Philip R Leduc

Summary

Affiliation: Carnegie Mellon University
Country: USA

Publications

  1. ncbi request reprint Nanoscale intracellular organization and functional architecture mediating cellular behavior
    Philip P LeDuc
    Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Ann Biomed Eng 34:102-13. 2006
  2. doi request reprint How do control-based approaches enter into biology?
    Philip R Leduc
    Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Annu Rev Biomed Eng 13:369-96. 2011
  3. doi request reprint Towards an in vivo biologically inspired nanofactory
    Philip R Leduc
    Department of Mechanical and Biomedical Engineering, Carnegie Mellon University, Pittsburgh, Philadelphia 15213, USA
    Nat Nanotechnol 2:3-7. 2007
  4. ncbi request reprint Modulation of fluidic resistance and capacitance for long-term, high-speed feedback control of a microfluidic interface
    YongTae Kim
    Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Lab Chip 9:2603-9. 2009
  5. pmc Calcium signaling is gated by a mechanical threshold in three-dimensional environments
    Warren C Ruder
    Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA
    Sci Rep 2:554. 2012
  6. doi request reprint Probing cell structure responses through a shear and stretching mechanical stimulation technique
    Robert L Steward
    Departments of Mechanical and Biomedical Engineering and Biological Sciences, Carnegie Mellon University, 420 Scaife Hall, Pittsburgh, PA 15213, USA
    Cell Biochem Biophys 56:115-24. 2010
  7. pmc Mechanical stretch and shear flow induced reorganization and recruitment of fibronectin in fibroblasts
    Robert L Steward
    Departments of Mechanical Engineering, Biomedical Engineering, Computational Biology, and Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Sci Rep 1:147. 2011
  8. doi request reprint Dynamic control of 3D chemical profiles with a single 2D microfluidic platform
    YongTae Kim
    Department of Mechanical Engineering, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, PA 15213, USA
    Lab Chip 11:2182-8. 2011
  9. doi request reprint Three-dimensional microfiber devices that mimic physiological environments to probe cell mechanics and signaling
    Warren C Ruder
    Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA
    Lab Chip 12:1775-9. 2012
  10. doi request reprint Localized bimodal response of neurite extensions and structural proteins in dorsal-root ganglion neurons with controlled polydimethylsiloxane substrate stiffness
    Chao Min Cheng
    Department of Mechanical and Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    J Biomech 44:856-62. 2011

