Yu li Wang

Summary

Affiliation: Carnegie Mellon University
Country: USA

Publications

  1. ncbi Traction forces and rigidity sensing of adherent cells
    Yu li Wang
    University of Massachusetts Medical School, Worcester, MA 01605, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:3339-40. 2009
  2. ncbi Probing the dynamics and functions of aurora B kinase in living cells during mitosis and cytokinesis
    Maki Murata-Hori
    Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Biol Cell 13:1099-108. 2002
  3. ncbi The mechanism of cortical ingression during early cytokinesis: thinking beyond the contractile ring hypothesis
    Yu li Wang
    University of Massachusetts Medical School, 377 Plantation Street, Suite 327, Worcester, MA 01605, USA
    Trends Cell Biol 15:581-8. 2005
  4. ncbi Assessing the spatial resolution of cellular rigidity sensing using a micropatterned hydrogel-photoresist composite
    Ian T Hoffecker
    Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15219, USA
    Lab Chip 11:3538-44. 2011
  5. ncbi Flux at focal adhesions: slippage clutch, mechanical gauge, or signal depot
    Yu li Wang
    University of Massachusetts Medical School, 377 Plantation Street, Suite 327, Worcester, MA 01605, USA
    Sci STKE 2007:pe10. 2007
  6. ncbi Nonmuscle myosin IIb is involved in the guidance of fibroblast migration
    Chun Min Lo
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Mol Biol Cell 15:982-9. 2004
  7. ncbi Regulation of cell cycle by the anaphase spindle midzone
    Maki Murata-Hori
    Department of Physiology, University of Massachusetts Medical School, 377 Plantation St, Worcester, Massachusetts 01605, USA
    BMC Cell Biol 5:49. 2004
  8. ncbi Dynamics of membrane clathrin-coated structures during cytokinesis
    Anne K Warner
    Department of Physiology, University of Massachusetts Medical School, 377 Plantation Street, Worcester, MA 01605, USA
    Traffic 7:205-15. 2006
  9. ncbi Noise-induced systematic errors in ratio imaging: serious artefacts and correction with multi-resolution denoising
    Yu li Wang
    University of Massachusetts Medical School, 377 Plantation Street, Suite 327, Worcester, MA 01605, USA
    J Microsc 228:123-31. 2007
  10. ncbi Transcription factors RUNX1/AML1 and RUNX2/Cbfa1 dynamically associate with stationary subnuclear domains
    Kimberly S Harrington
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655 0106, USA
    J Cell Sci 115:4167-76. 2002

Research Grants

  1. DYNAMICS OF ACTIN IN NORMAL AND TRANSFORMED CELLS
    Yu li Wang; Fiscal Year: 2010

Collaborators

  • Maki Murata-Hori
  • Denis B Buxton
  • Micah Dembo
  • Amjad Javed
  • Kris Noel Dahl
  • Wei hui Guo
  • Ian T Hoffecker
  • Brian D Holt
  • Mian Zhou
  • Javier Satulovsky
  • Margo T Frey
  • Anne K Warner
  • Chun Min Lo
  • Kimberly S Harrington
  • Andrew D Rape
  • Philip A Short
  • Mohammad F Islam
  • Roger Lui
  • Adam Engler
  • Wei-Hui Guo
  • Juliet Lee
  • Dennis E Discher
  • James H Keen
  • Gregory C H Chua
  • Robert S Adelstein
  • Chun-Min Lo
  • Andre J Van Wijnen
  • Janet L Stein
  • Sandra McNeil
  • Gary S Stein
  • Jane B Lian
  • Hicham Drissi

