Research Topics
| Changhuei YangSummaryAffiliation: California Institute of Technology Country: USA Publications
Research Grants
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Detail Information
Publications
Amplification of optical delay by use of matched linearly chirped fiber Bragg gratingsChanghuei Yang
Department of Biomedical Engineering, 136 Hudson Hall, Duke University, Durham, North Carolina 27708, USA
Opt Lett 29:685-7. 2004..We demonstrate operation of such an optical delay line over a delay range of 3.5 mm using a pair of matched 1300-nm chirped FBGs with a bandwidth of 20 nm each...
Molecular contrast optical coherence tomography: a reviewChanghuei Yang
Electrical Engineering Department, Engineering and Applied Sciences Division, California Institute of Technology, Pasadena, CA 91125, USA
Photochem Photobiol 81:215-37. 2005..We will conclude by outlining a few areas of pursuit that deserve a greater degree of research and development...- Spectral triangulation molecular contrast optical coherence tomography with indocyanine green as the contrast agentChanghuei Yang
Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA
Opt Lett 29:2016-8. 2004..We demonstrate molecular imaging with this new MCOCT modality by mapping the distribution of indocyanine green, a FDA-approved infrared red dye, within a stage 54 Xenopus laevis... - Protein-based molecular contrast optical coherence tomography with phytochrome as the contrast agentChanghuei Yang
Department of Biomedical Engineering, 136 Hudson Hall, Duke University, Durham, North Carolina 27708, USA
Opt Lett 29:1396-8. 2004..We demonstrate molecular imaging with this new MCOCT modality in a target sample containing a mixture of 0.2% Intralipid and 83 microM of phyA... - Molecular contrast optical coherence tomography: A pump-probe scheme using indocyanine green as a contrast agentZahid Yaqoob
California Institute of Technology, Department of Electrical Engineering, Biophotonics Laboratory, 4 Moore Building, M C 136 93, 1200 E California Blvd, Pasadena, California 91125, USA
J Biomed Opt 11:054017. 2006..The paper also demonstrates ICG-based MCOCT imaging in tissue phantoms as well as within stage 54 Xenopus laevis... - Homodyne en face optical coherence tomographyZahid Yaqoob
Department of Electrical Engineering, MC 136 93, California Institute of Technology, Pasadena, 91125, USA
Opt Lett 31:1815-7. 2006..4 microm laterally with a 90 dB signal-to-noise ratio at 10 micros integration time. En face OCT imaging of a stage 52 Xenopus laevis was successfully demonstrated at a depth of 600 microm within the sample... - Harmonically matched grating-based full-field quantitative high-resolution phase microscope for observing dynamics of transparent biological samplesJigang Wu
Department of Electrical Engineering, California Institute of Technology, Pasadena, California 91125, USA
Opt Express 15:18141-55. 2007..The system has a lateral resolution of 1.6 mum and a phase sensitivity of 62 mrad. We employed the system to acquire high resolution phase images of onion skin cells and a phase movie of amoeba proteus in motion... 
