Alan Trounson

Summary

Affiliation: California Environmental Protection Agency
Country: USA

Publications

  1. doi request reprint Pluripotent stem cells from cloned human embryos: success at long last
    Alan Trounson
    California Institute for Regenerative Medicine, 210 King Street, San Francisco, CA 94107, USA
    Cell Stem Cell 12:636-8. 2013
  2. pmc The Alpha Stem Cell Clinic: a model for evaluating and delivering stem cell-based therapies
    Alan Trounson
    California Institute for Regenerative Medicine CIRM, 210 King Street, San Francisco, California 94107, USA
    Stem Cells Transl Med 1:9-14. 2012
  3. doi request reprint Human disease modeling with induced pluripotent stem cells
    Alan Trounson
    California Institute for Regenerative Medicine, San Francisco, CA 94107, USA
    Curr Opin Genet Dev 22:509-16. 2012
  4. doi request reprint Stem cell biology: Towards the reality of cell therapeutics
    Alan Trounson
    California Institute for Regenerative Medicine, 210 King Street, San Francisco, California 94123, USA
    Nat Cell Biol 14:331. 2012
  5. ncbi request reprint Chimeric primates: embryonic stem cells need not apply
    Alan Trounson
    California Institute for Regenerative Medicine, 210 King Street, San Francisco, CA 94107, USA
    Cell 148:19-21. 2012
  6. pmc Reduced developmental competence of immature, in-vitro matured and postovulatory aged mouse oocytes following IVF and ICSI
    Orly Lacham-Kaplan
    Monash Immunology and Stem Cell Laboratories, Monash University, Clayton, Victoria, Australia
    Reprod Biol Endocrinol 6:58. 2008
  7. doi request reprint Stem cell research in California: the game is on
    Alan Trounson
    California Institute for Regenerative Medicine CIRM, San Francisco, CA 94107, USA
    Cell 132:522-4. 2008
  8. doi request reprint Integration and translation: driving stem cell therapies toward the clinic
    Alan Trounson
    California Institute for Regenerative Medicine CIRM, 210 King Street, 3rd Floor, San Francisco, CA 94107, USA
    Regen Med 3:269-73. 2008
  9. doi request reprint Rats, cats, and elephants, but still no unicorn: induced pluripotent stem cells from new species
    Alan Trounson
    California Institute for Regenerative Medicine, San Francisco, CA 94107, USA
    Cell Stem Cell 4:3-4. 2009
  10. pmc New perspectives in human stem cell therapeutic research
    Alan Trounson
    California Institute for Regenerative Medicine, 210 King Street, San Francisco, CA 94107, USA
    BMC Med 7:29. 2009

