey
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Biophys J 90:3774-82. 2006
    ..We propose that increased surface contact provided by topographic features guides cell migration by regulating the strength of local adhesions and contractions, through a FAK- and myosin II-dependent mechanism...
  7. ncbi request reprint Cortical actin turnover during cytokinesis requires myosin II
    Minakshi Guha
    Department of Physiology, University of Massachussetts Medical School, Worcester, 01605, USA
    Curr Biol 15:732-6. 2005
    ..Our observations indicate that myosin II ATPase is not required for the assembly of equatorial cortex during cytokinesis but is essential for its subsequent turnover and remodeling...
  8. ncbi request reprint Computational restoration of fluorescence images: noise reduction, deconvolution, and pattern recognition
    Yu li Wang
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Methods Cell Biol 72:337-48. 2003
  9. pmc Substrate rigidity regulates the formation and maintenance of tissues
    Wei hui Guo
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Biophys J 90:2213-20. 2006
    ....
  10. pmc Both midzone and astral microtubules are involved in the delivery of cytokinesis signals: insights from the mobility of aurora B
    Maki Murata-Hori
    University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Cell Biol 159:45-53. 2002
    ..We suggest that cultured cells use midzone microtubules as the primary signaling pathway for cytokinesis, whereas embryos, with their stockpile of cytoplasmic proteins and large sizes, rely primarily on astral microtubules...
  11. pmc Probing the dynamics and functions of aurora B kinase in living cells during mitosis and cytokinesis
    Maki Murata-Hori
    Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Biol Cell 13:1099-108. 2002
    ..Our results suggest that microtubules, CDK1, and the kinase activity each play a distinct role in the dynamics and functions of aurora B in dividing cells...
  12. doi request reprint Assessing the spatial resolution of cellular rigidity sensing using a micropatterned hydrogel-photoresist composite
    Ian T Hoffecker
    Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15219, USA
    Lab Chip 11:3538-44. 2011
    ..Our finding may serve as a guideline for the design of biomaterials for tissue engineering...
  13. ncbi request reprint The mechanism of cortical ingression during early cytokinesis: thinking beyond the contractile ring hypothesis
    Yu li Wang
    University of Massachusetts Medical School, 377 Plantation Street, Suite 327, Worcester, MA 01605, USA
    Trends Cell Biol 15:581-8. 2005
    ..In this article (which is part of the Cytokinesis series), I evaluate critically key observations on when, where and how early ingression of animal cells takes place...
  14. ncbi request reprint Fc-receptor-mediated phagocytosis is regulated by mechanical properties of the target
    Karen A Beningo
    University of Massachusetts Medical School, Department of Physiology, 377 Plantation, Room 327, Worcester, MA 01605, USA
    J Cell Sci 115:849-56. 2002
    ..These data suggest a Rac1-dependent mechanosensory mechanism for phagocytosis, which probably plays an important role in a number of physiological and pathological processes from embryonic development to autoimmune diseases...
  15. ncbi request reprint Flexible substrata for the detection of cellular traction forces
    Karen A Beningo
    Dept of Physiology, University of Massachusetts Medical School, 377 Plantation Street, Worcester, MA 01605, USA
    Trends Cell Biol 12:79-84. 2002
    ....
  16. ncbi request reprint Flux at focal adhesions: slippage clutch, mechanical gauge, or signal depot
    Yu li Wang
    University of Massachusetts Medical School, 377 Plantation Street, Suite 327, Worcester, MA 01605, USA
    Sci STKE 2007:pe10. 2007
    ....
  17. ncbi request reprint Computational restoration of fluorescence images: noise reduction, deconvolution, and pattern recognition
    Yu li Wang
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Methods Cell Biol 81:435-45. 2007
  18. pmc Nonmuscle myosin IIb is involved in the guidance of fibroblast migration
    Chun Min Lo
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Mol Biol Cell 15:982-9. 2004
    ..Our results suggest that myosin IIB is involved not in propelling but in directing the cell movement, by coordinating protrusive activities and stabilizing the cell polarity...
