Gary M Shaw

Summary

Affiliation: California Birth Defects Monitoring Program
Country: USA

Publications

  1. pmc Association between CFL1 gene polymorphisms and spina bifida risk in a California population
    Huiping Zhu
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas 77030, USA
    BMC Med Genet 8:12. 2007
  2. pmc CHKA and PCYT1A gene polymorphisms, choline intake and spina bifida risk in a California population
    James O Ebot Enaw
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas 77030, USA
    BMC Med 4:36. 2006
  3. ncbi Maternal height and prepregnancy body mass index as risk factors for selected congenital anomalies
    G M Shaw
    March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Emeryville 94608, USA
    Paediatr Perinat Epidemiol 14:234-9. 2000
  4. ncbi Maternal occupational chemical exposures and biotransformation genotypes as risk factors for selected congenital anomalies
    Gary M Shaw
    March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Oakland, CA, USA
    Am J Epidemiol 157:475-84. 2003
  5. ncbi Strenuous work, nutrition and adverse pregnancy outcomes: a brief review
    Gary M Shaw
    March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Oakland, CA 94606, USA
    J Nutr 133:1718S-1721S. 2003
  6. ncbi Epidemiologic characteristics of anotia and microtia in California, 1989-1997
    Gary M Shaw
    March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Berkeley, California, USA
    Birth Defects Res A Clin Mol Teratol 70:472-5. 2004
  7. ncbi Food fortification with folic acid and twinning among California infants
    Gary M Shaw
    March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Oakland, California 94606, USA
    Am J Med Genet A 119:137-40. 2003
  8. ncbi Neural tube defects associated with maternal periconceptional dietary intake of simple sugars and glycemic index
    Gary M Shaw
    March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Berkeley, CA 94710, USA
    Am J Clin Nutr 78:972-8. 2003
  9. ncbi Periconceptional dietary intake of choline and betaine and neural tube defects in offspring
    Gary M Shaw
    March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Berkeley, CA 94710, USA
    Am J Epidemiol 160:102-9. 2004
  10. pmc Occurrence of low birthweight and preterm delivery among California infants before and after compulsory food fortification with folic acid
    Gary M Shaw
    March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Berkeley, CA, USA
    Public Health Rep 119:170-3. 2004

Research Grants

Detail Information

Publications96

  1. pmc Association between CFL1 gene polymorphisms and spina bifida risk in a California population
    Huiping Zhu
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas 77030, USA
    BMC Med Genet 8:12. 2007
    ..Such alterations may be associated with an increased risk for neural tube defects (NTDs)...
  2. pmc CHKA and PCYT1A gene polymorphisms, choline intake and spina bifida risk in a California population
    James O Ebot Enaw
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas 77030, USA
    BMC Med 4:36. 2006
    ..Choline is an essential nutrient and it is also a methyl donor critical for the maintenance of cell membrane integrity and methyl metabolism. Perturbations in choline metabolism in vitro have been shown to induce NTDs in mouse embryos...
  3. ncbi Maternal height and prepregnancy body mass index as risk factors for selected congenital anomalies
    G M Shaw
    March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Emeryville 94608, USA
    Paediatr Perinat Epidemiol 14:234-9. 2000
    ..Exploration of other data sets will be needed to determine whether similar patterns of NTD risk or lack of risk for other anomalies are associated with the two maternal anthropometric variables, height and prepregnant weight...
  4. ncbi Maternal occupational chemical exposures and biotransformation genotypes as risk factors for selected congenital anomalies
    Gary M Shaw
    March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Oakland, CA, USA
    Am J Epidemiol 157:475-84. 2003
    ..Although potential associations were observed, most results suggested that maternal occupational chemical exposures did not contribute substantially to the occurrence of these anomalies in this California population...
  5. ncbi Strenuous work, nutrition and adverse pregnancy outcomes: a brief review
    Gary M Shaw
    March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Oakland, CA 94606, USA
    J Nutr 133:1718S-1721S. 2003
    ..Effects on nutritional status, micronutrients in particular, of pregnant women from strenuous physical activities at work or in other lifestyle events require further study in developing countries...
  6. ncbi Epidemiologic characteristics of anotia and microtia in California, 1989-1997
    Gary M Shaw
    March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Berkeley, California, USA
    Birth Defects Res A Clin Mol Teratol 70:472-5. 2004
    ..There is a paucity of epidemiologic information about the external ear malformations anotia and microtia...
  7. ncbi Food fortification with folic acid and twinning among California infants
    Gary M Shaw
    March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Oakland, California 94606, USA
    Am J Med Genet A 119:137-40. 2003
    ..Our results do not suggest a change in twinning prevalence associated with folic acid fortification of the US food supply among women delivering in California...
