Alison L Barth

Summary

Affiliation: Carnegie Mellon University
Country: USA

Publications

  1. pmc Visualizing circuits and systems using transgenic reporters of neural activity
    Alison L Barth
    Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Curr Opin Neurobiol 17:567-71. 2007
  2. pmc The brain-specific Beta4 subunit downregulates BK channel cell surface expression
    Sonal Shruti
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e33429. 2012
  3. pmc Synaptic lability after experience-dependent plasticity is not mediated by calcium-permeable AMPARs
    Jing A Wen
    Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh PA, USA
    Front Mol Neurosci 5:15. 2012
  4. doi request reprint The many layers of specification and plasticity in the neocortex
    Alison L Barth
    Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA 15232, USA Electronic address
    Neuron 79:829-31. 2013
  5. ncbi request reprint Differential plasticity in neocortical networks
    Alison L Barth
    Department of Biological Sciences, Center for the Neural Basis of Cognition, Carnegie Mellon University, 4400 Fifth Avenue, 15213, Pittsburgh, PA, USA
    Physiol Behav 77:545-50. 2002
  6. ncbi request reprint Alteration of neuronal firing properties after in vivo experience in a FosGFP transgenic mouse
    Alison L Barth
    Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 24:6466-75. 2004
  7. pmc Initiation, labile, and stabilization phases of experience-dependent plasticity at neocortical synapses
    Jing A Wen
    Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 33:8483-93. 2013
  8. pmc Cortical up state activity is enhanced after seizures: a quantitative analysis
    Richard C Gerkin
    Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    J Clin Neurophysiol 27:425-32. 2010
  9. pmc Input-specific critical periods for experience-dependent plasticity in layer 2/3 pyramidal neurons
    Jing A Wen
    Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 31:4456-65. 2011
  10. pmc Reliable and precise neuronal firing during sensory plasticity in superficial layers of primary somatosensory cortex
    Brett L Benedetti
    Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 29:11817-27. 2009

