Philip R Leduc

Summary

Affiliation: Carnegie Mellon University
Country: USA

Publications

  1. pmc Calcium signaling is gated by a mechanical threshold in three-dimensional environments
    Warren C Ruder
    Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA
    Sci Rep 2:554. 2012
  2. pmc Controlling magnetotactic bacteria through an integrated nanofabricated metallic island and optical microscope approach
    Lina M González
    Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA
    Sci Rep 4:4104. 2014
  3. ncbi request reprint Modulation of fluidic resistance and capacitance for long-term, high-speed feedback control of a microfluidic interface
    YongTae Kim
    Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Lab Chip 9:2603-9. 2009
  4. doi request reprint Towards an in vivo biologically inspired nanofactory
    Philip R Leduc
    Department of Mechanical and Biomedical Engineering, Carnegie Mellon University, Pittsburgh, Philadelphia 15213, USA
    Nat Nanotechnol 2:3-7. 2007
  5. doi request reprint How do control-based approaches enter into biology?
    Philip R Leduc
    Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Annu Rev Biomed Eng 13:369-96. 2011
  6. ncbi request reprint Nanoscale intracellular organization and functional architecture mediating cellular behavior
    Philip P LeDuc
    Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Ann Biomed Eng 34:102-13. 2006
  7. doi request reprint Three-dimensional microfiber devices that mimic physiological environments to probe cell mechanics and signaling
    Warren C Ruder
    Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA
    Lab Chip 12:1775-9. 2012
  8. doi request reprint Probing cell structure responses through a shear and stretching mechanical stimulation technique
    Robert L Steward
    Departments of Mechanical and Biomedical Engineering and Biological Sciences, Carnegie Mellon University, 420 Scaife Hall, Pittsburgh, PA 15213, USA
    Cell Biochem Biophys 56:115-24. 2010
  9. doi request reprint Probing cell structure by controlling the mechanical environment with cell-substrate interactions
    Chao Min Cheng
    Department of Mechanical and Biomedical Engineering, Carnegie Mellon University, Scaife Hall, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA
    J Biomech 42:187-92. 2009
  10. doi request reprint Localized bimodal response of neurite extensions and structural proteins in dorsal-root ganglion neurons with controlled polydimethylsiloxane substrate stiffness
    Chao Min Cheng
    Department of Mechanical and Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    J Biomech 44:856-62. 2011

