Kris Noel Dahl

Summary

Affiliation: Carnegie Mellon University
Country: USA

Publications

  1. pmc Distinct structural and mechanical properties of the nuclear lamina in Hutchinson-Gilford progeria syndrome
    Kris Noel Dahl
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 103:10271-6. 2006
  2. pmc Nuclear shape, mechanics, and mechanotransduction
    Kris Noel Dahl
    Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, PA 15213, USA
    Circ Res 102:1307-18. 2008
  3. pmc Mechanobiology and the microcirculation: cellular, nuclear and fluid mechanics
    Kris Noel Dahl
    Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Microcirculation 17:179-91. 2010
  4. ncbi request reprint Hutchinson-Gilford progeria syndrome alters nuclear shape and reduces cell motility in three dimensional model substrates
    Elizabeth A Booth-Gauthier
    Department of Chemical Engineering, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, PA 15213, USA
    Integr Biol (Camb) 5:569-77. 2013
  5. doi request reprint In the middle of it all: mutual mechanical regulation between the nucleus and the cytoskeleton
    Kris Noel Dahl
    Carnegie Mellon University, Department of Biomedical Engineering, 5000 Forbes Avenue, Pittsburgh, PA 15213, United States
    J Biomech 43:2-8. 2010
  6. pmc Calcium causes a conformational change in lamin A tail domain that promotes farnesyl-mediated membrane association
    Agnieszka Kalinowski
    Biomedical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA
    Biophys J 104:2246-53. 2013
  7. doi request reprint Not all protein-mediated single-wall carbon nanotube dispersions are equally bioactive
    Brian D Holt
    Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA
    Nanoscale 4:7425-34. 2012
  8. pmc Beyond lamins other structural components of the nucleoskeleton
    Zhixia Zhong
    Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    Methods Cell Biol 98:97-119. 2010
  9. doi request reprint Carbon nanotubes reorganize actin structures in cells and ex vivo
    Brian D Holt
    Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, Pennsylvania 15213 3890, USA
    ACS Nano 4:4872-8. 2010
  10. pmc Mechanical characterization of adult stem cells from bone marrow and perivascular niches
    Alexandre J S Ribeiro
    Department of Biomedical Engineering, Carnegie Mellon University, Pittsburg, PA 15213, United States
    J Biomech 45:1280-7. 2012