Collaborators

Detail Information

Publications22

  1. pmc Visualizing circuits and systems using transgenic reporters of neural activity
    Alison L Barth
    Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Curr Opin Neurobiol 17:567-71. 2007
    ....
  2. pmc The brain-specific Beta4 subunit downregulates BK channel cell surface expression
    Sonal Shruti
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e33429. 2012
    ..5-fold increase in whole-cell BK channel current, indicating that β4 also regulates current magnitude in vivo. Thus, we propose that a major function of the brain-specific β4 subunit in CA3 neurons is control of surface trafficking...
  3. pmc Synaptic lability after experience-dependent plasticity is not mediated by calcium-permeable AMPARs
    Jing A Wen
    Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh PA, USA
    Front Mol Neurosci 5:15. 2012
    ..This article is part of a Special Issue entitled "Calcium permeable AMPARs in synaptic plasticity and disease."..
  4. doi request reprint The many layers of specification and plasticity in the neocortex
    Alison L Barth
    Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA 15232, USA Electronic address
    Neuron 79:829-31. 2013
    ....
  5. ncbi request reprint Differential plasticity in neocortical networks
    Alison L Barth
    Department of Biological Sciences, Center for the Neural Basis of Cognition, Carnegie Mellon University, 4400 Fifth Avenue, 15213, Pittsburgh, PA, USA
    Physiol Behav 77:545-50. 2002
    ..Experimental support for this hypothesis is presented, as well as some predictions about the function of different types of neocortical pathways and plasticity...
  6. ncbi request reprint Alteration of neuronal firing properties after in vivo experience in a FosGFP transgenic mouse
    Alison L Barth
    Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 24:6466-75. 2004
    ..In addition, because activated neurons can be functionally characterized, this tool may enable the development of better pharmaceuticals that directly affect the neurons involved in disease states...
  7. pmc Initiation, labile, and stabilization phases of experience-dependent plasticity at neocortical synapses
    Jing A Wen
    Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 33:8483-93. 2013
    ..Identification of these three phases will facilitate a molecular dissection of the pathways that regulate synaptic lability and stabilization, and suggest potential approaches to modulate learning...
  8. pmc Cortical up state activity is enhanced after seizures: a quantitative analysis
    Richard C Gerkin
    Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    J Clin Neurophysiol 27:425-32. 2010
    ....
  9. pmc Input-specific critical periods for experience-dependent plasticity in layer 2/3 pyramidal neurons
    Jing A Wen
    Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 31:4456-65. 2011
    ....
  10. pmc Reliable and precise neuronal firing during sensory plasticity in superficial layers of primary somatosensory cortex
    Brett L Benedetti
    Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 29:11817-27. 2009
    ....
  11. pmc An embedded subnetwork of highly active neurons in the neocortex
    Lina Yassin
    Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA
    Neuron 68:1043-50. 2010
    ..These findings indicate that highly active, interconnected neuronal ensembles are present in the neocortex and suggest these cells may play a role in the encoding of sensory information...
  12. doi request reprint Experimental evidence for sparse firing in the neocortex
    Alison L Barth
    Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Trends Neurosci 35:345-55. 2012
    ..Superficial layers of the cortex may employ specific cell and circuit mechanisms to increase sparseness...
  13. doi request reprint Ongoing in vivo experience triggers synaptic metaplasticity in the neocortex
    Roger L Clem
    Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Science 319:101-4. 2008
    ....
  14. doi request reprint Anticonvulsant effects of the BK-channel antagonist paxilline
    Jesse J Sheehan
    Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    Epilepsia 50:711-20. 2009
    ..In this study, we sought to examine whether administration of BK-channel antagonists possess anticonvulsant activity in vivo...
  15. pmc A seizure-induced gain-of-function in BK channels is associated with elevated firing activity in neocortical pyramidal neurons
    Sonal Shruti
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Neurobiol Dis 30:323-30. 2008
    ..Because BK channel antagonists can reduce elevated firing activity in neocortical neurons, BK channels might serve as a new target for anticonvulsant therapy...
  16. pmc Differential wiring of layer 2/3 neurons drives sparse and reliable firing during neocortical development
    Brett L Benedetti
    Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA, USA
    Cereb Cortex 23:2690-9. 2013
    ..Paired recordings show fosGFP+ neurons spike at lower stimulus thresholds than neighboring, fosGFP- neurons. These data indicate that differences in circuit construction can underlie response heterogeneity amongst neocortical neurons...
  17. pmc A high-throughput framework to detect synapses in electron microscopy images
    Saket Navlakha
    Machine Learning Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Bioinformatics 29:i9-17. 2013
    ..g. electrophysiology), prone to error and difficult to automate (e.g. standard electron microscopy) or too coarse (e.g. magnetic resonance imaging) to provide accurate and large-scale measurements...
  18. doi request reprint Phase-resetting curve determines how BK currents affect neuronal firing
    Cheng Ly
    Department of Mathematics, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Comput Neurosci 30:211-23. 2011
    ..These results provide a formal explanation for the apparently contradictory effects of BK channel antagonists on firing rates...
  19. doi request reprint The barista on the bus: cellular and synaptic mechanisms for visual recognition memory
    Alison L Barth
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Neuron 58:159-61. 2008
    ..In this issue of Neuron, Griffiths et al. now provide evidence that this form of memory requires AMPA receptor endocytosis and long-term depression of excitatory synapses in this brain area...
  20. pmc A comparative genomics approach to identifying the plasticity transcriptome
    Andreas R Pfenning
    Department of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    BMC Neurosci 8:20. 2007
    ..The gene targets of these two transcription factors are of considerable interest, since they may help develop hypotheses about how neural activity is coupled to changes in neural function...
  21. ncbi request reprint Ipsilateral whiskers suppress experience-dependent plasticity in the barrel cortex
    Stanislaw Glazewski
    Institute for Science and Technology in Medicine and School of Life Sciences, Keele University, Keele, Staffordshire ST5 5BG, United Kingdom
    J Neurosci 27:3910-20. 2007
    ..The increase in spared whisker responses was progressive with longer deprivation periods. These data show that ipsilateral whiskers can constrain receptive field size in the barrel cortex...
  22. ncbi request reprint A developmental switch in the signaling cascades for LTP induction
    Hiroki Yasuda
    Department of Psychiatry and Behavioral Sciences, Nancy Pritzker Laboratory, Stanford University School of Medicine, Stanford, California 94304, USA
    Nat Neurosci 6:15-6. 2003
    ....