Jean A Frazier

Summary

Affiliation: Cambridge Health Alliance
Country: USA

Publications

  1. pmc Cortical gray matter differences identified by structural magnetic resonance imaging in pediatric bipolar disorder
    Jean A Frazier
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Bipolar Disord 7:555-69. 2005
  2. ncbi Treatment of early-onset schizophrenia spectrum disorders (TEOSS): demographic and clinical characteristics
    Jean A Frazier
    Cambridge Health Alliance, Harvard Medical School, Cambridge, MA, USA
    J Am Acad Child Adolesc Psychiatry 46:979-88. 2007
  3. ncbi Magnetic resonance imaging studies in early-onset bipolar disorder: a critical review
    Jean A Frazier
    Department of Child and Adolescent Psychiatry, Cambridge Health Alliance, 1493 Cambridge Street, Cambridge, MA 02139, USA
    Harv Rev Psychiatry 13:125-40. 2005
  4. ncbi Structural brain magnetic resonance imaging of limbic and thalamic volumes in pediatric bipolar disorder
    Jean A Frazier
    Child and Adolescent Neuropsychiatric Research Program, Cambridge Health Alliance Mystic Center, 1493 Cambridge Street, Cambridge, MA 02139, USA
    Am J Psychiatry 162:1256-65. 2005
  5. pmc Diagnostic and sex effects on limbic volumes in early-onset bipolar disorder and schizophrenia
    Jean A Frazier
    Department of Psychiatry, Harvard Medical School, Massachusetts, USA
    Schizophr Bull 34:37-46. 2008
  6. ncbi White matter abnormalities in children with and at risk for bipolar disorder
    Jean A Frazier
    Department of Psychiatry, Harvard Medical School, Boston, USA
    Bipolar Disord 9:799-809. 2007
  7. ncbi Anatomic brain magnetic resonance imaging of the basal ganglia in pediatric bipolar disorder
    Mary S Ahn
    Cambridge Health Alliance Department of Psychiatry 1493 Cambridge St Cambridge, MA 02139, USA
    J Affect Disord 104:147-54. 2007
  8. pmc Cerebellum, language, and cognition in autism and specific language impairment
    Steven M Hodge
    Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA 02114, USA
    J Autism Dev Disord 40:300-16. 2010
  9. ncbi Is there a role for clozapine in the treatment of children and adolescents?
    Robert L Findling
    Department of Psychiatry, University Hospitals of Cleveland Case Western Reserve University, USA
    J Am Acad Child Adolesc Psychiatry 46:423-8. 2007
  10. doi Empirical evidence for psychopharmacologic treatment in early-onset psychosis and schizophrenia
    Ann E Maloney
    Department of Psychiatry, Child and Adolescent NeuroDevelopment Initiative CANDI, University of Massachusetts Memorial Health Care, University of Massachusetts Medical School, Worcester, MA, USA
    Child Adolesc Psychiatr Clin N Am 21:885-909. 2012

