Ahmed Zewail

Summary

Affiliation: California Institute of Technology
Country: USA

Publications

  1. ncbi request reprint 4D ultrafast electron diffraction, crystallography, and microscopy
    Ahmed H Zewail
    Laboratory for Molecular Sciences and Physical Biology Center for Ultrafast Science and Technology, California Institute of Technology, Pasadena, California 91125, USA
    Annu Rev Phys Chem 57:65-103. 2006
  2. ncbi request reprint Ultrafast electron microscopy (UEM): four-dimensional imaging and diffraction of nanostructures during phase transitions
    Vladimir A Lobastov
    Physical Biology Center for Ultrafast Science and Technology, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, California 91125, USA
    Nano Lett 7:2552-8. 2007
  3. doi request reprint Unusual molecular material formed through irreversible transformation and revealed by 4D electron microscopy
    Renske M van der Veen
    Physical Biology Center for Ultrafast Science and Technology, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA
    Phys Chem Chem Phys 15:7831-8. 2013
  4. doi request reprint Science for the "haves"
    Ahmed Zewail
    Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, 91125, USA
    Angew Chem Int Ed Engl 52:108-11. 2013
  5. doi request reprint Four-dimensional electron microscopy
    Ahmed H Zewail
    Physical Biology Center for Ultrafast Science and Technology, California Institute of Technology, Pasadena, CA 91125, USA
    Science 328:187-93. 2010
  6. pmc Micrographia of the twenty-first century: from camera obscura to 4D microscopy
    Ahmed H Zewail
    Physical Biology Center for Ultrafast Science and Technology, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA
    Philos Transact A Math Phys Eng Sci 368:1191-204. 2010
  7. doi request reprint The new age of structural dynamics
    Ahmed H Zewail
    Physical Biology Center for Ultrafast Science and Technology, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA
    Acta Crystallogr A 66:135-6. 2010
  8. ncbi request reprint Diffraction, crystallography and microscopy beyond three dimensions: structural dynamics in space and time
    Ahmed H Zewail
    Laboratory for Molecular Sciences, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA
    Philos Trans A Math Phys Eng Sci 363:315-29. 2005
  9. doi request reprint New light on molecular and materials complexity: 4D electron imaging
    Dmitry Shorokhov
    Physical Biology Center for Ultrafast Science and Technology, Arthur Amos Noyes Laboratory for Chemical Physics, California Institute of Technology, Pasadena, California 91125, USA
    J Am Chem Soc 131:17998-8015. 2009
  10. doi request reprint 4D electron imaging: principles and perspectives
    Dmitry Shorokhov
    Physical Biology Center for Ultrafast Science and Technology, Arthur Amos Noyes Laboratory for Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA
    Phys Chem Chem Phys 10:2879-93. 2008

Collaborators

  • Lars Meinhold
  • Liang Zhao
  • R W Roberts
  • JAU TANG
  • Oh Hoon Kwon
  • David J Flannigan
  • Ding Shyue Yang
  • Milo M Lin
  • Brett Barwick
  • Dmitry Shorokhov
  • Samir Kumar Pal
  • J Spencer Baskin
  • I Ren Lee
  • Hairong Ma
  • Vladimir A Lobastov
  • Chaozhi Wan
  • Hyun Soon Park
  • Andreas Gahlmann
  • Peter Baum
  • Weihong Qiu
  • Songye Chen
  • Omar F Mohammed
  • Christina M Othon
  • Tianbing Xia
  • Renske M van der Veen
  • Peter C Samartzis
  • Fabrizio Carbone
  • Sang Tae Park
  • Nuh Gedik
  • Wonchul Lee
  • Jonas Weissenrieder
  • Luyuan Zhang
  • Lijuan Wang
  • Agathe Espagne
  • Dongping Zhong
  • Yi Yang
  • Po Yuan Cheng
  • Michael S Grinolds
  • Marco T Seidel
  • Yuhong Wang
  • Melanie A O'Neill
  • Torsten Fiebig
  • Jorge Peon
  • Shouzhong Zou
  • Andreas Hauser
  • Antoine Tissot
  • Tae Hyeon Yoo
  • James A Van Deventer
  • David A Tirrell
  • Aycan Yurtsever
  • Changshi Lao
  • Luis BaƱares
  • Gennady Logvenov
  • Aiguo Wu
  • Ivan Bozovic
  • Oghaghare Okobiah
  • Ya Ting Kao
  • Pascale Changenet-Barret
  • Wesley E Stites
  • Daniel H Paik
  • Monique M Martin
  • Ramesh Srinivasan
  • Jacqueline K Barton
  • Hans Christian Becker

