P W Sternberg

Summary

Affiliation: California Institute of Technology
Country: USA

Publications

  1. ncbi request reprint Evolution of cell lineage
    P W Sternberg
    Howard Hughes Medical Institute, California Institute of Technology Biology, Pasadena 91125, USA
    Curr Opin Genet Dev 7:543-50. 1997
  2. ncbi request reprint Genetics of RAS signaling in C. elegans
    P W Sternberg
    Trends Genet 14:466-72. 1998
  3. ncbi request reprint The lin-11 LIM domain transcription factor is necessary for morphogenesis of C. elegans uterine cells
    A P Newman
    Howard Hughes Medical Institute, Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Development 126:5319-26. 1999
  4. ncbi request reprint The gene lin-3 encodes an inductive signal for vulval development in C. elegans
    R J Hill
    Howard Hughes Medical Institute, California Institute of Technology, Pasadena 91125
    Nature 358:470-6. 1992
  5. pmc The lin-15 locus encodes two negative regulators of Caenorhabditis elegans vulval development
    L S Huang
    Howard Hughes Medical Institute, Division of Biology, California Institute of Technology, Pasadena 91125
    Mol Biol Cell 5:395-411. 1994
  6. ncbi request reprint Inositol trisphosphate mediates a RAS-independent response to LET-23 receptor tyrosine kinase activation in C. elegans
    T R Clandinin
    Howard Hughes Medical Institute and Division of Biology, California Institute of Technology, Pasadena 91125, USA
    Cell 92:523-33. 1998
  7. pmc sli-1, a negative regulator of let-23-mediated signaling in C. elegans
    G D Jongeward
    Howard Hughes Medical Institute, California Institute of Technology, Pasadena 91125, USA
    Genetics 139:1553-66. 1995
  8. ncbi request reprint A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans
    M M Barr
    Howard Hughes Medical Institute and Division of Biology, California Institute of Technology, Pasadena 91125, USA
    Nature 401:386-9. 1999
  9. ncbi request reprint Regulation of distinct muscle behaviors controls the C. elegans male's copulatory spicules during mating
    L R Garcia
    Howard Hughes Medical Institute, Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Cell 107:777-88. 2001
  10. ncbi request reprint The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily
    R V Aroian
    Howard Hughes Medical Institute, Division of Biology, California Institute of Technology, Pasadena 91125
    Nature 348:693-9. 1990

Collaborators

  • M Han
  • M M Barr
  • R V Aroian
  • L R Garcia
  • T R Clandinin
  • A P Newman
  • P Mehta
  • G D Jongeward
  • G Z Acton
  • H R Horvitz
  • E Hartwieg
  • J A DeModena
  • L S Huang
  • H M Chamberlin
  • P Tzou
  • R J Hill

Detail Information

Publications11

  1. ncbi request reprint Evolution of cell lineage
    P W Sternberg
    Howard Hughes Medical Institute, California Institute of Technology Biology, Pasadena 91125, USA
    Curr Opin Genet Dev 7:543-50. 1997
    ..Stochastic specification of cell fate may evolve to a fixed cell lineage and specification by cell interactions to autonomous specification. Comparative developmental studies also shed light on the evolution of asymmetry...
  2. ncbi request reprint Genetics of RAS signaling in C. elegans
    P W Sternberg
    Trends Genet 14:466-72. 1998
    ..The stereotyped development of C. elegans has allowed many of the functions of RAS to be elucidated at the level of fates of individual cells...
  3. ncbi request reprint The lin-11 LIM domain transcription factor is necessary for morphogenesis of C. elegans uterine cells
    A P Newman
    Howard Hughes Medical Institute, Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Development 126:5319-26. 1999
    ..These findings indicate that lin-11 is essential for uterine-vulval morphogenesis...
  4. ncbi request reprint The gene lin-3 encodes an inductive signal for vulval development in C. elegans
    R J Hill
    Howard Hughes Medical Institute, California Institute of Technology, Pasadena 91125
    Nature 358:470-6. 1992
    ..Expression of lin-3 in the anchor cell stimulates vulval induction; lin-3 may encode the vulval inducing signal...
  5. pmc The lin-15 locus encodes two negative regulators of Caenorhabditis elegans vulval development
    L S Huang
    Howard Hughes Medical Institute, Division of Biology, California Institute of Technology, Pasadena 91125
    Mol Biol Cell 5:395-411. 1994
    ..We have identified a molecular null allele of lin-15 and have used it to analyze the role of lin-15 in the signaling pathway. We find that lin-15 acts upstream of let-23 and in parallel to the inductive signal...
  6. ncbi request reprint Inositol trisphosphate mediates a RAS-independent response to LET-23 receptor tyrosine kinase activation in C. elegans
    T R Clandinin
    Howard Hughes Medical Institute and Division of Biology, California Institute of Technology, Pasadena 91125, USA
    Cell 92:523-33. 1998
    ..Our results demonstrate that one mechanism by which receptor tyrosine kinases can evoke tissue-specific responses is through activation of distinct signal transduction cascades in different tissues...
  7. pmc sli-1, a negative regulator of let-23-mediated signaling in C. elegans
    G D Jongeward
    Howard Hughes Medical Institute, California Institute of Technology, Pasadena 91125, USA
    Genetics 139:1553-66. 1995
    ..Our analysis suggests that let-23 can activate distinct signaling pathways in different tissues: one pathway is required for vulval induction; another pathway is involved in hermaphrodite fertility and is not regulated by sli-1...
  8. ncbi request reprint A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans
    M M Barr
    Howard Hughes Medical Institute and Division of Biology, California Institute of Technology, Pasadena 91125, USA
    Nature 401:386-9. 1999
    ..PKD-2, the C. elegans homologue of PKD2, is localized to the same neurons as LOV-1, suggesting that they function in the same pathway...
  9. ncbi request reprint Regulation of distinct muscle behaviors controls the C. elegans male's copulatory spicules during mating
    L R Garcia
    Howard Hughes Medical Institute, Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Cell 107:777-88. 2001
    ..The male gonad then lengthens the duration of EGL-19-mediated prolonged muscle contraction. This regulation of muscle contraction provides a paradigm to explain how animals initiate, monitor, and maintain a behavioral motor program...
  10. ncbi request reprint The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily
    R V Aroian
    Howard Hughes Medical Institute, Division of Biology, California Institute of Technology, Pasadena 91125
    Nature 348:693-9. 1990
    ....
  11. ncbi request reprint The lin-3/let-23 pathway mediates inductive signalling during male spicule development in Caenorhabditis elegans
    H M Chamberlin
    Howard Hughes Medical Institute, California Institute of Technology, Pasadena 91125, USA
    Development 120:2713-21. 1994
    ..We have also investigated the role of lin-12 in forming the anterior/posterior pattern of fates. A lin-12 gain-of-function defect is masked by redundant positional information from F and U...