Collaborators

Detail Information

Publications40

  1. pmc Calcium signaling is gated by a mechanical threshold in three-dimensional environments
    Warren C Ruder
    Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA
    Sci Rep 2:554. 2012
    ..We believe these findings significantly increase our understanding of the critical role of calcium signaling in cells in three-dimensional environments with broad implications in development and disease...
  2. pmc Controlling magnetotactic bacteria through an integrated nanofabricated metallic island and optical microscope approach
    Lina M González
    Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA
    Sci Rep 4:4104. 2014
    ..Our system could be useful for a variety of applications including magnetic fabrication, self-assembly, and probing the sensing apparatus of magnetotactic bacteria...
  3. ncbi request reprint Modulation of fluidic resistance and capacitance for long-term, high-speed feedback control of a microfluidic interface
    YongTae Kim
    Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Lab Chip 9:2603-9. 2009
    ..Our system has a diversity of potential applications including long-term cellular studies in cancer metastasis or embryonic development...
  4. doi request reprint Towards an in vivo biologically inspired nanofactory
    Philip R Leduc
    Department of Mechanical and Biomedical Engineering, Carnegie Mellon University, Pittsburgh, Philadelphia 15213, USA
    Nat Nanotechnol 2:3-7. 2007
  5. doi request reprint How do control-based approaches enter into biology?
    Philip R Leduc
    Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Annu Rev Biomed Eng 13:369-96. 2011
    ..Much work remains to apply simplified control models and develop new technologies to aid researchers in studying and utilizing cellular and molecular processes...
  6. ncbi request reprint Nanoscale intracellular organization and functional architecture mediating cellular behavior
    Philip P LeDuc
    Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Ann Biomed Eng 34:102-13. 2006
    ..Through investigating these organic systems that have evolved over billions of years, understanding in biology, engineering, and nanometer-scaled science will be advanced...
  7. doi request reprint Three-dimensional microfiber devices that mimic physiological environments to probe cell mechanics and signaling
    Warren C Ruder
    Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA
    Lab Chip 12:1775-9. 2012
    ..We anticipate that this device will broadly impact research in fields including biomaterials, tissue engineering, and biophysics...
  8. doi request reprint Probing cell structure responses through a shear and stretching mechanical stimulation technique
    Robert L Steward
    Departments of Mechanical and Biomedical Engineering and Biological Sciences, Carnegie Mellon University, 420 Scaife Hall, Pittsburgh, PA 15213, USA
    Cell Biochem Biophys 56:115-24. 2010
    ..We believe that this will be important in a diversity of fields including cell mechanotransduction, cell-material interactions, biophysics, and tissue engineering...
  9. doi request reprint Probing cell structure by controlling the mechanical environment with cell-substrate interactions
    Chao Min Cheng
    Department of Mechanical and Biomedical Engineering, Carnegie Mellon University, Scaife Hall, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA
    J Biomech 42:187-92. 2009
    ..These findings have implications for research in a diversity of fields including cell-material interactions, mechanotransduction, and tissue engineering...
  10. doi request reprint Localized bimodal response of neurite extensions and structural proteins in dorsal-root ganglion neurons with controlled polydimethylsiloxane substrate stiffness
    Chao Min Cheng
    Department of Mechanical and Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    J Biomech 44:856-62. 2011
    ..This work is important in fields including biomaterials, neuron-material interactions, and neuroscience...
  11. doi request reprint Dynamic control of 3D chemical profiles with a single 2D microfluidic platform
    YongTae Kim
    Department of Mechanical Engineering, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, PA 15213, USA
    Lab Chip 11:2182-8. 2011
    ..Our integrated approach combining feedback control with simple microfluidics will be useful for researchers in diverse disciplines including chemistry, engineering, physics, and biology...
  12. pmc Mechanical stretch and shear flow induced reorganization and recruitment of fibronectin in fibroblasts
    Robert L Steward
    Departments of Mechanical Engineering, Biomedical Engineering, Computational Biology, and Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Sci Rep 1:147. 2011
    ..Our findings will help elucidate the mechanisms of FN biosynthesis and organization by furthering the link of the role of mechanics with FN...
  13. doi request reprint Composite polymer systems with control of local substrate elasticity and their effect on cytoskeletal and morphological characteristics of adherent cells
    Szu Yuan Chou
    Department of Mechanical and Biomedical Engineering, Carnegie Mellon University, 420 Scaife Hall, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA
    Biomaterials 30:3136-42. 2009
    ....
  14. pmc Probing cellular dynamics with a chemical signal generator
    Brandon Kuczenski
    Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA
    PLoS ONE 4:e4847. 2009