Detail Information

Publications60

  1. ncbi request reprint 4D ultrafast electron diffraction, crystallography, and microscopy
    Ahmed H Zewail
    Laboratory for Molecular Sciences and Physical Biology Center for Ultrafast Science and Technology, California Institute of Technology, Pasadena, California 91125, USA
    Annu Rev Phys Chem 57:65-103. 2006
    ..Future applications of these methods are foreseen across areas of physics, chemistry, and biology...
  2. ncbi request reprint Ultrafast electron microscopy (UEM): four-dimensional imaging and diffraction of nanostructures during phase transitions
    Vladimir A Lobastov
    Physical Biology Center for Ultrafast Science and Technology, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, California 91125, USA
    Nano Lett 7:2552-8. 2007
    ..A theoretical two-dimensional (2D) diffusion model for nanoscale materials is presented, and its results account for the observed behavior...
  3. doi request reprint Unusual molecular material formed through irreversible transformation and revealed by 4D electron microscopy
    Renske M van der Veen
    Physical Biology Center for Ultrafast Science and Technology, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA
    Phys Chem Chem Phys 15:7831-8. 2013
    ..This in situ visualization of single nanostructures during reactions should be extendable to other classes of reactive systems...
  4. doi request reprint Science for the "haves"
    Ahmed Zewail
    Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, 91125, USA
    Angew Chem Int Ed Engl 52:108-11. 2013
    ..This state of affairs could exacerbate a dearth of innovations and lead to a transition of the "haves" into the "have-nots" of the world population...
  5. doi request reprint Four-dimensional electron microscopy
    Ahmed H Zewail
    Physical Biology Center for Ultrafast Science and Technology, California Institute of Technology, Pasadena, CA 91125, USA
    Science 328:187-93. 2010
    ..We conclude with current explorations in imaging of nanomaterials and biostructures and an outlook on possible future directions in space-time, 4D electron microscopy...
  6. pmc Micrographia of the twenty-first century: from camera obscura to 4D microscopy
    Ahmed H Zewail
    Physical Biology Center for Ultrafast Science and Technology, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA
    Philos Transact A Math Phys Eng Sci 368:1191-204. 2010
    ..Such observations provide the means for visualizing materials behaviour and biological function, with the aim of understanding emergent phenomena in complex systems...
  7. doi request reprint The new age of structural dynamics
    Ahmed H Zewail
    Physical Biology Center for Ultrafast Science and Technology, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA
    Acta Crystallogr A 66:135-6. 2010
    ..A perspective on the new developments of structural dynamics is presented. The scope of applications and advances, from microscopy to diffraction and spectroscopy, defines the new age of endeavour...
  8. ncbi request reprint Diffraction, crystallography and microscopy beyond three dimensions: structural dynamics in space and time
    Ahmed H Zewail
    Laboratory for Molecular Sciences, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA
    Philos Trans A Math Phys Eng Sci 363:315-29. 2005
    ..With the extension to ultrafast electron microscopy, discussed here and elsewhere, we present an overview of one major research area at our centre, the Laboratory for Molecular Sciences...
  9. doi request reprint New light on molecular and materials complexity: 4D electron imaging
    Dmitry Shorokhov
    Physical Biology Center for Ultrafast Science and Technology, Arthur Amos Noyes Laboratory for Chemical Physics, California Institute of Technology, Pasadena, California 91125, USA
    J Am Chem Soc 131:17998-8015. 2009
    ..This contribution provides an expose of emerging developments and an outlook on future applications in materials and biological sciences...
  10. doi request reprint 4D electron imaging: principles and perspectives
    Dmitry Shorokhov
    Physical Biology Center for Ultrafast Science and Technology, Arthur Amos Noyes Laboratory for Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA
    Phys Chem Chem Phys 10:2879-93. 2008
    ..We conclude with an outlook on the potential of the approach and with some questions that may define new frontiers of research...
  11. doi request reprint 4D imaging of transient structures and morphologies in ultrafast electron microscopy
    Brett Barwick
    Physical Biology Center for Ultrafast Science and Technology, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA
    Science 322:1227-31. 2008
    ..The success of these studies demonstrates the promise of UEM in real-space imaging of dynamics...
