David MacPherson

Summary

Affiliation: Carnegie Institution
Country: USA

Publications

  1. ncbi request reprint Retinoblastoma: from the two-hit hypothesis to targeted chemotherapy
    David MacPherson
    Department of Embryology, Carnegie Institution, Baltimore, Maryland, USA
    Cancer Res 67:7547-50. 2007
  2. pmc Insights from mouse models into human retinoblastoma
    David MacPherson
    Department of Embryology, Carnegie Institution, Baltimore, MD, USA
    Cell Div 3:9. 2008
  3. pmc Murine bilateral retinoblastoma exhibiting rapid-onset, metastatic progression and N-myc gene amplification
    David MacPherson
    Department of Embryology, Carnegie Institution, Baltimore, MD 21218, USA
    EMBO J 26:784-94. 2007
  4. pmc Cooperation between Rb and Arf in suppressing mouse retinoblastoma
    Karina Conkrite
    Department of Embryology, Carnegie Institution, Baltimore, Maryland 21218, USA
    J Clin Invest 122:1726-33. 2012
  5. pmc miR-17~92 cooperates with RB pathway mutations to promote retinoblastoma
    Karina Conkrite
    Department of Embryology, Carnegie Institution, Baltimore, Maryland 21218, USA
    Genes Dev 25:1734-45. 2011
  6. ncbi request reprint PTEN is a potent suppressor of small cell lung cancer
    Min Cui
    Authors Affiliations Department of Embryology, Carnegie Institution, Baltimore, Maryland 2Fred Hutchinson Cancer Research Center, Seattle, Washington and 3Department of Biomedical Sciences, Cornell University, Ithaca, New York
    Mol Cancer Res 12:654-9. 2014
  7. pmc Cell type-specific effects of Rb deletion in the murine retina
    David MacPherson
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genes Dev 18:1681-94. 2004
  8. doi request reprint BACE-1 inhibitors part 3: identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells
    Paul Beswick
    Neurology and Gastrointestinal Centre of Excellence for Drug Discovery, GlaxoSmithKline R and D, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW, UK
    Bioorg Med Chem Lett 18:1022-6. 2008
  9. pmc Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23
    David MacPherson
    MIT Department of Biology and Center for Cancer Research, Cambridge, MA, USA
    EMBO J 23:3689-99. 2004
  10. pmc ARF mutation accelerates pituitary tumor development in Rb+/- mice
    Kenneth Y Tsai
    Department of Biology and Center for Cancer Research, and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 99:16865-70. 2002

Research Grants

Collaborators

  • Michael Dyer
  • Karina Conkrite
  • Min Cui
  • Kenneth Y Tsai
  • Maggie Sundby
  • David Mu
  • Shizuo Mukai
  • Paul Beswick
  • Alexander Yu Nikitin
  • Michael Rongione
  • Douglas A Rubinson
  • Susan Parazzoli
  • Denise Crowley
  • Nicholas Ingolia
  • Tyler Jacks
  • Arnaud Augert
  • J Michael Thomson
  • Scott M Hammond
  • Alistair O'Brien
  • Daryl S Walter
  • Virginie Soleil
  • John Ward
  • Paul Rowland
  • Emmanuel Demont
  • Sally Redshaw
  • Gareth Wayne
  • Alistair Stuart
  • Geoffrey Stemp
  • David Riddell
  • Julie Hawkins
  • Sharon Sweitzer
  • Brian Clarke
  • Peter Milner
  • Julie Mosley
  • Andrew Faller
  • Robert Gleave
  • Alan Naylor
  • John Skidmore
  • Pam Theobald
  • Steven Stanway
  • Rachel Dunsdon
  • Nicolas Charrier
  • David Vesey
  • Graham Maile
  • Ishrut Hussain
  • Colin Dingwall
  • Kathrine J Smith
  • Christopher N Johnson
  • Rosalie Matico
  • Kim L Mercer
  • Roderick Bronson

