F Modugno

Summary

Affiliation: Carnegie Mellon University
Country: USA

Publications

  1. pmc Ovarian cancer: prevention, detection, and treatment of the disease and its recurrence. Molecular mechanisms and personalized medicine meeting report
    Francesmary Modugno
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Int J Gynecol Cancer 22:S45-57. 2012
  2. ncbi Allelic variants of aromatase and the androgen and estrogen receptors: toward a multigenic model of prostate cancer risk
    F Modugno
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Clin Cancer Res 7:3092-6. 2001
  3. ncbi Ovarian cancer and polymorphisms in the androgen and progesterone receptor genes: a HuGE review
    Francesmary Modugno
    Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Am J Epidemiol 159:319-35. 2004
  4. ncbi A potential role for the estrogen-metabolizing cytochrome P450 enzymes in human breast carcinogenesis
    Francesmary Modugno
    Department of Epidemiology, University of Pittsburgh, PA 15261, USA
    Breast Cancer Res Treat 82:191-7. 2003
  5. ncbi Alcohol consumption and the risk of mucinous and nonmucinous epithelial ovarian cancer
    Francesmary Modugno
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Obstet Gynecol 102:1336-43. 2003
  6. ncbi Reproductive factors and ovarian cancer risk in Jewish BRCA1 and BRCA2 mutation carriers (United States)
    Francesmary Modugno
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Cancer Causes Control 14:439-46. 2003
  7. ncbi Effect of raloxifene on sexual function in older postmenopausal women with osteoporosis
    Francesmary Modugno
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Obstet Gynecol 101:353-61. 2003
  8. ncbi Cigarette smoking and the risk of mucinous and nonmucinous epithelial ovarian cancer
    Francesmary Modugno
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 516A Parran Hall, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Epidemiology 13:467-71. 2002
  9. ncbi Reproductive risk factors for epithelial ovarian cancer according to histologic type and invasiveness
    F Modugno
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Ann Epidemiol 11:568-74. 2001
  10. ncbi The epidemiology and risk factors of head and neck cancer: a focus on human papillomavirus
    C C R Ragin
    Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA
    J Dent Res 86:104-14. 2007

