CHARLES ETTENSOHN

Summary

Affiliation: Carnegie Mellon University
Country: USA

Publications

  1. ncbi request reprint The emergence of pattern in embryogenesis: regulation of beta-catenin localization during early sea urchin development
    Charles A Ettensohn
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Sci STKE 2006:pe48. 2006
  2. doi request reprint Encoding anatomy: developmental gene regulatory networks and morphogenesis
    Charles A Ettensohn
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    Genesis 51:383-409. 2013
  3. doi request reprint Lessons from a gene regulatory network: echinoderm skeletogenesis provides insights into evolution, plasticity and morphogenesis
    Charles A Ettensohn
    Department of Biological Sciences, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA
    Development 136:11-21. 2009
  4. ncbi request reprint Gene regulatory networks and developmental plasticity in the early sea urchin embryo: alternative deployment of the skeletogenic gene regulatory network
    Charles A Ettensohn
    Department of Biological Sciences, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA
    Development 134:3077-87. 2007
  5. ncbi request reprint Cell movements in the sea urchin embryo
    C A Ettensohn
    Department of Biological Sciences, Science and Technology Center for Light Microscope Imaging and Biotechnology, Carnegie Mellon University 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA
    Curr Opin Genet Dev 9:461-5. 1999
  6. ncbi request reprint Alx1, a member of the Cart1/Alx3/Alx4 subfamily of Paired-class homeodomain proteins, is an essential component of the gene network controlling skeletogenic fate specification in the sea urchin embryo
    Charles A Ettensohn
    Department of Biological Sciences, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA
    Development 130:2917-28. 2003
  7. ncbi request reprint The role of micromere signaling in Notch activation and mesoderm specification during sea urchin embryogenesis
    H C Sweet
    Department of Biological Sciences and Science and Technology Center for Light Microscope Imaging and Biotechnology, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Development 126:5255-65. 1999
  8. ncbi request reprint A large-scale analysis of mRNAs expressed by primary mesenchyme cells of the sea urchin embryo
    X Zhu
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Development 128:2615-27. 2001
  9. ncbi request reprint Identification and developmental expression of new biomineralization proteins in the sea urchin Strongylocentrotus purpuratus
    Michele R Illies
    Department of Biological Sciences, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA
    Dev Genes Evol 212:419-31. 2002
  10. pmc Analysis of dishevelled localization and function in the early sea urchin embryo
    Jennifer D Leonard
    Department of Biological Sciences, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA
    Dev Biol 306:50-65. 2007

Research Grants

  1. REGULATION OF BETA-CATENIN NUCLEARIZATION
    CHARLES ETTENSOHN; Fiscal Year: 2003
  2. REGULATION OF BETA-CATENIN NUCLEARIZATION
    CHARLES ETTENSOHN; Fiscal Year: 2006