Detail Information

Publications11

  1. ncbi request reprint Retinoblastoma: from the two-hit hypothesis to targeted chemotherapy
    David MacPherson
    Department of Embryology, Carnegie Institution, Baltimore, Maryland, USA
    Cancer Res 67:7547-50. 2007
    ..More importantly, these new mouse models of retinoblastoma have contributed to clinical trials and novel therapeutic approaches for treating this debilitating childhood cancer...
  2. pmc Insights from mouse models into human retinoblastoma
    David MacPherson
    Department of Embryology, Carnegie Institution, Baltimore, MD, USA
    Cell Div 3:9. 2008
    ..Recent investigation of the p53 pathway in retinoblastoma, and evidence of spatial topology to early murine retinoblastoma are also discussed in this review...
  3. pmc Murine bilateral retinoblastoma exhibiting rapid-onset, metastatic progression and N-myc gene amplification
    David MacPherson
    Department of Embryology, Carnegie Institution, Baltimore, MD 21218, USA
    EMBO J 26:784-94. 2007
    ..These murine models closely resemble human retinoblastoma in their progression and secondary genetic changes, making them ideal tools for further dissection of steps to tumorigenesis and for testing novel therapies...
  4. pmc Cooperation between Rb and Arf in suppressing mouse retinoblastoma
    Karina Conkrite
    Department of Embryology, Carnegie Institution, Baltimore, Maryland 21218, USA
    J Clin Invest 122:1726-33. 2012
    ..Moreover, p53 inactivation completely eliminated any selection for Arf LOH. Thus, our data reveal important insights into the p53 pathway in retinoblastoma and show that Arf is a key collaborator with Rb in retinoblastoma suppression...
  5. pmc miR-17~92 cooperates with RB pathway mutations to promote retinoblastoma
    Karina Conkrite
    Department of Embryology, Carnegie Institution, Baltimore, Maryland 21218, USA
    Genes Dev 25:1734-45. 2011
    ..These results demonstrate that the oncogenic determinants of miR-17~92 are context-specific and provide new insights into miR-17~92 function as an RB-collaborating gene in cancer...
  6. ncbi request reprint PTEN is a potent suppressor of small cell lung cancer
    Min Cui
    Authors Affiliations Department of Embryology, Carnegie Institution, Baltimore, Maryland 2Fred Hutchinson Cancer Research Center, Seattle, Washington and 3Department of Biomedical Sciences, Cornell University, Ithaca, New York
    Mol Cancer Res 12:654-9. 2014
    ....
  7. pmc Cell type-specific effects of Rb deletion in the murine retina
    David MacPherson
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genes Dev 18:1681-94. 2004
    ..Conditional Rb mutation in the retina did not result in retinoblastoma formation even in a p53-mutant background. However, on a p107- or p130-deficient background, Rb mutation in the retina caused retinal dysplasia or retinoblastoma...
  8. doi request reprint BACE-1 inhibitors part 3: identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells
    Paul Beswick
    Neurology and Gastrointestinal Centre of Excellence for Drug Discovery, GlaxoSmithKline R and D, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW, UK
    Bioorg Med Chem Lett 18:1022-6. 2008
    ..Optimization of the non-prime side of our inhibitors and introduction of a 6-membered sultam substituent binding to Asn-294 as well as a fluorine in the C-2 position led to derivatives with nanomolar potency in cell-based assays...
  9. pmc Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23
    David MacPherson
    MIT Department of Biology and Center for Cancer Research, Cambridge, MA, USA
    EMBO J 23:3689-99. 2004
    ..Instead, Ser23 mutant animals died between 1 and 2 years with tumors that were most commonly of B-cell lineage. These data support an important role for Ser20/23 phosphorylation in p53 stabilization, apoptosis and tumor suppression...
  10. pmc ARF mutation accelerates pituitary tumor development in Rb+/- mice
    Kenneth Y Tsai
    Department of Biology and Center for Cancer Research, and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 99:16865-70. 2002
    ..We conclude that inactivation of ARF acts more broadly than that of p53 in connecting abrogation of the Rb pathway to tumorigenesis...
  11. ncbi request reprint ARF is not required for apoptosis in Rb mutant mouse embryos
    Kenneth Y Tsai
    MIT Department of Biology and Center for Cancer Research, Cambridge, MA 02139, USA
    Curr Biol 12:159-63. 2002
    ..From the analysis of Rb/ARF compound mutants we demonstrate that ARF is not an obligatory link between Rb inactivation and p53-dependent apoptosis...

Research Grants1

  1. Using mouse models to understand retinoblastoma initiation and progression
    David MacPherson; Fiscal Year: 2010
    ..We use mouse models and studies of human retinoblastoma samples to learn how RB- cooperating genes contribute to cancer. ..