  12. pmc Ordered water structure at hydrophobic graphite interfaces observed by 4D, ultrafast electron crystallography
    Ding Shyue Yang
    Physical Biology Center for Ultrafast Science and Technology, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 106:4122-6. 2009
    ..We provide the time scales involved, the nature of ice-graphite structural dynamics, and relevance to properties related to confined water...
  13. doi request reprint Optomechanical and crystallization phenomena visualized with 4D electron microscopy: interfacial carbon nanotubes on silicon nitride
    David J Flannigan
    Physical Biology Center for Ultrafast Science and Technology, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, California 91125, USA
    Nano Lett 10:1892-9. 2010
    ....
  14. pmc 4D visualization of embryonic, structural crystallization by single-pulse microscopy
    Oh Hoon Kwon
    Physical Biology Center for Ultrafast Science and Technology, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 105:8519-24. 2008
    ..Similar mechanisms of two distinct time scales may perhaps be important in biomolecular folding...
  15. doi request reprint Ultrashort electron pulses for diffraction, crystallography and microscopy: theoretical and experimental resolutions
    Andreas Gahlmann
    Physical Biology Center for Ultrafast Science and Technology, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA
    Phys Chem Chem Phys 10:2894-909. 2008
    ..The resulting implications on the spatiotemporal resolution capabilities are discussed both for the N-electron pulse and for single-electron coherent packets introduced for microscopy without space-charge...
  16. pmc Conformations and coherences in structure determination by ultrafast electron diffraction
    Milo M Lin
    Physical Biology Center for Ultrafast Science and Technology, Arthur Amos Noyes Laboratory for Chemical Physics, California Institute of Technology, Pasadena, California 91125, USA
    J Phys Chem A 113:4075-93. 2009
    ....
  17. ncbi request reprint Dynamics of electrons in ammonia cages: the discovery system of solvation
    I Ren Lee
    Physical Biology Center for Ultrafast Science and Technology, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA
    Chemphyschem 9:83-8. 2008
    ....
  18. pmc Attosecond electron pulses for 4D diffraction and microscopy
    Peter Baum
    Physical Biology Center for Ultrafast Science and Technology, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 104:18409-14. 2007
    ....
  19. ncbi request reprint Nonequilibrium phase transitions in cuprates observed by ultrafast electron crystallography
    Nuh Gedik
    Physical Biology Center for Ultrafast Science and Technology, California Institute of Technology Caltech, Pasadena, CA 91125, USA
    Science 316:425-9. 2007
    ..This threshold for photon doping occurs at approximately 0.12 photons per copper site, which is unexpectedly close to the density (per site) of chemically doped carriers needed to induce superconductivity...
  20. pmc Four-dimensional ultrafast electron microscopy of phase transitions
    Michael S Grinolds
    Physical Biology Center for Ultrafast Science and Technology, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 103:18427-31. 2006
    ....
  21. pmc Atomic-scale dynamical structures of fatty acid bilayers observed by ultrafast electron crystallography
    Songye Chen
    Laboratory for Molecular Sciences, Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 102:8854-9. 2005
    ..The ability to observe such atomic motions of complex structures and at interfaces is a significant leap forward for the determination of macromolecular dynamical structures by using ultrafast electron crystallography...
  22. ncbi request reprint Dynamics of water in biological recognition
    Samir Kumar Pal
    Laboratory for Molecular Sciences, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, California 91125, USA
    Chem Rev 104:2099-123. 2004
  23. pmc Scanning ultrafast electron microscopy
    Ding Shyue Yang
    Physical Biology Center for Ultrafast Science and Technology, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 107:14993-8. 2010
    ..Scanning pulsed-electron microscopy with the acquired spatiotemporal resolutions, and its efficient heat-dissipation feature, is now poised to provide in situ 4D imaging and with environmental capability...
  24. pmc Four-dimensional ultrafast electron microscopy
    Vladimir A Lobastov
    Laboratory for Molecular Sciences, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 102:7069-73. 2005
    ..Ultrafast electron microscopy should have an impact on all areas of microscopy, including biological imaging...
  25. doi request reprint 4D electron diffraction reveals correlated unidirectional behavior in zinc oxide nanowires