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Nanoscale intracellular organization and functional architecture mediating cellular behavior
    Philip P LeDuc
    Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Ann Biomed Eng 34:102-13. 2006
    ..Through investigating these organic systems that have evolved over billions of years, understanding in biology, engineering, and nanometer-scaled science will be advanced...
  2. doi request reprint How do control-based approaches enter into biology?
    Philip R Leduc
    Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Annu Rev Biomed Eng 13:369-96. 2011
    ..Much work remains to apply simplified control models and develop new technologies to aid researchers in studying and utilizing cellular and molecular processes...
  3. doi request reprint Towards an in vivo biologically inspired nanofactory
    Philip R Leduc
    Department of Mechanical and Biomedical Engineering, Carnegie Mellon University, Pittsburgh, Philadelphia 15213, USA
    Nat Nanotechnol 2:3-7. 2007
  4. ncbi request reprint Modulation of fluidic resistance and capacitance for long-term, high-speed feedback control of a microfluidic interface
    YongTae Kim
    Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Lab Chip 9:2603-9. 2009
    ..Our system has a diversity of potential applications including long-term cellular studies in cancer metastasis or embryonic development...
  5. pmc Calcium signaling is gated by a mechanical threshold in three-dimensional environments
    Warren C Ruder
    Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA
    Sci Rep 2:554. 2012
    ..We believe these findings significantly increase our understanding of the critical role of calcium signaling in cells in three-dimensional environments with broad implications in development and disease...
  6. doi request reprint Probing cell structure responses through a shear and stretching mechanical stimulation technique
    Robert L Steward
    Departments of Mechanical and Biomedical Engineering and Biological Sciences, Carnegie Mellon University, 420 Scaife Hall, Pittsburgh, PA 15213, USA
    Cell Biochem Biophys 56:115-24. 2010
    ..We believe that this will be important in a diversity of fields including cell mechanotransduction, cell-material interactions, biophysics, and tissue engineering...
  7. pmc Mechanical stretch and shear flow induced reorganization and recruitment of fibronectin in fibroblasts
    Robert L Steward
    Departments of Mechanical Engineering, Biomedical Engineering, Computational Biology, and Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Sci Rep 1:147. 2011
    ..Our findings will help elucidate the mechanisms of FN biosynthesis and organization by furthering the link of the role of mechanics with FN...
  8. doi request reprint Dynamic control of 3D chemical profiles with a single 2D microfluidic platform
    YongTae Kim
    Department of Mechanical Engineering, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, PA 15213, USA
    Lab Chip 11:2182-8. 2011
    ..Our integrated approach combining feedback control with simple microfluidics will be useful for researchers in diverse disciplines including chemistry, engineering, physics, and biology...
  9. doi request reprint Three-dimensional microfiber devices that mimic physiological environments to probe cell mechanics and signaling
    Warren C Ruder
    Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA
    Lab Chip 12:1775-9. 2012
    ..We anticipate that this device will broadly impact research in fields including biomaterials, tissue engineering, and biophysics...
  10. doi request reprint Localized bimodal response of neurite extensions and structural proteins in dorsal-root ganglion neurons with controlled polydimethylsiloxane substrate stiffness
    Chao Min Cheng
    Department of Mechanical and Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    J Biomech 44:856-62. 2011
    ..This work is important in fields including biomaterials, neuron-material interactions, and neuroscience...
  11. doi request reprint Composite polymer systems with control of local substrate elasticity and their effect on cytoskeletal and morphological characteristics of adherent cells
    Szu Yuan Chou
    Department of Mechanical and Biomedical Engineering, Carnegie Mellon University, 420 Scaife Hall, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA
    Biomaterials 30:3136-42. 2009
    ....
  12. doi request reprint Frontiers of optofluidics in synthetic biology
    Cheemeng Tan
    Lane Center for Computational Biology, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Lab Chip 12:3654-65. 2012
    ..Next, we propose several areas for potential applications of optofluidics in synthetic biology. The integration of optofluidics and synthetic biology would have a broad impact on point-of-care diagnostics and biotechnology...
  13. pmc Mechanical loading of stem cells for improvement of transplantation outcome in a model of acute myocardial infarction: the role of loading history
    Theresa R Cassino
    Department of Orthopaedic Surgery, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Tissue Eng Part A 18:1101-8. 2012
    ..These findings highlight an important role for cyclic mechanical loading preconditioning of donor MDSCs in optimizing MDSC transplantation for myocardial repair...
  14. pmc Investigating circular dorsal ruffles through varying substrate stiffness and mathematical modeling
    Yukai Zeng
    Mechanical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA
    Biophys J 101:2122-30. 2011
    ..Negative feedback by WAVE-related RacGAP on Rac explained how CDR actin propagates as an excitable wave, much like wave propagation in other excitable medium, e.g., nerve signal transmission...
  15. doi request reprint Probing localized neural mechanotransduction through surface-modified elastomeric matrices and electrophysiology
    Chao Min Cheng
    Department of Mechanical and Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA
    Nat Protoc 5:714-24. 2010
    ..The entire process from fabrication to cellular recording takes 5 to 6 d...
  16. pmc Response of an actin filament network model under cyclic stretching through a coarse grained Monte Carlo approach
    John Kang
    Lane Center for Computational Biology, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, PA 15213, USA
    J Theor Biol 274:109-19. 2011
    ..Identifying minimal mechanisms sufficient to reproduce mechanical influences on cellular structure has important implications in a diversity of fields, including biology, physics, medicine, computer science, and engineering...
  17. pmc Detection of dynamic spatiotemporal response to periodic chemical stimulation in a Xenopus embryonic tissue