Collaborators

Detail Information

Publications34

  1. doi request reprint Pluripotent stem cells from cloned human embryos: success at long last
    Alan Trounson
    California Institute for Regenerative Medicine, 210 King Street, San Francisco, CA 94107, USA
    Cell Stem Cell 12:636-8. 2013
    ..Recently in Cell, Mitalipov and colleagues report an advance that has eluded scientists for over a decade-the successful derivation of embryonic stem cell lines using somatic cell nuclear transfer, or SCNT (Tachibana et al., 2013)...
  2. pmc The Alpha Stem Cell Clinic: a model for evaluating and delivering stem cell-based therapies
    Alan Trounson
    California Institute for Regenerative Medicine CIRM, 210 King Street, San Francisco, California 94107, USA
    Stem Cells Transl Med 1:9-14. 2012
    ....
  3. doi request reprint Human disease modeling with induced pluripotent stem cells
    Alan Trounson
    California Institute for Regenerative Medicine, San Francisco, CA 94107, USA
    Curr Opin Genet Dev 22:509-16. 2012
    ....
  4. doi request reprint Stem cell biology: Towards the reality of cell therapeutics
    Alan Trounson
    California Institute for Regenerative Medicine, 210 King Street, San Francisco, California 94123, USA
    Nat Cell Biol 14:331. 2012
    ..Five years into its mission, the California Institute of Regenerative Medicine is laying a foundation for this new form of medical treatment...
  5. ncbi request reprint Chimeric primates: embryonic stem cells need not apply
    Alan Trounson
    California Institute for Regenerative Medicine, 210 King Street, San Francisco, CA 94107, USA
    Cell 148:19-21. 2012
    ..Unlike mice, rhesus chimeras fail to form when embryonic stem cells are injected into blastocysts. Instead, chimera formation is achieved by aggregation of several four-cell embryos...
  6. pmc Reduced developmental competence of immature, in-vitro matured and postovulatory aged mouse oocytes following IVF and ICSI
    Orly Lacham-Kaplan
    Monash Immunology and Stem Cell Laboratories, Monash University, Clayton, Victoria, Australia
    Reprod Biol Endocrinol 6:58. 2008
    ....
  7. doi request reprint Stem cell research in California: the game is on
    Alan Trounson
    California Institute for Regenerative Medicine CIRM, San Francisco, CA 94107, USA
    Cell 132:522-4. 2008
    ..With funding starting to flow, the stem cell revolution is now underway...
  8. doi request reprint Integration and translation: driving stem cell therapies toward the clinic
    Alan Trounson
    California Institute for Regenerative Medicine CIRM, 210 King Street, 3rd Floor, San Francisco, CA 94107, USA
    Regen Med 3:269-73. 2008
  9. doi request reprint Rats, cats, and elephants, but still no unicorn: induced pluripotent stem cells from new species
    Alan Trounson
    California Institute for Regenerative Medicine, San Francisco, CA 94107, USA
    Cell Stem Cell 4:3-4. 2009
    ..2009; Li et al., 2009) derive rat induced pluripotent stem cells (iPSCs). In one report, the method used results in rat and human iPSCs that exhibit phenotypic traits similar to mouse embryonic stem cells...
  10. pmc New perspectives in human stem cell therapeutic research
    Alan Trounson
    California Institute for Regenerative Medicine, 210 King Street, San Francisco, CA 94107, USA
    BMC Med 7:29. 2009
    ..The active participation of governments, academia, biotechnology, pharmaceutical companies, and private investment is a powerful consortium for advances in health...
  11. doi request reprint Developing a case study model for successful translation of stem cell therapies
    Alan Trounson
    California Institute for Regenerative Medicine, San Francisco, CA 94107, USA
    Cell Stem Cell 6:513-6. 2010
    ..We describe a new approach by California to form global public-private "disease team" partnerships to enable new clinical opportunities to be evaluated in the complex regulatory environment...
  12. ncbi request reprint Organizational Profile: California Institute for Regenerative Medicine: the road ahead
    Alan Trounson
    California Institute for Regenerative Medicine, 210 King Street, San Francisco, CA 94107, USA
    Regen Med 6:285-90. 2011
    ....
  13. pmc Clinical trials for stem cell therapies
    Alan Trounson
    California Institute for Regenerative Medicine, 210 King Street, San Francisco, CA 9107, USA
    BMC Med 9:52. 2011
    ..At the same time, the first three trials using cells derived from pluripotent cells have begun...
  14. doi request reprint A critical time for stem cell research in Australia
    Alan Trounson
    Monash Immunology and Stem Cell Laboratories, Faculty of Medicine, Monash University, Clayton, Victoria, 3800, Australia
    Cell Stem Cell 2:118-22. 2008
    ..However, the inevitable "brain drain" and government and community expectations of quick commercial gains and rapid cures necessitate careful reconsideration of the identity and future of stem cell science in Australia...
  15. ncbi request reprint Q&A: King of the stem cells. Interviewed by Erika Check Hayden
    Alan Trounson
    Nature 449:385. 2007
  16. ncbi request reprint Derivation characteristics and perspectives for mammalian pluripotential stem cells
    Alan Trounson
    Monash Immunology and Stem Cell Laboratories, Monash University, Wellington Road, Clayton, Victoria 3800, Australia
    Reprod Fertil Dev 17:135-41. 2005
    ..There is considerable interest in the development of pluripotential stem cell lines in many mammalian species for similar research interests and applications...
  17. ncbi request reprint Keystone symposia - stem cells
    Alan Trounson
