Genomes and Genes
Allan C Spradling
Affiliation: Carnegie Institution
- Yarosh W, Spradling A. Incomplete replication generates somatic DNA alterations within Drosophila polytene salivary gland cells. Genes Dev. 2014;28:1840-55 pubmed publisher..We suggest that the extensive somatic DNA instability described here underlies position effect variegation, molds the structure of polytene chromosomes, and should be investigated for possible functions. ..
- Sieber M, Thomsen M, Spradling A. Electron Transport Chain Remodeling by GSK3 during Oogenesis Connects Nutrient State to Reproduction. Cell. 2016;164:420-32 pubmed publisher..Our studies reveal an important link between metabolism and oocyte maturation. ..
- Lee M, Skora A, Spradling A. Identification of Genes Mediating Drosophila Follicle Cell Progenitor Differentiation by Screening for Modifiers of GAL4::UAS Variegation. G3 (Bethesda). 2017;7:309-318 pubmed publisher..Five of the modifier genes accelerate the acquisition of progenitor competence and reduce follicle cell number, however, the other three genes affect follicle cell number in an unexpected manner. ..