    Ding Shyue Yang
    Physical Biology Center for Ultrafast Science and Technology, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA
    Science 321:1660-4. 2008
    ..This unanticipated ultrafast carrier-driven expansion highlights the optoelectronic consequences of nanoscale morphologies...
  26. doi request reprint Nanoscale mechanical drumming visualized by 4D electron microscopy
    Oh Hoon Kwon
    Physical Biology Center for Ultrafast Science and Technology, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, California 91125, USA
    Nano Lett 8:3557-62. 2008
    ..0 TPa for the in-plane stress-strain profile. Because of its real-time dimension, this 4D microscopy should have applications in the study of these and other types of materials structures...
  27. doi request reprint Structure of isolated biomolecules by electron diffraction-laser desorption: uracil and guanine
    Andreas Gahlmann
    Physical Biology Center for Ultrafast Science and Technology, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, California 91125, USA
    J Am Chem Soc 131:2806-8. 2009
    ..Such experimental capability opens the door for many other studies of the structure (and dynamics) of biomolecules...
  28. doi request reprint Nanomechanical motions of cantilevers: direct imaging in real space and time with 4D electron microscopy
    David J Flannigan
    Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, California 91125, USA
    Nano Lett 9:875-81. 2009
    ..We note that the observables here are real material changes in time, in contrast to those based on changes of optical/contrast intensity or diffraction...
  29. pmc Hydration dynamics at fluorinated protein surfaces
    Oh Hoon Kwon
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 107:17101-6. 2010
    ..Using ultrafast fluorescence spectroscopy, we find that fluorinated side chains exert electrostatic drag on neighboring water molecules, slowing water motion at the protein surface...
  30. ncbi request reprint Ultrafast dynamics in DNA-mediated electron transfer: base gating and the role of temperature
    Melanie A O'Neill
    Laboratory for Molecular Sciences, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91 125, USA
    Angew Chem Int Ed Engl 42:5896-900. 2003
  31. pmc Water at DNA surfaces: ultrafast dynamics in minor groove recognition
    Samir Kumar Pal
    Laboratory for Molecular Sciences, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 100:8113-8. 2003
    ..Because of their ultrafast time scale, the "ordered" water molecules are the most weakly bound and are accordingly involved in the entropic (hydration/dehydration) process of recognition...
  32. doi request reprint Photon-induced near-field electron microscopy
    Brett Barwick
    Physical Biology Center for Ultrafast Science and Technology, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, California 91125, USA
    Nature 462:902-6. 2009
    ....
  33. pmc Biological imaging with 4D ultrafast electron microscopy
    David J Flannigan
    Physical Biology Center for Ultrafast Science and Technology, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 107:9933-7. 2010
    ..The high-magnification PINEM imaging provides the nanometer scale and the fs temporal resolution. The potential of applications is discussed and includes the study of antibodies and immunolabeling within the cell...
  34. doi request reprint Dynamics of chemical bonding mapped by energy-resolved 4D electron microscopy
    Fabrizio Carbone
    Physical Biology Center for Ultrafast Science and Technology, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA
    Science 325:181-4. 2009
    ..The reported femtosecond time resolution of four-dimensional (4D) electron microscopy represents an advance of 10 orders of magnitude over that of conventional EELS methods...
  35. pmc Molecular recognition of oxygen by protein mimics: dynamics on the femtosecond to microsecond time scale
    Shouzhong Zou
    Laboratory for Molecular Sciences, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 99:9625-30. 2002
    ..In the recognition process, the net entropy decrease is -33 cal mol(-1) K(-1); Delta H is -13.4 kcal mol(-1)...
  36. pmc Dynamics of clusters: from elementary to biological structures
    Po Yuan Cheng
    Laboratory for Molecular Sciences, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 103:10570-6. 2006
    ....
  37. ncbi request reprint Ultrafast electron crystallography of phospholipids
    Songye Chen
    Laboratory for Molecular Sciences, Physical Biology Center for Ultrafast Science and Technology, California Institute of Technology, Pasadena, CA 91125, USA
    Angew Chem Int Ed Engl 45:5154-8. 2006
  38. pmc Breaking resolution limits in ultrafast electron diffraction and microscopy
    Peter Baum
