Marnie E Halpern

Summary

Affiliation: Carnegie Institution
Country: USA

Publications

  1. ncbi request reprint Otx5 regulates genes that show circadian expression in the zebrafish pineal complex
    Joshua T Gamse
    Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland, 21210 USA
    Nat Genet 30:117-21. 2002
  2. ncbi request reprint The parapineal mediates left-right asymmetry in the zebrafish diencephalon
    Joshua T Gamse
    Carnegie Institution of Washington, Department of Embryology, 115 W University Parkway, Baltimore, MD 21210, USA
    Development 130:1059-68. 2003
  3. pmc Tbx2b is required for the development of the parapineal organ
    Corey D Snelson
    Department of Biological Sciences, Vanderbilt University, VU Station B, Box 35 1634, Nashville, TN 37235, USA
    Development 135:1693-702. 2008
  4. doi request reprint Gal4/UAS transgenic tools and their application to zebrafish
    Marnie E Halpern
    Carnegie Institution for Science, Baltimore, Maryland, USA
    Zebrafish 5:97-110. 2008
  5. ncbi request reprint Leaning to the left: laterality in the zebrafish forebrain
    Marnie E Halpern
    Carnegie Institution of Washington, Department of Embryology, 115 West University Parkway, Baltimore, MD 21210, USA
    Trends Neurosci 26:308-13. 2003
  6. pmc Lateralization of the vertebrate brain: taking the side of model systems
    Marnie E Halpern
    Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21218, USA
    J Neurosci 25:10351-7. 2005
  7. ncbi request reprint Neuropilin asymmetry mediates a left-right difference in habenular connectivity
    Yung Shu Kuan
    Carnegie Institution of Washington, Department of Embryology, 3520 San Martin Drive, Baltimore, MD 21218, USA
    Development 134:857-65. 2007
  8. ncbi request reprint Selective asymmetry in a conserved forebrain to midbrain projection
    Yung Shu Kuan
    Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21218, USA
    J Exp Zool B Mol Dev Evol 308:669-78. 2007
  9. ncbi request reprint Directional asymmetry of the zebrafish epithalamus guides dorsoventral innervation of the midbrain target
    Joshua T Gamse
    Carnegie Institution of Washington, Department of Embryology, Baltimore, MD 21218, USA
    Development 132:4869-81. 2005
  10. pmc Transgenerational analysis of transcriptional silencing in zebrafish
    Courtney M Akitake
    Department of Embryology, Carnegie Institution for Science, Baltimore, MD 21218, USA
    Dev Biol 352:191-201. 2011

