Research Topics
Genomes and Genes | Marnie E HalpernSummaryAffiliation: Carnegie Institution Country: USA Publications
Research Grants
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Publications
Otx5 regulates genes that show circadian expression in the zebrafish pineal complexJoshua T Gamse
Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland, 21210 USA
Nat Genet 30:117-21. 2002..Our results indicate that Otx5 rather than Crx regulates genes that show circadian expression in the zebrafish pineal complex...- The parapineal mediates left-right asymmetry in the zebrafish diencephalonJoshua T Gamse
Carnegie Institution of Washington, Department of Embryology, 115 W University Parkway, Baltimore, MD 21210, USA
Development 130:1059-68. 2003..The left-sided parapineal therefore influences the left-right identity of adjacent brain nuclei, indicating that laterality of the dorsal diencephalon arises in a step-wise fashion... 
Tbx2b is required for the development of the parapineal organCorey D Snelson
Department of Biological Sciences, Vanderbilt University, VU Station B, Box 35 1634, Nashville, TN 37235, USA
Development 135:1693-702. 2008..We conclude that tbx2b functions to specify the correct number of parapineal cells and to regulate their asymmetric migration...
Gal4/UAS transgenic tools and their application to zebrafishMarnie E Halpern
Carnegie Institution for Science, Baltimore, Maryland, USA
Zebrafish 5:97-110. 2008..We describe some exciting new directions, in large part afforded by the Tol2 transposition system, that are generating valuable new Gal4/UAS reagents for zebrafish research...- Leaning to the left: laterality in the zebrafish forebrainMarnie E Halpern
Carnegie Institution of Washington, Department of Embryology, 115 West University Parkway, Baltimore, MD 21210, USA
Trends Neurosci 26:308-13. 2003..Results from the genetically tractable zebrafish system provide a promising entry point for exploring how left-right biases are established and propagated in the developing vertebrate brain... - Lateralization of the vertebrate brain: taking the side of model systemsMarnie E Halpern
Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21218, USA
J Neurosci 25:10351-7. 2005 - Selective asymmetry in a conserved forebrain to midbrain projectionYung Shu Kuan
Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21218, USA
J Exp Zool B Mol Dev Evol 308:669-78. 2007..Thus, although the habenulo-interpeduncular conduction system is highly conserved in the vertebrate brain, the stereotypic dorsoventral topography of left-right connections appears to be a feature that is specific to teleosts... - Neuropilin asymmetry mediates a left-right difference in habenular connectivityYung Shu Kuan
Carnegie Institution of Washington, Department of Embryology, 3520 San Martin Drive, Baltimore, MD 21218, USA
Development 134:857-65. 2007..The results indicate that Sema3D acts in concert with Nrp1a to guide neurons on the left side of the brain to innervate the target nucleus differently than those on the right side... - Directional asymmetry of the zebrafish epithalamus guides dorsoventral innervation of the midbrain targetJoshua T Gamse
Carnegie Institution of Washington, Department of Embryology, Baltimore, MD 21218, USA
Development 132:4869-81. 2005..The results demonstrate that laterality of the dorsal forebrain influences the formation of midbrain connections and their molecular properties... - Unexpected diversity and photoperiod dependence of the zebrafish melanopsin systemVanessa Matos-Cruz
Department of Embryology, Carnegie Institution for Science, Baltimore, Maryland, United States of America
PLoS ONE 6:e25111. 2011..Moreover, both genes are expressed in a robust diurnal rhythm but with different phases in relation to the light-dark cycle. The results suggest that melanopsin has an expanded role in modulating the retinal circuitry of fish... - Transgenerational analysis of transcriptional silencing in zebrafishCourtney M Akitake
Department of Embryology, Carnegie Institution for Science, Baltimore, MD 21218, USA
Dev Biol 352:191-201. 2011.... - Transcriptional silencing and reactivation in transgenic zebrafishMary G Goll
Department of Embryology, Carnegie Institution for Science, Baltimore, Maryland 21218, USA
Genetics 182:747-55. 2009..The results demonstrate the power of the zebrafish system for in vivo monitoring of epigenetic processes using a genetic approach... - Visualization of estrogen receptor transcriptional activation in zebrafishDaniel A Gorelick