    Physical Biology Center for Ultrafast Science and Technology and Laboratory for Molecular Sciences, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 103:16105-10. 2006
    ....
  39. ncbi request reprint Ultrafast T-jump in water: studies of conformation and reaction dynamics at the thermal limit
    Hairong Ma
    Physical Biology Center for Ultrafast Science and Technology, and Laboratory for Molecular Sciences, California Institute of Technology, Pasadena, California 91125, USA
    J Am Chem Soc 128:6338-40. 2006
    ..5 mum. The example given here shows the application of the methodology, for the first time, and the results demonstrate distinct time scales for solvation, conformational change, and thermal reaction...
  40. pmc Double proton transfer dynamics of model DNA base pairs in the condensed phase
    Oh Hoon Kwon
    Physical Biology Center for Ultrafast Science and Technology and Laboratory for Molecular Sciences, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 104:8703-8. 2007
    ..The nonconcerted mechanism is in agreement with previous isolated-molecule femtosecond dynamics and is also consistent with the most-recent high-level theoretical study on the same pair...
  41. ncbi request reprint Femtosecond charge transfer dynamics of a modified DNA base: 2-aminopurine in complexes with nucleotides
    Torsten Fiebig
    Laboratory for Molecular Sciences, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA
    Chemphyschem 3:781-8. 2002
    ..From the measured rates and using electron transfer theory we estimate the driving force for charge transfer between all four nucleobases and Ap. The results are important for the studies of dynamics using Ap in DNA assemblies...
  42. doi request reprint Structural ultrafast dynamics of macromolecules: diffraction of free DNA and effect of hydration
    Milo M Lin
    Physical Biology Center for Ultrafast Science and Technology, Arthur Amos Noyes Laboratory for Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA
    Phys Chem Chem Phys 11:10619-32. 2009
    ....
  43. ncbi request reprint Dynamics of ordered water in interfacial enzyme recognition: bovine pancreatic phospholipase A2
    Liang Zhao
    Laboratory for Molecular Sciences, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA
    Angew Chem Int Ed Engl 43:60-3. 2004
  44. pmc Ultrafast surface hydration dynamics and expression of protein functionality: alpha -Chymotrypsin
    Samir Kumar Pal
    Laboratory for Molecular Sciences, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena 91125, USA
    Proc Natl Acad Sci U S A 99:15297-302. 2002
    ..For the substrate-enzyme complex, the function and dynamics at the probe site are correlated, and the relevance to the enzymatic action is clear...
  45. pmc DNA folding and melting observed in real time redefine the energy landscape
    Hairong Ma
    Physical Biology Center for Ultrafast Science and Technology and Laboratory for Molecular Sciences, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 104:712-6. 2007
    ..We propose a landscape that is defined by these nucleation structures and destacking for efficient folding and melting...
  46. pmc Biological water at the protein surface: dynamical solvation probed directly with femtosecond resolution
    Samir Kumar Pal
    Laboratory for Molecular Sciences, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 99:1763-8. 2002
    ..At a distance of approximately 7 A from the surface, essentially all trajectories are bulk-type. The theoretical framework for these observations is discussed...
  47. pmc RNA-protein recognition: single-residue ultrafast dynamical control of structural specificity and function
    Tianbing Xia
    Laboratory for Molecular Sciences, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 102:13013-8. 2005
    ..Remarkably, in vivo antitermination experiments show strong correlation with our femtosecond dynamics, demonstrating how conformational interplay can control the activity of a macromolecular machine...
  48. doi request reprint Heating and cooling dynamics of carbon nanotubes observed by temperature-jump spectroscopy and electron microscopy
    Omar F Mohammed
    Physical Biology Center for Ultrafast Science and Technology, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, California 91125, USA
    J Am Chem Soc 131:16010-1. 2009
    ..They also provide the rate information needed for optimization of photothermal therapy that invokes infrared irradiation to selectively heat and annihilate cancer cells...
  49. pmc Solvation in protein (un)folding of melittin tetramer-monomer transition
    Christina M Othon
    Physical Biology Center for Ultrafast Science and Technology, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 106:12593-8. 2009