Research Grants

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Otx5 regulates genes that show circadian expression in the zebrafish pineal complex
    Joshua T Gamse
    Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland, 21210 USA
    Nat Genet 30:117-21. 2002
    ..Our results indicate that Otx5 rather than Crx regulates genes that show circadian expression in the zebrafish pineal complex...
  2. ncbi request reprint The parapineal mediates left-right asymmetry in the zebrafish diencephalon
    Joshua T Gamse
    Carnegie Institution of Washington, Department of Embryology, 115 W University Parkway, Baltimore, MD 21210, USA
    Development 130:1059-68. 2003
    ..The left-sided parapineal therefore influences the left-right identity of adjacent brain nuclei, indicating that laterality of the dorsal diencephalon arises in a step-wise fashion...
  3. pmc Tbx2b is required for the development of the parapineal organ
    Corey D Snelson
    Department of Biological Sciences, Vanderbilt University, VU Station B, Box 35 1634, Nashville, TN 37235, USA
    Development 135:1693-702. 2008
    ..We conclude that tbx2b functions to specify the correct number of parapineal cells and to regulate their asymmetric migration...
  4. doi request reprint Gal4/UAS transgenic tools and their application to zebrafish
    Marnie E Halpern
    Carnegie Institution for Science, Baltimore, Maryland, USA
    Zebrafish 5:97-110. 2008
    ..We describe some exciting new directions, in large part afforded by the Tol2 transposition system, that are generating valuable new Gal4/UAS reagents for zebrafish research...
  5. ncbi request reprint Leaning to the left: laterality in the zebrafish forebrain
    Marnie E Halpern
    Carnegie Institution of Washington, Department of Embryology, 115 West University Parkway, Baltimore, MD 21210, USA
    Trends Neurosci 26:308-13. 2003
    ..Results from the genetically tractable zebrafish system provide a promising entry point for exploring how left-right biases are established and propagated in the developing vertebrate brain...
  6. pmc Lateralization of the vertebrate brain: taking the side of model systems
    Marnie E Halpern
    Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21218, USA
    J Neurosci 25:10351-7. 2005
  7. ncbi request reprint Neuropilin asymmetry mediates a left-right difference in habenular connectivity
    Yung Shu Kuan
    Carnegie Institution of Washington, Department of Embryology, 3520 San Martin Drive, Baltimore, MD 21218, USA
    Development 134:857-65. 2007
    ..The results indicate that Sema3D acts in concert with Nrp1a to guide neurons on the left side of the brain to innervate the target nucleus differently than those on the right side...
  8. ncbi request reprint Selective asymmetry in a conserved forebrain to midbrain projection
    Yung Shu Kuan
    Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21218, USA
    J Exp Zool B Mol Dev Evol 308:669-78. 2007
    ..Thus, although the habenulo-interpeduncular conduction system is highly conserved in the vertebrate brain, the stereotypic dorsoventral topography of left-right connections appears to be a feature that is specific to teleosts...
  9. ncbi request reprint Directional asymmetry of the zebrafish epithalamus guides dorsoventral innervation of the midbrain target
    Joshua T Gamse
    Carnegie Institution of Washington, Department of Embryology, Baltimore, MD 21218, USA
    Development 132:4869-81. 2005
    ..The results demonstrate that laterality of the dorsal forebrain influences the formation of midbrain connections and their molecular properties...
  10. pmc Transgenerational analysis of transcriptional silencing in zebrafish
    Courtney M Akitake
    Department of Embryology, Carnegie Institution for Science, Baltimore, MD 21218, USA
    Dev Biol 352:191-201. 2011
    ....
  11. pmc Unexpected diversity and photoperiod dependence of the zebrafish melanopsin system
    Vanessa Matos-Cruz
    Department of Embryology, Carnegie Institution for Science, Baltimore, Maryland, United States of America
    PLoS ONE 6:e25111. 2011
    ..Moreover, both genes are expressed in a robust diurnal rhythm but with different phases in relation to the light-dark cycle. The results suggest that melanopsin has an expanded role in modulating the retinal circuitry of fish...
  12. pmc Transcriptional silencing and reactivation in transgenic zebrafish
    Mary G Goll
    Department of Embryology, Carnegie Institution for Science, Baltimore, Maryland 21218, USA
    Genetics 182:747-55. 2009
    ..The results demonstrate the power of the zebrafish system for in vivo monitoring of epigenetic processes using a genetic approach...
  13. pmc Visualization of estrogen receptor transcriptional activation in zebrafish
    Daniel A Gorelick
    Carnegie Institution for Science, Department of Embryology, 3520 San Martin Drive, Baltimore, Maryland 21218, USA
    Endocrinology 152:2690-703. 2011
    ..The transgenic estrogen-responsive zebrafish allow ER signaling to be monitored visually and serve as in vivo sentinels for detection of estrogenic compounds...
  14. pmc Determining the function of zebrafish epithalamic asymmetry
    Lucilla Facchin
    Department of Embryology, Carnegie Institution for Science, 3520 San Martin Drive, Baltimore, MD 21218, USA
    Philos Trans R Soc Lond B Biol Sci 364:1021-32. 2009
    ..We discuss these findings with respect to previous studies and recent work linking the habenular region with control of the motivation/reward pathway of the vertebrate brain...
  15. pmc Transactivation from Gal4-VP16 transgenic insertions for tissue-specific cell labeling and ablation in zebrafish
    Jon M Davison
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Dev Biol 304:811-24. 2007
    ....
  16. doi request reprint Nogo-Nogo receptor signalling in PNS axon outgrowth and pathfinding
    Christian Brösamle
    Carnegie Institution of Washington, Department of Embryology, 3520 San Martin Drive, Baltimore, MD 21218, USA
    Mol Cell Neurosci 40:401-9. 2009
    ..We propose that localized Nogo expression defines inhibitory territories that through repulsion restrict axon growth to permissive regions...
  17. pmc Aversive cues fail to activate fos expression in the asymmetric olfactory-habenula pathway of zebrafish
    Tagide N deCarvalho
    Department of Embryology, Carnegie Institution for Science Baltimore, MD, USA
    Front Neural Circuits 7:98. 2013
    ..The results indicate that L-R asymmetry of the epithalamus sets the directionality of olfactory innervation, however, the lhx2a:YFP OB-Ha pathway does not appear to mediate fear responses to aversive odorants...
  18. doi request reprint Androgen receptor gene expression in the developing and adult zebrafish brain
    Daniel A Gorelick
    Carnegie Institution for Science, Department of Embryology, Baltimore, Maryland 21218, USA
    Dev Dyn 237:2987-95. 2008
    ....
  19. ncbi request reprint Characterization of myelination in the developing zebrafish
    Christian Brösamle
    Department of Embryology, Carnegie Institution of Washington, Baltimore Maryland
    Glia 39:47-57. 2002
    ..Conservation in gene expression patterns and the early appearance of myelinated axons, support using the zebrafish to dissect the process of myelination by a genetic approach...
  20. pmc The zebrafish annexin gene family
    Steven A Farber
    Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
    Genome Res 13:1082-96. 2003
    ..The differences in gene expression of recently duplicated anx genes could explain why highly related paralogs were maintained in the genome and did not rapidly become pseudogenes...
  21. doi request reprint Cholinergic left-right asymmetry in the habenulo-interpeduncular pathway
    Elim Hong
    Department of Embryology, Carnegie Institution for Science, Baltimore, MD 21218
    Proc Natl Acad Sci U S A 110:21171-6. 2013
    ..Our studies of the newly identified cholinergic gene locus resolve the neurotransmitter identity of the zebrafish habenular nuclei and reveal functional asymmetry in a major cholinergic neuromodulatory pathway of the vertebrate brain. ..
  22. pmc A versatile aquatics facility inventory system with real-time barcode scan entry
    Jennifer L Anderson
    Department of Embryology, Carnegie Institution for Science, Baltimore, Maryland 21218, USA
    Zebrafish 7:281-7. 2010
    ....
  23. ncbi request reprint Radiographic analysis of zebrafish skeletal defects
    Shannon Fisher
    Department of Embryology, Carnegie Institution of Washington, Baltimore, MD 21210, USA
    Dev Biol 264:64-76. 2003
    ..Radiography is a practical screening tool to detect subtle skeletal abnormalities in the adult zebrafish. The identification of chihuahua demonstrates that mutant phenotypes analogous to human skeletal dysplasias will be discovered...
  24. ncbi request reprint Specification of left-right asymmetry
    Christopher V E Wright
    Department of Embryology, Carnegie Institution of Washington, 115 W University Parkway, Baltimore, Maryland 21210, USA
    Results Probl Cell Differ 40:96-116. 2002

