A Fire

Summary

Affiliation: Carnegie Institution
Country: USA

Publications

  1. ncbi RNA-triggered gene silencing
    A Fire
    Carnegie Institution of Washington, 115 West University Parkway, Baltimore, MD 21210, USA
    Trends Genet 15:358-63. 1999
  2. ncbi Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    A Fire
    Carnegie Institution of Washington, Department of Embryology, Baltimore, Maryland 21210, USA
    Nature 391:806-11. 1998
  3. pmc RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans
    M K Montgomery
    Carnegie Institution of Washington, Department of Embryology, 115 West University Parkway, Baltimore, MD 21210, USA
    Proc Natl Acad Sci U S A 95:15502-7. 1998
  4. pmc Analysis of a Caenorhabditis elegans Twist homolog identifies conserved and divergent aspects of mesodermal patterning
    B D Harfe
    Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210 USA
    Genes Dev 12:2623-35. 1998
  5. ncbi The Caenorhabditis elegans MYOD homologue HLH-1 is essential for proper muscle function and complete morphogenesis
    L Chen
    Carnegie Institute of Washington, Department of Embryology, Baltimore, MD 21210
    Development 120:1631-41. 1994
  6. pmc The RING finger/B-box factor TAM-1 and a retinoblastoma-like protein LIN-35 modulate context-dependent gene silencing in Caenorhabditis elegans
    J Hsieh
    Carnegie Institution of Washington, Department of Embryology, Baltimore, Maryland 21210, USA
    Genes Dev 13:2958-70. 1999
  7. ncbi Identification and molecular-genetic characterization of a LAMP/CD68-like protein from Caenorhabditis elegans
    M Kostich
    Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Cell Sci 113:2595-606. 2000
  8. ncbi Soma-germline asymmetry in the distributions of embryonic RNAs in Caenorhabditis elegans
    G Seydoux
    Carnegie Institution of Washington, Baltimore, MD 21210, USA
    Development 120:2823-34. 1994
  9. pmc Distinct requirements for somatic and germline expression of a generally expressed Caernorhabditis elegans gene
    W G Kelly
    Carnegie Institution of Washington, Department of Embryology, Baltimore, Maryland 21210, USA
    Genetics 146:227-38. 1997
  10. ncbi Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans
    L Timmons
    Department of Embryology, Carnegie Institution of Washington, 115 West University Parkway, Baltimore, MD 21210, USA
    Gene 263:103-12. 2001