Collaborators

Detail Information

Publications18

  1. ncbi request reprint The emergence of pattern in embryogenesis: regulation of beta-catenin localization during early sea urchin development
    Charles A Ettensohn
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Sci STKE 2006:pe48. 2006
    ..Further studies will be required to determine the extent to which mechanisms that control beta-catenin nuclearization in early embryogenesis have been conserved during animal evolution...
  2. doi request reprint Encoding anatomy: developmental gene regulatory networks and morphogenesis
    Charles A Ettensohn
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    Genesis 51:383-409. 2013
    ....
  3. doi request reprint Lessons from a gene regulatory network: echinoderm skeletogenesis provides insights into evolution, plasticity and morphogenesis
    Charles A Ettensohn
    Department of Biological Sciences, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA
    Development 136:11-21. 2009
    ..These new studies highlight powerful new ways in which GRNs can be used to dissect development and the evolution of morphogenesis...
  4. ncbi request reprint Gene regulatory networks and developmental plasticity in the early sea urchin embryo: alternative deployment of the skeletogenic gene regulatory network
    Charles A Ettensohn
    Department of Biological Sciences, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA
    Development 134:3077-87. 2007
    ..Our studies reveal that, although most features of the micromere-PMC GRN are recapitulated in transfating NSM cells, different inputs activate this GRN during normal and regulative development...
  5. ncbi request reprint Cell movements in the sea urchin embryo
    C A Ettensohn
    Department of Biological Sciences, Science and Technology Center for Light Microscope Imaging and Biotechnology, Carnegie Mellon University 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA
    Curr Opin Genet Dev 9:461-5. 1999
    ..In addition, light-microscopic studies continue to provide a unique picture of dynamic cell behavior in vivo...
  6. ncbi request reprint Alx1, a member of the Cart1/Alx3/Alx4 subfamily of Paired-class homeodomain proteins, is an essential component of the gene network controlling skeletogenic fate specification in the sea urchin embryo
    Charles A Ettensohn
    Department of Biological Sciences, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA
    Development 130:2917-28. 2003
    ..Our findings suggest that the ancestral deuterostome had a population of biomineral-forming mesenchyme cells that expressed an Alx1-like protein...
  7. ncbi request reprint The role of micromere signaling in Notch activation and mesoderm specification during sea urchin embryogenesis
    H C Sweet
    Department of Biological Sciences and Science and Technology Center for Light Microscope Imaging and Biotechnology, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Development 126:5255-65. 1999
    ..We propose that the micromeres induce adjacent cells to form SMCs, possibly by presenting a ligand for the Notch receptor...
  8. ncbi request reprint A large-scale analysis of mRNAs expressed by primary mesenchyme cells of the sea urchin embryo
    X Zhu
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Development 128:2615-27. 2001
    ..Our analysis has also led to the cloning of several key components of signaling pathways that play crucial roles in early sea urchin development...
  9. ncbi request reprint Identification and developmental expression of new biomineralization proteins in the sea urchin Strongylocentrotus purpuratus
    Michele R Illies
    Department of Biological Sciences, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA
    Dev Genes Evol 212:419-31. 2002
    ..This work identifies new proteins that may regulate the process of biomineralization in this tractable model system...
  10. pmc Analysis of dishevelled localization and function in the early sea urchin embryo
    Jennifer D Leonard
    Department of Biological Sciences, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA
    Dev Biol 306:50-65. 2007
    ....
  11. ncbi request reprint Cloning and developmental expression of a novel, secreted frizzled-related protein from the sea urchin, Strongylocentrotus purpuratus
    Michele R Illies
    Department of Biological Sciences, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA
    Mech Dev 113:61-4. 2002
    ....
  12. pmc The genome of the sea urchin Strongylocentrotus purpuratus
    Erica Sodergren
    Science 314:941-52. 2006
    ..This echinoderm genome provides an evolutionary outgroup for the chordates and yields insights into the evolution of deuterostomes...
  13. ncbi request reprint LvDelta is a mesoderm-inducing signal in the sea urchin embryo and can endow blastomeres with organizer-like properties
    Hyla C Sweet
    Department of Biological Sciences, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA
    Development 129:1945-55. 2002
    ..Finally, we find that expression of LvDelta is sufficient to endow blastomeres with the ability to function as a vegetal organizing center and to coordinate the development of a complete pluteus larva...
  14. ncbi request reprint Differential stability of beta-catenin along the animal-vegetal axis of the sea urchin embryo mediated by dishevelled
    Heather E Weitzel
    Department of Biological Sciences, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA
    Development 131:2947-56. 2004
    ..An extensive mutational analysis of Dsh identifies several regions of the protein that are required for vegetal cortical targeting, including a phospholipid-binding motif near the N-terminus...
  15. ncbi request reprint A functional genomic and proteomic perspective of sea urchin calcium signaling and egg activation
    Michelle M Roux
    Department MCD Biology and Marine Science Institute, University of California, Santa Barbara, CA 93106 9610, USA
    Dev Biol 300:416-33. 2006
    ..Key outstanding questions regarding the activation of the developmental program are framed in the context of what has been learned from the genome and how this knowledge can be applied to functional studies...
  16. ncbi request reprint P16 is an essential regulator of skeletogenesis in the sea urchin embryo
    Melani S Cheers
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Dev Biol 283:384-96. 2005
    ..Finally, we place P16 downstream of Alx1 in the PMC gene network, thereby linking the network to a specific "effector" protein involved in biomineralization...
  17. ncbi request reprint The invertebrate deuterostomes: an introduction to their phylogeny, reproduction, development, and genomics
    Charles A Ettensohn
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    Methods Cell Biol 74:1-13. 2004
  18. ncbi request reprint Rapid microinjection of fertilized eggs
    Melani S Cheers
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    Methods Cell Biol 74:287-310. 2004

Research Grants4

  1. REGULATION OF BETA-CATENIN NUCLEARIZATION
    CHARLES ETTENSOHN; Fiscal Year: 2003
    ..In addition, using dominant negative constructs and morpholinos, we will examine the developmental function of two regulators of GSK3 activity, disheveled and Akt/PKB. ..
  2. REGULATION OF BETA-CATENIN NUCLEARIZATION
    CHARLES ETTENSOHN; Fiscal Year: 2006
    ..In addition, using dominant negative constructs and morpholinos, we will examine the developmental function of two regulators of GSK3 activity, disheveled and Akt/PKB. ..