    ..The spatiotemporal precision of the generated signals opens avenues to previously unapproachable areas for potential investigation of cell signaling and material behavior...
  15. pmc Investigating circular dorsal ruffles through varying substrate stiffness and mathematical modeling
    Yukai Zeng
    Mechanical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA
    Biophys J 101:2122-30. 2011
    ..Negative feedback by WAVE-related RacGAP on Rac explained how CDR actin propagates as an excitable wave, much like wave propagation in other excitable medium, e.g., nerve signal transmission...
  16. pmc Three-dimensional stochastic off-lattice model of binding chemistry in crowded environments
    Byoungkoo Lee
    Department of Biological Sciences and Lane Center for Computational Biology, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e30131. 2012
    ..Simulation results over broader parameter ranges further show that the impact of molecular crowding is highly dependent on the specific reaction system examined...
  17. pmc Structure and dynamics of single DNA molecules manipulated by magnetic tweezers and or flow
    Sanford H Leuba
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Methods 47:214-22. 2009
    ..Finally, we present some past successful examples of using these approaches to elucidate unique information about protein-nucleic acid interactions...
  18. pmc Parameter effects on binding chemistry in crowded media using a two-dimensional stochastic off-lattice model
    Byoungkoo Lee
    654 Mellon Institute, Carnegie Mellon University of Pittsburgh Joint Program in Computational Biology, 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 80:041918. 2009
    ..The simulation work suggests that predictive models of crowding effects can accommodate a wider variety of parameter variations than prior theoretical models have so far achieved...
  19. pmc Mechanical loading of stem cells for improvement of transplantation outcome in a model of acute myocardial infarction: the role of loading history
    Theresa R Cassino
    Department of Orthopaedic Surgery, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Tissue Eng Part A 18:1101-8. 2012
    ..These findings highlight an important role for cyclic mechanical loading preconditioning of donor MDSCs in optimizing MDSC transplantation for myocardial repair...
  20. pmc Response of an actin filament network model under cyclic stretching through a coarse grained Monte Carlo approach
    John Kang
    Lane Center for Computational Biology, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, PA 15213, USA
    J Theor Biol 274:109-19. 2011
    ..Identifying minimal mechanisms sufficient to reproduce mechanical influences on cellular structure has important implications in a diversity of fields, including biology, physics, medicine, computer science, and engineering...
  21. doi request reprint Probing localized neural mechanotransduction through surface-modified elastomeric matrices and electrophysiology
    Chao Min Cheng
    Department of Mechanical and Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA
    Nat Protoc 5:714-24. 2010
    ..The entire process from fabrication to cellular recording takes 5 to 6 d...
  22. doi request reprint Three-dimensional chemical profile manipulation using two-dimensional autonomous microfluidic control
    YongTae Kim
    Departments of Mechanical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, Pennsylvania 15213 3890, USA
    J Am Chem Soc 132:1339-47. 2010
    ..These results will be useful for research areas including embryonic development, cellular stimulation, and chemical fabrication approaches...
  23. ncbi request reprint Creating ordered small-scale biologically-based rods through force-controlled stamping
    Chao Min Cheng
    Department of Mechanical and Biomedical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    J Am Chem Soc 129:9546-7. 2007
  24. doi request reprint Fabricating small-scale, curved, polymeric structures with convex and concave menisci through interfacial free energy equilibrium
    Chao Min Cheng
    Department of Mechanical and Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Lab Chip 9:3306-9. 2009
    ..In addition, these structures are shown to be biocompatible for cell culture. Our system provides a simple, efficient and economical method for generating integrateable optical components without costly fabrication facilities...
  25. doi request reprint Spatiotemporal control of apical and basal living subcellular chemical environments through vertical phase separation
    Jui Ming Yang
    Department of Mechanical and Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA
    Small 5:1984-9. 2009
    ..By employing this technique, the examination of localized subcellular domain responses in polarization, lipid bilayer mobility, and apical-to-basal signal transduction can be explored...
  26. pmc Detection of dynamic spatiotemporal response to periodic chemical stimulation in a Xenopus embryonic tissue
    YongTae Kim
    Departments of Mechanical Engineering, Biomedical Engineering, and Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 6:e14624. 2011
    ....
  27. doi request reprint Frontiers of optofluidics in synthetic biology
    Cheemeng Tan
    Lane Center for Computational Biology, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Lab Chip 12:3654-65. 2012
    ..Next, we propose several areas for potential applications of optofluidics in synthetic biology. The integration of optofluidics and synthetic biology would have a broad impact on point-of-care diagnostics and biotechnology...