Research Grants

Detail Information

Publications30

  1. pmc Cortical gray matter differences identified by structural magnetic resonance imaging in pediatric bipolar disorder
    Jean A Frazier
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Bipolar Disord 7:555-69. 2005
    ..Cortical gray matter (GM) volume deficits have been reported in some studies of adults with BPD; this study assessed the presence of such deficits in children with BPD...
  2. ncbi Treatment of early-onset schizophrenia spectrum disorders (TEOSS): demographic and clinical characteristics
    Jean A Frazier
    Cambridge Health Alliance, Harvard Medical School, Cambridge, MA, USA
    J Am Acad Child Adolesc Psychiatry 46:979-88. 2007
    ..We examined baseline demographic and clinical profiles of youths enrolled from 2001 to 2006 in the publicly funded multicenter, randomized controlled trial Treatment of Early-Onset Schizophrenia Spectrum Disorders...
  3. ncbi Magnetic resonance imaging studies in early-onset bipolar disorder: a critical review
    Jean A Frazier
    Department of Child and Adolescent Psychiatry, Cambridge Health Alliance, 1493 Cambridge Street, Cambridge, MA 02139, USA
    Harv Rev Psychiatry 13:125-40. 2005
    ....
  4. ncbi Structural brain magnetic resonance imaging of limbic and thalamic volumes in pediatric bipolar disorder
    Jean A Frazier
    Child and Adolescent Neuropsychiatric Research Program, Cambridge Health Alliance Mystic Center, 1493 Cambridge Street, Cambridge, MA 02139, USA
    Am J Psychiatry 162:1256-65. 2005
    ..On the basis of adult studies, the authors hypothesized a priori that youths with bipolar disorder would have amygdalar, hippocampal, and thalamic volume abnormalities...
  5. pmc Diagnostic and sex effects on limbic volumes in early-onset bipolar disorder and schizophrenia
    Jean A Frazier
    Department of Psychiatry, Harvard Medical School, Massachusetts, USA
    Schizophr Bull 34:37-46. 2008
    ..The limbic structures in early-onset schizophrenia-spectrum illness (SZ) and bipolar disorder (BPD) were studied to discern patterns associated with diagnosis and sex...
  6. ncbi White matter abnormalities in children with and at risk for bipolar disorder
    Jean A Frazier
    Department of Psychiatry, Harvard Medical School, Boston, USA
    Bipolar Disord 9:799-809. 2007
    ..To more fully examine this possibility, we scanned children with DSM-IV BPD and compared them to healthy peers and children at risk for BPD (AR-BPD), defined as having a first-degree relative with the disorder...
  7. ncbi Anatomic brain magnetic resonance imaging of the basal ganglia in pediatric bipolar disorder
    Mary S Ahn
    Cambridge Health Alliance Department of Psychiatry 1493 Cambridge St Cambridge, MA 02139, USA
    J Affect Disord 104:147-54. 2007
    ..The BG (caudate, putamen, globus pallidus, nucleus accumbens) is interconnected with limbic and prefrontal cortical structures and therefore may be implicated in BPD...
  8. pmc Cerebellum, language, and cognition in autism and specific language impairment
    Steven M Hodge
    Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA 02114, USA
    J Autism Dev Disord 40:300-16. 2010
    ..These findings suggest ALI and SLI subjects show abnormalities in neurodevelopment of fronto-corticocerebellar circuits that manage motor control and the processing of language, cognition, working memory, and attention...
  9. ncbi Is there a role for clozapine in the treatment of children and adolescents?
    Robert L Findling
    Department of Psychiatry, University Hospitals of Cleveland Case Western Reserve University, USA
    J Am Acad Child Adolesc Psychiatry 46:423-8. 2007
  10. doi Empirical evidence for psychopharmacologic treatment in early-onset psychosis and schizophrenia
    Ann E Maloney
    Department of Psychiatry, Child and Adolescent NeuroDevelopment Initiative CANDI, University of Massachusetts Memorial Health Care, University of Massachusetts Medical School, Worcester, MA, USA
    Child Adolesc Psychiatr Clin N Am 21:885-909. 2012
    ..Nonpharmacologic therapies targeting relatively treatment-resistant domains of dysfunction such as neurocognition are also necessary as adjunctive treatments to our extant pharmacologic agents...
  11. pmc The internet brain volume database: a public resource for storage and retrieval of volumetric data
    David N Kennedy
    Department of Psychiatry, University of Massachusetts Medical School, 356 Plantation St, Biotech 1, Suite 100, Worcester, MA 01605, USA
    Neuroinformatics 10:129-40. 2012
    ..It offers valuable functionality for quality assurance assessment of results as well as support for meta-analysis across large segments of the published literature that are obscured from traditional text-based search engines...
  12. ncbi Clozapine pharmacokinetics in children and adolescents with childhood-onset schizophrenia
    Jean A Frazier
    Consolidated Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Psychopharmacol 23:87-91. 2003
    ..In addition, clinical response and total number of side effects correlated with NOR concentrations. NOR (a neuropharmacologically active metabolite) and free CLZ may contribute to the effectiveness and adverse effects in youth...
  13. doi Metformin for weight control in pediatric patients on atypical antipsychotic medication
    Lauren Shin
    Child Psychiatry Department, Cambridge Health Alliance, Cambridge, Massachusetts, USA
    J Child Adolesc Psychopharmacol 19:275-9. 2009
    ..Metformin was assessed as an interventional medication for weight gain in children and adolescents taking atypical antipsychotic agents...
  14. pmc Bioenergetic measurements in children with bipolar disorder: a pilot 31P magnetic resonance spectroscopy study
    Elif M Sikoglu
    Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    PLoS ONE 8:e54536. 2013