Improving weak-signal identification via predetection background suppression by a pixel-level, surface-wave enabled dark-field apertureGuoan Zheng
Department of Electrical Engineering, California Institute of Technology, Pasadena, California 91125, USA
Opt Lett 35:2636-8. 2010..96W/m(2), integration time=5ms), we further demonstrate that a SWEDA pixel can detect a weak localized signal buried in a high background, while conventional postdetection background subtraction cannot (improved SNR=2.2 versus SNR=0.26)...- On-chip continuous monitoring of motile microorganisms on an ePetri platformSeung Ah Lee
Department of Electrical Engineering, California Institute of Technology, Pasadena, CA 91125, USA
Lab Chip 12:2385-90. 2012..As a miniaturized and automated culture monitoring platform, this ePetri technology can greatly improve studies and experiments with motile microorganisms... - Turbidity suppression from the ballistic to the diffusive regime in biological tissues using optical phase conjugationEmily J McDowell
California Institute of Technology, Department of Bioengineering, 1200 East California Boulevard, Mail Code 136 93, Pasadena, California 91125, USA
J Biomed Opt 15:025004. 2010..Our results describe the highest level of scattering that has been phase conjugated in biological tissues to date... - The application of Fresnel zone plate based projection in optofluidic microscopyJigang Wu
Department of Electrical Engineering, California Institute of Technology, Pasadena, California 91125, USA
Opt Express 16:15595-602. 2008..We demonstrate the capability of the integrated system by flowing the protist Euglena gracilis across the aperture array microfluidically and performing OFM imaging of the samples... - Methods and application areas of endoscopic optical coherence tomographyZahid Yaqoob
Engineering and Applied Sciences Division, Electrical Engineering Department, California Institute of Technology, Pasadena, California 91125, USA
J Biomed Opt 11:063001. 2006..We highlight two additional applications--biopsy procedures and neurosurgery--where sufficiently compact OCT-based endoscopes can have significant clinical impacts... - Color capable sub-pixel resolving optofluidic microscope and its application to blood cell imaging for malaria diagnosisSeung Ah Lee
Department of Electrical Engineering, California Institute of Technology, Pasadena, California, United States of America
PLoS ONE 6:e26127. 2011..We applied the prototypes to perform color imaging of red blood cells (RBCs) infected with Plasmodium falciparum, a particularly harmful type of malaria parasites and one of the major causes of death in the developing world... - Lensless high-resolution on-chip optofluidic microscopes for Caenorhabditis elegans and cell imagingXiquan Cui
Department of Electrical Engineering, California Institute of Technology, Pasadena, CA 91125, USA
Proc Natl Acad Sci U S A 105:10670-5. 2008..We anticipate that the OFM can significantly address a range of biomedical and bioscience needs, and engender new microscope applications... - Manual-scanning optical coherence tomography probe based on position trackingJian Ren
Department of Electrical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA
Opt Lett 34:3400-2. 2009..A phantom target was used to validate the method. In addition, we report OCT images of a 54-stage Xenopus laevis tadpole acquired by manual scanning... - Characterization of light collection through a subwavelength aperture from a point sourceXin Heng
Department of Electrical Engineering MC136 93, California Institute of Technology, Pasadena, CA 91125, USA
Opt Express 14:10410-25. 2006..5 is achievable with subwavelength aperture based devices when the aperture size is smaller than 225 nm... - Handheld forward-imaging needle endoscope for ophthalmic optical coherence tomography inspectionShuo Han
California Institute of Technology, Department of Electrical Engineering, Pasadena, California 91125, USA
J Biomed Opt 13:020505. 2008..g., vitrectomy)... - Characterization of acceptance angles of small circular aperturesYing Min Wang
Department of Bioengineering MC138 78, California Institute of Technology, Pasadena, CA 91125, USA
Opt Express 17:23903-13. 2009..This work in understanding of the behavior of light transmission through subwavelength apertures will guide the design of better aperture based imaging devices where apertures are used as light collection units... - Implementation of a digital optical phase conjugation system and its application to study the robustness of turbidity suppression by phase conjugationMeng Cui
Department of Electrical Engineering, California Institute of Technology, 1200 E California Blvd, MC 136 93, CA, 91125, USA
Opt Express 18:3444-55. 2010.... - Wide field-of-view microscope based on holographic focus grid illuminationJigang Wu
Department of Electrical Engineering, California Institute of Technology, 1200 E California Boulevard, Pasadena, California 91125, USA