    National Stem Cell Centre and Monash Immunology and Stem Cell Laboratories, Monash University, Clayton, Victoria, Australia
    Expert Opin Biol Ther 4:749-52. 2004
    ..The formation of germ cells and their renewal and differentiation was also a major interest of the symposium...
  18. ncbi request reprint The production and directed differentiation of human embryonic stem cells
    Alan Trounson
    Monash Immunology and Stem Cell Laboratories, Monash University, and Australian Stem Cell Centre, Wellington Road, Clayton, Victoria 3800, Australia
    Endocr Rev 27:208-19. 2006
    ..The prospects for use of hESC derivatives in regenerative medicine are significant, and there is much optimism for their potential contributions to human regenerative medicine...
  19. ncbi request reprint Human embryonic stem cells: mother of all cell and tissue types
    Alan Trounson
    Institute of Reproduction and Development, Monash University, 27 31 Wright Street, Clayton, Victoria 3168, Australia
    Reprod Biomed Online 4:58-63. 2002
    ..For compatible transplantation, ES may need to be derived with a range of HLA types or by nuclear transplantation or stem cell fusion...
  20. ncbi request reprint Regulation of human embryonic stem cell differentiation by BMP-2 and its antagonist noggin
    Martin F Pera
    Monash Institute of Reproduction and Development, Monash University, 246 Clayton Road, Clayton, Victoria 3168, Australia
    J Cell Sci 117:1269-80. 2004
    ....
  21. ncbi request reprint A crime against humanity
    Alan Trounson
    Monash University, Melbourne, Australia
    New Sci 180:23. 2003
  22. ncbi request reprint The fine structure of human embryonic stem cells
    Henry Sathananthan
    Monash Institute of Reproduction and Development, Monash University, Melbourne, Australia
    Reprod Biomed Online 4:56-61. 2002
    ..Approximately 3-5% of all cells were mitotic, with typical bipolar spindles organized by centrosomes, pivotally located at the poles, and appeared to resemble typical somatic cells...
  23. ncbi request reprint Stem cells, plasticity and cancer - uncomfortable bed fellows
    Alan Trounson
    Monash Immunology and Stem Cell Laboratories, Faculty of Medicine, Monash University, Wellington Road, Clayton, Victoria, 3800, Australia
    Development 131:2763-8. 2004
    ..The recent Keystone Symposium in Colorado on stem cells, organised by Fiona Watt and Leonard Zon, brought together both leading and upcoming researchers in the field to explore stem cell biology and these issues...
  24. ncbi request reprint Alan Trounson, Scientific Director of Monash IVF, Australia
    Angela Pirisi
    Lancet 364:133. 2004
  25. ncbi request reprint A fluid means of stem cell generation
    Alan Trounson
    Nat Biotechnol 25:62-3. 2007
  26. ncbi request reprint Developments in infertility therapy--diagnosis of genetic disease in embryos
    Alan Trounson
    Monash IVF Pty Ltd, Victoria
    Aust Fam Physician 34:123-5. 2005
    ..The general practitioner plays a vital role in assisting couples through the difficult and emotional field of assisted reproductive techniques including in vitro fertilisation (IVF)...
  27. ncbi request reprint Testicular cell conditioned medium supports differentiation of embryonic stem cells into ovarian structures containing oocytes
    Orly Lacham-Kaplan
    Monash Immunology and Stem Cell Laboratories, Monash University, Wellington Rd, Clayton, Australia 3165
    Stem Cells 24:266-73. 2006
    ..The production of oocytes using this method is repeatable and reliable and may be applicable to other mammalian species, including the human...
  28. doi request reprint Tolerance strategies for stem-cell-based therapies
    Ann P Chidgey
    Monash Immunology and Stem Cell Laboratories, Building 75, STRIP, Monash University, Wellington Road, Clayton 3800, Victoria, Australia
    Nature 453:330-7. 2008
    ....
  29. ncbi request reprint Neural stem cells express non-neural markers during embryoid body coculture
    Mark Denham
    Centre for Reproduction and Development, Monash Institute of Medical Research, Clayton, Australia
    Stem Cells 24:918-27. 2006
    ..These results suggest that given an appropriate environment, NSC may lose their in vivo restrictions and display non-neuronal phenotypes...
  30. ncbi request reprint A role for neurotrophins in embryonic stem cell growth
    Alan Trounson
    Monash Immunology and Stem Cell Laboratories, Monash University, Building 75, Clayton, Victoria 3800, Australia
    Dev Cell 10:158-9. 2006
    ..In a recent paper in Nature Biotechnology, show that the presence of selected neurotrophins enables cloning of trypsinized single embryonic stem cells and potentially increases the availability and usefulness of these stem cells...
  31. ncbi request reprint Stem cells in biology, tissue engineering and medicine: the leading edge keeps moving
    Alan Trounson
    Curr Opin Biotechnol 18:432-3. 2007
  32. ncbi request reprint Spindle abnormalities in oocytes
    Alan Trounson
    Monash Immunology and Stem Cell Laboratories, Monash University, Clayton, Victoria, Australia
    Fertil Steril 85:838; discussion 841. 2006
    ..However, the immature oocytes recovered from patients with polycystic ovary syndrome might include a high proportion of oocytes from degenerating and atretic follicles that are not selected for maturation in vivo...
  33. ncbi request reprint Regenerative medicine. Australian scientist to head California stem cell effort
    Constance Holden
    Science 317:1667. 2007
  34. ncbi request reprint The genesis of embryonic stem cells
    Alan Trounson
    Institute of Reproduction and Development, Monash University, Melbourne, Australia
    Nat Biotechnol 20:237-8. 2002