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Genomes and Genes | A FireSummaryAffiliation: Carnegie Institution Country: USA Publications
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Publications
RNA-triggered gene silencingA Fire
Carnegie Institution of Washington, 115 West University Parkway, Baltimore, MD 21210, USA
Trends Genet 15:358-63. 1999..In addition to providing a surprisingly effective set of tools to interfere selectively with gene function, these observations are spurring new inquiries to understand RNA-triggered genetic-control mechanisms and their biological roles...- Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegansA Fire
Carnegie Institution of Washington, Department of Embryology, Baltimore, Maryland 21210, USA
Nature 391:806-11. 1998.... 
RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegansM K Montgomery
Carnegie Institution of Washington, Department of Embryology, 115 West University Parkway, Baltimore, MD 21210, USA
Proc Natl Acad Sci U S A 95:15502-7. 1998..elegans responsible for targeting and destroying aberrant messages. We suggest a model of how dsRNA might function in a catalytic mechanism to target homologous mRNAs for degradation...- Analysis of a Caenorhabditis elegans Twist homolog identifies conserved and divergent aspects of mesodermal patterningB D Harfe
Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210 USA
Genes Dev 12:2623-35. 1998..These results suggest the possibility that a conserved pathway may be used for diverse functions in mesodermal specification... - The Caenorhabditis elegans MYOD homologue HLH-1 is essential for proper muscle function and complete morphogenesisL Chen
Carnegie Institute of Washington, Department of Embryology, Baltimore, MD 21210
Development 120:1631-41. 1994..Mosaic studies using the point mutation and an extrachromosomal transgene indicate that the requirement for hlh-1 is fully zygotic, with no maternal hlh-1 requirement for either muscle development or viability... - The RING finger/B-box factor TAM-1 and a retinoblastoma-like protein LIN-35 modulate context-dependent gene silencing in Caenorhabditis elegansJ Hsieh
Carnegie Institution of Washington, Department of Embryology, Baltimore, Maryland 21210, USA
Genes Dev 13:2958-70. 1999..Molecular analysis reveals that tam-1 encodes a broadly expressed nuclear protein with RING finger and B-box motifs... - Identification and molecular-genetic characterization of a LAMP/CD68-like protein from Caenorhabditis elegansM Kostich
Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218, USA
J Cell Sci 113:2595-606. 2000..elegans mutant revealed that LMP-1 is not required for viability under laboratory conditions, but the absence of LMP-1 leads to an alteration in intestinal granule populations, with apparent loss of one type of granule... - Soma-germline asymmetry in the distributions of embryonic RNAs in Caenorhabditis elegansG Seydoux
Carnegie Institution of Washington, Baltimore, MD 21210, USA
Development 120:2823-34. 1994..These observations suggest that mechanisms which distinguish between soma and germline cause asymmetries in mRNA stability and transcription within the first few cleavages of C. elegans embryogenesis... - Distinct requirements for somatic and germline expression of a generally expressed Caernorhabditis elegans geneW G Kelly
Carnegie Institution of Washington, Department of Embryology, Baltimore, Maryland 21210, USA
Genetics 146:227-38. 1997..The resulting transgenes show robust expression in both germline and soma. Our results suggest the possibility of concerted mechanisms for silencing unwanted germiline expression of repetitive sequences... - Overlapping roles of two Hox genes and the exd ortholog ceh-20 in diversification of the C. elegans postembryonic mesodermJ Liu
Carnegie Institution of Washington, Department of Embryology, Baltimore, MD 21210, USA
Development 127:5179-90. 2000..We present evidence from mutant phenotypes that twist is not the only target for Hox genes in the M lineage: in particular we show that lin-39 mab-5 double mutants exhibit a more severe M lineage defect than the hlh-8 null mutant... - Sequence requirements for myosin gene expression and regulation in Caenorhabditis elegansP G Okkema
Carnegie Institution of Washington, Department of Embryology, Baltimore, Maryland 21210
Genetics 135:385-404. 1993..elegans genomic DNA for fragments capable of enhancing the myo-2 promoter. The properties of enhancers recovered from this screen suggest that the promoter is limited to muscle cells in its ability to respond to enhancers... - Essential roles for Caenorhabditis elegans lamin gene in nuclear organization, cell cycle progression, and spatial organization of nuclear pore complexesJ Liu
Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
Mol Biol Cell 11:3937-47. 2000..Our observations show that lmn-1 is an essential gene in C. elegans, and that the nuclear lamins are involved in chromatin organization, cell cycle progression, chromosome segregation, and correct spacing of NPCs... - Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegansL Timmons
Department of Embryology, Carnegie Institution of Washington, 115 West University Parkway, Baltimore, MD 21210, USA
Gene 263:103-12. 2001.... - Muscle and nerve-specific regulation of a novel NK-2 class homeodomain factor in Caenorhabditis elegansB D Harfe
Carnegie Institution of Washington, Department of Embryology, Baltimore, MD 21210, USA
Development 125:421-9. 1998..briggsae contains a close homologue of C. elegans ceh-24 including a highly conserved and functionally equivalent set of cis-acting control signals... - Repression of gene expression in the embryonic germ lineage of C. elegansG Seydoux
Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
Nature 382:713-6. 1996..Taken together, these results suggest that germ-cell fate depends on an inhibitory mechanism that blocks new gene expression in the early embryonic germ lineage... - Distinct roles for RDE-1 and RDE-4 during RNA interference in Caenorhabditis elegansS Parrish
Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
RNA 7:1397-402. 2001..These results support a model in which RDE-4 is involved before or during production of siRNAs, whereas RDE-1 acts after the siRNAs have been formed... - Recognition and silencing of repeated DNAJ Hsieh
Carnegie Institution of Washington, Department of Embryology, Baltimore, Maryland 21210, USA
Annu Rev Genet 34:187-204. 2000..This review focuses (a) on the nature of these recognition mechanisms, and (b) on types of chromatin modification and gene silencing that are used to control repeated DNA... - The Caenorhabditis elegans NK-2 class homeoprotein CEH-22 is involved in combinatorial activation of gene expression in pharyngeal muscleP G Okkema
Carnegie Institution of Washington, Department of Embryology, Baltimore, MD 21210
Development 120:2175-86. 1994..Expression continues throughout embryonic and larval development. This expression pattern suggests CEH-22 plays a key role in pharyngeal muscle-specific activity of the myo-2 enhancer...