Collaborators

Detail Information

Publications18

  1. ncbi RNA-triggered gene silencing
    A Fire
    Carnegie Institution of Washington, 115 West University Parkway, Baltimore, MD 21210, USA
    Trends Genet 15:358-63. 1999
    ..In addition to providing a surprisingly effective set of tools to interfere selectively with gene function, these observations are spurring new inquiries to understand RNA-triggered genetic-control mechanisms and their biological roles...
  2. ncbi Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    A Fire
    Carnegie Institution of Washington, Department of Embryology, Baltimore, Maryland 21210, USA
    Nature 391:806-11. 1998
    ....
  3. pmc RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans
    M K Montgomery
    Carnegie Institution of Washington, Department of Embryology, 115 West University Parkway, Baltimore, MD 21210, USA
    Proc Natl Acad Sci U S A 95:15502-7. 1998
    ..elegans responsible for targeting and destroying aberrant messages. We suggest a model of how dsRNA might function in a catalytic mechanism to target homologous mRNAs for degradation...
  4. pmc Analysis of a Caenorhabditis elegans Twist homolog identifies conserved and divergent aspects of mesodermal patterning
    B D Harfe
    Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210 USA
    Genes Dev 12:2623-35. 1998
    ..These results suggest the possibility that a conserved pathway may be used for diverse functions in mesodermal specification...
  5. ncbi The Caenorhabditis elegans MYOD homologue HLH-1 is essential for proper muscle function and complete morphogenesis
    L Chen
    Carnegie Institute of Washington, Department of Embryology, Baltimore, MD 21210
    Development 120:1631-41. 1994
    ..Mosaic studies using the point mutation and an extrachromosomal transgene indicate that the requirement for hlh-1 is fully zygotic, with no maternal hlh-1 requirement for either muscle development or viability...
  6. pmc The RING finger/B-box factor TAM-1 and a retinoblastoma-like protein LIN-35 modulate context-dependent gene silencing in Caenorhabditis elegans
    J Hsieh
    Carnegie Institution of Washington, Department of Embryology, Baltimore, Maryland 21210, USA
    Genes Dev 13:2958-70. 1999
    ..Molecular analysis reveals that tam-1 encodes a broadly expressed nuclear protein with RING finger and B-box motifs...
  7. ncbi Identification and molecular-genetic characterization of a LAMP/CD68-like protein from Caenorhabditis elegans
    M Kostich
    Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Cell Sci 113:2595-606. 2000
    ..elegans mutant revealed that LMP-1 is not required for viability under laboratory conditions, but the absence of LMP-1 leads to an alteration in intestinal granule populations, with apparent loss of one type of granule...
  8. ncbi Soma-germline asymmetry in the distributions of embryonic RNAs in Caenorhabditis elegans
    G Seydoux
    Carnegie Institution of Washington, Baltimore, MD 21210, USA
    Development 120:2823-34. 1994
    ..These observations suggest that mechanisms which distinguish between soma and germline cause asymmetries in mRNA stability and transcription within the first few cleavages of C. elegans embryogenesis...
  9. pmc Distinct requirements for somatic and germline expression of a generally expressed Caernorhabditis elegans gene
    W G Kelly
    Carnegie Institution of Washington, Department of Embryology, Baltimore, Maryland 21210, USA
    Genetics 146:227-38. 1997
    ..The resulting transgenes show robust expression in both germline and soma. Our results suggest the possibility of concerted mechanisms for silencing unwanted germiline expression of repetitive sequences...
  10. ncbi Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans
    L Timmons
    Department of Embryology, Carnegie Institution of Washington, 115 West University Parkway, Baltimore, MD 21210, USA
    Gene 263:103-12. 2001
    ....
  11. ncbi Overlapping roles of two Hox genes and the exd ortholog ceh-20 in diversification of the C. elegans postembryonic mesoderm
    J Liu
    Carnegie Institution of Washington, Department of Embryology, Baltimore, MD 21210, USA
    Development 127:5179-90. 2000
    ..We present evidence from mutant phenotypes that twist is not the only target for Hox genes in the M lineage: in particular we show that lin-39 mab-5 double mutants exhibit a more severe M lineage defect than the hlh-8 null mutant...
  12. pmc Sequence requirements for myosin gene expression and regulation in Caenorhabditis elegans
    P G Okkema
    Carnegie Institution of Washington, Department of Embryology, Baltimore, Maryland 21210
    Genetics 135:385-404. 1993
    ..elegans genomic DNA for fragments capable of enhancing the myo-2 promoter. The properties of enhancers recovered from this screen suggest that the promoter is limited to muscle cells in its ability to respond to enhancers...
  13. pmc Essential roles for Caenorhabditis elegans lamin gene in nuclear organization, cell cycle progression, and spatial organization of nuclear pore complexes
    J Liu
    Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
    Mol Biol Cell 11:3937-47. 2000
    ..Our observations show that lmn-1 is an essential gene in C. elegans, and that the nuclear lamins are involved in chromatin organization, cell cycle progression, chromosome segregation, and correct spacing of NPCs...
  14. ncbi Muscle and nerve-specific regulation of a novel NK-2 class homeodomain factor in Caenorhabditis elegans
    B D Harfe
    Carnegie Institution of Washington, Department of Embryology, Baltimore, MD 21210, USA
    Development 125:421-9. 1998
    ..briggsae contains a close homologue of C. elegans ceh-24 including a highly conserved and functionally equivalent set of cis-acting control signals...
  15. ncbi Repression of gene expression in the embryonic germ lineage of C. elegans
    G Seydoux
    Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
    Nature 382:713-6. 1996
    ..Taken together, these results suggest that germ-cell fate depends on an inhibitory mechanism that blocks new gene expression in the early embryonic germ lineage...
  16. pmc Distinct roles for RDE-1 and RDE-4 during RNA interference in Caenorhabditis elegans
    S Parrish
    Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
    RNA 7:1397-402. 2001
    ..These results support a model in which RDE-4 is involved before or during production of siRNAs, whereas RDE-1 acts after the siRNAs have been formed...
  17. ncbi Recognition and silencing of repeated DNA
    J Hsieh
    Carnegie Institution of Washington, Department of Embryology, Baltimore, Maryland 21210, USA
    Annu Rev Genet 34:187-204. 2000
    ..This review focuses (a) on the nature of these recognition mechanisms, and (b) on types of chromatin modification and gene silencing that are used to control repeated DNA...
  18. ncbi The Caenorhabditis elegans NK-2 class homeoprotein CEH-22 is involved in combinatorial activation of gene expression in pharyngeal muscle
    P G Okkema
    Carnegie Institution of Washington, Department of Embryology, Baltimore, MD 21210
    Development 120:2175-86. 1994
    ..Expression continues throughout embryonic and larval development. This expression pattern suggests CEH-22 plays a key role in pharyngeal muscle-specific activity of the myo-2 enhancer...