Opt Lett 35:2188-90. 2010..74 microm. We demonstrate the prototype by imaging a U.S. Air Force target and a lily anther. This technology is scalable and represents a cost-effective way to implement wide FOV microscopy systems... - The application of on-chip optofluidic microscopy for imaging Giardia lamblia trophozoites and cystsLap Man Lee
Department of Bioengineering MC138 78, California Institute of Technology, Pasadena, CA 91125, USA
Biomed Microdevices 11:951-8. 2009..Finally, we report the successful microscopy imaging of both Giardia trophozoites and cysts with an OFM that has a focal plane resolution of 0.8 microns... - Quantitative surface normal measurement by a wavefront cameraJian Ren
Department of Electrical Engineering, California Institute of Technology, Pasadena, California 91125, USA
Opt Lett 37:199-201. 2012..The results agree well with their expected values. To demonstrate the application of the camera, we applied this method to measure the deformation of a microfluidic channel under pressure... - The ePetri dish, an on-chip cell imaging platform based on subpixel perspective sweeping microscopy (SPSM)Guoan Zheng
Electrical Engineering, California Institute of Technology, Pasadena, CA 91125, USA
Proc Natl Acad Sci U S A 108:16889-94. 2011..Smart Petri dish based on this technology can significantly streamline and improve cell culture experiments by cutting down on human labor and contamination risks... - Pixel level optical-transfer-function design based on the surface-wave-interferometry apertureGuoan Zheng
Department of Electrical Engineering, California Institute of Technology, Pasadena, CA 91125, USA
Opt Express 18:16499-506. 2010..Pixel level OTF design provides a low-cost, ultra robust, highly compact method for numerous applications such as optofluidic microscopy, wavefront detection, darkfield imaging, and computational photography... - Focal plane tuning in wide-field-of-view microscope with Talbot pattern illuminationJigang Wu
Department of Electrical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA
Opt Lett 36:2179-81. 2011..By tuning the wavelength of the laser, we can tune the focal plane of the WFM and acquire images of different depth into the sample. Images of a green algae microscope slide were acquired at different focal planes for demonstration... - Sub-pixel resolving optofluidic microscope for on-chip cell imagingGuoan Zheng
Department of Electrical Engineering, California Institute of Technology, Pasadena, CA 91125, USA
Lab Chip 10:3125-9. 2010.... - Implementation of a color-capable optofluidic microscope on a RGB CMOS color sensor chip substrateShuo Pang
Department of Electrical Engineering, California Institute of Technology, Pasadena, CA 91125, USA
Lab Chip 10:411-4. 2010.... - Instantaneous quadrature low-coherence interferometry with 3 x 3 fiber-optic couplersMichael A Choma
Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA
Opt Lett 28:2162-4. 2003.... - Spectral-domain phase microscopyMichael A Choma
Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA
Opt Lett 30:1162-4. 2005..A shot-noise limit to the displacement sensitivity of this technique is derived. Measurement of cellular dynamics was performed on spontaneously beating cardiomyocytes isolated from chick embryos... - Paired-angle-rotation scanning optical coherence tomography forward-imaging probeJigang Wu
Department of Electrical Engineering, California Institute of Technology, California 91125, USA
Opt Lett 31:1265-7. 2006..The system sensitivity was measured to be 93 dB by using the prototype probe with an illumination power of 450 microW on the sample. Moreover, the axial and the lateral resolutions of the probe are 9.3 and 10.3-12.5 microm, respectively... - Deep-tissue focal fluorescence imaging with digitally time-reversed ultrasound-encoded lightYing Min Wang
Bioengineering and Electrical Engineering, California Institute of Technology, 1200 E California Boulevard, Pasadena, California 91125, USA
Nat Commun 3:928. 2012..5 mm in biological tissues at a lateral resolution of 36 μm×52 μm and an axial resolution of 657 μm. Our results set the stage for a range of deep-tissue imaging applications in biomedical research and medical diagnostics... - Fluorescence microscopy imaging with a Fresnel zone plate array based optofluidic microscopeShuo Pang
Department of Electrical Engineering, California Institute of Technology, Pasadena, CA 91125, USA
Lab Chip 11:3698-702. 2011..0 μm due to Nyquist criterion consideration. As a demonstration, we show that such a system can be used to image the cell nuclei stained by Acridine Orange and cytoplasm labeled by Qtracker(®)... - Ex vivo optical coherence tomography imaging of collector channels with a scanning endoscopic probeJian Ren
Department of Electrical Engineering, California Institute of Technology, Pasadena, California 91125, USA
Invest Ophthalmol Vis Sci 52:3921-5. 2011..To achieve high-fidelity optical coherence tomography (OCT) imaging of ex vivo collector channels (CCs) exiting Schlemm's canal (SC) using a paired-angle rotating scanning endoscopic probe... - Polarization-resolved second-harmonic-generation optical coherence tomography in collagenBrian E Applegate
Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA
Opt Lett 29:2252-4. 2004..We demonstrate this new technique on a skin sample from the belly of Icelandic salmon, acquiring polarization-resolved SHOCT and OCT images simultaneously... - Fundamental sensitivity limit imposed by dark 1/f noise in the low optical signal detection regimeEmily J McDowell
Department of Bioengineering, Mail Code 136 93, California Institute of Technology, Pasadena, CA 91125, USA
Opt Express 16:6822-32. 2008.... - Surface-wave-enabled darkfield aperture for background suppression during weak signal detectionGuoan Zheng
Department of Electrical Engineering, California Institute of Technology, Pasadena, CA 91125, USA
Proc Natl Acad Sci U S A 107:9043-8. 2010.... - Optofluidic microscopy--a method for implementing a high resolution optical microscope on a chipXin Heng
Department of Electrical Engineering, California Institute of Technology, Pasadena, CA 91125, USA
Lab Chip 6:1274-6. 2006.... - An in vivo study of turbidity suppression by optical phase conjugation (TSOPC) on rabbit earMeng Cui
California Institute of Technology, Pasadena, CA 91125, USA
Opt Express 18:25-30. 2010..The experimental findings address the minimum speed limit of a broad range of optical time reversal experiments for in vivo applications on tissues... - Microscopy refocusing and dark-field imaging by using a simple LED arrayGuoan Zheng
Electrical Engineering, California Institute of Technology, Pasadena, California 91125, USA
Opt Lett 36:3987-9. 2011..Images of a starfish embryo were acquired by using such an approach for demonstration... - Fourier-domain low-coherence interferometry for light-scattering spectroscopyAdam Wax
Department of Biomedical Engineering and the Fitzpatrick Center for Photonics, Duke University, Durham, North Carolina 27708, USA
Opt Lett 28:1230-2. 2003..Application of the technique to probing the size of cell nuclei in living epithelial tissues is discussed... - Wavefront image sensor chipXiquan Cui
Department of Electrical Engineering, California Institute of Technology, Pasadena, CA 91125, USA
Opt Express 18:16685-701. 2010..Besides phase microscopy, WIS can benefit machine recognition, object ranging, and texture assessment for a variety of applications... - Developing optofluidic technology through the fusion of microfluidics and opticsDemetri Psaltis
Department of Electrical Engineering, California Institute of Technology, Pasadena, California 91125, USA
Nature 442:381-6. 2006..We categorize optofluidics according to three broad categories of interactions: fluid-solid interfaces, purely fluidic interfaces and colloidal suspensions. We describe examples of optofluidic devices in each category... - In situ detection of neoplastic transformation and chemopreventive effects in rat esophagus epithelium using angle-resolved low-coherence interferometryAdam Wax
Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA
Cancer Res 63:3556-9. 2003..This technique also may provide a new screening tool for intraepithelial neoplasia... - Cellular organization and substructure measured using angle-resolved low-coherence interferometryAdam Wax
G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge Massachusetts 02139, USA
Biophys J 82:2256-64. 2002..We also identify spatial correlations on a scale large compared with the size of a cell, indicating an overlying order within the monolayer... - Determination of particle size by using the angular distribution of backscattered light as measured with low-coherence interferometryAdam Wax
G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge 02139, USA
J Opt Soc Am A Opt Image Sci Vis 19:737-44. 2002..We also present various considerations for extending this technique to determining structural information in biological tissues, such as the effects of a distribution of particle sizes and the need to average out speckle contributions... - Harmonic phase-dispersion microscope with a Mach-Zehnder interferometerAndrew Ahn
G. R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Appl Opt 44:1188-90. 2005..We demonstrate quantitative phase-dispersion images of test structures and biological samples... - Images of spinal nerves and adjacent structures with optical coherence tomography: preliminary animal studiesDavid T Raphael
Keck School of Medicine, University of Southern California, Department of Anesthesiology, Los Angeles, California 90033, USA
J Pain 8:767-73. 2007..Advances in this technology may provide effective needle tip vision for pain interventionalists and may help to reduce complications from spine needle injection procedures...
Research Grants
- Spectral Triangulation Molecular Contrast OCTChanghuei Yang; Fiscal Year: 2005..abstract_text> ..
- Optofluidic MicroscopeChanghuei Yang; Fiscal Year: 2007..elegans phenotyping. With the completion of the proposed research, we expect the technology will be sufficiently refined to tackle a wide range of basic research and biomedicine challenges. ..