  19. pmc Noise-induced systematic errors in ratio imaging: serious artefacts and correction with multi-resolution denoising
    Yu li Wang
    University of Massachusetts Medical School, 377 Plantation Street, Suite 327, Worcester, MA 01605, USA
    J Microsc 228:123-31. 2007
    ..These filters are also capable of restoring structural details and photometric accuracy, and may serve as a general tool for retrieving reliable information from low-light live cell images...
  20. pmc Regulation of cell cycle by the anaphase spindle midzone
    Maki Murata-Hori
    Department of Physiology, University of Massachusetts Medical School, 377 Plantation St, Worcester, Massachusetts 01605, USA
    BMC Cell Biol 5:49. 2004
    ..Besides proteins essential for cytokinesis, there are also components essential for interphase functions, suggesting that the spindle midzone and/or midbody may play a role in regulating the following cell cycle...
  21. ncbi request reprint Dynamics of membrane clathrin-coated structures during cytokinesis
    Anne K Warner
    Department of Physiology, University of Massachusetts Medical School, 377 Plantation Street, Worcester, MA 01605, USA
    Traffic 7:205-15. 2006
    ..Clathrin-containing structures may also play a role in transporting signaling or structural components into the cleavage furrow...
  22. ncbi request reprint Microscopic methods for measuring the elasticity of gel substrates for cell culture: microspheres, microindenters, and atomic force microscopy
    Margo T Frey
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Methods Cell Biol 83:47-65. 2007
    ..Here we describe three methods that have been applied successfully to probe the flexibility of soft culture substrates...
  23. ncbi request reprint Transcription factors RUNX1/AML1 and RUNX2/Cbfa1 dynamically associate with stationary subnuclear domains
    Kimberly S Harrington
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655 0106, USA
    J Cell Sci 115:4167-76. 2002
    ..We propose that the dynamic shuttling of RUNX factors in living cells to positionally stabilized foci, which is dependent on the C-terminus, is a component of the mechanism for gene regulation in vivo...
  24. pmc Retrograde fluxes of focal adhesion proteins in response to cell migration and mechanical signals
    Wei hui Guo
    Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Biol Cell 18:4519-27. 2007
    ..The retrograde transport of associated focal adhesion proteins may play additional roles in delivering signals from focal adhesions to the interior of the cell...
  25. doi request reprint Carbon nanotubes reorganize actin structures in cells and ex vivo
    Brian D Holt
    Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, Pennsylvania 15213 3890, USA
    ACS Nano 4:4872-8. 2010
    ..While purified, isolated SWCNTs do not appear acutely toxic, this subcellular reorganization may cause chronic changes to cellular functions...
  26. pmc Distinct pathways for the early recruitment of myosin II and actin to the cytokinetic furrow
    Mian Zhou
    University of Massachusetts Medical School, Department of Physiology, Worcester, MA 01605, USA
    Mol Biol Cell 19:318-26. 2008
    ..Our results indicate that cytokinesis involves signals that regulate both assembly and disassembly activities and argue against mechanisms that are coupled to global cortical movements...
  27. pmc Exploring the control circuit of cell migration by mathematical modeling
    Javier Satulovsky
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Biophys J 94:3671-83. 2008
    ..A similar top-down approach may be applied to other complex problems and combined with molecular manipulations to define specific protein functions...

Research Grants3

  1. DYNAMICS OF ACTIN IN NORMAL AND TRANSFORMED CELLS
    Yu li Wang; Fiscal Year: 2009
    ..The proposed experiments will apply highly innovative approaches to overcome the barrier, and to obtain crucial information for understanding and treating many health issues related to cell shape control and cell migration. ..
  2. DYNAMICS OF ACTIN IN NORMAL AND TRANSFORMED CELLS
    Yu li Wang; Fiscal Year: 2010
    ..The proposed experiments will apply highly innovative approaches to overcome the barrier, and to obtain crucial information for understanding and treating many health issues related to cell shape control and cell migration. ..