Detail Information

Publications43

  1. pmc Ovarian cancer: prevention, detection, and treatment of the disease and its recurrence. Molecular mechanisms and personalized medicine meeting report
    Francesmary Modugno
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Int J Gynecol Cancer 22:S45-57. 2012
    ....
  2. ncbi Allelic variants of aromatase and the androgen and estrogen receptors: toward a multigenic model of prostate cancer risk
    F Modugno
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Clin Cancer Res 7:3092-6. 2001
    ....
  3. ncbi Ovarian cancer and polymorphisms in the androgen and progesterone receptor genes: a HuGE review
    Francesmary Modugno
    Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Am J Epidemiol 159:319-35. 2004
    ..The sensitivity, specificity, positive and negative predictive values, and clinical validity of the PROGINS and AR CAG repeat assays are unknown. No recommendations for population-based screening can be made...
  4. ncbi A potential role for the estrogen-metabolizing cytochrome P450 enzymes in human breast carcinogenesis
    Francesmary Modugno
    Department of Epidemiology, University of Pittsburgh, PA 15261, USA
    Breast Cancer Res Treat 82:191-7. 2003
    ..The goals of this study are to identify CYPs expressed in breast tissue by measuring mRNA levels and to determine whether there are differences in mRNA levels between breast tumors and histologically-normal adjacent breast tissue...
  5. ncbi Alcohol consumption and the risk of mucinous and nonmucinous epithelial ovarian cancer
    Francesmary Modugno
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Obstet Gynecol 102:1336-43. 2003
    ..To examine alcohol consumption as a risk factor for epithelial ovarian cancer according to tumor histology...
  6. ncbi Reproductive factors and ovarian cancer risk in Jewish BRCA1 and BRCA2 mutation carriers (United States)
    Francesmary Modugno
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Cancer Causes Control 14:439-46. 2003
    ..To determine whether oral contraceptive (OC) use, childbearing, breastfeeding and tubal ligation differ between ovarian cancer cases with and without a BRCA1/2 mutation...
  7. ncbi Effect of raloxifene on sexual function in older postmenopausal women with osteoporosis
    Francesmary Modugno
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Obstet Gynecol 101:353-61. 2003
    ..To assess the effect of raloxifene compared with placebo on sexual function in older postmenopausal women undergoing therapy for the treatment of osteoporosis...
  8. ncbi Cigarette smoking and the risk of mucinous and nonmucinous epithelial ovarian cancer
    Francesmary Modugno
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 516A Parran Hall, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Epidemiology 13:467-71. 2002
    ..The association between cigarette smoking and ovarian cancer may vary according to the histologic type of tumor...
  9. ncbi Reproductive risk factors for epithelial ovarian cancer according to histologic type and invasiveness
    F Modugno
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Ann Epidemiol 11:568-74. 2001
    ..We examined reproductive risk factors for epithelial ovarian cancer according to histologic subtype and tumor invasiveness...
  10. ncbi The epidemiology and risk factors of head and neck cancer: a focus on human papillomavirus
    C C R Ragin
    Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA
    J Dent Res 86:104-14. 2007
    ..This review presents our current understanding of the relationship between HPV and HNSCC, and describes future research directions that may lead to a better understanding of the involvement of HPV in head and neck cancer...
  11. ncbi Anthropometry and the risk of epithelial ovarian cancer
    Julia B Greer
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Cancer 106:2247-57. 2006
    ..Because factors such as oral contraceptive (OC), hormone therapy (HT), and parity may affect weight and hormone levels, the associations were examined in women with and without these characteristics...
  12. ncbi Oral contraceptive use, reproductive history, and risk of epithelial ovarian cancer in women with and without endometriosis
    Francesmary Modugno
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15261, USA
    Am J Obstet Gynecol 191:733-40. 2004
    ..We investigated whether the odds ratios for ovarian cancer that were associated with oral contraceptive use, childbearing, hysterectomy, and tubal ligation differ among women with and without endometriosis...
  13. ncbi Short-term oral contraceptive use and the risk of epithelial ovarian cancer
    Julia B Greer
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Epidemiol 162:66-72. 2005
    ..Mediating factors may reflect endogenous hormone levels, OC metabolism, or OC bioactivity...
  14. ncbi Hormone replacement therapy formulations and risk of epithelial ovarian carcinoma
    Anita S Y Sit
    Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15213, USA
    Gynecol Oncol 86:118-23. 2002
    ..The aim of the study is to evaluate the impact of various HRT formulations and their characteristics of use on the risk of epithelial ovarian carcinoma (EOC)...
  15. ncbi Peroxisome proliferator-activated receptor-gamma polymorphism, body mass and prostate cancer risk: evidence for gene-environment interaction
    Joseph M Zmuda
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Oncology 70:185-9. 2006
    ..Peroxisome proliferator-activated receptor (PPAR)-gamma has been implicated in prostate cancer. In the present case-control study, we tested if a common Pro12Ala polymorphism in PPAR-gamma is associated with the risk of prostate cancer...
