Affiliation: Caliper Life Sciences
- A spontaneous acinar cell carcinoma model for monitoring progression of pancreatic lesions and response to treatment through noninvasive bioluminescence imagingNing Zhang
Caliper Life Sciences, Alameda, CA 94501, USA
Clin Cancer Res 15:4915-24. 2009..We have generated an EL1-luc/TAg transgenic mouse model that develops spontaneous and bioluminescent acinar cell carcinomas. We applied this model to noninvasively monitor tumor development and drug response...
- Enhanced detection of myeloperoxidase activity in deep tissues through luminescent excitation of near-infrared nanoparticlesNing Zhang
Caliper Life Sciences, Alameda, California, USA
Nat Med 19:500-5. 2013..We developed a sensitive MPO detection methodology that provides a means for visualizing and quantifying oxidative stress in deep tissue. This method is amenable to rapid evaluation of anti-inflammatory agents in animal models...
- Imaging pulmonary NF-kappaB activation and therapeutic effects of MLN120B and TDZD-8Dan Ansaldi
Caliper Life Sciences, Alameda, California, United States of America
PLoS ONE 6:e25093. 2011..This approach will potentiate further studies on NF-κB regulation under various inflammatory conditions...
- Serum amyloid A-luciferase transgenic mice: response to sepsis, acute arthritis, and contact hypersensitivity and the effects of proteasome inhibitionNing Zhang
Xenogen, Alameda, CA 94501, USA
J Immunol 174:8125-34. 2005..These results suggest that both local and systemic induction of A-SAA occur during inflammation and may contribute to the pathogenesis of chronic inflammatory diseases associated with amyloid deposition...