  8. ncbi Neural tube defects associated with maternal periconceptional dietary intake of simple sugars and glycemic index
    Gary M Shaw
    March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Berkeley, CA 94710, USA
    Am J Clin Nutr 78:972-8. 2003
    ..The interdependence of these factors suggests a common pathogenesis via altered glycemic control and insulin demand...
  9. ncbi Periconceptional dietary intake of choline and betaine and neural tube defects in offspring
    Gary M Shaw
    March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Berkeley, CA 94710, USA
    Am J Epidemiol 160:102-9. 2004
    ..17 (95% confidence interval: 0.04, 0.76). Study findings for dietary components other than folic acid offer additional clues about the complex etiologies of NTDs...
  10. pmc Occurrence of low birthweight and preterm delivery among California infants before and after compulsory food fortification with folic acid
    Gary M Shaw
    March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Berkeley, CA, USA
    Public Health Rep 119:170-3. 2004
    ..S. The objective of this study was to investigate the frequencies of low birthweight and preterm delivery after mandatory folic acid fortification among approximately six million California births...
  11. ncbi Congenital malformations in births with orofacial clefts among 3.6 million California births, 1983-1997
    Gary M Shaw
    March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Oakland, California 94710, USA
    Am J Med Genet A 125:250-6. 2004
    ..These observed patterns tended to be similar for CP and for CLP...
  12. ncbi Genetic variation of infant reduced folate carrier (A80G) and risk of orofacial and conotruncal heart defects
    Gary M Shaw
    March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Oakland, CA, USA
    Am J Epidemiol 158:747-52. 2003
    ..Thus, this study found modest evidence for a gene-nutrient interaction between infant RFC1 genotype and periconceptional intake of vitamins on the risk of conotruncal defects...
  13. ncbi Trihalomethane exposures from municipal water supplies and selected congenital malformations
    Gary M Shaw
    March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Oakland, CA 94606, USA
    Epidemiology 14:191-9. 2003
    ....
  14. ncbi Differential risks to males and females for congenital malformations among 2.5 million California births, 1989-1997
    Gary M Shaw
    March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Berkeley, California 94710, USA
    Birth Defects Res A Clin Mol Teratol 67:953-8. 2003
    ..Although many studies have observed variations in the prevalence of specific malformations by sex, there is a lack of population-based data on potential malformation prevalence differences by sex at birth...
  15. ncbi Role of structural birth defects in preterm delivery
    G M Shaw
    March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Oakland 94606, USA
    Paediatr Perinat Epidemiol 15:106-9. 2001
    ..These data indicate that structural birth defects may contribute significantly to the proportion of infants who are delivered before 37 weeks gestation...
  16. ncbi Assessing combined chemical exposures as risk factors for neural tube defects
    G M Shaw
    March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Oakland, CA, USA
    Reprod Toxicol 15:631-5. 2001
    ....
  17. ncbi Maternal nutrient intakes and risk of orofacial clefts
    Gary M Shaw
    March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Berkeley, CA 94710, USA
    Epidemiology 17:285-91. 2006
    ..Information about nutritional factors as potential risks of orofacial clefts is limited...
  18. ncbi Risks of human conotruncal heart defects associated with 32 single nucleotide polymorphisms of selected cardiovascular disease-related genes
    Gary M Shaw
    March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Berkeley 94710, USA
    Am J Med Genet A 138:21-6. 2005
    ..In particular, NPPA appears to be a good candidate gene for conotruncal defects and warrants further investigation...
  19. ncbi Congenital malformations in offspring of Vietnamese women in California, 1985-97
    Gary M Shaw
    March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Oakland, California 94606, USA
    Teratology 65:121-4. 2002
    ..Little is known about reproductive outcome risks for Vietnamese women delivering infants and fetuses in the U.S...
  20. ncbi Infant C677T MTHFR polymorphism and severe mental retardation
    Gary M Shaw
    California Birth Defects Monitoring Program, Berkeley, California 94710, USA
    Birth Defects Res A Clin Mol Teratol 79:24-6. 2007
    ..We investigated whether infants with homozygous genotype TT of the MTHFR gene were at increased risk of severe mental retardation...
  21. ncbi Paternal occupational group and risk of offspring with neural tube defects
    Gary M Shaw
    March of Dimes Birth Defects Foundation, California Department of Health Services, California Birth Defects Monitoring Program, Oakland, CA 94606, USA
    Paediatr Perinat Epidemiol 16:328-33. 2002
    ..8 [0.5, 1.3]. These analyses generated potential clues regarding paternal occupational exposures as NTD risk factors. Risk variation observed by spina bifida phenotype is interesting and will need to be investigated further...
  22. ncbi Periconceptional dietary intake of myo-inositol and neural tube defects in offspring
    Gary M Shaw
    March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, 1917 Fifth St, Berkeley, CA 94710, USA
    Birth Defects Res A Clin Mol Teratol 73:184-7. 2005
    ..We investigated whether maternal periconceptional dietary intake of myo-inositol influenced NTD risk...