  16. ncbi Contribution of the prostate limits the usefulness of survivin for the detection of bladder cancer
    Benjamin Davies
    Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania 15232, USA
    J Urol 174:1767-70. 2005
    ..We determined if urinary survivin is influenced by the prostate and analyzed survivin levels in a healthy control population...
  17. ncbi Recreational physical activity and mammographic breast density characteristics
    Katherine W Reeves
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Suite 510, 3520 Fifth Avenue, Pittsburgh, PA 15213, USA
    Cancer Epidemiol Biomarkers Prev 16:934-42. 2007
    ..These results suggest that the mechanism by which physical activity reduces breast cancer risk may not involve breast density...
  18. ncbi Body mass index and mortality among older breast cancer survivors in the Study of Osteoporotic Fractures
    Katherine W Reeves
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 516A Parran Hall, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Cancer Epidemiol Biomarkers Prev 16:1468-73. 2007
    ..This study investigated the association between BMI and mortality after breast cancer diagnosis in a cohort of older Caucasian women enrolled in the Study of Osteoporotic Fractures...
  19. ncbi Ovarian cancer and high-risk women-implications for prevention, screening, and early detection
    Francesmary Modugno
    Department of Epidemmiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Gynecol Oncol 91:15-31. 2003
    ....
  20. ncbi Transvaginal ultrasound measurement of endometrial thickness as a biomarker for estrogen exposure
    Anita S Y Sit
    Graduate School of Public Health, Magee Women s Hospital, University of Pittsburgh, Pennsylvania, USA
    Cancer Epidemiol Biomarkers Prev 13:1459-65. 2004
    ....
  21. ncbi Relations of gestational length and timing and type of incomplete pregnancy to ovarian cancer risk
    Gretchen L Gierach
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Epidemiol 161:452-61. 2005
    ..80, 95% CI: 0.44, 1.47). These data do not support an independent association between incomplete pregnancies, either spontaneous or induced, and ovarian cancer risk...
  22. pmc 11q13 amplification status and human papillomavirus in relation to p16 expression defines two distinct etiologies of head and neck tumours
    C C R Ragin
    Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA
    Br J Cancer 95:1432-8. 2006
    ..8-23.9). As HPV+ HNSCC lack the genetic alterations which are common in other tumours, we hypothesise that HPV infection may represent an early event in the HNSCC carcinogenic process, thus suggesting a distinct molecular pathway...
  23. ncbi Androgenic progestins in oral contraceptives and the risk of epithelial ovarian cancer
    Julia B Greer
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
    Obstet Gynecol 105:731-40. 2005
    ..The authors investigated whether OC efficacy might differ according to androgenicity by using data from a large, population-based, case-control study (the Steroid Hormones and Reproductions [SHARE] Study)...
  24. ncbi Endometriosis and its treatment with danazol or lupron in relation to ovarian cancer
    Carrie M Cottreau
    University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania 15261, USA
    Clin Cancer Res 9:5142-4. 2003
    ..The androgenic medication, danazol, and the antiandrogenic medications, leuprolide and nafarelin, are commonly used in the treatment of endometriosis. We assessed the associations between the use of these medications and ovarian cancer...
  25. doi Nonsteroidal anti-inflammatory drug use and serum total estradiol in postmenopausal women
    Alana G Hudson
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Cancer Epidemiol Biomarkers Prev 17:680-7. 2008
    ..These cross-sectional findings suggest that NSAID use may be associated with lower circulating estradiol levels, potentially representing one mechanism through which NSAIDs exert protective effects on breast cancer...
  26. ncbi Estrogen metabolizing polymorphisms and breast cancer risk among older white women
    Francesmary Modugno
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA, USA
    Breast Cancer Res Treat 93:261-70. 2005
    ..To investigate breast cancer risk according to metabolizing genes polymorphisms in older women...
  27. ncbi Association of estrogen receptor alpha polymorphisms with breast cancer risk in older Caucasian women
    Francesmary Modugno
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Int J Cancer 116:984-91. 2005
    ..60 vs. 1.12 for nulliparous vs. parous women; interaction p = 0.03). ESR1 polymorphisms in combination with lifestyle factors may be associated with breast cancer risk in older Caucasian women...
  28. ncbi Obesity, hormone therapy, estrogen metabolism and risk of postmenopausal breast cancer
    Francesmary Modugno
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 516A Parran Hall, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Int J Cancer 118:1292-301. 2006
    ..Estrogen metabolism differs according to both BMI and HT use, potentially explaining the interaction between BMI and HT in relation to breast cancer risk...
  29. ncbi Multiplexed immunobead-based cytokine profiling for early detection of ovarian cancer
    Elieser Gorelik
    Department of Pathology and Immunology, University of Pittsburg School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Cancer Epidemiol Biomarkers Prev 14:981-7. 2005