  28. doi request reprint Microbial electricity generation via microfluidic flow control
    Zhiqiang Li
    Department of Civil and Environmental Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, Pennsylvania 15213, USA
    Biotechnol Bioeng 108:2061-9. 2011
    ..42 mA m(-2) (127 A m(-3)) by Shewanella oneidensis. The µ-scale biological fuel cell introduces the necessary small size and fuel flexibility for applications in vivo and in situ sensors which may be remotely deployed and self-powered...
  29. ncbi request reprint Chemically encapsulated structural elements for probing the mechanical responses of biologically inspired systems
    Ying Zhang
    Department of Mechanical and Biomedical Engineering and Biological Science, Department of Chemistry, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA
    Langmuir 23:8129-34. 2007
    ..This work will have implications in a variety of fields, including chemistry, polymer physics, structural biology, and engineering mechanics...
  30. ncbi request reprint Artificial cells: building bioinspired systems using small-scale biology
    Ying Zhang
    Department of Mechanical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA
    Trends Biotechnol 26:14-20. 2008
    ..We believe that this type of work is in its infancy and that exploiting small-scale biological inspiration in the field of artificial cells has great potential for successes in the future...
  31. ncbi request reprint Micropatterning polyvinyl alcohol as a biomimetic material through soft lithography with cell culture
    Chao Min Cheng
    Department of Mechanical and Biomedical Engineering, Carnegie Mellon University, Scaife Hall, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA
    Mol Biosyst 2:299-303. 2006
    ..We show the utility of PVA for cellular patterning using soft lithography. Based on these results, PVA can be applied in a diversity of areas including tissue engineering, biomimetics, and cellular micropatterning...
  32. pmc Dynamics of individual polymers using microfluidic based microcurvilinear flow
    Chao Min Cheng
    Departments of Mechanical and Biomedical Engineering and Biological Sciences, Carnegie Mellon University, Scaife Hall, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA
    Lab Chip 9:2339-47. 2009
    ....
  33. doi request reprint Fabrication of circular microfluidic channels by combining mechanical micromilling and soft lithography
    Mary E Wilson
    Department of Biomedical Engineering, Carnegie Mellon University, Pittsburg, PA 15213, USA
    Lab Chip 11:1550-5. 2011
    ..We believe that this approach will be important for many fields from biomimetics and vascular engineering to microfabrication and microreactor technologies...
  34. doi request reprint Bioinspirations: cell-inspired small-scale systems for enabling studies in experimental biomechanics
    Warren C Ruder
    Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Integr Comp Biol 51:133-41. 2011
    ..Eventually, artificial cells designed to function as small-scale controllers may help alter organisms' phenotypes...
  35. ncbi request reprint Force-controlled inorganic crystallization lithography
    Chao Min Cheng
    Department of Mechanical, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    J Am Chem Soc 128:12080-1. 2006
    ..This work has potential applications in a variety of fields, including studying inorganic material patterning and small-scale fabrication technology...
  36. doi request reprint Spatiotemporal response of living cell structures in Dictyostelium discoideum with semiconductor quantum dots
    Lam Helmick
    Department of Mechanical, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, Pennsylvania 15213, USA
    Nano Lett 8:1303-8. 2008
    ....
  37. pmc Unified regression model of binding equilibria in crowded environments
    Byoungkoo Lee
    Department of Biological Sciences and Lane Center for Computational Biology, Carnegie Mellon University, 654 Mellon Institute, 4400 Fifth Avenue, Pittsburgh, PA, USA
    Sci Rep 1:97. 2011
    ..The work represents an important step toward the long-term goal of computationally tractable predictive models of reaction chemistry in the cellular environment...
  38. ncbi request reprint Integrated lithographic membranes and surface adhesion chemistry for three-dimensional cellular stimulation
    James D Kubicek
    Department of Mechanical and Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, Pennsylvania 15213, USA
    Langmuir 20:11552-6. 2004
    ..This research provides the capacity to probe biological patterns and tissue formation under the influence of mechanical stress...
  39. ncbi request reprint Understanding actin organization in cell structure through lattice based Monte Carlo simulations
    Kathleen Puskar
    Department of Mechanical Engineering Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, Pennsylvania 15213, USA
    Mech Chem Biosyst 1:123-31. 2004
    ..The method and results have potential applications in cell and molecular biology as well as self-assembly for organic and inorganic systems...
  40. ncbi request reprint Stochastic off-lattice modeling of molecular self-assembly in crowded environments by Green's function reaction dynamics
    Byoungkoo Lee
    Joint Program in Computational Biology, Carnegie Mellon University and University of Pittsburgh, 654 Mellon Institute, 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 78:031911. 2008
    ....