  23. ncbi Endothelial nitric oxide synthase (NOS3) genetic variants, maternal smoking, vitamin use, and risk of human orofacial clefts
    Gary M Shaw
    California Birth Defects Monitoring Program, March of Dimes Birth Defects Foundation, Berkeley, CA 94710, USA
    Am J Epidemiol 162:1207-14. 2005
    ..6, 95% CI: 2.1, 10.2; for 894T, OR = 4.4, 95% CI: 1.8, 10.7). No similar patterns were observed for risk of cleft palate...
  24. pmc 118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects
    Gary M Shaw
    Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, CA, USA
    BMC Med Genet 10:49. 2009
    ..Investigations into genetic variation that influences transport and metabolism of folate will help fill this data gap. We focused on 118 SNPs involved in folate transport and metabolism...
  25. ncbi Risk of limb deficiency defects associated with NAT1, NAT2, GSTT1, GSTM1, and NOS3 genetic variants, maternal smoking, and vitamin supplement intake
    Suzan L Carmichael
    March of Dimes Birth Defect Foundation California Department of Health Services, California Birth Defects Monitoring Program, Berkeley, California 94710, USA
    Am J Med Genet A 140:1915-22. 2006
    ..Further studies exploring genetic susceptibility and combined gene-environment effects with respect to limb development will be important to continued improvement of our understanding of the etiology of limb anomalies...
  26. ncbi Risks of human limb deficiency anomalies associated with 29 SNPs of genes involved in homocysteine metabolism, coagulation, cell-cell interactions, inflammatory response, and blood pressure regulation
    Suzan L Carmichael
    California Birth Defects Monitoring Program, March of Dimes Birth Defects Foundation, Berkeley, California 94710, USA
    Am J Med Genet A 140:2433-40. 2006
    ..These results suggest involvement of genetic variation of biologically relevant candidate genes, and gene-environment interaction, for some limb anomalies whose pathogenesis may be related to altered vascular tone or integrity...
  27. pmc Nested case-control study of one-carbon metabolites in mid-pregnancy and risks of cleft lip with and without cleft palate
    Gary M Shaw
    Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, 94305, USA
    Pediatr Res 66:501-6. 2009
    ..These data did not show meaningful differences between cases and controls for any other analytes...
  28. ncbi Selected gene polymorphisms and their interaction with maternal smoking, as risk factors for gastroschisis
    Claudine P Torfs
    Public Health Institute, Oakland, California, USA
    Birth Defects Res A Clin Mol Teratol 76:723-30. 2006
    ..Its etiology is unknown, but the prevailing hypothesis is that it results from a vascular accident at the time of involution of the right umbilical vein or of the development of the superior mesenteric artery...
  29. doi Periconceptional glycaemic load and intake of sugars and their association with neural tube defects in offspring
    Gary M Shaw
    March of Dimes, California Research Division, Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    Paediatr Perinat Epidemiol 22:514-9. 2008
    ..The reasons for current findings to be inconsistent with previous findings are unknown...
  30. ncbi Maternal periconceptional vitamin use, genetic variation of infant reduced folate carrier (A80G), and risk of spina bifida
    Gary M Shaw
    March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Oakland, California 94606, USA
    Am J Med Genet 108:1-6. 2002
    ....
  31. ncbi Maternal smoking, genetic variation of glutathione s-transferases, and risk for orofacial clefts
    Edward J Lammer
    Children s Hospital Oakland Research Institute, Oakland, CA, USA
    Epidemiology 16:698-701. 2005
    ..We investigated whether risk is greater among offspring who lack the genetic capacity to produce glutathione S-transferase enzymes relevant to detoxification of chemicals in cigarette smoke...
  32. ncbi Periconceptional multivitamin intake during early pregnancy, genetic variation of acetyl-N-transferase 1 (NAT1), and risk for orofacial clefts
    Edward J Lammer
    Children s Hospital Research Institute, Oakland, California 94609, USA
    Birth Defects Res A Clin Mol Teratol 70:846-52. 2004
    ....
  33. ncbi NTD prevalences in central California before and after folic acid fortification
    Brian H Chen
    March of Dimes Foundation, California Research Division, Oakland, California 94609, USA
    Birth Defects Res A Clin Mol Teratol 82:547-52. 2008
    ..This study examined whether the declining prefortification (1989-1996) NTD prevalences continued into the postfortification period (1998-2003) in selected California counties...
  34. ncbi Limb deficiency defects, MSX1, and exposure to tobacco smoke
    Suzan L Carmichael
    March of Dimes Birth Defect Foundation California Department of Health Services, California Birth Defects Monitoring Program, Oakland, California 94710, USA
    Am J Med Genet A 125:285-9. 2004
    ..This finding contrasts with results of a previous study, which provided initial evidence for such an interaction. Several important methodological differences may have contributed to the differences in findings between the two studies...