    ..Previous studies have found abnormal cerebral pH levels in adults with BD, which may be directly linked to abnormal mitochondrial activity. To date no such studies have been reported in children with BD...
  15. ncbi Risperidone-induced psychosis and depression in a child with a mitochondrial disorder
    Mary S Ahn
    Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    J Child Adolesc Psychopharmacol 15:520-5. 2005
    ..To our knowledge, this is the first published case report of an adolescent girl with a mitochondrial disorder and depression who displayed both new-onset psychotic and increased mood symptoms during treatment with risperidone...
  16. ncbi Diagnostic and treatment issues in childhood-onset bipolar disorder
    Mary S Ahn
    Harvard Medical School, Boston, MA, USA
    Essent Psychopharmacol 6:25-44. 2004
  17. ncbi Treating a child with Asperger's disorder and comorbid bipolar disorder
    Jean A Frazier
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Am J Psychiatry 159:13-21. 2002
  18. ncbi Empirical evidence for the use of lithium and anticonvulsants in children with psychiatric disorders
    Melissa Lopez-Larson
    Department of Psychiatry, Harvard Medical School, USA
    Harv Rev Psychiatry 14:285-304. 2006
    ....
  19. pmc Glutamine and glutamate levels in children and adolescents with bipolar disorder: a 4.0-T proton magnetic resonance spectroscopy study of the anterior cingulate cortex
    Constance M Moore
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    J Am Acad Child Adolesc Psychiatry 46:524-34. 2007
    ..We hypothesized that unmedicated children with BPD would have reduced glutamine and glutamate levels compared with HCSs and medicated children with BPD...
  20. ncbi Treatment of early-onset schizophrenia spectrum disorders (TEOSS): rationale, design, and methods
    Jon McClellan
    University of Washington, Seattle, USA
    J Am Acad Child Adolesc Psychiatry 46:969-78. 2007
    ..The rationale, design, and methods of the Treatment of Early Onset Schizophrenia Spectrum Disorders Study are described...
  21. ncbi An open-label trial of divalproex in children and adolescents with bipolar disorder
    Karen Dineen Wagner
    University of Texas Medical Branch, Galveston, TX 77555 0188, USA
    J Am Acad Child Adolesc Psychiatry 41:1224-30. 2002
    ..This study evaluated the safety and effectiveness of divalproex sodium (Depakote ) in the treatment of youths with bipolar disorder...
  22. ncbi Double-blind comparison of first- and second-generation antipsychotics in early-onset schizophrenia and schizo-affective disorder: findings from the treatment of early-onset schizophrenia spectrum disorders (TEOSS) study
    Linmarie Sikich
    University of North Carolina at Chapel Hill, NC 27514, USA
    Am J Psychiatry 165:1420-31. 2008
    ....
  23. ncbi Attention-deficit/hyperactivity disorder in children and adolescents with obsessive-compulsive disorder: fact or artifact?
    Daniel A Geller
    Obsessive Compulsive Disorder Clinic, McLean Hospital, Belmont, MA 02478, USA
    J Am Acad Child Adolesc Psychiatry 41:52-8. 2002
    ....
  24. ncbi Clinical significance of brain white matter hyperintensities in young adults with psychiatric illness
    Janis L Breeze
    McLean Hospital, Belmont, MA 02478, USA
    Harv Rev Psychiatry 11:269-83. 2003
    ....
  25. ncbi Language-association cortex asymmetry in autism and specific language impairment
    Lies De Fossé
    Center for Morphometric Analysis, Massachusetts General Hospital
    Ann Neurol 56:757-66. 2004
    ..Linguistically unimpaired boys with autism had similar asymmetry compared with the control group, suggesting that Broca's area asymmetry reversal is related more to language impairment than specifically to autism diagnosis...
  26. ncbi Emerging interventions
    Laurence M Hirshberg
    The NeuroDevelopment Center, 260 West Exchange Street, Suite 302, Providence, RI 02903, USA
    Child Adolesc Psychiatr Clin N Am 14:xiii-xvii. 2005
  27. ncbi Emerging brain-based interventions for children and adolescents: overview and clinical perspective
    Laurence M Hirshberg
    The NeuroDevelopment Center, 260 West Exchange Street, Suite 302, Providence, RI 02903, USA
    Child Adolesc Psychiatr Clin N Am 14:1-19, v. 2005
    ..Several conditions are discussed regarding the use of evidence based thinking related to these emerging interventions and future directions...
  28. ncbi Diagnostically homeless and needing appropriate placement
    Jean A Frazier
    J Child Adolesc Psychopharmacol 15:337-42. 2005
  29. ncbi Adjustment for whole brain and cranial size in volumetric brain studies: a review of common adjustment factors and statistical methods
    Liam M O'Brien
    Colby College
    Harv Rev Psychiatry 14:141-51. 2006
    ..These issues come into play in logically framing the assessment of putative abnormalities in regional brain volumes...
  30. ncbi Integrating treatment and education for mood disorders: an adolescent case report
    Carryl P Navalta
    Child Outpatient Program and Developmental Biopsychiatry Research Program, McLean Hospital, Belmont 02478 9106, USA
    Clin Child Psychol Psychiatry 11:555-68. 2006
    ..A discussion of intervention pluses and pitfalls specific to the case highlight the necessity to influence the various spheres of the young person's life...

Research Grants2

  1. BRAIN ANATOMIC MRI IN CHILDHOOD BIPOLAR DISORDER
    Jean Frazier; Fiscal Year: 2002
    ..By allowing the Candidate to focus time and energy on acquiring the necessary skills, the Award is an important step in her goal to pursue independent research in neuroimaging of childhood mania. ..
  2. TREATMENT OF EARLY ONSET SCHIZOPRENIA SPECTRUM (TEOSS)
    Jean Frazier; Fiscal Year: 2005
    ..This study will provide information about the comparative effectiveness of the most commonly used and representative antipsychotic drugs in youth with schizophrenia spectrum disorders. ..