ROBERT JAMES CARMAN

Summary

Country: USA

Publications

  1. pmc In vivo selection of rifamycin-resistant Clostridium difficile during rifaximin therapy
    Robert J Carman
    TechLab, Inc, Blacksburg, Virginia, USA
    Antimicrob Agents Chemother 56:6019-20. 2012
  2. pmc Glutamate dehydrogenase is highly conserved among Clostridium difficile ribotypes
    R J Carman
    TechLab, Inc, Blacksburg, Virginia, USA
    J Clin Microbiol 50:1425-6. 2012
  3. ncbi request reprint Ciprofloxacin at low levels disrupts colonization resistance of human fecal microflora growing in chemostats
    Robert J Carman
    TechLab, Inc, 2001 Kraft Drive, Blacksburg, VA 24060 6358, USA
    Regul Toxicol Pharmacol 40:319-26. 2004
  4. ncbi request reprint Antibiotics in the human food chain: establishing no effect levels of tetracycline, neomycin, and erythromycin using a chemostat model of the human colonic microflora
    Robert J Carman
    TechLab, Inc, 2001 Kraft Drive, Blacksburg, VA 24060 6358, USA
    Regul Toxicol Pharmacol 43:168-80. 2005
  5. pmc Clostridium perfringens toxin genotypes in the feces of healthy North Americans
    Robert J Carman
    TechLab, Inc, Blacksburg, VA 24060 6358, USA
    Anaerobe 14:102-8. 2008
  6. doi request reprint Diversity of moxifloxacin resistance during a nosocomial outbreak of a predominantly ribotype ARU 027 Clostridium difficile diarrhea
    Robert J Carman
    TechLab Inc, 2001 Kraft Drive, Blacksburg, VA 24060 6358, USA
    Anaerobe 15:244-8. 2009
  7. doi request reprint Clostridium difficile binary toxin (CDT) and diarrhea
    Robert J Carman
    TechLab Inc, Blacksburg, VA 24060 6358, USA
    Anaerobe 17:161-5. 2011

Research Grants

Detail Information

Publications7

  1. pmc In vivo selection of rifamycin-resistant Clostridium difficile during rifaximin therapy
    Robert J Carman
    TechLab, Inc, Blacksburg, Virginia, USA
    Antimicrob Agents Chemother 56:6019-20. 2012
    ..difficile diarrhea. Resistance was associated with single nucleotide substitutions within rpoB...
  2. pmc Glutamate dehydrogenase is highly conserved among Clostridium difficile ribotypes
    R J Carman
    TechLab, Inc, Blacksburg, Virginia, USA
    J Clin Microbiol 50:1425-6. 2012
    ..All ribotypes, including ARL 002, ARL 027, and ARL 106, were reactive in assays that detect C. difficile GDH...
  3. ncbi request reprint Ciprofloxacin at low levels disrupts colonization resistance of human fecal microflora growing in chemostats
    Robert J Carman
    TechLab, Inc, 2001 Kraft Drive, Blacksburg, VA 24060 6358, USA
    Regul Toxicol Pharmacol 40:319-26. 2004
    ..coli may contribute to the CR against salmonella. We further conclude that, even at fecal levels below those reached during therapy, CI may impact the human gut flora sufficiently to facilitate colonization by S. kedougou...
  4. ncbi request reprint Antibiotics in the human food chain: establishing no effect levels of tetracycline, neomycin, and erythromycin using a chemostat model of the human colonic microflora
    Robert J Carman
    TechLab, Inc, 2001 Kraft Drive, Blacksburg, VA 24060 6358, USA
    Regul Toxicol Pharmacol 43:168-80. 2005
    ..Based on our results, the no observed effect level (NOEL) of both tetracycline and erythromycin was 15 mg/60 kg person/d. The NOEL for neomycin was 1.5 mg/60 kg person/d...
  5. pmc Clostridium perfringens toxin genotypes in the feces of healthy North Americans
    Robert J Carman
    TechLab, Inc, Blacksburg, VA 24060 6358, USA
    Anaerobe 14:102-8. 2008
    ..Though some isolates carried toxin genes (e.g. cpe and cpb2) on plasmids, we saw no indication that healthy humans are the reservoir for the chromosomally-borne cpe recovered from cases of C. perfringens food poisoning...
  6. doi request reprint Diversity of moxifloxacin resistance during a nosocomial outbreak of a predominantly ribotype ARU 027 Clostridium difficile diarrhea
    Robert J Carman
    TechLab Inc, 2001 Kraft Drive, Blacksburg, VA 24060 6358, USA
    Anaerobe 15:244-8. 2009
    ..The G1396A (Glu(466)Delta Lys) mutation was not associated with increased resistance...
  7. doi request reprint Clostridium difficile binary toxin (CDT) and diarrhea
    Robert J Carman
    TechLab Inc, Blacksburg, VA 24060 6358, USA
    Anaerobe 17:161-5. 2011
    ..Possible implications of the detection of CDT in patients are discussed...

Research Grants3

  1. Mucin-degrading microflora for prophylactic antibiotics
    ROBERT CARMAN; Fiscal Year: 2007
    ..Our goal is to determine if the mucin-degrading flora restores or preserves normal mucin metabolism, enhances resistance to colonization by C. difficile, and reduces the incidence of C. difficile- induced antibiotic-associated diarrhea. ..
  2. C. difficile Toxin Membrane Test with Magnetic Particles
    ROBERT CARMAN; Fiscal Year: 2004
    ..perfringens enterotoxin, another cause of AAD. The technology developed in this project will be widely applicable for the development of new highly sensitive stool antigen tests. ..