  35. ncbi Maternal reproductive and demographic characteristics as risk factors for hypospadias
    Suzan L Carmichael
    March of Dimes Birth Defect Foundation California Department of Health Services, California Birth Defects Monitoring Program, Berkeley, CA 94710, USA
    Paediatr Perinat Epidemiol 21:210-8. 2007
    ..Although the potential contribution of underlying maternal endocrine parameters to the current findings are unknown, the results do provide clues regarding hypospadias aetiology that merit further investigation...
  36. ncbi Hypospadias and maternal exposures to cigarette smoke
    Suzan L Carmichael
    March of Dimes Birth Defect Foundation California Department of Health Services, California Birth Defects Monitoring Program, Berkeley, CA 94710, USA
    Paediatr Perinat Epidemiol 19:406-12. 2005
    ..This analysis does not confirm a recent report suggesting that maternal smoking is associated with a reduced risk of having offspring with hypospadias...
  37. pmc Maternal corticosteroid use and hypospadias
    Suzan L Carmichael
    California Research Division, March of Dimes Foundation, Oakland, CA 94609, USA
    J Pediatr 155:39-44, 44.e1. 2009
    ..To explore whether women who reported corticosteroid use during pregnancy were more likely to deliver an infant with hypospadias than women who did not...
  38. pmc Periconceptional nutrient intakes and risks of neural tube defects in California
    Suzan L Carmichael
    California Research Division, March of Dimes Foundation, Oakland, California 94609 1673, USA
    Birth Defects Res A Clin Mol Teratol 88:670-8. 2010
    ....
  39. doi Mid-pregnancy cotinine and risks of orofacial clefts and neural tube defects
    Gary M Shaw
    March of Dimes California Research Division, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    J Pediatr 154:17-9. 2009
    ..We have correlated measurements of cotinine (a nicotine metabolite) in mid-pregnancy sera with clefts and NTDs...
  40. doi Choline and risk of neural tube defects in a folate-fortified population
    Gary M Shaw
    Stanford University School of Medicine, Stanford, California, USA
    Epidemiology 20:714-9. 2009
    ..Even so, NTDs continue to occur despite individual supplementation or population fortification with folic acid. We investigated other nutrients related to one-carbon metabolism that may affect NTD risk...
  41. ncbi Maternal smoking and the risk of orofacial clefts: Susceptibility with NAT1 and NAT2 polymorphisms
    Edward J Lammer
    Children s Hospital Research Institute, 5700 Martin Luther King, Jr Way, Oakland, CA 94609, USA
    Epidemiology 15:150-6. 2004
    ..We investigated whether polymorphic variants of fetal acetyl-N-transferases 1 (NAT1) and 2 (NAT2) interact with maternal cigarette smoking during early pregnancy to increase the risk of delivering an infant with an orofacial cleft...
  42. ncbi Socio-economic status and risk of conotruncal heart defects and orofacial clefts
    Suzan L Carmichael
    March of Dimes Birth Defects Foundation California Department of Health Services, California Birth Defects Monitoring Program, Oakland, CA 94710, USA
    Paediatr Perinat Epidemiol 17:264-71. 2003
    ..4 for dTGA, and ORs for all six measures were < 0.7 for TOF. ORs for clefts tended to be closer to 1. This study suggests that SES risks are birth defect specific...
  43. pmc Association between weight gain during pregnancy and neural tube defects and gastroschisis in offspring
    Wei Yang
    Department of Pediatrics, Stanford University, Stanford, California, USA
    Birth Defects Res A Clin Mol Teratol 94:1019-25. 2012
    ..The objective of this study was to investigate the association of maternal weight gain with neural tube defects (NTDs) and gastroschisis among offspring...
  44. pmc Environmental and genetic contributors to hypospadias: a review of the epidemiologic evidence
    Suzan L Carmichael
    Department of Pediatrics, Division of Neonatology, Stanford University School of Medicine, California, USA
    Birth Defects Res A Clin Mol Teratol 94:499-510. 2012
    ....
  45. ncbi Maternal periconceptional vitamins: interactions with selected factors and congenital anomalies?
    Gary M Shaw
    March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Oakland, California 94606, USA
    Epidemiology 13:625-30. 2002
    ..We hypothesized that effects of congenital anomalies associated with maternal fever, cigarette smoking or alcohol use would be modified by intake of vitamins...
  46. pmc Maternal stressful life events and risks of birth defects
    Suzan L Carmichael
    March of Dimes Birth Defect Foundation, California Department of Health Services, California Birth Defects Monitoring Program, Berkeley, CA, USA
    Epidemiology 18:356-61. 2007
    ..Several previous studies suggest that maternal stress may be associated with increased risk of certain birth defects. This study examined the association of maternal stressful life events with risks of several birth defects...