Detail Information

Publications15

  1. ncbi Traction forces and rigidity sensing of adherent cells
    Yu li Wang
    University of Massachusetts Medical School, Worcester, MA 01605, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:3339-40. 2009
    ..This article is a concise review of our efforts in understanding the biological functions of traction forces, particularly in relation to the detection of rigidity of adhesive materials by fibroblasts...
  2. ncbi Probing the dynamics and functions of aurora B kinase in living cells during mitosis and cytokinesis
    Maki Murata-Hori
    Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Biol Cell 13:1099-108. 2002
    ..Our results suggest that microtubules, CDK1, and the kinase activity each play a distinct role in the dynamics and functions of aurora B in dividing cells...
  3. ncbi The mechanism of cortical ingression during early cytokinesis: thinking beyond the contractile ring hypothesis
    Yu li Wang
    University of Massachusetts Medical School, 377 Plantation Street, Suite 327, Worcester, MA 01605, USA
    Trends Cell Biol 15:581-8. 2005
    ..In this article (which is part of the Cytokinesis series), I evaluate critically key observations on when, where and how early ingression of animal cells takes place...
  4. ncbi Assessing the spatial resolution of cellular rigidity sensing using a micropatterned hydrogel-photoresist composite
    Ian T Hoffecker
    Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15219, USA
    Lab Chip 11:3538-44. 2011
    ..Our finding may serve as a guideline for the design of biomaterials for tissue engineering...
  5. ncbi Flux at focal adhesions: slippage clutch, mechanical gauge, or signal depot
    Yu li Wang
    University of Massachusetts Medical School, 377 Plantation Street, Suite 327, Worcester, MA 01605, USA
    Sci STKE 2007:pe10. 2007
    ....
  6. ncbi Nonmuscle myosin IIb is involved in the guidance of fibroblast migration
    Chun Min Lo
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Mol Biol Cell 15:982-9. 2004
    ..Our results suggest that myosin IIB is involved not in propelling but in directing the cell movement, by coordinating protrusive activities and stabilizing the cell polarity...
  7. ncbi Regulation of cell cycle by the anaphase spindle midzone
    Maki Murata-Hori
    Department of Physiology, University of Massachusetts Medical School, 377 Plantation St, Worcester, Massachusetts 01605, USA
    BMC Cell Biol 5:49. 2004
    ..Besides proteins essential for cytokinesis, there are also components essential for interphase functions, suggesting that the spindle midzone and/or midbody may play a role in regulating the following cell cycle...
  8. ncbi Dynamics of membrane clathrin-coated structures during cytokinesis
    Anne K Warner
    Department of Physiology, University of Massachusetts Medical School, 377 Plantation Street, Worcester, MA 01605, USA
    Traffic 7:205-15. 2006
    ..Clathrin-containing structures may also play a role in transporting signaling or structural components into the cleavage furrow...
  9. ncbi Noise-induced systematic errors in ratio imaging: serious artefacts and correction with multi-resolution denoising
    Yu li Wang
    University of Massachusetts Medical School, 377 Plantation Street, Suite 327, Worcester, MA 01605, USA
    J Microsc 228:123-31. 2007
    ..These filters are also capable of restoring structural details and photometric accuracy, and may serve as a general tool for retrieving reliable information from low-light live cell images...
  10. ncbi Transcription factors RUNX1/AML1 and RUNX2/Cbfa1 dynamically associate with stationary subnuclear domains
    Kimberly S Harrington
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655 0106, USA
    J Cell Sci 115:4167-76. 2002
    ..We propose that the dynamic shuttling of RUNX factors in living cells to positionally stabilized foci, which is dependent on the C-terminus, is a component of the mechanism for gene regulation in vivo...
  11. ncbi Microscopic methods for measuring the elasticity of gel substrates for cell culture: microspheres, microindenters, and atomic force microscopy
    Margo T Frey
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Methods Cell Biol 83:47-65. 2007
    ..Here we describe three methods that have been applied successfully to probe the flexibility of soft culture substrates...
  12. ncbi Retrograde fluxes of focal adhesion proteins in response to cell migration and mechanical signals
    Wei hui Guo
    Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Biol Cell 18:4519-27. 2007
    ..The retrograde transport of associated focal adhesion proteins may play additional roles in delivering signals from focal adhesions to the interior of the cell...
  13. ncbi Carbon nanotubes reorganize actin structures in cells and ex vivo
    Brian D Holt
    Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, Pennsylvania 15213 3890, USA
    ACS Nano 4:4872-8. 2010
    ..While purified, isolated SWCNTs do not appear acutely toxic, this subcellular reorganization may cause chronic changes to cellular functions...
  14. ncbi Exploring the control circuit of cell migration by mathematical modeling
    Javier Satulovsky
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Biophys J 94:3671-83. 2008
    ..A similar top-down approach may be applied to other complex problems and combined with molecular manipulations to define specific protein functions...
  15. ncbi Distinct pathways for the early recruitment of myosin II and actin to the cytokinetic furrow
    Mian Zhou
    University of Massachusetts Medical School, Department of Physiology, Worcester, MA 01605, USA
    Mol Biol Cell 19:318-26. 2008
    ..Our results indicate that cytokinesis involves signals that regulate both assembly and disassembly activities and argue against mechanisms that are coupled to global cortical movements...

Research Grants3

  1. DYNAMICS OF ACTIN IN NORMAL AND TRANSFORMED CELLS
    Yu li Wang; Fiscal Year: 2010
    ..The proposed experiments will apply highly innovative approaches to overcome the barrier, and to obtain crucial information for understanding and treating many health issues related to cell shape control and cell migration. ..