Research Topics
| Jean A FrazierSummaryAffiliation: Cambridge Health Alliance Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Cortical gray matter differences identified by structural magnetic resonance imaging in pediatric bipolar disorderJean A Frazier
Department of Psychiatry, Harvard Medical School, Boston, MA, USA
Bipolar Disord 7:555-69. 2005..Cortical gray matter (GM) volume deficits have been reported in some studies of adults with BPD; this study assessed the presence of such deficits in children with BPD...
White matter abnormalities in children with and at risk for bipolar disorderJean A Frazier
Department of Psychiatry, Harvard Medical School, Boston, USA
Bipolar Disord 9:799-809. 2007..To more fully examine this possibility, we scanned children with DSM-IV BPD and compared them to healthy peers and children at risk for BPD (AR-BPD), defined as having a first-degree relative with the disorder...- Diagnostic and sex effects on limbic volumes in early-onset bipolar disorder and schizophreniaJean A Frazier
Department of Psychiatry, Harvard Medical School, Massachusetts, USA
Schizophr Bull 34:37-46. 2008..The limbic structures in early-onset schizophrenia-spectrum illness (SZ) and bipolar disorder (BPD) were studied to discern patterns associated with diagnosis and sex... - Treatment of early-onset schizophrenia spectrum disorders (TEOSS): demographic and clinical characteristicsJean A Frazier
Cambridge Health Alliance, Harvard Medical School, Cambridge, MA, USA
J Am Acad Child Adolesc Psychiatry 46:979-88. 2007..We examined baseline demographic and clinical profiles of youths enrolled from 2001 to 2006 in the publicly funded multicenter, randomized controlled trial Treatment of Early-Onset Schizophrenia Spectrum Disorders... - Magnetic resonance imaging studies in early-onset bipolar disorder: a critical reviewJean A Frazier
Department of Child and Adolescent Psychiatry, Cambridge Health Alliance, 1493 Cambridge Street, Cambridge, MA 02139, USA
Harv Rev Psychiatry 13:125-40. 2005.... - Structural brain magnetic resonance imaging of limbic and thalamic volumes in pediatric bipolar disorderJean A Frazier
Child and Adolescent Neuropsychiatric Research Program, Cambridge Health Alliance Mystic Center, 1493 Cambridge Street, Cambridge, MA 02139, USA
Am J Psychiatry 162:1256-65. 2005..On the basis of adult studies, the authors hypothesized a priori that youths with bipolar disorder would have amygdalar, hippocampal, and thalamic volume abnormalities... - Anatomic brain magnetic resonance imaging of the basal ganglia in pediatric bipolar disorderMary S Ahn
Cambridge Health Alliance Department of Psychiatry 1493 Cambridge St Cambridge, MA 02139, USA
J Affect Disord 104:147-54. 2007..The BG (caudate, putamen, globus pallidus, nucleus accumbens) is interconnected with limbic and prefrontal cortical structures and therefore may be implicated in BPD... 
Cerebellum, language, and cognition in autism and specific language impairmentSteven M Hodge
Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA 02114, USA
J Autism Dev Disord 40:300-16. 2010..These findings suggest ALI and SLI subjects show abnormalities in neurodevelopment of fronto-corticocerebellar circuits that manage motor control and the processing of language, cognition, working memory, and attention...- Is there a role for clozapine in the treatment of children and adolescents?Robert L Findling
Department of Psychiatry, University Hospitals of Cleveland Case Western Reserve University, USA
J Am Acad Child Adolesc Psychiatry 46:423-8. 2007 - The internet brain volume database: a public resource for storage and retrieval of volumetric dataDavid N Kennedy
Department of Psychiatry, University of Massachusetts Medical School, 356 Plantation St, Biotech 1, Suite 100, Worcester, MA 01605, USA
Neuroinformatics 10:129-40. 2012..It offers valuable functionality for quality assurance assessment of results as well as support for meta-analysis across large segments of the published literature that are obscured from traditional text-based search engines... - Clozapine pharmacokinetics in children and adolescents with childhood-onset schizophreniaJean A Frazier
Consolidated Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
J Clin Psychopharmacol 23:87-91. 2003..In addition, clinical response and total number of side effects correlated with NOR concentrations. NOR (a neuropharmacologically active metabolite) and free CLZ may contribute to the effectiveness and adverse effects in youth... - Metformin for weight control in pediatric patients on atypical antipsychotic medicationLauren Shin
Child Psychiatry Department, Cambridge Health Alliance, Cambridge, Massachusetts, USA
J Child Adolesc Psychopharmacol 19:275-9. 2009..Metformin was assessed as an interventional medication for weight gain in children and adolescents taking atypical antipsychotic agents... - Diagnostic and treatment issues in childhood-onset bipolar disorderMary S Ahn
Harvard Medical School, Boston, MA, USA
Essent Psychopharmacol 6:25-44. 2004 - Risperidone-induced psychosis and depression in a child with a mitochondrial disorderMary S Ahn