  47. ncbi Congenital malformations in offspring of Hispanic and African-American women in California, 1989-1997
    Suzan L Carmichael
    March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Berkeley, California 94710, USA
    Birth Defects Res A Clin Mol Teratol 70:382-8. 2004
    ..Little is known about risks of most specific birth defects among infants born to U.S.-born and foreign-born Hispanic or African-American women...
  48. doi Hypospadias and intake of nutrients related to one-carbon metabolism
    Suzan L Carmichael
    California Research Division, March of Dimes Foundation, Oakland, California, USA
    J Urol 181:315-21; discussion 321. 2009
    ....
  49. ncbi Maternal periconceptional alcohol consumption and risk for conotruncal heart defects
    Suzan L Carmichael
    March of Dimes Birth Defects Foundation California Department of Health Services, California Birth Defects Monitoring Program, Oakland, California, USA
    Birth Defects Res A Clin Mol Teratol 67:875-8. 2003
    ..e., 1 month before conception to 3 months after conception)...
  50. ncbi Maternal smoking during early pregnancy, GSTP1 and EPHX1 variants, and risk of isolated orofacial clefts
    Dorian Ramirez
    Department of Emergency Medicine, Harbor UCLA Medical Center, Torrance, and Children s Hospital and Research Center, Oakland, CA 94609, USA
    Cleft Palate Craniofac J 44:366-73. 2007
    ..To examine the interactions between four fetal xenobiotic metabolizing gene polymorphisms, maternal cigarette smoking, and risk for oral cleft defects...
  51. ncbi Nutrient pathways and neural tube defects: a semi-Bayesian hierarchical analysis
    Suzan L Carmichael
    California Research Division, March of Dimes Foundation, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Epidemiology 20:67-73. 2009
    ..The hierarchical approach produces more plausible, more stable estimates than the conventional approach, while adjusting for potential confounding by other nutrients...
  52. doi Considering the vascular hypothesis for the pathogenesis of small intestinal atresia: a case control study of genetic factors
    Tanya Gupta
    University of California San Diego School of Medicine, La Jolla, CA, USA
    Am J Med Genet A 161:702-10. 2013
    ..These results also identify genes meriting further exploration in SIA studies. Hence, this study makes an important contribution by exploring the long-held but not well-investigated vascular hypothesis...
  53. pmc A genetic signature of spina bifida risk from pathway-informed comprehensive gene-variant analysis
    Nicholas J Marini
    Department of Molecular and Cellular Biology, California Institute for Quantitative Biosciences, University of California, Berkeley, California, United States of America
    PLoS ONE 6:e28408. 2011
    ..Furthermore, the identification of ethnic-specific risk signatures for spina bifida resonated with epidemiological data suggesting that the underlying pathogenesis may differ between Hispanic and non-Hispanic groups...
  54. ncbi Craniosynostosis and maternal smoking
    Suzan L Carmichael
    March of Dimes Foundation, California Research Division, Oakland, California, USA
    Birth Defects Res A Clin Mol Teratol 82:78-85. 2008
    ..Several previous studies suggested increased risk of craniosynostosis among infants born to women who smoked...
  55. ncbi Nutrient intakes in women and risks of anophthalmia and microphthalmia in their offspring
    Gary M Shaw
    March of Dimes Birth Defects Foundation, California Research Division, Oakland, California, USA
    Birth Defects Res A Clin Mol Teratol 79:708-13. 2007
    ..In this population-based case-control study we investigated whether periconceptional intakes of supplemental folic acid, dietary folate, vitamin A, and several other nutrients were associated with these eye defects...
  56. ncbi Congenital malformations co-occurring with hypospadias in California, 1983-1997
    Wei Yang
    March of Dimes, California Research Division, Children s Hospital Oakland Research Institute, Oakland, California, USA
    Am J Med Genet A 143:2627-34. 2007
    ..Computations were extended to 4-digit level BPA codes. Almost all observed relative risks for malformations co-occurring with hypospadias overall and three subgroups were less than 1...
  57. ncbi Dieting behaviors and risk of neural tube defects
    Suzan L Carmichael
    March of Dimes Birth Defects Foundation California Department of Health Services, California Birth Defects Monitoring Program, Oakland, CA, USA
    Am J Epidemiol 158:1127-31. 2003
    ..7, 95% confidence interval: 0.7, 10.2). This study suggests that maternal dieting behaviors involving restricted food intake during the first trimester may be associated with increased NTD risk...
  58. ncbi Maternal corticosteroid use and orofacial clefts
    Suzan L Carmichael
    March of Dimes Foundation California Department of Health Services, California Birth Defects Monitoring Program, Berkeley, CA, USA
    Am J Obstet Gynecol 197:585.e1-7; discussion 683-4, e1-7. 2007
    ..The purpose of this study was to examine whether maternal corticosteroid use during pregnancy is associated with delivering an infant with an orofacial cleft...