    YongTae Kim
    Departments of Mechanical Engineering, Biomedical Engineering, and Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 6:e14624. 2011
    ....
  18. pmc Dynamics of individual polymers using microfluidic based microcurvilinear flow
    Chao Min Cheng
    Departments of Mechanical and Biomedical Engineering and Biological Sciences, Carnegie Mellon University, Scaife Hall, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA
    Lab Chip 9:2339-47. 2009
    ....
  19. doi request reprint Spatiotemporal response of living cell structures in Dictyostelium discoideum with semiconductor quantum dots
    Lam Helmick
    Department of Mechanical, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, Pennsylvania 15213, USA
    Nano Lett 8:1303-8. 2008
    ....
  20. doi request reprint Bioinspirations: cell-inspired small-scale systems for enabling studies in experimental biomechanics
    Warren C Ruder
    Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Integr Comp Biol 51:133-41. 2011
    ..Eventually, artificial cells designed to function as small-scale controllers may help alter organisms' phenotypes...
  21. doi request reprint Three-dimensional chemical profile manipulation using two-dimensional autonomous microfluidic control
    YongTae Kim
    Departments of Mechanical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, Pennsylvania 15213 3890, USA
    J Am Chem Soc 132:1339-47. 2010
    ..These results will be useful for research areas including embryonic development, cellular stimulation, and chemical fabrication approaches...
  22. doi request reprint Fabrication of circular microfluidic channels by combining mechanical micromilling and soft lithography
    Mary E Wilson
    Department of Biomedical Engineering, Carnegie Mellon University, Pittsburg, PA 15213, USA
    Lab Chip 11:1550-5. 2011
    ..We believe that this approach will be important for many fields from biomimetics and vascular engineering to microfabrication and microreactor technologies...
  23. pmc Unified regression model of binding equilibria in crowded environments
    Byoungkoo Lee
    Department of Biological Sciences and Lane Center for Computational Biology, Carnegie Mellon University, 654 Mellon Institute, 4400 Fifth Avenue, Pittsburgh, PA, USA
    Sci Rep 1:97. 2011
    ..The work represents an important step toward the long-term goal of computationally tractable predictive models of reaction chemistry in the cellular environment...
  24. doi request reprint Microbial electricity generation via microfluidic flow control
    Zhiqiang Li
    Department of Civil and Environmental Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, Pennsylvania 15213, USA
    Biotechnol Bioeng 108:2061-9. 2011
    ..42 mA m(-2) (127 A m(-3)) by Shewanella oneidensis. The ”-scale biological fuel cell introduces the necessary small size and fuel flexibility for applications in vivo and in situ sensors which may be remotely deployed and self-powered...
  25. ncbi request reprint Creating ordered small-scale biologically-based rods through force-controlled stamping
    Chao Min Cheng
    Department of Mechanical and Biomedical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    J Am Chem Soc 129:9546-7. 2007
  26. doi request reprint Spatiotemporal control of apical and basal living subcellular chemical environments through vertical phase separation
    Jui Ming Yang
    Department of Mechanical and Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA
    Small 5:1984-9. 2009
    ..By employing this technique, the examination of localized subcellular domain responses in polarization, lipid bilayer mobility, and apical-to-basal signal transduction can be explored...
  27. pmc Structure and dynamics of single DNA molecules manipulated by magnetic tweezers and or flow
    Sanford H Leuba
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Methods 47:214-22. 2009
    ..Finally, we present some past successful examples of using these approaches to elucidate unique information about protein-nucleic acid interactions...
  28. doi request reprint Probing cell structure by controlling the mechanical environment with cell-substrate interactions
    Chao Min Cheng
    Department of Mechanical and Biomedical Engineering, Carnegie Mellon University, Scaife Hall, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA
    J Biomech 42:187-92. 2009
    ..These findings have implications for research in a diversity of fields including cell-material interactions, mechanotransduction, and tissue engineering...
  29. pmc Probing cellular dynamics with a chemical signal generator
    Brandon Kuczenski
    Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA
    PLoS ONE 4:e4847. 2009
    ..The spatiotemporal precision of the generated signals opens avenues to previously unapproachable areas for potential investigation of cell signaling and material behavior...
  30. doi request reprint Fabricating small-scale, curved, polymeric structures with convex and concave menisci through interfacial free energy equilibrium
    Chao Min Cheng
    Department of Mechanical and Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Lab Chip 9:3306-9. 2009
    ..In addition, these structures are shown to be biocompatible for cell culture. Our system provides a simple, efficient and economical method for generating integrateable optical components without costly fabrication facilities...
  31. pmc Three-dimensional stochastic off-lattice model of binding chemistry in crowded environments
    Byoungkoo Lee
    Department of Biological Sciences and Lane Center for Computational Biology, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e30131. 2012
    ..Simulation results over broader parameter ranges further show that the impact of molecular crowding is highly dependent on the specific reaction system examined...
  32. ncbi request reprint Artificial cells: building bioinspired systems using small-scale biology
    Ying Zhang
    Department of Mechanical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA
    Trends Biotechnol 26:14-20. 2008
    ..We believe that this type of work is in its infancy and that exploiting small-scale biological inspiration in the field of artificial cells has great potential for successes in the future...
  33. ncbi request reprint Chemically encapsulated structural elements for probing the mechanical responses of biologically inspired systems
    Ying Zhang
    Department of Mechanical and Biomedical Engineering and Biological Science, Department of Chemistry, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA
    Langmuir 23:8129-34. 2007
    ..This work will have implications in a variety of fields, including chemistry, polymer physics, structural biology, and engineering mechanics...