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
J Child Adolesc Psychopharmacol 15:520-5. 2005..To our knowledge, this is the first published case report of an adolescent girl with a mitochondrial disorder and depression who displayed both new-onset psychotic and increased mood symptoms during treatment with risperidone... - Empirical evidence for the use of lithium and anticonvulsants in children with psychiatric disordersMelissa Lopez-Larson
Department of Psychiatry, Harvard Medical School, USA
Harv Rev Psychiatry 14:285-304. 2006.... - Treating a child with Asperger's disorder and comorbid bipolar disorderJean A Frazier
Department of Psychiatry, Harvard Medical School, Boston, MA, USA
Am J Psychiatry 159:13-21. 2002 - An open-label trial of divalproex in children and adolescents with bipolar disorderKaren Dineen Wagner
University of Texas Medical Branch, Galveston, TX 77555 0188, USA
J Am Acad Child Adolesc Psychiatry 41:1224-30. 2002..This study evaluated the safety and effectiveness of divalproex sodium (Depakote ) in the treatment of youths with bipolar disorder... - Glutamine and glutamate levels in children and adolescents with bipolar disorder: a 4.0-T proton magnetic resonance spectroscopy study of the anterior cingulate cortexConstance M Moore
Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
J Am Acad Child Adolesc Psychiatry 46:524-34. 2007..We hypothesized that unmedicated children with BPD would have reduced glutamine and glutamate levels compared with HCSs and medicated children with BPD... - Double-blind comparison of first- and second-generation antipsychotics in early-onset schizophrenia and schizo-affective disorder: findings from the treatment of early-onset schizophrenia spectrum disorders (TEOSS) studyLinmarie Sikich
University of North Carolina at Chapel Hill, NC 27514, USA
Am J Psychiatry 165:1420-31. 2008.... - Treatment of early-onset schizophrenia spectrum disorders (TEOSS): rationale, design, and methodsJon McClellan
University of Washington, Seattle, USA
J Am Acad Child Adolesc Psychiatry 46:969-78. 2007..The rationale, design, and methods of the Treatment of Early Onset Schizophrenia Spectrum Disorders Study are described... - Attention-deficit/hyperactivity disorder in children and adolescents with obsessive-compulsive disorder: fact or artifact?Daniel A Geller
Obsessive Compulsive Disorder Clinic, McLean Hospital, Belmont, MA 02478, USA
J Am Acad Child Adolesc Psychiatry 41:52-8. 2002.... - Clinical significance of brain white matter hyperintensities in young adults with psychiatric illnessJanis L Breeze
McLean Hospital, Belmont, MA 02478, USA
Harv Rev Psychiatry 11:269-83. 2003.... - Language-association cortex asymmetry in autism and specific language impairmentLies De Fossé
Center for Morphometric Analysis, Massachusetts General Hospital
Ann Neurol 56:757-66. 2004..Linguistically unimpaired boys with autism had similar asymmetry compared with the control group, suggesting that Broca's area asymmetry reversal is related more to language impairment than specifically to autism diagnosis... - Emerging interventionsLaurence M Hirshberg
The NeuroDevelopment Center, 260 West Exchange Street, Suite 302, Providence, RI 02903, USA
Child Adolesc Psychiatr Clin N Am 14:xiii-xvii. 2005 - Emerging brain-based interventions for children and adolescents: overview and clinical perspectiveLaurence M Hirshberg
The NeuroDevelopment Center, 260 West Exchange Street, Suite 302, Providence, RI 02903, USA
Child Adolesc Psychiatr Clin N Am 14:1-19, v. 2005..Several conditions are discussed regarding the use of evidence based thinking related to these emerging interventions and future directions... - Diagnostically homeless and needing appropriate placementJean A Frazier
J Child Adolesc Psychopharmacol 15:337-42. 2005 - Integrating treatment and education for mood disorders: an adolescent case reportCarryl P Navalta
Child Outpatient Program and Developmental Biopsychiatry Research Program, McLean Hospital, Belmont 02478 9106, USA
Clin Child Psychol Psychiatry 11:555-68. 2006..A discussion of intervention pluses and pitfalls specific to the case highlight the necessity to influence the various spheres of the young person's life... - Adjustment for whole brain and cranial size in volumetric brain studies: a review of common adjustment factors and statistical methodsLiam M O'Brien
Colby College
Harv Rev Psychiatry 14:141-51. 2006..These issues come into play in logically framing the assessment of putative abnormalities in regional brain volumes...
Research Grants
- BRAIN ANATOMIC MRI IN CHILDHOOD BIPOLAR DISORDERJean Frazier; Fiscal Year: 2002..By allowing the Candidate to focus time and energy on acquiring the necessary skills, the Award is an important step in her goal to pursue independent research in neuroimaging of childhood mania. ..
- TREATMENT OF EARLY ONSET SCHIZOPRENIA SPECTRUM (TEOSS)Jean Frazier; Fiscal Year: 2005..This study will provide information about the comparative effectiveness of the most commonly used and representative antipsychotic drugs in youth with schizophrenia spectrum disorders. ..