Paul A Wiggins

Summary

Affiliation: California Institute of Technology
Country: USA

Publications

  1. pmc Membrane-protein interactions in mechanosensitive channels
    Paul Wiggins
    Department of Physics, California Institute of Technology, Pasadena, California 91106, USA
    Biophys J 88:880-902. 2005
  2. pmc Exact theory of kinkable elastic polymers
    Paul A Wiggins
    Division of Physics, Mathematics, and Astronomy, California Institute of Technology, Pasadena, California 91125, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 71:021909. 2005
  3. ncbi request reprint Generalized theory of semiflexible polymers
    Paul A Wiggins
    Division of Physics, Mathematics, and Astronomy, California Institute of Technology, Pasadena, California 91125, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 73:031906. 2006
  4. pmc Analytic models for mechanotransduction: gating a mechanosensitive channel
    Paul Wiggins
    Division of Physics, Mathematics, and Astronomy, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125 9500, USA
    Proc Natl Acad Sci U S A 101:4071-6. 2004
  5. pmc Biological consequences of tightly bent DNA: the other life of a macromolecular celebrity
    Hernan G Garcia
    Department of Physics, California Institute of Technology, Pasadena, CA 91125, USA
    Biopolymers 85:115-30. 2007
  6. pmc Emerging roles for lipids in shaping membrane-protein function
    Rob Phillips
    Department of Applied Physics, California Institute of Technology, Pasadena, California 91125, USA
    Nature 459:379-85. 2009
  7. pmc Membrane shape as a reporter for applied forces
    Heun Jin Lee
    Department of Applied Physics, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 105:19253-7. 2008
  8. ncbi request reprint Measuring chromosome conformation with degenerate labels
    Brian C Ross
    Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 86:011918. 2012
  9. doi request reprint High flexibility of DNA on short length scales probed by atomic force microscopy
    Paul A Wiggins
    Whitehead Institute, Cambridge Massachusetts 02142, USA
    Nat Nanotechnol 1:137-41. 2006

Collaborators

Detail Information

Publications9

  1. pmc Membrane-protein interactions in mechanosensitive channels
    Paul Wiggins
    Department of Physics, California Institute of Technology, Pasadena, California 91106, USA
    Biophys J 88:880-902. 2005
    ..Finally, we compare the predictions of our model to experimental results from the recent investigations of the MscL channel by a variety of investigators and suggest a suite of new experiments...
  2. pmc Exact theory of kinkable elastic polymers
    Paul A Wiggins
    Division of Physics, Mathematics, and Astronomy, California Institute of Technology, Pasadena, California 91125, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 71:021909. 2005
    ....
  3. ncbi request reprint Generalized theory of semiflexible polymers
    Paul A Wiggins
    Division of Physics, Mathematics, and Astronomy, California Institute of Technology, Pasadena, California 91125, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 73:031906. 2006
    ..Finally, we discuss the applicability of these models to DNA chain statistics in the context of future experiments...
  4. pmc Analytic models for mechanotransduction: gating a mechanosensitive channel
    Paul Wiggins
    Division of Physics, Mathematics, and Astronomy, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125 9500, USA
    Proc Natl Acad Sci U S A 101:4071-6. 2004
    ....
  5. pmc Biological consequences of tightly bent DNA: the other life of a macromolecular celebrity
    Hernan G Garcia
    Department of Physics, California Institute of Technology, Pasadena, CA 91125, USA
    Biopolymers 85:115-30. 2007
    ..The aim of this review is to describe the physical forces associated with tightly bent DNA in all of these settings and to explore the biological consequences of such bending, as increasingly accessible by single-molecule techniques...
  6. pmc Emerging roles for lipids in shaping membrane-protein function
    Rob Phillips
    Department of Applied Physics, California Institute of Technology, Pasadena, California 91125, USA
    Nature 459:379-85. 2009
    ..The free-energy cost of such perturbations can be estimated quantitatively, and measurements of channel gating in model systems of membrane proteins with their lipid partners are now confirming predictions of simple models...
  7. pmc Membrane shape as a reporter for applied forces
    Heun Jin Lee
    Department of Applied Physics, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 105:19253-7. 2008
    ..To illustrate the potential power of this technique, we apply an axial force with optical tweezers to vesicles and explicitly demonstrate that the applied force is equal to the force computed from the membrane conformation...
  8. ncbi request reprint Measuring chromosome conformation with degenerate labels
    Brian C Ross
    Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 86:011918. 2012
    ..We evaluate our technique using simulated conformations with lengths ranging from 10 to 100 kilobases, and discuss the prospects for an experiment...
  9. doi request reprint High flexibility of DNA on short length scales probed by atomic force microscopy
    Paul A Wiggins
    Whitehead Institute, Cambridge Massachusetts 02142, USA
    Nat Nanotechnol 1:137-41. 2006
    ..We test our data and model with an interlocking set of consistency checks. Our analysis also shows how our model is compatible with previous experiments, which have sometimes been viewed as confirming the WLC...