Research Grants18

  1. GENERATION OF A DELETION PANEL FOR THE ZEBRAFISH GENOME
    Marnie Halpern; Fiscal Year: 2001
    ..As in non-vertebrate genetic systems, a zebrafish deletion panel is an essential resource, providing the necessary bridge between DNA sequence and gene function. ..
  2. Left-Right Asymmetry of the Developing Diecephalon
    Marnie E Halpern; Fiscal Year: 2010
    ....
  3. Left-Right Asymmetry of the Developing Diecephalon
    Marnie E Halpern; Fiscal Year: 2010
    ....
  4. Transgenic tools for Gal4 regulated gene expression in zebrafish
    Michael Parsons; Fiscal Year: 2010
    ..An additional goal is to optimize the Gal4/UAS system by exploring the basis of transcriptional silencing of zebrafish transgenes and devising approaches to overcome it. ..
  5. Left-Right Asymmetry of the Developing Diencephalon
    Marnie Halpern; Fiscal Year: 2006
    ..Together, the proposed experiments will provide a greater understanding of the genetic mechanisms that underlie left-right specialization of the vertebrate forebrain. ..
  6. Left-Right Asymmetry of the Developing Diencephalon
    Marnie Halpern; Fiscal Year: 2007
    ..abstract_text> ..
  7. Left-Right Asymmetry of the Developing Diencephalon
    Marnie Halpern; Fiscal Year: 2003
    ..Together, the proposed experiments will provide a greater understanding of the genetic mechanisms that underlie left-right specialization of the vertebrate forebrain. ..