  59. pmc Craniosynostosis and nutrient intake during pregnancy
    Suzan L Carmichael
    California Research Division, March of Dimes Foundation, Oakland, California, USA
    Birth Defects Res A Clin Mol Teratol 88:1032-9. 2010
    ..To examine the association of craniosynostosis with maternal intake of folic acid-containing supplements and dietary nutrients...
  60. pmc Prepregnant obesity and risks of selected birth defects in offspring
    Gary M Shaw
    March of Dimes, California Research Division, Children s Hospital Oakland Research Institute, Oakland, CA, USA
    Epidemiology 19:616-20. 2008
    ..We investigated the previously observed association between obesity and spina bifida and also possible associations between obesity and other birth defects...
  61. ncbi Social networks and risk of neural tube defects
    Suzan L Carmichael
    March of Dimes Birth Defects Foundation California Department of Health Services, California Birth Defects Monitoring Program, Oakland, CA 94606 5226, USA
    Eur J Epidemiol 18:129-33. 2003
    ..This study is the first to investigate the association between social networks and risk of NTDs. Stronger inferences await replication and extension of these results...
  62. ncbi Diet quality and risk of neural tube defects
    Suzan L Carmichael
    March of Dimes Birth Defects Foundation California Birth Defects Monitoring Program, Oakland 94606, USA
    Med Hypotheses 60:351-5. 2003
    ..Stratified analyses suggested that the effect may be restricted to certain groups of women who may be at greater nutritional risk (i.e., women who did not take vitamin supplements or regularly consume breakfast cereals before pregnancy)...
  63. doi Association of microtia with maternal obesity and periconceptional folic acid use
    Chen Ma
    California Research Division, March of Dimes Foundation, Children s Hospital Oakland Research Institute, 5700 Martin Luther King, Jr Way, Oakland, CA 94609, USA
    Am J Med Genet A 152:2756-61. 2010
    ..This analysis suggests that maternal periconceptional intake of folic-acid-containing supplements may provide protection from microtia for non-obese women...
  64. ncbi Risks of selected congenital malformations among offspring of mixed race-ethnicity
    Juan Yang
    March of Dimes Birth Defects Foundation, California Birth Defect Monitoring Program, Berkeley, CA 94710, USA
    Birth Defects Res A Clin Mol Teratol 70:820-4. 2004
    ..Little is known about the occurrence of specific congenital malformations among offspring of mixed race-ethnicity...
  65. ncbi Neural tube defects and maternal residential proximity to agricultural pesticide applications
    Rudolph P Rull
    Northern California Cancer Center, Berkeley, CA 94704 1204, USA
    Am J Epidemiol 163:743-53. 2006
    ..These results suggest that ambient exposure to certain categories of agricultural pesticides may increase the risk of NTDs...
  66. ncbi Epidemiologic characteristics of anophthalmia and bilateral microphthalmia among 2.5 million births in California, 1989-1997
    Gary M Shaw
    March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Berkeley, USA
    Am J Med Genet A 137:36-40. 2005
    ..These data show descriptive epidemiologic features of anophthalmia and bilateral microphthalmia...
  67. ncbi Screening for novel PAX3 polymorphisms and risks of spina bifida
    Wei Lu
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas 77030, and Children s Hospital Oakland Research Institute, CA, USA
    Birth Defects Res A Clin Mol Teratol 79:45-9. 2007
    ..Mutations in the murine homologue, pax3, are responsible for the phenotype of splotch mice, in which nullizygotes are 100% penetrant for NTDs...
  68. pmc Chromosomal abnormalities among children born with conotruncal cardiac defects
    Edward J Lammer
    Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    Birth Defects Res A Clin Mol Teratol 85:30-5. 2009
    ..This study describes the frequency of chromosome abnormalities and microdeletion of 22q11 associated among infants and fetuses delivered with conotruncal heart malformations...
  69. ncbi Risks for severe mental retardation occurring in isolation and with other developmental disabilities
    Laura L Jelliffe-Pawlowski
    March of Dimes Birth Defect Foundation, California Birth Defects Monitoring Program, Berkeley, USA
    Am J Med Genet A 136:152-7. 2005
    ..4, 95% CI 1.5, 7.9), Blacks compared to Whites (RR = 5.1, 95% CI 1.7, 15.5), and Asians compared to Whites (RR = 3.9, 95% CI 1.3, 12.0). Etiologic heterogeneity when SMR occurs with a PDD was suggested...
  70. ncbi Risk of mental retardation among children born with birth defects
    Laura L Jelliffe-Pawlowski
    California Birth Defects Monitoring Program, March of Dimes Birth Defects Foundation, Oakland, CA 94612, USA
    Arch Pediatr Adolesc Med 157:545-50. 2003
    ..A paucity of epidemiologic research exists concerning the co-occurrence of birth defects and mental retardation (MR). Study of this co-occurrence may yield important clues about the causes of both...