Collaborators

Detail Information

Publications21

  1. pmc Distinct structural and mechanical properties of the nuclear lamina in Hutchinson-Gilford progeria syndrome
    Kris Noel Dahl
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 103:10271-6. 2006
    ....
  2. pmc Nuclear shape, mechanics, and mechanotransduction
    Kris Noel Dahl
    Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, PA 15213, USA
    Circ Res 102:1307-18. 2008
    ..Together, these studies suggest that the nucleus itself may play an important role in the response of the cell to force...
  3. pmc Mechanobiology and the microcirculation: cellular, nuclear and fluid mechanics
    Kris Noel Dahl
    Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Microcirculation 17:179-91. 2010
    ..This integrated approach to study--including medicine, molecular and cell biology, biophysics and engineering--provides a unique understanding of multi-scale interactions in the microcirculation...
  4. ncbi request reprint Hutchinson-Gilford progeria syndrome alters nuclear shape and reduces cell motility in three dimensional model substrates
    Elizabeth A Booth-Gauthier
    Department of Chemical Engineering, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, PA 15213, USA
    Integr Biol (Camb) 5:569-77. 2013
    ..We suggest that ECM changes during aging could be compounded by the increasing stiffness of the nucleus and thus changes in cell migration through 3D tissues...
  5. doi request reprint In the middle of it all: mutual mechanical regulation between the nucleus and the cytoskeleton
    Kris Noel Dahl
    Carnegie Mellon University, Department of Biomedical Engineering, 5000 Forbes Avenue, Pittsburgh, PA 15213, United States
    J Biomech 43:2-8. 2010
    ..Thus the nucleus plays a role in developing mechanical territories and niches, affecting rates of wound healing and allowing cells to transmigrate through tissues for developmental, repair or pathological means...
  6. pmc Calcium causes a conformational change in lamin A tail domain that promotes farnesyl-mediated membrane association
    Agnieszka Kalinowski
    Biomedical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA
    Biophys J 104:2246-53. 2013
    ..We suggest that a conformational change induced in Δ50 lamin A with divalent cations plays a regulatory role in the posttranslational processing of lamin A, which may be important in disease pathogenesis...
  7. doi request reprint Not all protein-mediated single-wall carbon nanotube dispersions are equally bioactive
    Brian D Holt
    Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA
    Nanoscale 4:7425-34. 2012
    ..Hence, the quality of SWCNT-protein dispersions in water does not necessarily correlate with bulk cellular uptake, and quantification at the level of individual cells is required to determine delivery efficacy...
  8. pmc Beyond lamins other structural components of the nucleoskeleton
    Zhixia Zhong
    Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    Methods Cell Biol 98:97-119. 2010
    ....
  9. doi request reprint Carbon nanotubes reorganize actin structures in cells and ex vivo
    Brian D Holt
    Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, Pennsylvania 15213 3890, USA
    ACS Nano 4:4872-8. 2010
    ..While purified, isolated SWCNTs do not appear acutely toxic, this subcellular reorganization may cause chronic changes to cellular functions...
  10. pmc Mechanical characterization of adult stem cells from bone marrow and perivascular niches
    Alexandre J S Ribeiro
    Department of Biomedical Engineering, Carnegie Mellon University, Pittsburg, PA 15213, United States
    J Biomech 45:1280-7. 2012
    ..Since different types of adult stem cells can be used for similar applications, we suggest considering mechanical properties of stem cells to match optimal mechanical characteristics of therapies...
  11. pmc Computational image analysis of nuclear morphology associated with various nuclear-specific aging disorders
    Siwon Choi
    Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA
    Nucleus 2:570-9. 2011
    ..Both methods yielded similar results, but PCA proves to be a powerful pre-analysis methodology for unknown systems...
  12. pmc Single wall carbon nanotubes enter cells by endocytosis and not membrane penetration
    Peter N Yaron
    Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA
    J Nanobiotechnology 9:45. 2011
    ..We investigated cellular uptake of Pluronic copolymer-stabilized, purified ~145 nm long single wall carbon nanotubes (SWCNTs) through a series of complementary cellular, cell-mimetic, and in vitro model membrane experiments...
  13. doi request reprint Nuclear mechanotransduction: response of the lamina to extracellular stress with implications in aging
    Julia T Philip
    Department of Chemical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA
    J Biomech 41:3164-70. 2008
    ..These results provide insight into the development of cardiovascular disease both in patients with HGPS and in normal aging...
  14. ncbi request reprint Quantification of uptake and localization of bovine serum albumin-stabilized single-wall carbon nanotubes in different human cell types
    Brian D Holt
    Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213 3890, USA
    Small 7:2348-55. 2011
    ..BSA is widely available and inexpensive, which make these concentrated, highly-dispersed, noncovalently modified SWCNT-BSAs suitable for the development of SWCNT-based biotechnologies. ..
  15. doi request reprint Cells take up and recover from protein-stabilized single-wall carbon nanotubes with two distinct rates
    Brian D Holt
    Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, Pennsylvania 15213 3890, United States
    ACS Nano 6:3481-90. 2012
    ..Cells were able to recover from SWCNTs-BSA over ∼30 h, regardless of dosage level or exposure time. We suggest that these differential rates of uptake and recovery, quantified in our work, may enable cell-based SWCNT delivery systems...
  16. pmc Modeling nuclear blebs in a nucleoskeleton of independent filament networks
    Nicholas S Wren
    Department of Chemical Engineering, Carnegie Mellon University
    Cell Mol Bioeng 5:73-81. 2012
    ..Also, the kinetics of retraction is influenced by the composition of the bleb. These results match with our experiments and others...
  17. pmc Power-law rheology of isolated nuclei with deformation mapping of nuclear substructures
    Kris Noel Dahl
    Johns Hopkins University, Baltimore, MD 21202, USA
    Biophys J 89:2855-64. 2005
    ..Such results indicate an essentially infinite spectrum of timescales for structural reorganization, with implications for regulating genome expression kinetics...
  18. ncbi request reprint The nuclear envelope lamina network has elasticity and a compressibility limit suggestive of a molecular shock absorber
    Kris Noel Dahl
    Department of Chemical and Biomolecular Engineering, 220 South 33rd Street, University of Pennsylvania, Philadelphia, PA 19104 6393, USA
    J Cell Sci 117:4779-86. 2004
    ....
  19. ncbi request reprint Nuclear mechanics and methods
    Jan Lammerding
    Department of Medicine, Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Methods Cell Biol 83:269-94. 2007
    ..Various methods to measure nuclear mechanics, isolated or in situ, are outlined here in some detail...
  20. pmc Physical plasticity of the nucleus in stem cell differentiation
    J David Pajerowski
    Molecular and Cell Biophysics Laboratory, 129 Towne Building, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 104:15619-24. 2007
    ..The rheological character of the nucleus is thus set largely by nucleoplasm/chromatin, whereas the extent of deformation is modulated by the lamina...
  21. ncbi request reprint Protein 4.2 is critical to CD47-membrane skeleton attachment in human red cells
    Kris Noel Dahl
    Department of Chemical and Biomolecular Engineering and School of Engineering and Applied Science, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Blood 103:1131-6. 2004
    ..2 strongly influences CD47 levels as well as the extent of membrane skeleton attachment in the RBC, whereas protein 4.2 affects membrane skeletal attachment of RhAG, Rh, and band 3 to a lesser extent...