Allan C Spradling


Affiliation: Carnegie Institution
Country: USA


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    Spradling A, Zheng Y. Developmental biology. The mother of all stem cells?. Science. 2007;315:469-70 pubmed
  2. Lei L, Spradling A. Mouse oocytes differentiate through organelle enrichment from sister cyst germ cells. Science. 2016;352:95-9 pubmed publisher
  3. Greenblatt E, Spradling A. Fragile X mental retardation 1 gene enhances the translation of large autism-related proteins. Science. 2018;361:709-712 pubmed publisher
  4. Losick V, Fox D, Spradling A. Polyploidization and cell fusion contribute to wound healing in the adult Drosophila epithelium. Curr Biol. 2013;23:2224-2232 pubmed publisher
  5. Sieber M, Spradling A. Steroid Signaling Establishes a Female Metabolic State and Regulates SREBP to Control Oocyte Lipid Accumulation. Curr Biol. 2015;25:993-1004 pubmed publisher
    ..Ecdysone regulation allows females to assess the demands of oogenesis and alter their behavior and metabolic state to support the biosynthetic requirements of oocyte production. ..
  6. Spradling A. The Carnegie Department of Embryology at 100: Looking Forward. Curr Top Dev Biol. 2016;117:405-15 pubmed publisher
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    Lei L, Spradling A. Single-Cell Lineage Analysis of Oogenesis in Mice. Methods Mol Biol. 2017;1463:125-138 pubmed
    ..We illustrate the value of single-cell lineage analysis using a recent study of fetal germ cell development and a recent search for female germ-line stem cells in adult mouse ovaries. ..
  8. Sieber M, Spradling A. The role of metabolic states in development and disease. Curr Opin Genet Dev. 2017;45:58-68 pubmed publisher
    ..Finally, we discuss how a model system, such as Drosophila egg development, can provide a versatile platform to discover novel mechanisms controlling programmed shift in metabolism. ..
  9. Spradling A, Bellen H, Hoskins R. Drosophila P elements preferentially transpose to replication origins. Proc Natl Acad Sci U S A. 2011;108:15948-53 pubmed publisher
    ..The advantage transposons gain by moving from replicated to unreplicated genomic regions may contribute to the association of heterochromatin with late-replicating genomic regions. ..

More Information


  1. Yarosh W, Spradling A. Incomplete replication generates somatic DNA alterations within Drosophila polytene salivary gland cells. Genes Dev. 2014;28:1840-55 pubmed publisher
    ..We suggest that the extensive somatic DNA instability described here underlies position effect variegation, molds the structure of polytene chromosomes, and should be investigated for possible functions. ..
  2. Lee M, Spradling A. The progenitor state is maintained by lysine-specific demethylase 1-mediated epigenetic plasticity during Drosophila follicle cell development. Genes Dev. 2014;28:2739-49 pubmed publisher
  3. Sieber M, Thomsen M, Spradling A. Electron Transport Chain Remodeling by GSK3 during Oogenesis Connects Nutrient State to Reproduction. Cell. 2016;164:420-32 pubmed publisher
    ..Our studies reveal an important link between metabolism and oocyte maturation. ..
  4. Lee M, Skora A, Spradling A. Identification of Genes Mediating Drosophila Follicle Cell Progenitor Differentiation by Screening for Modifiers of GAL4::UAS Variegation. G3 (Bethesda). 2017;7:309-318 pubmed publisher
    ..Five of the modifier genes accelerate the acquisition of progenitor competence and reduce follicle cell number, however, the other three genes affect follicle cell number in an unexpected manner. ..