    ..The large amplitude conformational changes are regulated by the local solvent hydrophobicity and bulk solvent viscosity...
  50. doi request reprint Direct observation of the primary bond-twisting dynamics of stilbene anion radical
    I Ren Lee
    Physical Biology Center of Ultrafast Science and Technology, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, California 91125, USA
    J Am Chem Soc 130:6708-9. 2008
    ..The observed coherent vibrational motion (approximately 42 cm(-1)) and the primary bond-twisting dynamics (approximately 650 fs) for the D2 state are on a vastly different time scale from that reported (approximately 10 ns) in solution...
  51. pmc Primary steps of the photoactive yellow protein: isolated chromophore dynamics and protein directed function
    I Ren Lee
    Arthur Amos Noyes Laboratory of Chemical Physics, Laboratory for Molecular Sciences, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 103:258-62. 2006
    ....
  52. pmc Unfolding and melting of DNA (RNA) hairpins: the concept of structure-specific 2D dynamic landscapes
    Milo M Lin
    Physical Biology Center for Ultrafast Science and Technology, California Institute of Technology, Pasadena, CA 91125, USA
    Phys Chem Chem Phys 10:4227-39. 2008
    ..The model allows for lucid prediction of the collapsed state(s) in simple 2D space and we term it the kinetic intermediate structure (KIS) model...
  53. pmc Dynamics of ligand substitution in labile cobalt complexes resolved by ultrafast T-jump
    Hairong Ma
    Physical Biology Center for Ultrafast Science and Technology and Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 105:12754-7. 2008
    ..The reaction time scale deviates by one to two orders of magnitude from that of ionic diffusion, suggesting the involvement of a collisional barrier between the ion and the much larger complex...
  54. pmc Human myoglobin recognition of oxygen: dynamics of the energy landscape
    Yuhong Wang
    Laboratory for Molecular Sciences, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 101:18000-5. 2004
    ..We discuss the relevance of these findings to the bimolecular function of the protein...
  55. ncbi request reprint Atomic-scale imaging in real and energy space developed in ultrafast electron microscopy
    Hyun Soon Park
    Physical Biology Center for Ultrafast Science and Technology, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, California 91125, USA
    Nano Lett 7:2545-51. 2007
    ....
  56. pmc Site- and sequence-selective ultrafast hydration of DNA
    Samir Kumar Pal
    Laboratory for Molecular Sciences, Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 100:13746-51. 2003
    ....
  57. ncbi request reprint Controlled nanoscale mechanical phenomena discovered with ultrafast electron microscopy
    David J Flannigan
    Physical Biology Center for Ultrafast Science and Technology, California Institute of Technology, Pasadena, CA 91125, USA
    Angew Chem Int Ed Engl 46:9206-10. 2007
  58. ncbi request reprint Ultrafast photoisomerization of photoactive yellow protein chromophore analogues in solution: influence of the protonation state
    Agathe Espagne
    UMR CNRS ENS 8640 PASTEUR, Departement de Chimie, Ecole Normale Superieure, 24 rue Lhomond, 75231 Paris Cedex 05, France
    Chemphyschem 7:1717-26. 2006
    ..A trans-to-cis isomerization mechanism involving mainly the ethylenic double-bond torsion and/or solvation is proposed for the anionic forms, whereas "concerted" intramolecular motions are proposed for the neutral forms...
  59. pmc Protein surface hydration mapped by site-specific mutations
    Weihong Qiu
    Department of Physics, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 103:13979-84. 2006
    ..We discuss the role of protein fluctuation on the time scale of labile hydration and suggest reexamination of recent molecular dynamics simulations...
  60. ncbi request reprint Ultrafast solvation dynamics of human serum albumin: correlations with conformational transitions and site-selected recognition
    Weihong Qiu
    Department of Physics, 191 West Woodruff Avenue, The Ohio State University, Columbus, Ohio 43210, USA
    J Phys Chem B 110:10540-9. 2006
    ..These changes in the solvation dynamics are correlated with the conformational transitions and related to their structural integrity...

Research Grants4

  1. Ultrafast Electron Cryomicroscopy of Single Protein Particles
    Ahmed Zewail; Fiscal Year: 2007
    ..If successful, this advance could make structure determination to near-atomic resolution routine for large macromolecular complexes. ..
  2. Ultrafast Electron Cryomicroscopy of Single Protein Particles
    Ahmed H Zewail; Fiscal Year: 2010
    ..If successful, this advance could make structure determination to near-atomic resolution routine for large macromolecular complexes. ..