Carnegie Institution for Science, Department of Embryology, 3520 San Martin Drive, Baltimore, Maryland 21218, USA
Endocrinology 152:2690-703. 2011..The transgenic estrogen-responsive zebrafish allow ER signaling to be monitored visually and serve as in vivo sentinels for detection of estrogenic compounds... - Determining the function of zebrafish epithalamic asymmetryLucilla Facchin
Department of Embryology, Carnegie Institution for Science, 3520 San Martin Drive, Baltimore, MD 21218, USA
Philos Trans R Soc Lond B Biol Sci 364:1021-32. 2009..We discuss these findings with respect to previous studies and recent work linking the habenular region with control of the motivation/reward pathway of the vertebrate brain... - Transactivation from Gal4-VP16 transgenic insertions for tissue-specific cell labeling and ablation in zebrafishJon M Davison
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Dev Biol 304:811-24. 2007.... - Nogo-Nogo receptor signalling in PNS axon outgrowth and pathfindingChristian Brösamle
Carnegie Institution of Washington, Department of Embryology, 3520 San Martin Drive, Baltimore, MD 21218, USA
Mol Cell Neurosci 40:401-9. 2009..We propose that localized Nogo expression defines inhibitory territories that through repulsion restrict axon growth to permissive regions... - Androgen receptor gene expression in the developing and adult zebrafish brainDaniel A Gorelick
Carnegie Institution for Science, Department of Embryology, Baltimore, Maryland 21218, USA
Dev Dyn 237:2987-95. 2008.... - Characterization of myelination in the developing zebrafishChristian Brösamle
Department of Embryology, Carnegie Institution of Washington, Baltimore Maryland
Glia 39:47-57. 2002..Conservation in gene expression patterns and the early appearance of myelinated axons, support using the zebrafish to dissect the process of myelination by a genetic approach... - The zebrafish annexin gene familySteven A Farber
Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
Genome Res 13:1082-96. 2003..The differences in gene expression of recently duplicated anx genes could explain why highly related paralogs were maintained in the genome and did not rapidly become pseudogenes... - A versatile aquatics facility inventory system with real-time barcode scan entryJennifer L Anderson
Department of Embryology, Carnegie Institution for Science, Baltimore, Maryland 21218, USA
Zebrafish 7:281-7. 2010.... - Specification of left-right asymmetryChristopher V E Wright
Department of Embryology, Carnegie Institution of Washington, 115 W. University Parkway, Baltimore, Maryland 21210, USA
Results Probl Cell Differ 40:96-116. 2002 - Radiographic analysis of zebrafish skeletal defectsShannon Fisher
Department of Embryology, Carnegie Institution of Washington, Baltimore, MD 21210, USA
Dev Biol 264:64-76. 2003..Radiography is a practical screening tool to detect subtle skeletal abnormalities in the adult zebrafish. The identification of chihuahua demonstrates that mutant phenotypes analogous to human skeletal dysplasias will be discovered...
Research Grants
- GENERATION OF A DELETION PANEL FOR THE ZEBRAFISH GENOMEMarnie Halpern; Fiscal Year: 2001..As in non-vertebrate genetic systems, a zebrafish deletion panel is an essential resource, providing the necessary bridge between DNA sequence and gene function. ..
- Left-Right Asymmetry of the Developing DiecephalonMarnie E Halpern; Fiscal Year: 2010....
- Left-Right Asymmetry of the Developing DiecephalonMarnie E Halpern; Fiscal Year: 2010....
- Transgenic tools for Gal4 regulated gene expression in zebrafishMichael Parsons; Fiscal Year: 2010..An additional goal is to optimize the Gal4/UAS system by exploring the basis of transcriptional silencing of zebrafish transgenes and devising approaches to overcome it. ..
- Left-Right Asymmetry of the Developing DiencephalonMarnie Halpern; Fiscal Year: 2006..Together, the proposed experiments will provide a greater understanding of the genetic mechanisms that underlie left-right specialization of the vertebrate forebrain. ..
- Left-Right Asymmetry of the Developing DiencephalonMarnie Halpern; Fiscal Year: 2007..abstract_text> ..
- Left-Right Asymmetry of the Developing DiencephalonMarnie Halpern; Fiscal Year: 2003..Together, the proposed experiments will provide a greater understanding of the genetic mechanisms that underlie left-right specialization of the vertebrate forebrain. ..