  71. ncbi Hypospadias in California: trends and descriptive epidemiology
    Suzan L Carmichael
    March of Dimes Birth Defect Foundation, California Birth Defects Monitoring Program, Oakland, California, USA
    Epidemiology 14:701-6. 2003
    ..We used actively ascertained, population-based data for which detailed clinical descriptions permitted careful phenotypic classifications...
  72. ncbi Timing of prenatal care initiation and risk of congenital malformations
    Suzan L Carmichael
    March of Dimes Birth Defect Foundation, California Birth Defects Monitoring Program, Oakland, California 94606, USA
    Teratology 66:326-30. 2002
    ..This study uses data from a large population-based registry to explore the association of timing of prenatal care initiation with risks of selected congenital malformation phenotypes...
  73. pmc Markers of acculturation and risk of NTDs among Hispanic women in California
    Suzan L Carmichael
    California Research Division, March of Dimes Foundation, Oakland, California 94609, USA
    Birth Defects Res A Clin Mol Teratol 82:755-62. 2008
    ..It also examines whether known NTD risk factors explain observed differences in risk among Hispanic women who are more and less acculturated...
  74. ncbi Physical activity and risk of neural tube defects
    Suzan L Carmichael
    March of Dimes Birth Defects Foundation California Department of Health Services, Oakland 94606 5226, USA
    Matern Child Health J 6:151-7. 2002
    ..Owing to its association with known risk factors for neural tube defects (NTDs) and its impact on physiologic processes relevant to fetal development, physical activity was identified as a potential risk factor for NTD-affected pregnancy...
  75. pmc Maternal food insecurity is associated with increased risk of certain birth defects
    Suzan L Carmichael
    March of Dimes Foundation, California Birth Defects Monitoring Program, Berkeley, CA 94710, USA
    J Nutr 137:2087-92. 2007
    ..e. 2), the corresponding OR was 1.16 (95% CI 0.96, 1.38). This study suggests that increased risks of certain birth defects may be included among the negative consequences of food insecurity...
  76. ncbi Population-based analysis of left- and right-sided diaphragmatic hernias demonstrates different frequencies of selected additional anomalies
    Anne M Slavotinek
    Department of Pediatrics, Division of Genetics, University of California, San Francisco, California, USA
    Am J Med Genet A 143:3127-36. 2007
    ..Birth defects monitoring programs can provide the interface for epidemiology and clinical genetics, which in this case, may generate hypotheses to establish the pathogenesis of CDH laterality. (c) 2007 Wiley-Liss, Inc...
  77. ncbi Epidemiologic characteristics of congenital diaphragmatic hernia among 2.5 million California births, 1989-1997
    Wei Yang
    March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Berkeley, California 94710, USA
    Birth Defects Res A Clin Mol Teratol 76:170-4. 2006
    ..The aims of the current report were to extend the literature on the descriptive epidemiology of CDH and to determine whether its mortality rate decreased in California during the study period...
  78. pmc Socioeconomic measures, orofacial clefts, and conotruncal heart defects in California
    Suzan L Carmichael
    California Research Division, March of Dimes Foundation, Oakland, California 94609, USA
    Birth Defects Res A Clin Mol Teratol 85:850-7. 2009
    ..To examine the association of multiple measures of socioeconomic status (SES) with risks of orofacial clefts and conotruncal heart defects...
  79. ncbi Does prenatal screening for 5,10-methylenetetrahydrofolate reductase (MTHFR) mutations in high-risk neural tube defect pregnancies make sense?
    Richard H Finnell
    Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, TX 77030, USA
    Genet Test 6:47-52. 2002
    ....
  80. pmc Phosphatidylethanolamine N-methyltransferase (PEMT) gene polymorphisms and risk of spina bifida
    Jing Zhang
    Am J Med Genet A 140:785-9. 2006
  81. ncbi Understanding the increased risk of neural tube defect-affected pregnancies among Mexico-born women in California: immigration and anthropometric factors
    Ellen M Velie
    Department of Epidemiology, Michigan State University, East Lansing 48824, USA
    Paediatr Perinat Epidemiol 20:219-30. 2006
    ..Findings indicate that recent Mexican immigrants have a sevenfold increased risk for NTDs. Maternal BMI and height contributed very little, and inadequate weight gain contributed modestly to the NTD risk disparity for Mexican immigrants...
  82. ncbi Ambient air pollution and risk of birth defects in Southern California
    Beate Ritz
    Department of Epidemiology, School of Public Health, University of California, Los Angeles, Los Angeles, CA 90095 1772, USA
    Am J Epidemiol 155:17-25. 2002
    ..Confirmation by further studies is needed...
  83. ncbi Integration of DNA sample collection into a multi-site birth defects case-control study
    Sonja A Rasmussen
    National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Teratology 66:177-84. 2002
    ....
  84. ncbi Evaluation of infant methylenetetrahydrofolate reductase genotype, maternal vitamin use, and risk of high versus low level spina bifida defects
    Kelly A Volcik
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas 77030 0330, USA
    Birth Defects Res A Clin Mol Teratol 67:154-7. 2003
    ..It has been hypothesized that maternal folic acid supplementation prevents NTDs by partially correcting reduced MTHFR activity associated with the variant form of the enzyme...