    ..5% sensitivity and 93.0% specificity. The presented data show that simultaneous testing of a panel of serum cytokines and CA-125 using LabMAP technology may present a promising approach for ovarian cancer detection...
  30. ncbi Endometriosis as a model for inflammation-hormone interactions in ovarian and breast cancers
    Roberta B Ness
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Room 513 Parran Hall, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Eur J Cancer 42:691-703. 2006
    ..Moreover, treatments for endometriosis may require consideration of the impact on long-term cancer risk...
  31. ncbi Gender of offspring and maternal ovarian cancer risk
    Gretchen L Gierach
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, University of Pittsburgh Cancer Institute, 3520 5th Avenue, Suite 510, Pittsburgh, PA 15213, USA
    Gynecol Oncol 101:476-80. 2006
    ..We sought to determine whether offspring gender, which differentially alters maternal hormonal milieu, may be associated with maternal ovarian cancer risk...
  32. ncbi Breast cancer risk factors and mammographic breast density in women over age 70
    Francesmary Modugno
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Breast Cancer Res Treat 97:157-66. 2006
    ..Breast density is a strong risk factor for breast cancer, but little is known about factors associated with breast density in women over 70...
  33. ncbi Analysis of CHEK2 gene for ovarian cancer susceptibility
    Bora E Baysal
    Department of Obstetrics, Gynecology and Reproductive Sciences, The University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
    Gynecol Oncol 95:62-9. 2004
    ..A deletion variant in the CHEK2 gene (del1100C) has been implicated as a low-penetrance risk factor for breast cancer. We sought to determine contribution of CHEK2 mutations to the etiology of ovarian cancer (OvCa)...
  34. ncbi Circulating IL-8 and anti-IL-8 autoantibody in patients with ovarian cancer
    Anna E Lokshin
    University of Pittsburgh Cancer Institute, Hillman Cancer Center, University of Pittsburgh, 5117 Centre Avenue, Pittsburgh, PA 15213, USA
    Gynecol Oncol 102:244-51. 2006
    ..The objective of this study was, therefore, to evaluate the potential importance of circulating anti-IL-8 antibody as ovarian cancer biomarker...
  35. pmc Development of a multimarker assay for early detection of ovarian cancer
    Zoya Yurkovetsky
    University of Pittsburgh Hillman Cancer Center, 5117 Centre Ave, Pittsburgh, PA 15213, USA
    J Clin Oncol 28:2159-66. 2010
    ..Early detection of ovarian cancer has great promise to improve clinical outcome...
  36. doi Physical activity and mammographic density in a cohort of midlife women
    Nina Oestreicher
    Kaiser Permanente Division of Research, Oakland, CA 94612, USA
    Med Sci Sports Exerc 40:451-6. 2008
    ..Physical activity (PA) is one of few modifiable breast cancer risk factors. There have been few studies of the relation between PA and mammographic density, especially in multiethnic populations...
  37. doi Relation of demographic factors, menstrual history, reproduction and medication use to sex hormone levels in postmenopausal women
    Anne McTiernan
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Breast Cancer Res Treat 108:217-31. 2008
    ..These results suggest that while age, oophorectomy status, and NSAID use may be associated with selected sex hormone concentrations, few menstrual or reproductive factors affect endogenous sex hormones in the postmenopausal period...
  38. ncbi Oral contraceptive use as a risk factor for premenopausal breast cancer: a meta-analysis
    Chris Kahlenborn
    Department of Internal Medicine, Altoona Hospital, Altoona, PA, USA
    Mayo Clin Proc 81:1290-302. 2006
    ..To perform a meta-analysis of case-control studies that addressed whether prior oral contraceptive (OC) use is associated with premenopausal breast cancer...
  39. ncbi Estrogen receptor alpha haplotypes and breast cancer risk in older Caucasian women
    Jun Wang
    Human Genetics Department, Roche Molecular Systems, Inc, 1145 Atlantic Ave, Alameda, CA 94555, USA
    Breast Cancer Res Treat 106:273-80. 2007
    ..001% in cases and controls). No other statistically significant associations were observed between ESR1 haplotypes from the same four SNPs and the risk of breast cancer in older Caucasian women...
  40. ncbi Mammographic density in a multiethnic cohort
    Laurel A Habel
    Division of Research, Kaiser Permanente, Oakland, CA 94612, USA
    Menopause 14:891-9. 2007
    ..To compare mammographic density among premenopausal and early perimenopausal women from four racial/ethnic groups and to examine density and acculturation among Japanese and Chinese women...
  41. ncbi Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer
    Simon A Gayther
    Translational Research Laboratories, University College London, London, United Kingdom
    Cancer Res 67:3027-35. 2007
    ..This study highlights the need for multicenter collaborations for genetic association studies...
  42. doi Oral contraceptives and breast cancer
    Chris Kahlenborn
    Holy Spirit Hospital Camp Hill, PA
    Mayo Clin Proc 83:849-50; author reply 850-1. 2008
  43. ncbi Relation of BMI and physical activity to sex hormones in postmenopausal women
    Anne McTiernan
    Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Cancer Prevention Research Program, Seattle, WA 98109, USA
    Obesity (Silver Spring) 14:1662-77. 2006
    ..However, the determinants of these hormone concentrations are not established. The purpose of this study was to examine correlates of endogenous sex hormones...