  85. ncbi Associations between polymorphisms within the thymidylate synthase gene and spina bifida
    Kelly A Volcik
    Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas 77030, USA
    Birth Defects Res A Clin Mol Teratol 67:924-8. 2003
    ..We investigated whether TS polymorphisms contribute to spina bifida (SB) risk, given that a reduction in the risk of SB has been linked to folate metabolism...
  86. ncbi Prepregnancy obesity as a risk factor for structural birth defects
    D Kim Waller
    School of Public Health, The University of Texas at Houston, Houston, TX 77030, USA
    Arch Pediatr Adolesc Med 161:745-50. 2007
    ..To describe the relation between maternal obesity, overweight and underweight status, and 16 categories of structural birth defects...
  87. pmc Genes encoding catalytic subunits of protein kinase A and risk of spina bifida
    Huiping Zhu
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas
    Birth Defects Res A Clin Mol Teratol 73:591-6. 2005
    ..We hypothesized that sequence variations in human genes encoding the catalytic subunits may alter the PKA activity and similarly increase the risk of spina bifida...
  88. pmc A known functional polymorphism (Ile120Val) of the human PCMT1 gene and risk of spina bifida
    Huiping Zhu
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, TX 77030, USA
    Mol Genet Metab 87:66-70. 2006
    ..6, 95% confidence interval: 0.4-0.9). Our results showed that the Ile120Val polymorphism of PCMT1 gene is a genetic modifier for the risk of spina bifida. Val/Val genotype was associated with a reduction in risk for spina bifida...
  89. ncbi Validation of self-reported proximity to agricultural crops in a case-control study of neural tube defects
    Rudolph P Rull
    Center for Health Policy Research, University of California, Los Angeles, CA 90024, USA
    J Expo Sci Environ Epidemiol 16:147-55. 2006
    ..These results suggest differential reporting between case and control mothers as well as an influence from maternal demographic characteristics on reporting accuracy...
  90. ncbi Is Sonic hedgehog (SHH) a candidate gene for spina bifida? A pilot study
    Huiping Zhu
    Institute of BioScience and Technology, Texas A and M University System Health Science Center, Houston, Texas 77030, USA
    Am J Med Genet A 117:87-8. 2003
  91. ncbi Genetic variation in the proto-oncogene SKI and risk for orofacial clefting
    Wei Lu
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, TX 77030, USA
    Mol Genet Metab 86:412-6. 2005
    ..To identify genetic variants within the SKI gene and investigate the potential association between SKI polymorphisms and risk for orofacial defects, we initially re-sequenced the gene...
  92. pmc Nicotinamide N-methyl transferase (NNMT) gene polymorphisms and risk for spina bifida
    Wei Lu
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University Health Science Center, Houston, Texas 77030, USA
    Birth Defects Res A Clin Mol Teratol 82:670-5. 2008
    ..The enzyme nicotinamide N-methyl transferase (NNMT) was identified in a genome-wide linkage scan as being an important regulator of homocysteine homeostasis in a Spanish population, making it an interesting candidate gene for NTDs...
  93. pmc Agenesis of the corpus callosum in California 1983-2003: a population-based study
    Hannah C Glass
    Department of Neurology, University of California, San Francisco, California 94143 0137, USA
    Am J Med Genet A 146:2495-500. 2008
    ....
  94. pmc Maternal periconceptional smoking and alcohol consumption and risk for select congenital anomalies
    Jagteshwar Grewal
    Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
    Birth Defects Res A Clin Mol Teratol 82:519-26. 2008
    ..e., 2 months before through 2 months after conception) and the risk of orofacial clefts, NTDs, and conotruncal heart defects in offspring...
  95. ncbi Risk factors for neural tube defects: associations between uncoupling protein 2 polymorphisms and spina bifida
    Kelly A Volcik
    Institute of BioScience and Technology, Texas A and M University System Health Science Center, Houston, Texas 77030 3303, USA
    Birth Defects Res A Clin Mol Teratol 67:158-61. 2003
    ....
  96. ncbi Are the betaine-homocysteine methyltransferase (BHMT and BHMT2) genes risk factors for spina bifida and orofacial clefts?
    Huiping Zhu
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas 77030, USA
    Am J Med Genet A 135:274-7. 2005
    ..The results of these experiments suggest that variants of the BHMT/BHMT2 genes in infants do not substantially contribute to the risk of spina bifida or orofacial clefts in our study population...

Research Grants1

  1. Gene and Nutrient Etiologies of Human Heart Defects
    Gary Shaw; Fiscal Year: 2007
    ..Because these defects result in substantial morbidity as well as high emotional and economic costs, further scientific understanding leading to possible prevention would greatly benefit society. ..